CN108802309A - A kind of leukemia drug susceptibility detector - Google Patents
A kind of leukemia drug susceptibility detector Download PDFInfo
- Publication number
- CN108802309A CN108802309A CN201810921495.XA CN201810921495A CN108802309A CN 108802309 A CN108802309 A CN 108802309A CN 201810921495 A CN201810921495 A CN 201810921495A CN 108802309 A CN108802309 A CN 108802309A
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- Prior art keywords
- fixedly connected
- mounting
- drug
- cavity
- mounting blocks
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 63
- 229940079593 drug Drugs 0.000 title claims abstract description 56
- 208000032839 leukemia Diseases 0.000 title claims abstract description 20
- 230000007246 mechanism Effects 0.000 claims abstract description 19
- 238000007789 sealing Methods 0.000 claims description 19
- 241000883990 Flabellum Species 0.000 claims description 6
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract description 14
- 238000003255 drug test Methods 0.000 abstract description 9
- 238000004458 analytical method Methods 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000000719 anti-leukaemic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000003394 haemopoietic effect Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000022532 enlargement of lymph nodes Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of leukemia drug susceptibility detectors, including mounting blocks, the inside of the mounting blocks offers cavity, the mounting hole being connected to cavity is offered at the top of the mounting blocks, it is fixedly connected with driving motor at the top of the mounting blocks, the output shaft of the driving motor extends to the inside of mounting hole and is fixedly connected with Blast mechanism, and the bottom of the Blast mechanism is fixedly connected with mounting rod, and the bottom of the mounting rod extends to the inside of cavity and is fixedly connected with mill ball.Structure of the invention is reasonable, driving motor drives mounting rod and mill ball to crush grinding to the drug in cavity, drug powder after crushing can be blown into drug test device, it avoids artificial diversion medicaments powder and drug powder is caused to be contaminated, drug test device accurately analyzes the drug ingedient in drug powder, accuracy and the efficiency of drug ingedient analysis can greatly be increased, it is more sensitive to the content of each ingredient in drug.
Description
Technical field
The present invention relates to drug measurement techniques field more particularly to a kind of leukemia drug susceptibility detectors.
Background technology
Leukemia is another address of leukaemia, and leukaemia is a kind of candidate stem cell malignant clone disease.It is Clonal
Because proliferation out of control, dysdifferentiation, apoptosis are obstructed etc., mechanism are largely proliferated leukaemia cell in marrow and other hematopoietic tissues
Accumulation, and other non-hematopoietic tissues and organ are infiltrated, while inhibiting normal hematopoiesis function.Clinical visible different degrees of anaemia,
Bleeding, infectious fever and liver, spleen, enlargement of lymph nodes and skeleton pain.
There are many antileukemie drugs on the market now, because the deviation of some material compositions can all cause in drug
The drug effect and sensibility of drug are deteriorated, so being required for being detected drug before drug manufacture, if directly drug is used to examine
It surveys instrument to be detected drug, it is difficult to the proportioning of various composition in drug accurately be detected, for this purpose, it is proposed that a kind of leukemia
Drug susceptibility detector solves the above problems.
Invention content
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of leukemia drug susceptibility proposed
Detector.
To achieve the goals above, present invention employs following technical solutions：
The inside of a kind of leukemia drug susceptibility detector, including mounting blocks, the mounting blocks offers cavity, the mounting blocks
Top offer the mounting hole being connected to cavity, be fixedly connected with driving motor at the top of the mounting blocks.
The output shaft of the driving motor extends to the inside of mounting hole and is fixedly connected with Blast mechanism, the air blower
The bottom of structure is fixedly connected with mounting rod, and the bottom of the mounting rod extends to the inside of cavity and is fixedly connected with mill ball.
The inside of the mounting hole is fixedly connected with the Air Filter being set in outside driving motor output shaft, the mounting blocks
The top of right side is equipped with addition mechanism, and the right flank middle part of the mounting blocks is fixedly connected with drug test device.
Preferably, fixed link, the bottom of fixed link and mounting blocks have been fixedly connected at left and right sides of the driving motor
Top be fixedly connected.
Preferably, the Blast mechanism includes the mounting plate being fixedly connected with the output shaft of driving motor, a left side for mounting plate
Right two sides have been fixedly connected with air blast flabellum.
Preferably, the mounting rod is oblique, and the angle of inclination of the mounting rod is 20 degree, and the mounting hole is right
The bottom of side opening wall is fixedly connected with inclined plate.
Preferably, the bottom chamber wall of the cavity is hemispherical, and the outer surface of the mill ball is fixedly connected with uniformly
The grinding block of distribution, the bottom of the mill ball are contacted with the inner wall of hemispheric cavity.
