CN108815277A - A kind of Fish quality improving agent and its formulation method and application - Google Patents
A kind of Fish quality improving agent and its formulation method and application Download PDFInfo
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- CN108815277A CN108815277A CN201810889798.8A CN201810889798A CN108815277A CN 108815277 A CN108815277 A CN 108815277A CN 201810889798 A CN201810889798 A CN 201810889798A CN 108815277 A CN108815277 A CN 108815277A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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Abstract
The invention belongs to animal health fields, and in particular to a kind of Fish quality improving agent and its formulation method and application, problem to be solved are to improve fish body autoimmune ability；A kind of formula of Fish quality improving agent includes：18-47 parts of radix scutellariae, 27-58 parts of the coptis, 35-65 parts of Cortex Phellodendri, 50-75 parts of cape jasmine and 80-150 parts of Chinese gall；The formulation method of the Fish quality improving agent is：Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned, behind removal dis-medicinal part, impurity and mildew part, wind is carried out and washes, after weighing, dissection is crushed；Cape jasmine and two taste crude drug of Chinese gall are cleaned, behind removal dis-medicinal part, impurity and mildew part, wind is carried out and washes, after weighing, crush；Powder raw material is mixed uniform；The present invention can be used alone, and for preventing explosive hemorrhage, can be used with compatibility curative drug, for treating bacterium or viral explosive hemorrhage.
Description
Technical field
The invention belongs to animal health fields, and in particular to a kind of Fish quality improving agent and its formulation method and application.
Background technique
" blood " be it is a kind of operation in the blood vessel, being rich in nutrition red liquid.Traditional medicine often by " gas " and " blood " and claims,
One of the important sources for thinking blood are exactly the essence of water and grain of the transporting in taste.Taste play most important in the generation of blood
Effect, thus have the saying of the source of qi and blood metaplasia " taste be ".If blood is insufficient, virtual loss is too many, will " deficiency of blood ".Gas has member
Gas, ying-qi say occur Qi dysfunction in blood control situation if the deficiency of vital energy.
It can then be gone out due to the explosive bleeding of qi-blood deficiency appearance, referred to as burst for the aquatic livestocks such as fish
Blood disease.Explosive hemorrhage is also known as bacillary hemorrhage, Ascites Disease, hemorrhagic ascites disease and hemorrhage, harm weight, prevalence
Extensively, burst is by force, the period is long, it is more to bring disaster to fish species, infection is fast, from falling ill to death only 3-5 days, will cause in a short time a large amount of
Fish is dead, or even total crop failure, is more serious one of the disease of pond culture.
Summary of the invention
In order to improve fish constitution, burst bleeding caused by avoiding as having a delicate constitution, being qi-blood deficiency, the present invention
Provide a kind of Fish quality improving agent and its formulation method and application.
The technical solution adopted by the present invention is：A kind of Fish quality improving agent, including following raw material：18-47 parts of radix scutellariae, Huang
Even 27-58 parts, 35-65 parts of Cortex Phellodendri, 50-75 parts of cape jasmine and 80-150 parts of Chinese gall.
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 3-5 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in one or more of radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine and Chinese Gall raw material, is stirred
Mixing frame revolving speed is 20 revs/min, stirs 15 minutes, pours out；
（4）Two-dimensional mixing machine is added in remainder raw material again, puddle support revolving speed is 20 revs/min, and mixing time is 15 minutes,
It pours out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
Compared with the prior art, the invention has the beneficial effects that：
（One）The raw material that the present invention uses has radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine and Chinese gall.Wherein radix scutellariae has heat-clearing and damp-drying drug, rushes down
Fiery detoxicating functions are mainly used in deficiency of vial QI caused by the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, carbuncle swells furuncle sore etc.
Disease is monarch drug in a prescription.The coptis has effects that heat-clearing and damp-drying drug, purging fire for removing toxin, for damp-heat dysentery, jaundice, heart-fire hyperactivity, dysphoria and insomnia,
Blood-head tells nosebleed controls eczema and wet sore outside.It is Cortex Phellodendri its bitter, cold in nature, have effects that clearing heat and detoxicating, purging intense heat eliminating dampness, it is main to use
The fires of deficiency type disease such as the dysentery, chordapsus of the incoordination between the spleen and the stomach appearance caused by deficiency of vial QI, acute icteric hepatitis plays association with radix scutellariae
Same-action.Cape jasmine belongs to first dual-purpose of drug and food resource of Ministry of Public Health's promulgation, has protect liver, cholagogue, decompression, calmness, stops blooding, disappears
The effects of swollen, for assisting radix scutellariae to play heat-clearing and damp-drying drug.Its is sour for Chinese gall, puckery, cold in nature, has puckery intestines, hemostasis, removing toxic substances function
Effect, has apparent relaxation effect to various bleedings, carbuncle swells boil.
