CN108813588A - A kind of the auxotype health care product and preparation method of pre- preventing bone rarefaction - Google Patents
A kind of the auxotype health care product and preparation method of pre- preventing bone rarefaction Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to field of health care products, disclose the auxotype health care product and preparation method of a kind of pre- preventing bone rarefaction.Including following preparation process：（1）Egg-shell meal is impregnated in spirit of vinegar, activation egg-shell meal is obtained after dry；（2）With aerosil, alginic acid glue assisted milling, activation egg-shell meal is ground to nanoscale in sand mill, obtains nanometer activation egg-shell meal；（3）Egg-shell meal is activated with nanometer after radix cyathulae, red clover, bone meal, fennel seeds are ground and collagen, chondroitin sulfate mix, and the auxotype health care product after bonding auxiliary material to get pre- preventing bone rarefaction is added.Health care product produced by the present invention has significant bioactivity, and the slow release calcium after taking is easy to be absorbed, and can be effectively improved and prevent middle-aged and the old's osteoporosis, reach the healthcare function for increasing middle-aged and the old's bone density.
Description
Technical field
The present invention relates to field of health care products, disclose the auxotype health care product and preparation method of a kind of pre- preventing bone rarefaction.
Background technique
Osteoporosis be it is a kind of main feature is reduced to bone amount, the microstructure of bone tissue changes, and crisp with sclerotin
Property increase and the raised systemic skeletal disease of risk of fractures degree.That is when osteoporosis, bone amount reduction is bone mineral
（Calcium, phosphorus etc.）And bone matrix（Ossein, protein, inorganic salts etc.）The reduction of ratio is examined by line transfer and Trabecular area
The variation for looking into discovery bone loss shows as bone density reduction, the one kind that may be fractured under slight external force
Disease.
Generate osteoporosis the reason of be it is various, osteoporosis and sclerotin reduction have a variety of pathogenic factors, wherein
Including heredity, life style, nutrition condition, disease and drug etc..Osteoporosis can be divided into high conversion hysteria bone according to bone conversion
Matter is loose or low conversion hysteria osteoporosis, can be divided into primary or secondary osteoporosis by Pathogeny types.
About treatment osteoporosis method, still need to put prevention first early period, keep it is appropriate movement and it is enough
Nutrients help effectively improves bone mineral content, achievees the purpose that prevention, clinical treatment.Appropriate intake calcium agent, vitamin D, diphosphate,
Estrogen and isoflavones can effectively reduce bone-loss, and fluoride, anabolic steroids, parathyroid hormone can then promote into
Bone improves bone density.Replenishing the calcium is the preferred version for preventing osteoporosis at present.Initially, the insoluble calcium used is carried out as calcium source
It replenishes the calcium, but since insoluble calcium is insoluble, it is difficult to be effectively absorbed, mostly be replenished the calcium now using soluble calcium.
Chinese invention patent application number 201610807140.9 discloses a kind of increase bone density, prevention senile osteoporosis
Composite collagen gel, active component includes following composite collagen composition：In parts by weight, compound adhesive
Former protein composition includes：50 ~ 100 parts of collagen, 50 ~ 100 parts of jujube, 50 ~ 100 parts of donkey-hide gelatin, carboxymethyl cellulose 10 ~ 40
Part, 5 ~ 20 parts of astragalus polyose, 5 ~ 20 parts of hericium erinaceum polysaccharide, 0.5 ~ 5 part of lactobacillus and 0.5 ~ 5 part of Bifidobacterium.The invention is adopted
With food-borne material, have no toxic side effect, carried out scientific compatibility, ideal therapeutic effect can be reached, can effectively increase bone density,
Pre- preventing bone rarefaction.