Preferably, the addition mechanism includes dispensing hole that be opened in right side at the top of mounting blocks and mounting hole connection,
The right side hole wall in the dispensing hole offers sliding groove, and the internal slide of the sliding groove is connected with sealing plate, the sealing plate
Left end and the left side hole wall in dispensing hole be clamped, sliding groove bottom hole wall offers limiting slot, the inside of the limiting slot
Slide plate is slidably connected, the top of the slide plate is fixedly connected with the bottom of sealing plate, and the right side of the slide plate is fixedly connected
There are resetting spring, the right end of the resetting spring to be fixedly connected with the right side cell wall of limiting slot.
Compared with prior art, beneficial effects of the present invention are：
1, manufactured anti-leukemia medicine is put into and is thrown by pulling sealing plate that can be connected in dispensing hole with mounting hole by the present invention
Medicine hole, drug can enter across mounting hole in cavity, unclamp sealing plate, and resetting spring pushes slide plate to reset, and slide plate is in sliding groove
Interior sliding hauls sealing plate and is slided in sliding groove, can seal dispensing hole, and driving motor drives mounting rod and mill ball to sky
The drug of intracavitary crushes grinding, and the drug powder after grinding enters drug test device, and drug test device is in drug powder
Drug ingedient accurately analyzed, can greatly increase accuracy and the efficiency of drug ingedient analysis, to each in drug
The content of a ingredient is more sensitive.
2, the present invention is rotated by driving motor belt driven blower structure, and mounting plate drives the rotation of air blast flabellum by air permeable
Air Filter is sent into cavity, and the drug powder after crushing is blown into drug test device by the formation of wind, avoids artificial diversion medicaments
Powder and cause drug powder to be contaminated, cause detection structure to be affected.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of leukemia drug susceptibility detector proposed by the present invention；
Fig. 2 is the partial structurtes enlarged drawing in the portions A in a kind of leukemia drug susceptibility detector Fig. 1 proposed by the present invention.
In figure：It is 1 mounting blocks, 2 cavitys, 3 mounting holes, 4 driving motors, 5 Blast mechanisms, 6 mounting rods, 7 mill balls, 8 dust-proof
Net, 9 addition mechanisms, 10 drug test devices, 11 dispensing holes, 12 sliding grooves, 13 sealing plates, 14 limiting slots, 15 slide plates, 16 reset bullet
Spring.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Referring to Fig.1-2, a kind of leukemia drug susceptibility detector, including mounting blocks 1, the inside of mounting blocks 1 open up free
Chamber 2, the top of mounting blocks 1 offer the mounting hole 3 being connected to cavity 2, and the top of mounting blocks 1 is fixedly connected with driving motor 4,
The left and right sides of driving motor 4 has been fixedly connected with fixed link, and the bottom of fixed link is fixedly connected with the top of mounting blocks 1, makes
The installation of driving motor 4 is more firm.
The output shaft of driving motor 4 extends to the inside of mounting hole 3 and is fixedly connected with Blast mechanism 5, and Blast mechanism 5 wraps
The mounting plate being fixedly connected with the output shaft of driving motor 4 is included, the left and right sides of mounting plate have been fixedly connected with air blast flabellum,
Driving motor 4 drives mounting plate rotation, mounting plate to drive the rotation of air blast flabellum that air permeable Air Filter 8 is sent into cavity 2, drum
The bottom of wind mechanism 5 is fixedly connected with mounting rod 6, and mounting rod 6 is oblique, and the angle of inclination of mounting rod 6 is 20 degree, peace
The bottom of dress 3 right side hole wall of hole is fixedly connected with inclined plate so that the range that mounting rod 6 is ground when driving mill ball 7 to rotate
The bottom of bigger, mounting rod 6 extends to the inside of cavity 2 and is fixedly connected with mill ball 7, and the bottom chamber wall of cavity 2 is in hemisphere
Shape, and the outer surface of mill ball 7 is fixedly connected with equally distributed grinding block, the bottom of mill ball 7 and hemispheric cavity 2
Inner wall contacts, and driving motor 4 drives mounting rod 6 and mill ball 7 to crush grinding to the drug in cavity 2.
