CN108785734A - A kind of stanch fibre material of absorbable and degradable - Google Patents
A kind of stanch fibre material of absorbable and degradable Download PDFInfo
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- CN108785734A CN108785734A CN201810785569.1A CN201810785569A CN108785734A CN 108785734 A CN108785734 A CN 108785734A CN 201810785569 A CN201810785569 A CN 201810785569A CN 108785734 A CN108785734 A CN 108785734A
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- absorbable
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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- A61L24/0015—Medicaments; Biocides
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0021—Plasticisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses a kind of stanch fibre material of absorbable and degradable, ingredient is calculated by weight as：80-90 parts of functional fibre, 3-8 parts of degradable high polymer material, 1-3 parts of reinforcing agent, 0.5-1.5 parts of catalyst, 0.4-0.8 parts of antitack agent, 0.3-0.7 parts of plasticizer.The present invention is by the way that functional fibre to be blended with degradable high polymer material spinning, and stanch fibre material prepared by reinforcing agent, catalyst, antitack agent and plasticizer is added, with good biocompatibility, biological degradability and bio-absorbable performance, it uses it for stopping blooding, not only haemostatic effect is good, and haemostatic effect is fast, and the stanch fibre material of the present invention can degrade absorption, it is safer.
Description
Technical field
The present invention relates to implantable medical field of material technology, the stanch fibre material of specially a kind of absorbable and degradable.
Background technology
Hemostatic material generally can be divided into nondegradable hemostatic material and degradable hemostatic material.Nondegradable hemostasis
Material stops blooding (such as common common gauze, the dressing of bacteria cellulose class) commonly used in body surface.When by nondegradable hemostatic material
It when material for stopping blooding in vivo, needs to remove after being finished, is otherwise contacted for a long time with the surface of a wound and be easy to cause serious foreign body sensation.And it can
The hemostatic material of degradation can be absorbed by human body and be degraded.
By the retrieval to the prior art, in Chinese invention patent application 201410848483.0 (publication date in May, 2015
6 days) a kind of preparation process of regenerated celulose fibre Absorbable hemostatic material is disclosed, it is the use need of clinical operation to be met
It asks, is conveniently operated, improve existing regenerated cellulose Absorbable hemostatic material oxidation technology, solve process costs height, pollute big, material
Material wastes serious problem.Although the hemostatic material improves degradation and the hemostasis effect of conventional cellulosic fibers to a certain extent
Fruit, but due to using organic solvent as medium, and nitrogen dioxide is relatively low in the solubility of organic solvent, to oxycellulose
Oxidization time it is long and degree of oxidation is poor；And cost is higher, and waste gas recovery is difficult, be easy to cause air pollution.
And disclose a kind of medical inhale in Chinese invention patent application 01126953.7 (publication date on March 6th, 2002)
The preparation method of regenerated oxycellulose as styptic material.The method of the present invention is to use oxidation system using regenerated cellulose as raw material
After being aoxidized under certain process conditions, obtained product is handled through acid again, is ionized and is stablized processing, and Medical absorbable oxygen is made
Change regenerated cellulose hemostatic material.The material made from the method for the present invention has good hemostasis and absorbability, faces in medicine
Be widely used value on bed.But the patent is cumbersome, and serious, intensity is broken according to sample degradation made from this method
Loss is big, from causing its haemostatic effect undesirable.
Based on this, it is necessary to a kind of stanch fibre material of absorbable and degradable is provided, it is existing in the prior art to solve
Problem.
Invention content
In view of the above-mentioned analysis to the prior art, the present invention provides a kind of stanch fibre material of absorbable and degradable, has
The short advantage of excellent anthemorrhagic performance and stanch fibre material degradation in vivo time, can reach quick-acting haemostatic powder and the mesh for the treatment of
's.
In order to achieve the above object, the present invention is achieved through the following technical solutions：
A kind of stanch fibre material of absorbable and degradable, ingredient are calculated by weight as：
Preferably, ingredient is calculated by weight as：
Preferably, the functional fibre be selected from chitin fiber, chitosan derivative fibres, chitin fiber,
One or more of chitin derivativ fiber, alginic acid fibre and cellulose derivative fibres.
Preferably, the hemostat is selected from collagen, fibrin, hyaluronic acid, alginic acid, porous-starch
And its one or more of derivative.
Preferably, the water absorbing agent is selected from polyanionic polysaccharide, starch derivatives, polyacrylic acid and its derivative
One or more of.
Preferably, it is high to be selected from polylactic acid-based high molecular material, polylactide class for the degradable high polymer material
Molecular material, poly caprolactone high molecular material and polyglycolide high molecular material.