（Two）Fish are vertebrates ancient in the world, there is the affiliation of species with the mankind, except breathing uses the gill
Outside, have and multiple histoorgans such as the substantially similar heart of the mankind, liver, kidney, stomach, large intestine.The selection of this formula is with traditional Chinese medicine
Theory is guidance, according to fish own characteristic, by System of Chinese medicine apply to Fish quality guarantee it is strong in.The burst of fish goes out
There is explosive bleeding and answers purging fire for removing toxin caused by fire toxin is full of the heart, liver, stomach, large intestine in blood.Above-mentioned Fish quality improving agent
The especially kind purge the sthenic heart-fire of the middle coptis and stomach fire, are primary crude drug, are equipped with radix scutellariae purge the green, Cortex Phellodendri rushes down the fire of large intestine, using Cape jasmine
Son is priming, and the fire of the heart, liver, stomach, large intestine is exported, per anum discharge.Chinese gall property acid, Bearberry Extract effect, fish are because of excess fire
After excess fire removing, bleeding is reduced for caused blood-heat bleeding, and each histoorgan restores normal immunological regulatory function, then adopts
It is restrained, can be stopped blooding with acid Chinese gall, reach the health-care effect for inhibiting the bleeding of fish body burst.
（Three）By quality and stability experimental study, Fish quality improving agent prepared by the present invention at 40 ± 2 DEG C of temperature,
After placing 6 months under the conditions of relative humidity 75 ± 5%, every quality detecting index is without significant changes.It is very good to illustrate that said preparation has
Quality stability.Therefore Fish quality improving agent prepared by the present invention has good safety in clinical application, is more suitable for
It is used as pre-mixing agent.
（Four）It is tested and is measured by angle of repose, the angle of repose of Fish quality improving agent prepared by the present invention is less than 35 degree, table
Its bright mobility is very good, can meet the need for liquidity in production process, it can be ensured that the stability of loading amount can satisfy production
Demand.
（Five）Fish quality improving agent prepared by the present invention can be used alone, and generate collaboration after being absorbed by fish in vivo
Effect, heat-clearing and damp-drying drug, strengthening the spleen and stomach, tonifying Qi and cooling blood and hemostasis can also be used with the other curative drugs of compatibility, thin for treating
Bacterium, viral explosive hemorrhage, other medicines used can be selected：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Water
It produces and uses）, Enrofloxacin（Aquatic products is used）Or erythromycin（Aquatic products is used）.
（Six）Fish quality improving agent powder prepared by the present invention can be fabricated to granular formulations, liquid preparation.
Specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 18g, coptis 27g, Cortex Phellodendri 35g, cape jasmine 50g and Chinese gall
80g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 3 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, the coptis and phellodendron powder raw material, puddle support revolving speed is 20 revs/min, stirs 15 points
Clock pours out；
（4）Two-dimensional mixing machine is added in cape jasmine and gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, mixing time
It is 15 minutes, pours out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
Embodiment 2
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 25g, coptis 30g, Cortex Phellodendri 40g, cape jasmine 55g and Chinese gall
90g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 3 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, the coptis and phellodendron powder raw material, puddle support revolving speed is 20 revs/min, stirs 15 points
Clock pours out；
（4）Two-dimensional mixing machine is added in cape jasmine and gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, mixing time
It is 15 minutes, pours out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
Embodiment 3
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 30g, coptis 37g, Cortex Phellodendri 45g, cape jasmine 60g and Chinese gall
100g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 3 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, the coptis and phellodendron powder raw material, puddle support revolving speed is 20 revs/min, stirs 15 points
Clock pours out；
（4）Two-dimensional mixing machine is added in cape jasmine and gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, mixing time
It is 15 minutes, pours out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
According to Chinese veterinary pharmacopoeia relevant regulations, accelerated test is carried out to Fish quality improving agent of the invention, respectively
Example 1,2 and 3 samples are appropriate, after being placed 6 months under the conditions of 40 ± 2 DEG C of temperature, relative humidity 75 ± 5%, respectively at
0.1.2.3.6 a the end of month is separately sampled, and to sample property, loss on drying equistability inspection target is measured and records, tool
Volume data see the table below：
Pass through quality and stability experimental study, the results showed that：Fish quality improving agent of the present invention is in temperature 40 ± 2
DEG C, after placing 6 months under the conditions of relative humidity 75 ± 5%, every quality detecting index is without significant changes.It is non-to illustrate that said preparation has
Often good quality stability.Therefore Fish quality improving agent of the present invention has good safety in clinical application.
