CN108785741A - 骨缺损石墨烯填充材料 - Google Patents

骨缺损石墨烯填充材料 Download PDF

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CN108785741A
CN108785741A CN201810649681.2A CN201810649681A CN108785741A CN 108785741 A CN108785741 A CN 108785741A CN 201810649681 A CN201810649681 A CN 201810649681A CN 108785741 A CN108785741 A CN 108785741A
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packing material
bone defect
silver
graphene
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李苏杨
徐勤霞
成清明
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Suzhou Bec Biological Technology Co Ltd
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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Abstract

本发明提供了一种骨缺损石墨烯填充材料，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石10‑30份，RGD多肽改性生物陶瓷10‑25份，磷酸钙5‑15份，海藻酸钠5‑10份和载银纳米二氧化硅5‑8份。本发明的填充材料能够促进骨生长，且具有良好抗菌性能和力学性能，能够大大促进骨创伤愈合，具有良好的应用前景。

Description

骨缺损石墨烯填充材料
技术领域
本发明涉及医用材料领域，具体涉及一种骨缺损石墨烯填充材料。
背景技术
在生物医学材料领域中，骨缺损材料在临床方面得到了广泛应用，对促进骨生长起到了积极的作用，同时也提供了宿主自身骨细胞和维管网络再生和愈合的框架。磷酸钙类材料具有很好的注射性，羟基磷灰石具有良好的生物活性和生物相容性，能传导骨生长，然而这些材料都存在着一些固有缺点限制了他们在骨缺损填充材料方面的应用。因而需要对现有材料进行改进，以适应骨缺损临床应用。
发明内容
为解决上述技术问题，本发明提供了一种骨缺损石墨烯填充材料，其能够很好地促进骨生长，生物相容性好且兼具抗菌性能，氧化石墨烯改性羟基磷灰石还可以增强骨缺损材料的力学性能。
为实现上述目的，本发明采用了以下技术方案：
一种骨缺损石墨烯填充材料，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石10-30份，RGD多肽改性生物陶瓷10-25份，磷酸钙5-15份，海藻酸钠5-10份和载银纳米二氧化硅5-8份。
优选地，氧化石墨烯改性羟基磷灰石中，氧化石墨烯的质量分数为15-10%。
优选地，RGD多肽改性生物陶瓷为RGD多肽修饰的HA-TCP双相多孔生物陶瓷。
优选地，纳米二氧化硅的粒径为10-50nm。
优选地，载银纳米二氧化硅中银粒子的质量分数为3-8%。
在一个具体实施例中，骨缺损石墨烯填充材料由以下重量份的材料制成：氧化石墨烯改性羟基磷灰石 10份，RGD多肽改性生物陶瓷10份，磷酸钙5份，海藻酸钠5份和载银纳米二氧化硅5份。
在另一个具体实施例中，骨缺损石墨烯填充材料由以下重量份的材料制成：氧化石墨烯改性羟基磷灰石 20份，RGD多肽改性生物陶瓷15份，磷酸钙10份，海藻酸钠8份和载银纳米二氧化硅6份。
在又一个具体实施例中，骨缺损石墨烯填充材料由以下重量份的材料制成：氧化石墨烯改性羟基磷灰石30份，RGD多肽改性生物陶瓷25份，磷酸钙15份，海藻酸钠10份和载银纳米二氧化硅8份。
借由上述技术方案，与现有技术相比，本发明具有以下优点：本发明提供了一种骨缺损石墨烯填充材料，其采用氧化石墨烯改性羟基磷灰石、RGD多肽改性生物陶瓷以及载银纳米二氧化硅等材料，能够很好地促进骨生长，且兼具抗菌性能，生物相容性好，力学性能佳，能够大大缩短治疗周期。
具体实施方式
下面对本发明的具体实施方式作进一步详细描述。应理解的是，以下实施例仅用于说明本发明，而不应理解为对本发明范围的限制。
实施例1
实施例1提供一种骨缺损石墨烯填充材料，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石 10份，RGD多肽修饰的HA-TCP双相多孔生物陶瓷10份，磷酸钙5份，海藻酸钠5份和载银纳米二氧化硅5份。所述氧化石墨烯改性羟基磷灰石中，氧化石墨烯的质量分数为5%。纳米二氧化硅的粒径为10nm。载银纳米二氧化硅中银粒子的质量分数为3%。
实施例2
实施例2提供一种骨缺损石墨烯填充材料，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石 20份，RGD多肽改性生物陶瓷15份，磷酸钙10份，海藻酸钠8份和载银纳米二氧化硅6份。氧化石墨烯改性羟基磷灰石中，氧化石墨烯的质量分数为8%。纳米二氧化硅的粒径为30nm。载银纳米二氧化硅中银粒子的质量分数为5%。
实施例3
实施例3提供一种骨缺损石墨烯填充材料，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石30份，RGD多肽改性生物陶瓷25份，磷酸钙15份，海藻酸钠10份和载银纳米二氧化硅8份。氧化石墨烯改性羟基磷灰石中，氧化石墨烯的质量分数为10%。纳米二氧化硅的粒径为50nm。载银纳米二氧化硅中银粒子的质量分数为8%。
以上所述仅是本发明的优选实施方式，并不用于限制本发明，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和变型，这些改进和变型也应视为本发明的保护范围。

Claims (8)

1.一种骨缺损石墨烯填充材料，其特征在于，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石 10-30份，RGD多肽改性生物陶瓷10-25份，磷酸钙5-15份，海藻酸钠5-10份和载银纳米二氧化硅5-8份。
2.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于：所述氧化石墨烯改性羟基磷灰石中，氧化石墨烯的质量分数为5-10%。
3.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于：所述RGD多肽改性生物陶瓷为RGD多肽修饰的HA-TCP双相多孔生物陶瓷。
4.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于：纳米二氧化硅的粒径为10-50nm。
5.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于：载银纳米二氧化硅中银粒子的质量分数为3-8%。
6.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石 10份，RGD多肽改性生物陶瓷10份，磷酸钙5份，海藻酸钠5份和载银纳米二氧化硅5份。
7.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石 20份，RGD多肽改性生物陶瓷15份，磷酸钙10份，海藻酸钠8份和载银纳米二氧化硅6份。
8.根据权利要求1所述的骨缺损石墨烯填充材料，其特征在于，以重量计，由以下组分制成：氧化石墨烯改性羟基磷灰石30份，RGD多肽改性生物陶瓷25份，磷酸钙15份，海藻酸钠10份和载银纳米二氧化硅8份。
CN201810649681.2A 2018-06-22 2018-06-22 骨缺损石墨烯填充材料 Withdrawn CN108785741A (zh)

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CN102716513A (zh) * 2012-05-02 2012-10-10 清华大学 一种在钙磷陶瓷材料表面修饰rgd的方法
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CN101422632A (zh) * 2007-11-01 2009-05-06 国家纳米技术与工程研究院 一种羟基磷灰石/藻酸钠纳米复合材料的制备方法
CN102613244A (zh) * 2012-03-11 2012-08-01 浙江大学 一种介孔中空球形载银二氧化硅抗菌剂的制备方法
CN102716513A (zh) * 2012-05-02 2012-10-10 清华大学 一种在钙磷陶瓷材料表面修饰rgd的方法
CN105536050A (zh) * 2016-02-05 2016-05-04 山东明德生物医学工程有限公司 一种氧化石墨烯改性骨水泥及制备方法和应用

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