Preferably, it is cellulosic polymer, pyrrolidone polymer, poly- third that the reinforcing agent, which is the reinforcing agent,
It is one or more of in alkene.
Preferably, the catalyst is stannous octoate.
Preferably, the antitack agent is the copolymer of polylactic acid, the one or both of polyglycolic acid；Institute
It is one or more of polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol to state plasticizer.
Preferably, the present invention also provides the preparation method of the stanch fibre material of above-mentioned absorbable and degradable, packets
Include following steps：
(1) in organic solvent by functional fibre dissolving, and hemostat, water absorbing agent, degradable macromolecule are added thereto
Material, reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) fiber solution is obtained to be fitted into the charging gear for the electrospinning device that temperature is 40-60 DEG C,
High voltage power supply is opened, is opened equipped with the charging gear pump containing fiber solution, injection stream is ejected on collector, obtains undulation degree
Material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, anhydrous second is used in combination
Alcohol elutes tunica fibrosa repeatedly until residual spinning solvent is washed away completely, and by fibrous material, vacuum is done in vacuum drying chamber
It is dry, obtain the stanch fibre material of absorbable and degradable.
Compared with prior art, the present invention the present invention has following advantageous effect：
(1) present invention is by the way that functional fibre to be blended with hemostat, water absorbing agent, degradable high polymer material spinning, and adds
Enter stanch fibre material prepared by reinforcing agent, catalyst, antitack agent and plasticizer, there is good biocompatibility, biodegradation
Property and bio-absorbable performance, use it for stopping blooding, not only haemostatic effect is good, but also haemostatic effect is fast, and the present invention hemostasis
Fibrous material can degrade absorption, safer.
(2) functional fibre of the present invention has three-dimensional space network structure, and degradable high polymer material secure rigid can be made to fill out
It fills wherein, keeps it not easily to fall off in hemostasis, but also, due to three-dimensional space network structure, its internal structure is loose, stopping blooding
After can form gel membranaceous material, wound has comfort, and is easy to fall off after stopping blooding, and is convenient for the processing of follow-up wound.
(3) reinforcing agent that the present invention adds can increase the intensity and tensile energy of blood clot, avoid secondary bleeding, accelerate
The healing of wound.
(4) water absorbing agent that the present invention adds can optimize the absorption property of material, further strengthen anthemorrhagic performance, stopping blooding
Simultaneously by water adsorption at bleeding, haemostatic effect is enhanced.
(5) antitack agent that the present invention adds can play the role of preventing various tissue adhesions in hemostasis, and add
The degradation time of stanch fibre material can be improved in plasticizer.
Specific implementation mode
Form by the following examples is described in further detail the above of the present invention again, but should not be by this
The range for being interpreted as the above-mentioned theme of the present invention is only limitted to following embodiment, all based on the technology realized belonging to the above of the present invention
It all belongs to the scope of the present invention.
Embodiment 1
The stanch fibre material of the absorbable and degradable of the present embodiment, ingredient are calculated by weight as：
Wherein, the functional fibre is selected from chitin fiber, chitosan derivative fibres, chitin fiber, chitin and spreads out
One or more of biological fiber, alginic acid fibre and cellulose derivative fibres.
Wherein, the hemostat is selected from collagen, fibrin, hyaluronic acid, alginic acid, porous-starch and its derivative
One or more of object.
Wherein, the one kind of the water absorbing agent in polyanionic polysaccharide, starch derivatives, polyacrylic acid and its derivative
Or it is several.
Wherein, the degradable high polymer material be selected from polylactic acid-based high molecular material, polylactide family macromolecule material,
Poly caprolactone high molecular material and polyglycolide high molecular material.
Wherein, the reinforcing agent is one or more of in cellulosic polymer, pyrrolidone polymer, polypropylene.
Wherein, the catalyst is stannous octoate.
Wherein, the antitack agent is the copolymer of polylactic acid, the one or both of polyglycolic acid；The plasticizer
For one or more of polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol.
The present invention also provides the preparation methods of the stanch fibre material of above-mentioned absorbable and degradable, include the following steps：
(1) in organic solvent by functional fibre dissolving, and hemostat, water absorbing agent, degradable macromolecule are added thereto
Material, reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) is obtained fiber solution to be fitted into the charging gear for the electrospinning device that temperature is 40 DEG C, is opened
High voltage power supply is opened equipped with the charging gear pump containing fiber solution, and injection stream is ejected on collector, obtains fibrous material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, anhydrous second is used in combination
Alcohol elutes tunica fibrosa repeatedly until residual spinning solvent is washed away completely, and by fibrous material, vacuum is done in vacuum drying chamber
It is dry, obtain the stanch fibre material of absorbable and degradable.