Angle of repose is the most short-cut method for examining powder fluidity quality, and angle of repose is smaller, illustrates that frictional force is smaller, is flowed
Property is better.This test measures the modifying agent angle of repose of embodiment using injection method.Sample is poured into funnel, makes it lightly,
Disc centre is fallen into evenly, forms a cone.Stop adding when material is freely fallen along disk border from powder bevel edge
Material measures angle of repose with protractor.Measurement result see the table below：
| Sample ID | Appearance | Angle of repose |
| Embodiment 1 | Chocolate brown powder | 28.3 |
| Embodiment 2 | Chocolate brown powder | 30.2 |
| Embodiment 3 | Chocolate brown powder | 31.3 |
The particle angle of repose of above-mentioned Fish quality improving agent shows mobility very less than 35 degree it can be seen from upper table result
It is good, the need for liquidity in production process can be met, it can be ensured that the stability of loading amount can satisfy production requirement.
Above-mentioned Fish quality improving agent can be with compatibility other medicines for treating bacterium, viral burst hemorrhage, institute
Stating other medicines includes：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Aquatic products is used）, Enrofloxacin（Aquatic products is used）Erythromycin
（Aquatic products is used）.
Above-mentioned Fish quality improving agent powder can be fabricated to granular formulations, liquid preparation.
Embodiment 4
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 35g, coptis 45g, Cortex Phellodendri 50g, cape jasmine 65g and Chinese gall
120g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 3.5 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, the coptis, Cortex Phellodendri and Cape Jasmine Fruit raw material, puddle support revolving speed is 20 revs/min, is stirred
It mixes 15 minutes, pours out；
（4）Two-dimensional mixing machine is added in gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, and mixing time is 15 points
Clock pours out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
By quality and stability experimental study, Fish quality improving agent prepared by the present invention is at 40 ± 2 DEG C of temperature, relatively
After placing 6 months under the conditions of humidity 75 ± 5%, every quality detecting index is without significant changes.Illustrate that said preparation has extraordinary matter
Measure stability.Therefore Fish quality improving agent prepared by the present invention have good safety in clinical application, be more suitable for as
Pre-mixing agent uses.
It is tested and is measured by angle of repose, the angle of repose of Fish quality improving agent prepared by the present invention is 30.5 degree（Less than 35
Degree）, show that its mobility is very good, the need for liquidity in production process can be met, it can be ensured that the stability of loading amount, Neng Gouman
Sufficient production requirement.
Above-mentioned Fish quality improving agent can be with compatibility other medicines for treating bacterium, viral burst hemorrhage, institute
Stating other medicines includes：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Aquatic products is used）, Enrofloxacin（Aquatic products is used）Erythromycin
（Aquatic products is used）.
Above-mentioned Fish quality improving agent powder can be fabricated to granular formulations, liquid preparation.
Embodiment 5
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 40g, coptis 52g, Cortex Phellodendri 60g, cape jasmine 67g and Chinese gall
140g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 4 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, Golden Thread raw material, puddle support revolving speed is 20 revs/min, stirs 15 minutes, inclines
Out；
（4）Two-dimensional mixing machine is added in Cortex Phellodendri, cape jasmine and gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, stirring
Time is 15 minutes, is poured out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
By quality and stability experimental study, Fish quality improving agent prepared by the present invention is at 40 ± 2 DEG C of temperature, relatively
After placing 6 months under the conditions of humidity 75 ± 5%, every quality detecting index is without significant changes.Illustrate that said preparation has extraordinary matter
Measure stability.Therefore Fish quality improving agent prepared by the present invention have good safety in clinical application, be more suitable for as
Pre-mixing agent uses.
It is tested and is measured by angle of repose, the angle of repose of Fish quality improving agent prepared by the present invention is 31.1 degree（Less than 35
Degree）, show that its mobility is very good, the need for liquidity in production process can be met, it can be ensured that the stability of loading amount, Neng Gouman
Sufficient production requirement.