The inside of mounting hole 3 is fixedly connected with the Air Filter 8 being set in outside 4 output shaft of driving motor, 1 right side of mounting blocks
The top in face is equipped with addition mechanism 9, and addition mechanism 9 includes throwing that be opened in the right side at the top of mounting blocks 1 and that mounting hole 3 is connected to
The right side hole wall in medicine hole 11, dispensing hole 11 offers sliding groove 12, and the internal slide of sliding groove 12 is connected with sealing plate 13, sealing
The left end of plate 13 and the left side hole wall in dispensing hole 11 are clamped, and 12 bottom hole wall of sliding groove offers limiting slot 14, limiting slot 14
Internal slide is connected with slide plate 15, and the top of slide plate 15 is fixedly connected with the bottom of sealing plate 13, and the right side of slide plate 15 is fixed
It is connected with resetting spring 16, the right end of resetting spring 16 is fixedly connected with the right side cell wall of limiting slot 14, by pulling sealing plate
13 can be connected in dispensing hole 11 with mounting hole 3, manufactured anti-leukemia medicine be put into dispensing hole 11, drug can pass through installation
Hole 3 enters in cavity 2, unclamps sealing plate 13, and resetting spring 16 pushes slide plate 15 to reset, and the sliding in limiting slot 14 of slide plate 15 is drawn
The sliding in sliding groove 12 of sealing plate 13, dispensing hole 11 can be sealed, the right flank middle part of mounting blocks 1 is fixedly connected with drug
Detector 10.
In the present invention, by pulling sealing plate 13 that can be connected in dispensing hole 11 with mounting hole 3, by manufactured anti-leukocythemia
Drug input dispensing hole 11, drug can pass through mounting hole 3 to enter in cavity 2, unclamp sealing plate 13, and resetting spring 16 pushes slide plate
15 reset, and the sliding in sliding groove 14 of slide plate 15 hauls the sliding in sliding groove 12 of sealing plate 13, can seal dispensing hole 11, drive
Dynamic motor 4 drives mounting rod 6 and mill ball 7 to crush grinding to the drug in cavity 2, and the drug powder after grinding is into being used as medicine
Analyte detection device 10, drug test device 10 accurately analyze the drug ingedient in drug powder, can greatly increase medicine
The accuracy of object constituent analysis and efficiency, it is more sensitive to the content of each ingredient in drug.
Also, it is rotated by 4 belt driven blower structure 5 of driving motor, mounting plate drives the rotation of air blast flabellum by air permeable
Air Filter 8 is sent into cavity 2, and the drug powder after crushing is blown into drug test device 10 by the formation of wind, avoids manually shifting
Drug powder and cause drug powder to be contaminated, cause detection structure to be affected.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of leukemia drug susceptibility detector, including mounting blocks（1）, it is characterised in that：The mounting blocks（1）Inside open
Equipped with cavity（2）, the mounting blocks（1）Top offer and cavity（2）The mounting hole of connection（3）, the mounting blocks（1）'s
Top is fixedly connected with driving motor（4）；
The driving motor（4）Output shaft extend to mounting hole（3）Inside and be fixedly connected with Blast mechanism（5）, described
Blast mechanism（5）Bottom be fixedly connected with mounting rod（6）, the mounting rod（6）Bottom extend to cavity（2）Inside simultaneously
It is fixedly connected with mill ball（7）；
The mounting hole（3）Inside be fixedly connected with and be set in driving motor（4）Air Filter outside output shaft（8）, described
Mounting blocks（1）The top of right side is equipped with addition mechanism（9）, the mounting blocks（1）Right flank middle part be fixedly connected with drug
Detector（10）.
2. a kind of leukemia drug susceptibility detector according to claim 1, which is characterized in that the driving motor（4）
The left and right sides be fixedly connected with fixed link, the bottom of fixed link and mounting blocks（1）Top be fixedly connected.
3. a kind of leukemia drug susceptibility detector according to claim 1, which is characterized in that the Blast mechanism（5）
Including with driving motor（4）The mounting plate that is fixedly connected of output shaft, the left and right sides of mounting plate have been fixedly connected with air blast
Flabellum.
4. a kind of leukemia drug susceptibility detector according to claim 1, which is characterized in that the mounting rod（6）It is in
It is skewed, and the mounting rod（6）Angle of inclination be 20 degree, the mounting hole（3）The bottom of right side hole wall is fixedly connected
There is inclined plate.
5. a kind of leukemia drug susceptibility detector according to claim 1, which is characterized in that the cavity（2）Bottom
Portion's cavity wall is hemispherical, and the mill ball（7）Outer surface be fixedly connected with equally distributed grinding block, the mill ball
（7）Bottom and hemispheric cavity（2）Inner wall contact.