Chinese invention patent application number 201310124058.2 discloses a kind of composition of pre- preventing bone rarefaction, including such as
The component of lower weight ratio：22 ~ 26 parts of calcium agent, 20 ~ 25 parts of cordyceps mycelia powder, 12 ~ 20 parts of mulberry fruit, 30 ~ 42 parts of Semen Lablab Album.The hair
The bright Chinese medicine used is integration of drinking and medicinal herbs, and mutual compatibility complements each other, and reaches bone not dystrophy, then be used in conjunction with calcium agent, collaboration
Synergy, on the one hand supplement is lost calcareous, and another aspect strengthening the muscles and bones makes bone not dystrophy, has to the improvement of osteoporosis symptoms
Splendid effect.It is taken suitable for the middle-aged and the old, production process conditional stability, is suitble to scale industrial production.
According to method that is above-mentioned, being replenished the calcium in existing scheme using soluble calcium, although good absorption effect, there are still all
More negative effects, the risk precipitated in enteron aisle presence such as soluble calcium, and due to water-soluble, the loss excreted is larger,
The invention proposes a kind of auxotype health care product of pre- preventing bone rarefaction and preparation methods, can effectively solve above-mentioned technical problem.
Summary of the invention
The technical method replenished the calcium at present using wider soluble calcium, the bioactivity of soluble calcium is poor, can deposit in enteron aisle
In precipitated risk, and due to water-soluble, the loss excreted is larger, and prevention and the effect for improving osteoporosis are paid no attention to
Think.
To solve the above problems, the present invention uses following technical scheme：
A kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction, the detailed process of preparation are：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, the calcium in egg-shell meal is activated, when control is impregnated
Between and acetate concentration to prevent calcium loss in acetic acid, then be dried, activation egg-shell meal be made；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, and by aerosil, alginic acid glue insulation blocking, obtains nanometer activation egg-shell meal；
（3）Radix cyathulae, red clover, nanometer activation bone meal, fennel seeds are first ground into sieving, then with step（2）It is made
Nanometer activation egg-shell meal and collagen, chondroitin sulfate be uniformly mixed, add bonding auxiliary material, soak, compacting is made pre-
The auxotype health care product of preventing bone rarefaction.
Preferably, step（1）The acetate concentration is 0.5 ~ 1mol/L.
Preferably, step（1）The soaking time is 1 ~ 2min.
Preferably, step（1）The temperature of the drying is 120 ~ 125 DEG C, and the time is 20 ~ 40min.
Preferably, step（2）The partial size of the nanometer activation egg-shell meal is 50 ~ 400nm.
Preferably, step（3）The pressure of the compacting is 70 ~ 90PIS, and pressurization time is 2 ~ 3s, is delayed as 4 ~ 5s.
Preferably, the bonding auxiliary material includes but is not limited to alginic acid glue, cellulose ether, micropore starch.
Preferably, step（3）Each raw material is by weight, wherein 5 ~ 8 parts of collagen, chondroitin sulfate 3 ~ 5
Part, 20 ~ 30 parts of egg-shell meal of nanometer activation, 2 ~ 4 parts of radix cyathulae, red clover 2 ~ 4 part, nanometer activate 36 ~ 60 parts of bone meal, fennel seeds
3 ~ 5 parts, 2 ~ 3 parts of auxiliary material of bonding.
By a kind of auxotype health care product of pre- preventing bone rarefaction obtained by the above method, which passes through egg shell is living
Change, nanosizing, and utilize aerosil, alginic acid glue protective separation in grinding, is effectively prevent by colloid protection
Nanoscale activates egg-shell meal and reunites, and nanometer activation egg-shell meal is completely dispersed with nano shape, has significant bioactivity；
It not only has good bioactivity, and takes rear slow release calcium, is easy to be absorbed, and avoids and existing directly takes liquid
Body soluble calcium is easy the fixed risk in enteron aisle.The red clover of addition is sustained isoflavones, is conducive to pre- preventing bone rarefaction；
The collagen of addition increases deposition of the calcium in bone, enhances sclerotin, can repair cartilage, improves osteoporosis；The present invention can
It is effectively improved and prevents middle-aged and the old's osteoporosis, reach the healthcare function for increasing middle-aged and the old's bone density.