Above-mentioned Fish quality improving agent can be with compatibility other medicines for treating bacterium, viral burst hemorrhage, institute
Stating other medicines includes：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Aquatic products is used）, Enrofloxacin（Aquatic products is used）Erythromycin
（Aquatic products is used）.
Above-mentioned Fish quality improving agent powder can be fabricated to granular formulations, liquid preparation.
Embodiment 6
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 47g, coptis 58g, Cortex Phellodendri 65g, cape jasmine 70g and Chinese gall
150g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 4.5 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, Golden Thread raw material, puddle support revolving speed is 20 revs/min, stirs 15 minutes, inclines
Out；
（4）Two-dimensional mixing machine is added in Cortex Phellodendri, cape jasmine and gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, stirring
Time is 15 minutes, is poured out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
By quality and stability experimental study, Fish quality improving agent prepared by the present invention is at 40 ± 2 DEG C of temperature, relatively
After placing 6 months under the conditions of humidity 75 ± 5%, every quality detecting index is without significant changes.Illustrate that said preparation has extraordinary matter
Measure stability.Therefore Fish quality improving agent prepared by the present invention have good safety in clinical application, be more suitable for as
Pre-mixing agent uses.
It is tested and is measured by angle of repose, the angle of repose of Fish quality improving agent prepared by the present invention is 29.6 degree（Less than 35
Degree）, show that its mobility is very good, the need for liquidity in production process can be met, it can be ensured that the stability of loading amount, Neng Gouman
Sufficient production requirement.
Above-mentioned Fish quality improving agent can be with compatibility other medicines for treating bacterium, viral burst hemorrhage, institute
Stating other medicines includes：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Aquatic products is used）, Enrofloxacin（Aquatic products is used）Erythromycin
（Aquatic products is used）.
Above-mentioned Fish quality improving agent powder can be fabricated to granular formulations, liquid preparation.
Embodiment 7
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 30g, coptis 50g, Cortex Phellodendri 35g, cape jasmine 60g and Chinese gall
175g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 5 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae, the coptis, Cortex Phellodendri, Cape Jasmine Fruit raw material, puddle support revolving speed is 20 revs/min, stirring
It 15 minutes, pours out；
（4）Two-dimensional mixing machine is added in gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, and mixing time is 15 points
Clock pours out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
By quality and stability experimental study, Fish quality improving agent prepared by the present invention is at 40 ± 2 DEG C of temperature, relatively
After placing 6 months under the conditions of humidity 75 ± 5%, every quality detecting index is without significant changes.Illustrate that said preparation has extraordinary matter
Measure stability.Therefore Fish quality improving agent prepared by the present invention have good safety in clinical application, be more suitable for as
Pre-mixing agent uses.
It is tested and is measured by angle of repose, the angle of repose of Fish quality improving agent prepared by the present invention is 30.7 degree（Less than 35
Degree）, show that its mobility is very good, the need for liquidity in production process can be met, it can be ensured that the stability of loading amount, Neng Gouman
Sufficient production requirement.
Above-mentioned Fish quality improving agent can be with compatibility other medicines for treating bacterium, viral burst hemorrhage, institute
Stating other medicines includes：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Aquatic products is used）, Enrofloxacin（Aquatic products is used）Erythromycin
（Aquatic products is used）.
Above-mentioned Fish quality improving agent powder can be fabricated to granular formulations, liquid preparation.
Embodiment 8
A kind of Fish quality improving agent, including following raw material：Radix scutellariae 43g, coptis 47g, Cortex Phellodendri 30g, cape jasmine 57g and Chinese gall
110g。
A kind of Fish quality improving agent formulation method, includes the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned in manual operation platform, removal dis-medicinal part, impurity and mould
After becoming part, carries out wind and wash, after weighing, using medicine cutter dissection to 3.5 centimetres, with Universalpulverizer powder to 80 mesh；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned in manual operation platform, removal dis-medicinal part, impurity and mildew portion
After point, carries out wind and wash, after weighing, with Universalpulverizer powder to 80 mesh；
（3）Two-dimensional mixing machine is added in radix scutellariae and Golden Thread raw material, puddle support revolving speed is 20 revs/min, stirs 15 minutes, inclines
Out；
（4）Two-dimensional mixing machine is added in Cortex Phellodendri, cape jasmine and gallnut extract powder stock again, puddle support revolving speed is 20 revs/min, stirring
Time is 15 minutes, is poured out；
（5）Two-dimensional mixing machine is added in above-mentioned steps 3 and step 4 component, puddle support revolving speed is 20 revs/min, and mixing time is
15 minutes, as uniformly mixed powdered finished product.