Wherein, in step (2), the distance between charging gear pump and collector are 10cm
Embodiment 2
The stanch fibre material of the absorbable and degradable of the present embodiment, ingredient are calculated by weight as：
Wherein, the functional fibre is selected from chitin fiber, chitosan derivative fibres, chitin fiber, chitin and spreads out
One or more of biological fiber, alginic acid fibre and cellulose derivative fibres.
Wherein, the hemostat is selected from collagen, fibrin, hyaluronic acid, alginic acid, porous-starch and its derivative
One or more of object.
Wherein, the one kind of the water absorbing agent in polyanionic polysaccharide, starch derivatives, polyacrylic acid and its derivative
Or it is several.
Wherein, the degradable high polymer material be selected from polylactic acid-based high molecular material, polylactide family macromolecule material,
Poly caprolactone high molecular material and polyglycolide high molecular material.
Wherein, the reinforcing agent is one or more of in cellulosic polymer, pyrrolidone polymer, polypropylene.
Wherein, the catalyst is stannous octoate.
Wherein, the antitack agent is the copolymer of polylactic acid, the one or both of polyglycolic acid；The plasticizer
For one or more of polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol.
The present invention also provides the preparation methods of the stanch fibre material of above-mentioned absorbable and degradable, include the following steps：
(1) in organic solvent by functional fibre dissolving, and hemostat, water absorbing agent, degradable macromolecule are added thereto
Material, reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) is obtained fiber solution to be fitted into the charging gear for the electrospinning device that temperature is 60 DEG C, is opened
High voltage power supply is opened equipped with the charging gear pump containing fiber solution, and injection stream is ejected on collector, obtains fibrous material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, anhydrous second is used in combination
Alcohol elutes tunica fibrosa repeatedly until residual spinning solvent is washed away completely, and by fibrous material, vacuum is done in vacuum drying chamber
It is dry, obtain the stanch fibre material of absorbable and degradable.
Wherein, in step (2), the distance between charging gear pump and collector are 25cm
Embodiment 3
The stanch fibre material of the absorbable and degradable of the present embodiment, ingredient are calculated by weight as：
Wherein, the functional fibre is selected from chitin fiber, chitosan derivative fibres, chitin fiber, chitin and spreads out
One or more of biological fiber, alginic acid fibre and cellulose derivative fibres.
Wherein, the hemostat is selected from collagen, fibrin, hyaluronic acid, alginic acid, porous-starch and its derivative
One or more of object.
Wherein, the one kind of the water absorbing agent in polyanionic polysaccharide, starch derivatives, polyacrylic acid and its derivative
Or it is several.
Wherein, the degradable high polymer material be selected from polylactic acid-based high molecular material, polylactide family macromolecule material,
Poly caprolactone high molecular material and polyglycolide high molecular material.
Wherein, the reinforcing agent is one or more of in cellulosic polymer, pyrrolidone polymer, polypropylene.
Wherein, the catalyst is stannous octoate.
Wherein, the antitack agent is the copolymer of polylactic acid, the one or both of polyglycolic acid；The plasticizer
For one or more of polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol.
The present invention also provides the preparation methods of the stanch fibre material of above-mentioned absorbable and degradable, include the following steps：
(1) in organic solvent by functional fibre dissolving, and hemostat, water absorbing agent, degradable macromolecule are added thereto
Material, reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) is obtained fiber solution to be fitted into the charging gear for the electrospinning device that temperature is 50 DEG C, is opened
High voltage power supply is opened equipped with the charging gear pump containing fiber solution, and injection stream is ejected on collector, obtains fibrous material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, anhydrous second is used in combination
Alcohol elutes tunica fibrosa repeatedly until residual spinning solvent is washed away completely, and by fibrous material, vacuum is done in vacuum drying chamber
It is dry, obtain the stanch fibre material of absorbable and degradable.
Wherein, in step (2), the distance between charging gear pump and collector are 18cm
Embodiment 4
The stanch fibre material of the absorbable and degradable of the present embodiment, ingredient are calculated by weight as：
Wherein, the functional fibre is selected from chitin fiber, chitosan derivative fibres, chitin fiber, chitin and spreads out
One or more of biological fiber, alginic acid fibre and cellulose derivative fibres.
Wherein, the hemostat is selected from collagen, fibrin, hyaluronic acid, alginic acid, porous-starch and its derivative
One or more of object.
