CN108785603A - Chinese medicine composition and preparation method thereof for treating osteoproliferation - Google Patents
Chinese medicine composition and preparation method thereof for treating osteoproliferation Download PDFInfo
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- CN108785603A CN108785603A CN201810860693.XA CN201810860693A CN108785603A CN 108785603 A CN108785603 A CN 108785603A CN 201810860693 A CN201810860693 A CN 201810860693A CN 108785603 A CN108785603 A CN 108785603A
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Abstract
The present invention provides a kind of Chinese medicine composition and preparation method for treating osteoproliferation, and the Chinese medicine composition is composed of the following components by mass percentage：Gingko 3%~5%, Semen sesami nigrum 7%~9%, Chinese yam 7%~9%, pawpaw 3%~5%, Chinese cassia tree 3%~5%, peach kernel 3%~5%, coix seed 6%~8%, fructus alpiniae oxyphyllae 3%~5%, pueraria lobata 6%~8%, arillus longan 7%~9%, Radix Angelicae Sinensis 6%~8%, mulberry fruit 6%~8%, raspberry 3%~5%, the fruit of Chinese wolfberry 7%~9%, sealwort 7%~9%, turmeric 6%~8%.It is dry with maltodextrin and potassium sorbate mixing granulation after adding water to be boiled into paste after above-mentioned component is mixed, sterilizing,.Drug of the present invention has swelling and pain relieving, clearing heat and detoxicating, promoting blood circulation to remove blood stasis, the work(of relaxing tendons and activating collaterals；The spur surrounding soft tissue inflammatory resolution that can make hyperplasia, repairs impaired bone tissue, and soften spur.
Description
Technical field
The invention belongs to the Chinese medicine compositions of integration of drinking and medicinal herbs scope, and in particular to a kind of Chinese medicine for treating osteoproliferation
Composition and preparation method thereof.
Background technology
Osteoproliferation, that is, Bones and joints edge hyperplasia comes out sclerotin, also known as spur, it is Osteoarthritis or degenerated joint
A kind of scorching performance.It is during bone is in growth, development and completion function, to a kind of generation of the degenerative change of bone
Repaying property is reacted.From the site of pathological change of osteoproliferation, osteoproliferation can be divided into four classes：1. cervical spondylosis, 1. cervical vertebra arteries and veins type：It shows as
Dizzy, headache, nausea, failure of memory；2. spondylotic radiculopathy：Show as side or both upper extremities numbness, pain；3. myeloid form：
The symptoms such as quadriplegia, gatism can be caused, but clinical rarely found；4. mixed type：Show as discomfort of neck area, headache,
And upper limb numbness pain.2. lumbar vertebrae hyperosteogeny：Show linear numb in one on the outside of double lower limb, shank and ankle portion arthritis
Bitterly, side numbness of lower limbs pain sometimes.3. double knee joint osteoproliferation：The vigor of showing as is limited, dystasia of squatting down, upper leave from office
Pain aggravates when rank, a other also ponding swelling.4. hyperosteogeny：Heel parts pain when walking is shown as, with morning
Morning get up after under when pain be very.
The cause of disease of osteoproliferation：1. at the age, in all primary degenerative arthritis risk factors, the age is strongest
Risk factor.Epidemiological study is shown, with the increase at age, the incidence of degenerative arthritis increases.There are two types of can for this
Energy：(1) development process of degenerative arthritis is very slow, thus life early stage by damage joint after several years
There is degenerative arthritis to change；(2) as the increase at age, the biomechanical environment in joint change, lead to degeneration
Arthritis.Specific mechanism may be to supply the blood flow progressive reduction in joint so that bone and the reconstruction rate of cartilage bonding pad decline；
This morphological change had not only interfered the nutrition of cartilage, but also changed the distribution born a heavy burden so that the cartilaginous areas that do not bear a heavy burden previously is present
Bear important pressure.2. damage, articular cartilage can cause bone to close due to primary serious wound or multiplicating damage
Section is scorching.Habitual arthrochalasis or subluxation such as kneecap habitual dislocation or subluxation belong to it.Clear-cut property bone cartilage is that bone closes
The scorching potentiality cause of disease of section, because of the sustainable injured joint cartilage of bone chip under not only falling off, and its fall off after leave it is coarse
Face gives corresponding surface with frequent abrasion wound.Equally, if fracture reset it is bad so that articular surface pairing not just, also can be very
Cause degenerative arthritis soon.5. articular surface is asymmetric, joint deformity can cause the degenerative change in joint, deformity that can make stress
Exception is conveyed, joint injury can be also made, if hip joint can be dislocated because of slipped epiphysis, occurs to turn up in knee in knee joint.