Femoral bmd of the pre- preventing bone rarefaction health care product prepared by the present invention for New Zealand White Rabbit zoopery is tested,
Carry out osteoporosis first, started to carry out at the 8th week using calcium supplement, in the case where adjusting part on an equal basis qualitatively with commercially available calcium and magnesium piece, city
It sells liquid calcium to compare, method of the invention has a clear superiority, as shown in table 1.
Table 1：
The present invention provides a kind of auxotype health care product of pre- preventing bone rarefaction and preparation methods, compared with prior art, dash forward
Out the characteristics of and excellent effect are：
1, the method for the auxotype health care product for using nanometer activation egg-shell meal etc. to prepare pre- preventing bone rarefaction for raw material is proposed.
2, by the way that egg shell is activated, nanosizing, and grinding when using aerosil, alginic acid glue protection every
From, effectively prevent nanoscale activation egg-shell meal reunite, have significant bioactivity.
3, health care product produced by the present invention slow release calcium after taking is easy to be absorbed, and avoids and existing directly takes
Liquid, soluble calcium is easy the fixed risk in enteron aisle.
4, the red clover added in preparation of the invention can pre- preventing bone rarefaction, the collagen of addition increases calcium and exists
Deposition in bone enhances sclerotin, can repair cartilage, improves osteoporosis, can be effectively improved and prevent middle-aged and the old's osteoporosis,
Reach the healthcare function for increasing middle-aged and the old's bone density.
Specific embodiment
In the following, the present invention will be further described in detail by way of specific embodiments, but this should not be interpreted as to the present invention
Range be only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill
The various replacements or change that knowledge and customary means are made, should be included in the scope of the present invention.
Embodiment 1
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 0.7mol/L；Soaking time is 1.5min；Dry temperature is 123 DEG C, and the time is
32min；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, obtains nanometer activation egg-shell meal；The average grain diameter of nanometer activation egg-shell meal is 280nm；Silica airsetting
Glue, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 82PIS, and pressurization time 2s is delayed as 4s.Each raw material by weight,
In, 7 parts of collagen, chondroitin sulfate 4 part, nanometer activate 26 parts of egg-shell meal, 3 parts of radix cyathulae, 3 part, nanometer work of red clover
Change 47 parts of bone meal, 4 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Pre- preventing bone rarefaction health care product made from embodiment 1, the femoral bmd of New Zealand White Rabbit zoopery such as table 2
It is shown.
Embodiment 2
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 0.5mol/L；Soaking time is 1min；Dry temperature is 120 DEG C, and the time is
40min；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, obtains nanometer activation egg-shell meal；The average grain diameter of nanometer activation egg-shell meal is 50nm；Silica airsetting
Glue, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 70PIS, and pressurization time 3s is delayed as 5s.Each raw material by weight,
In, 5 parts of collagen, chondroitin sulfate 3 part, nanometer activate 20 parts of egg-shell meal, 2 parts of radix cyathulae, 2 part, nanometer work of red clover
Change 60 parts of bone meal, 3 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Pre- preventing bone rarefaction health care product made from embodiment 2, the femoral bmd of New Zealand White Rabbit zoopery such as table 2
It is shown.
Embodiment 3
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 1mol/L；Soaking time is 2min；Dry temperature is 125 DEG C, time 20min；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, obtains nanometer activation egg-shell meal；The average grain diameter of nanometer activation egg-shell meal is 400nm；Silica airsetting
Glue, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 90PIS, and pressurization time 2s is delayed as 5s.Each raw material by weight,
In, 8 parts of collagen, chondroitin sulfate 5 part, nanometer activate 30 parts of egg-shell meal, 4 parts of radix cyathulae, 4 part, nanometer work of red clover
Change 36 parts of bone meal, 5 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Pre- preventing bone rarefaction health care product made from embodiment 3, the femoral bmd of New Zealand White Rabbit zoopery such as table 2
It is shown.