Wherein, the one kind of the water absorbing agent in polyanionic polysaccharide, starch derivatives, polyacrylic acid and its derivative
Or it is several.
Wherein, the degradable high polymer material be selected from polylactic acid-based high molecular material, polylactide family macromolecule material,
Poly caprolactone high molecular material and polyglycolide high molecular material.
Wherein, the reinforcing agent is one or more of in cellulosic polymer, pyrrolidone polymer, polypropylene.
Wherein, the catalyst is stannous octoate.
Wherein, the antitack agent is the copolymer of polylactic acid, the one or both of polyglycolic acid；The plasticizer
For one or more of polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol.
The present invention also provides the preparation methods of the stanch fibre material of above-mentioned absorbable and degradable, include the following steps：
(1) in organic solvent by functional fibre dissolving, and hemostat, water absorbing agent, degradable macromolecule are added thereto
Material, reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) is obtained fiber solution to be fitted into the charging gear for the electrospinning device that temperature is 45 DEG C, is opened
High voltage power supply is opened equipped with the charging gear pump containing fiber solution, and injection stream is ejected on collector, obtains fibrous material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, anhydrous second is used in combination
Alcohol elutes tunica fibrosa repeatedly until residual spinning solvent is washed away completely, and by fibrous material, vacuum is done in vacuum drying chamber
It is dry, obtain the stanch fibre material of absorbable and degradable.
Wherein, in step (2), the distance between charging gear pump and collector are 15cm
Embodiment 5
The stanch fibre material of the absorbable and degradable of the present embodiment, ingredient are calculated by weight as：
Wherein, the functional fibre is selected from chitin fiber, chitosan derivative fibres, chitin fiber, chitin and spreads out
One or more of biological fiber, alginic acid fibre and cellulose derivative fibres.
Wherein, the hemostat is selected from collagen, fibrin, hyaluronic acid, alginic acid, porous-starch and its derivative
One or more of object.
Wherein, the one kind of the water absorbing agent in polyanionic polysaccharide, starch derivatives, polyacrylic acid and its derivative
Or it is several.
Wherein, the degradable high polymer material be selected from polylactic acid-based high molecular material, polylactide family macromolecule material,
Poly caprolactone high molecular material and polyglycolide high molecular material.
Wherein, the reinforcing agent is one or more of in cellulosic polymer, pyrrolidone polymer, polypropylene.
Wherein, the catalyst is stannous octoate.
Wherein, the antitack agent is the copolymer of polylactic acid, the one or both of polyglycolic acid；The plasticizer
For one or more of polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol.
The present invention also provides the preparation methods of the stanch fibre material of above-mentioned absorbable and degradable, include the following steps：
(1) in organic solvent by functional fibre dissolving, and hemostat, water absorbing agent, degradable macromolecule are added thereto
Material, reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) is obtained fiber solution to be fitted into the charging gear for the electrospinning device that temperature is 55 DEG C, is opened
High voltage power supply is opened equipped with the charging gear pump containing fiber solution, and injection stream is ejected on collector, obtains fibrous material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, anhydrous second is used in combination
Alcohol elutes tunica fibrosa repeatedly until residual spinning solvent is washed away completely, and by fibrous material, vacuum is done in vacuum drying chamber
It is dry, obtain the stanch fibre material of absorbable and degradable.
Wherein, in step (2), the distance between charging gear pump and collector are 22cm.
Comparative example 1
The hemostatic material prepared using the method for Chinese invention patent application 201410848483.0.
Comparative example 2
The hemostatic material prepared using the method for Chinese invention patent application 01126953.7.
Experimental example 1
The hemostasis experiment of rabbit liver model
The abdomen rabbit hair is cut off, abdomen is opened in the center of standard, dissociates, exposure liver；It is cut off at away from every leaf liver front end about 1cm
Hepatic tissue establishes bleeding model；Embodiment 1-5 and comparative example 1, hemostatic material (the phase homogeneity of comparative example 2 are used respectively
Amount) apply pressure wound, until stopped bleeding, records the bleeding time, as shown in table 1.
Table 1
As shown in Table 1, stanch fibre material bleeding stopping period of the invention in 5min hereinafter, anthemorrhagic speed relative contrast example 1,
2 pieces of comparative example, haemostatic effect is good.
Experimental example 2
1-5 of the embodiment of the present invention and comparative example 1,2 gained hemostatic materials are tested for the property, using little white rabbit as test
Object, little white rabbit anesthesia is fixed onboard, it is first marked on rabbit leg, then trims the rabbit hair, cut 1cm's long after disinfecting
Wound, rapidly in the hemostatic material mechanics of the weight such as blutpunkte fixation.For the ease of comparing, using gauze wrapped pressing processing as
Blank control example, test result is as follows shown in table 2.