6. a kind of leukemia drug susceptibility detector according to claim 1, which is characterized in that the addition mechanism（9）
Including being opened in mounting blocks（1）The right side at top and mounting hole（3）The dispensing hole of connection（11）, the dispensing hole（11）The right side
Side opening wall offers sliding groove（12）, the sliding groove（12）Internal slide be connected with sealing plate（13）, the sealing plate
（13）Left end with dispensing hole（11）The clamping of left side hole wall, the sliding groove（12）Bottom hole wall offers limiting slot（14）,
The limiting slot（14）Internal slide be connected with slide plate（15）, the slide plate（15）Top and sealing plate（13）Bottom it is solid
Fixed connection, the slide plate（15）Right side be fixedly connected with resetting spring（16）, the resetting spring（16）Right end and limit
Position slot（14）Right side cell wall be fixedly connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810921495.XA CN108802309A (en) | 2018-08-14 | 2018-08-14 | A kind of leukemia drug susceptibility detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810921495.XA CN108802309A (en) | 2018-08-14 | 2018-08-14 | A kind of leukemia drug susceptibility detector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108802309A true CN108802309A (en) | 2018-11-13 |
Family
ID=64080042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810921495.XA Pending CN108802309A (en) | 2018-08-14 | 2018-08-14 | A kind of leukemia drug susceptibility detector |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108802309A (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104595219A (en) * | 2015-01-29 | 2015-05-06 | 周玉红 | Ventilation pipeline air blower |
| CN104807972A (en) * | 2015-04-29 | 2015-07-29 | 钱震雯 | Detection device for medical components |
| CN105109203A (en) * | 2013-07-23 | 2015-12-02 | 黑金刚（福建）自动化科技股份公司 | Energy-saving environment-friendly method for recovering ink material |
| CN205120698U (en) * | 2015-11-13 | 2016-03-30 | 江西杏林白马药业有限公司 | Synthetic drug active ingredient detection device |
| CN205731543U (en) * | 2016-01-28 | 2016-11-30 | 绵阳流能粉体设备有限公司 | A kind of air-flow diamond pulverizer |
| CN205903936U (en) * | 2016-06-24 | 2017-01-25 | 无锡市第二人民医院 | Tablet grinder |
| CN205903957U (en) * | 2016-04-01 | 2017-01-25 | 山东天振药业有限公司 | Device is smashed to high -efficient continuous type plastics |
| CN107192799A (en) * | 2017-04-06 | 2017-09-22 | 山东省药学科学院 | A kind of digestion instrument throws sampling device |
| CN107693354A (en) * | 2017-09-28 | 2018-02-16 | 曹威 | A kind of the elderly is with anti-error environment protection type edible to medicine box |
| CN207187501U (en) * | 2017-08-31 | 2018-04-06 | 天津众智飞扬环境科技有限公司 | A kind of electrocatalysis oxidation reaction device for handling industrial waste gas |
| CN207680753U (en) * | 2017-12-07 | 2018-08-03 | 高彩红 | A kind of medical treatment pediatric drugs product grinding device |
| CN208621597U (en) * | 2018-08-14 | 2019-03-19 | 南京融康博生物科技有限公司 | A kind of leukemia drug susceptibility detector |
-
2018
- 2018-08-14 CN CN201810921495.XA patent/CN108802309A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105109203A (en) * | 2013-07-23 | 2015-12-02 | 黑金刚（福建）自动化科技股份公司 | Energy-saving environment-friendly method for recovering ink material |
| CN104595219A (en) * | 2015-01-29 | 2015-05-06 | 周玉红 | Ventilation pipeline air blower |
| CN104807972A (en) * | 2015-04-29 | 2015-07-29 | 钱震雯 | Detection device for medical components |
| CN205120698U (en) * | 2015-11-13 | 2016-03-30 | 江西杏林白马药业有限公司 | Synthetic drug active ingredient detection device |
| CN205731543U (en) * | 2016-01-28 | 2016-11-30 | 绵阳流能粉体设备有限公司 | A kind of air-flow diamond pulverizer |
| CN205903957U (en) * | 2016-04-01 | 2017-01-25 | 山东天振药业有限公司 | Device is smashed to high -efficient continuous type plastics |
| CN205903936U (en) * | 2016-06-24 | 2017-01-25 | 无锡市第二人民医院 | Tablet grinder |
| CN107192799A (en) * | 2017-04-06 | 2017-09-22 | 山东省药学科学院 | A kind of digestion instrument throws sampling device |
| CN207187501U (en) * | 2017-08-31 | 2018-04-06 | 天津众智飞扬环境科技有限公司 | A kind of electrocatalysis oxidation reaction device for handling industrial waste gas |
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| CN207680753U (en) * | 2017-12-07 | 2018-08-03 | 高彩红 | A kind of medical treatment pediatric drugs product grinding device |
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