Embodiment 4
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 0.6mol/L；Soaking time is 2min；Dry temperature is 121 DEG C, and the time is
35min；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, obtains nanometer activation egg-shell meal；The average grain diameter of nanometer activation egg-shell meal is 100nm；Silica airsetting
Glue, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 75PIS, and pressurization time 2s is delayed as 5s.Each raw material by weight,
In, 6 parts of collagen, chondroitin sulfate 3 part, nanometer activate 22 parts of egg-shell meal, 2 parts of radix cyathulae, 3 part, nanometer work of red clover
Change 55 parts of bone meal, 4 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Pre- preventing bone rarefaction health care product made from embodiment 4, the femoral bmd of New Zealand White Rabbit zoopery such as table 2
It is shown.
Embodiment 5
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 0.8mol/L；Soaking time is 1min；Dry temperature is 124 DEG C, and the time is
25min；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, obtains nanometer activation egg-shell meal；The average grain diameter of nanometer activation egg-shell meal is 300nm；Silica airsetting
Glue, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 85PIS, and pressurization time 3s is delayed as 4s.Each raw material by weight,
In, 7 parts of collagen, chondroitin sulfate 5 part, nanometer activate 27 parts of egg-shell meal, 4 parts of radix cyathulae, 3 part, nanometer work of red clover
Change 43 parts of bone meal, 4 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Pre- preventing bone rarefaction health care product made from embodiment 5, the femoral bmd of New Zealand White Rabbit zoopery such as table 2
It is shown.
Embodiment 6
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 0.8mol/L；Soaking time is 2min；Dry temperature is 123 DEG C, and the time is
30min；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, obtains nanometer activation egg-shell meal；The average grain diameter of nanometer activation egg-shell meal is 200nm；Silica airsetting
Glue, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 80PIS, and pressurization time 2s is delayed as 5s.Each raw material by weight,
In, 6 parts of collagen, chondroitin sulfate 4 part, nanometer activate 25 parts of egg-shell meal, 3 parts of radix cyathulae, 3 part, nanometer work of red clover
Change 48 parts of bone meal, 4 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Pre- preventing bone rarefaction health care product made from embodiment 6, the femoral bmd of New Zealand White Rabbit zoopery such as table 2
It is shown.
Comparative example 1
The detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, activates the calcium in egg-shell meal, then be dried,
Activation egg-shell meal is made；Acetate concentration is 0.8mol/L；Soaking time is 2min；Dry temperature is 123 DEG C, and the time is
30min；
（2）In sand mill, by step（1）Activation egg-shell meal obtained is ground to nanoscale, obtains nanometer activation egg-shell meal；It receives
The average grain diameter of rice activation egg-shell meal is 200nm；
（3）Radix cyathulae, red clover, bone meal, fennel seeds are first ground into sieving, then with step（2）Nanometer obtained is living
Change egg-shell meal and collagen, chondroitin sulfate are uniformly mixed, add bonding auxiliary material, soak, compacting is made prevention sclerotin and dredges
The auxotype health care product of pine；The pressure of compacting is 80PIS, and pressurization time 2s is delayed as 5s.Each raw material by weight,
In, 6 parts of collagen, chondroitin sulfate 4 part, nanometer activate 25 parts of egg-shell meal, 3 parts of radix cyathulae, 3 part, nanometer work of red clover
Change 48 parts of bone meal, 4 parts of fennel seeds, bonding 1 part of auxiliary material alginic acid glue, 0.5 part of cellulose ether, 0.5 part of micropore starch.
Comparative example 1 does not use aerosil, alginic acid glue insulation blocking in grinding, and prevention sclerotin obtained is dredged
The femoral bmd of loose health care product, New Zealand White Rabbit zoopery is as shown in table 2.