Table 2
As shown in Table 2, the amount of bleeding of the hemostatic material of hemostatic material of the invention is less than 0.12, and bacteriostasis rate is higher than
99.2%, show good haemostatic effect, and the good biocompatibility of the hemostatic material of the present invention, the Wound healing time is short,
It has a good application prospect.
In conclusion the creativeness of the present invention is mainly reflected in the following：
(1) present invention is by the way that functional fibre to be blended with hemostat, water absorbing agent, degradable high polymer material spinning, and adds
Enter stanch fibre material prepared by reinforcing agent, catalyst, antitack agent and plasticizer, there is good biocompatibility, biodegradation
Property and bio-absorbable performance, use it for stopping blooding, not only haemostatic effect is good, but also haemostatic effect is fast, and the present invention hemostasis
Fibrous material can degrade absorption, safer.
(2) functional fibre of the present invention has three-dimensional space network structure, and degradable high polymer material secure rigid can be made to fill out
It fills wherein, keeps it not easily to fall off in hemostasis, but also, due to three-dimensional space network structure, its internal structure is loose, stopping blooding
After can form gel membranaceous material, wound has comfort, and is easy to fall off after stopping blooding, and is convenient for the processing of follow-up wound.
(3) reinforcing agent that the present invention adds can increase the intensity and tensile energy of blood clot, avoid secondary bleeding, accelerate
The healing of wound.
(4) water absorbing agent that the present invention adds can optimize the absorption property of material, further strengthen anthemorrhagic performance, stopping blooding
Simultaneously by water adsorption at bleeding, haemostatic effect is enhanced.
(5) antitack agent that the present invention adds can play the role of preventing various tissue adhesions in hemostasis, and add
The degradation time of stanch fibre material can be improved in plasticizer.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although with reference to aforementioned reality
Applying example, invention is explained in detail, for those skilled in the art, still can be to aforementioned each implementation
Technical solution recorded in example is modified or equivalent replacement of some of the technical features.All essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (10)
1. a kind of stanch fibre material of absorbable and degradable, which is characterized in that its ingredient is calculated by weight as：
2. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that its ingredient is in parts by weight
It is calculated as：
3. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the functional fibre is selected from
Chitin fiber, chitosan derivative fibres, chitin fiber, chitin derivativ fiber, alginic acid fibre and cellulose spread out
One or more of biological fiber.
4. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the hemostat is selected from glue
One or more of former albumen, fibrin, hyaluronic acid, alginic acid, porous-starch and its derivative.
5. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the water absorbing agent is selected from poly-
One or more of anion polysaccharide, starch derivatives, polyacrylic acid and its derivative.
6. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the degradable macromolecule
Material is selected from polylactic acid-based high molecular material, polylactide family macromolecule material, poly caprolactone high molecular material and poly- second and hands over
Esters high molecular material.
7. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the reinforcing agent is described
Reinforcing agent is one or more of in cellulosic polymer, pyrrolidone polymer, polypropylene.
8. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the catalyst is octanoic acid
Stannous.
9. the stanch fibre material of absorbable and degradable according to claim 1, which is characterized in that the antitack agent is
The copolymer of polylactic acid, the one or both of polyglycolic acid；The plasticizer is polyvinyl alcohol, polypropylene glycol, polytetramethylene glycol
One or more of.
10. according to the preparation method of the stanch fibre material of claim 1-9 any one of them absorbable and degradables, feature exists
In including the following steps：
(1) by functional fibre dissolving in organic solvent, and thereto be added hemostat, water absorbing agent, degradable high polymer material,
Reinforcing agent, catalyst, antitack agent and plasticizer, obtain fiber solution；
(2) step (1) is obtained fiber solution to be fitted into the charging gear for the electrospinning device that temperature is 40-60 DEG C, is opened
High voltage power supply is opened equipped with the charging gear pump containing fiber solution, and injection stream is ejected on collector, obtains fibrous material；
(3) fibrous material prepared by step (2) is impregnated in absolute ethyl alcohol to remove residual solvent, is used in combination absolute ethyl alcohol anti-
Again elution tunica fibrosa until residual spinning solvent washed away completely, fibrous material is dried in vacuo in vacuum drying chamber, is obtained
To the stanch fibre material of absorbable and degradable.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109289082A (en) * | 2018-11-22 | 2019-02-01 | 李忠 | A kind of absorbability medical hemostatic bibre material and preparation method thereof |
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Application publication date: 20181113 |