By quality and stability experimental study, Fish quality improving agent prepared by the present invention is at 40 ± 2 DEG C of temperature, relatively
After placing 6 months under the conditions of humidity 75 ± 5%, every quality detecting index is without significant changes.Illustrate that said preparation has extraordinary matter
Measure stability.Therefore Fish quality improving agent prepared by the present invention have good safety in clinical application, be more suitable for as
Pre-mixing agent uses.
It is tested and is measured by angle of repose, the angle of repose of Fish quality improving agent prepared by the present invention is 31.4 degree（Less than 35
Degree）, show that its mobility is very good, the need for liquidity in production process can be met, it can be ensured that the stability of loading amount, Neng Gouman
Sufficient production requirement.
Above-mentioned Fish quality improving agent can be with compatibility other medicines for treating bacterium, viral burst hemorrhage, institute
Stating other medicines includes：Florfenicol powder（Aquatic products is used）, Doxycycline Hyclate（Aquatic products is used）, Enrofloxacin（Aquatic products is used）Erythromycin
（Aquatic products is used）.
Above-mentioned Fish quality improving agent powder can be fabricated to granular formulations, liquid preparation.
Above embodiment is merely exemplary to illustrate the principle of the present invention and its effect, and is not intended to limit the present invention.For
Person skilled in the art all without departing from the spirit and scope of the present invention, modifies above-described embodiment or is improved.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by tool usually intellectual in all act technical fields
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (8)
1. a kind of Fish quality improving agent, which is characterized in that raw materials used according to following weight：18-47 parts of radix scutellariae, Huang
Even 27-58 parts, 35-65 parts of Cortex Phellodendri, 50-75 parts of cape jasmine, 80-150 parts of Chinese gall.
2. a kind of Fish quality improving agent formulation method according to claim 1, which is characterized in that include the following steps：
（1）Radix scutellariae, the coptis and three taste crude drug of Cortex Phellodendri are cleaned, behind removal dis-medicinal part, impurity and mildew part, carried out
Wind is washed, and after weighing, dissection is crushed；
（2）Cape jasmine and two taste crude drug of Chinese gall are cleaned, behind removal dis-medicinal part, impurity and mildew part, carry out wind
It washes, after weighing, crushes；
（3）Above-mentioned powder raw material is uniformly mixed.
3. a kind of Fish quality improving agent formulation method according to claim 3, which is characterized in that the step（3）In
The mixed method of powder raw material is as follows：
Two-dimensional mixing machine, stirring is added in one or more of radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine and Chinese Gall raw material
It is poured out after uniformly；Two-dimensional mixing machine is added in remainder raw material again, is poured out after being uniformly mixed；It finally will be above two mixed
It is combined point an addition two-dimensional mixing machine mixing, as uniformly mixed powdered finished product.
4. a kind of Fish quality improving agent formulation method according to claim 2 or 3, which is characterized in that the step（3）
Used in two-dimensional mixing machine puddle support revolving speed be 20 revs/min, mixing time be 15 minutes.
5. a kind of Fish quality improving agent formulation method according to claim 2 or 3, which is characterized in that the step（1）
It is middle using medicine cutter by raw material dissection to 3-5 centimetres, with Universalpulverizer by raw material powder to 80 mesh.
6. a kind of Fish quality improving agent formulation method according to claim 2 or 3, which is characterized in that the step（2）
It is middle to use Universalpulverizer by raw material powder to 80 mesh.
7. Fish quality improving agent described in claim 1 is fabricateing into explosive bleeding with qi and blood two due to having a delicate constitution
Using.
8. a kind of system for being used to treat bacterium or viral explosive hemorrhage comprising Fish quality improving agent described in claim 1
Agent, which is characterized in that further include one of florfenicol powder, Doxycycline Hyclate, Enrofloxacin or erythromycin.
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| CN113616698A (en) * | 2021-09-06 | 2021-11-09 | 广东海洋大学 | Pharmaceutical composition for preventing and treating vibriosis of Babylonia areolata as well as preparation method and application of pharmaceutical composition |
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| CN113616698A (en) * | 2021-09-06 | 2021-11-09 | 广东海洋大学 | Pharmaceutical composition for preventing and treating vibriosis of Babylonia areolata as well as preparation method and application of pharmaceutical composition |
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Application publication date: 20181116 |