The test method of above-mentioned performance indicator is：
It chooses 40 12 month female New Zealand White Rabbit and is used as experimental animal, weight is 3.9 ~ 4.6kg, and SPF grades, experimental temperature is
25 DEG C, relative humidity 35%, single cage is fed 2 weeks under identical environment temperature before experiment, using the toy of DXA borne densitometers
Bone density measurement software measures the initial bone density of white rabbit femur；Then using Bilateral oophorectomy+Econopred induction
8 weeks, osteoporosis model is established, the 8th weekend measured the bone density of white rabbit femur again；According to drug dose 60mg/（kg·d）
Drug to be mixed in feed, the physiological saline for spraying same dose mixes well, and it is administered, is administered once daily when daily 18, point
White rabbit anesthesia will not be tested at the weekend of the 12nd, 24 and 36 and is placed on DXA borne densitometers, measures bone density, it is average to calculate bone density
Value.
Table 2：
Claims (9)
1. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction, which is characterized in that the detailed process of preparation is：
（1）Eggshell is first refined as egg-shell meal, is then impregnated in spirit of vinegar, the calcium in egg-shell meal is activated, when control is impregnated
Between and acetate concentration to prevent calcium loss in acetic acid, then be dried, activation egg-shell meal be made；
（2）In sand mill, with aerosil, alginic acid glue assisted milling, by step（1）Activation egg-shell meal obtained
It is ground to nanoscale, and by aerosil, alginic acid glue insulation blocking, obtains nanometer activation egg-shell meal；Wherein, dioxy
SiClx aeroge, alginic acid glue, activate egg-shell meal mass ratio be 1:1:10；
（3）Radix cyathulae, red clover, nanometer activation bone meal, fennel seeds are first ground into sieving, then with step（2）It is made
Nanometer activation egg-shell meal and collagen, chondroitin sulfate be uniformly mixed, add bonding auxiliary material, soak, compacting is made pre-
The auxotype health care product of preventing bone rarefaction.
2. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Step
Suddenly (3) described each raw material is by weight, wherein 5 ~ 8 parts of collagen, chondroitin sulfate 3 ~ 5 part, nanometer activate egg-shell meal 20
~ 30 parts, 2 ~ 4 parts of radix cyathulae, 36 ~ 60 parts of bone meal of red clover 2 ~ 4 part, nanometer activation, 3 ~ 5 parts of fennel seeds, bonding auxiliary material 2 ~ 3
Part.
3. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Institute
Stating bonding auxiliary material includes but is not limited to alginic acid glue, cellulose ether, micropore starch.
4. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Step
Suddenly（1）The acetate concentration is 0.5 ~ 1mol/L.
5. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Step
Suddenly（1）The soaking time is 1 ~ 2min.
6. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Step
Suddenly（1）The temperature of the drying is 120 ~ 125 DEG C, and the time is 20 ~ 40min.
7. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Step
Suddenly（2）The partial size of the nanometer activation egg-shell meal is 50 ~ 400nm.
8. a kind of preparation method of the auxotype health care product of pre- preventing bone rarefaction according to claim 1, it is characterised in that：Step
Suddenly（3）The pressure of the compacting is 70 ~ 90PIS, and pressurization time is 2 ~ 3s, is delayed as 4 ~ 5s.
9. a kind of auxotype health care product of pre- preventing bone rarefaction, is prepared by any one of claim 1-8 the method.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110771886A (en) * | 2019-12-02 | 2020-02-11 | 怀化市富源油业有限公司 | Nutritional meal replacement product and preparation method thereof |
| CN111838680A (en) * | 2020-06-09 | 2020-10-30 | 质每(中国)有限公司 | Production method of high-absorption nano calcium, product and application thereof |
-
2018
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110771886A (en) * | 2019-12-02 | 2020-02-11 | 怀化市富源油业有限公司 | Nutritional meal replacement product and preparation method thereof |
| CN111838680A (en) * | 2020-06-09 | 2020-10-30 | 质每(中国)有限公司 | Production method of high-absorption nano calcium, product and application thereof |
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Application publication date: 20181116 |