6. cartilage matrix changes, the change of articular chondrocytes epimatrix is not main pathogenic to most of degenerative arthritis,
But it is heavy in the crystallization of hemochromatosis, Wolson diseases, ochronotic arthropathy, urarthritis and calcium pyrophosphate dihydrate (CPPD)
It in disease, since hemosiderin, copper, alcapton polymer, urate crystal or CPPD crystallization are calm in the substrate respectively
Damaged cartilage cell leads to cartilage degradation indirectly directly or through matrix solidity is increased.7. inflammation, inflammation itself are not
The reason of Bones and joints, and the consequence of inflammation causes the cause of osteoarthritis, such as rheumatoid arthrosis, articular cartilage is damaged
Harmful result results in bone joint degeneration.8. fat, the fat load for not only significantly increasing weight-bearing joints and being born,
It can cause change and the movable change of entire kinematic system of posture and gait.The symptomatic degenerative arthritis of overweight people's knee occurs
Rate increases, but hip degenerative arthritis incidence does not increase.The generation of hip degenerative arthritis is except related with obesity at that time, still
It is related with previous obesity.Descending genicular vessel is presented in most patient.Speculate that this is a kind of compensatory mechanism, when bone is crossed fattiness
When separating, foot is placed under the center of gravity, such load just focuses on the cartilage of knee joint middle section, so fat
The knee joint of person is easy to happen degenerative change.Whether obesity is degenerative arthritis has for metabolism, heredity or other factors
It closes unclear.9. inherent cause, inherent cause for distally refer to close between joint degenerative arthritis generation it is related.
The method for the treatment of osteoproliferation has acupuncture, traction, Dressed plaster, endo-medicine, operation excision etc. at present.Acupuncture and
Traction also can only respite pain, it is palliative, and be easy to cause soft patient tissues damage.Dressed plaster is part
Treatment, primarily serves analgesic activity, once stopping application pain will be repeatedly and bigger to skin irritatin, is easy to skin
Skin causes allergy, festers.Endo-medicine on existing market is also to mainly contain analgesic activity, can temporarily eliminate patient's pain
Hardship, but be once discontinued, pain just rebounds, and the purpose cured the disease is not achieved.The method most thoroughly cured is exactly operation excision spur,
But operation wound is big, costly, and post-operative recovery time is long, and very big pain is brought to patient.
Invention content
The object of the present invention is to provide a kind of Chinese medicine compositions for treating osteoproliferation, using the treatment of solid decoction of medicinal ingredients
Means, resolution, is eliminated or reduction of patient pain, softening spur, therapeutic effect are good.
The technical solution adopted in the present invention is,
Chinese medicine composition for treating osteoproliferation, it is raw materials used composed of the following components by mass percentage：
Gingko 3%~5%, Semen sesami nigrum 7%~9%, Chinese yam 7%~9%, pawpaw 3%~5%, Chinese cassia tree 3%~5%, peach
Benevolence 3%~5%, coix seed 6%~8%, fructus alpiniae oxyphyllae 3%~5%, pueraria lobata 6%~8%, arillus longan 7%~9%, Radix Angelicae Sinensis 6%
~8%, mulberry fruit 6%~8%, raspberry 3%~5%, the fruit of Chinese wolfberry 7%~9%, sealwort 7%~9%, turmeric 6%~8%, with
The mass percent summation of upper each component is 100%.
The above-mentioned preparation method for treating osteoproliferation Chinese medicine composition, including following operating procedure：
Step 1,
By mass percentage, weigh gingko 3%~5%, Semen sesami nigrum 7%~9%, Chinese yam 7%~9%, pawpaw 3%~
5%, Chinese cassia tree 3%~5%, peach kernel 3%~5%, coix seed 6%~8%, fructus alpiniae oxyphyllae 3%~5%, pueraria lobata 6%~8%, longan
Meat 7%~9%, Radix Angelicae Sinensis 6%~8%, mulberry fruit 6%~8%, raspberry 3%~5%, the fruit of Chinese wolfberry 7%~9%, sealwort 7%~
9%, the mass percent summation of turmeric 6%~8%, the above each component is 100%；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts decoct 2 hours, add for the second time
The water of 6 times of amounts decocts 2 hours, merges decocting liquid twice, filtering, it is 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density,
Thick paste；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is spare；
Step 4,
By mass percentage, thick paste 24%~26.97%, 73%~75.97% and of maltodextrin that step 2 obtains are weighed
The mass percent summation of potassium sorbate 0.01%~0.03%, the above each component is 100%；Thick paste and water are stirred evenly
To whitewashing, the weight ratio of thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating premix, obtain mixed material, so
Pelletize afterwards toward whitewashing on mixed material, finally dry, cool down, discharging, shutdown；
Step 6,
Last whole grain and it is filling to get.
In above-mentioned steps 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set as 15m3/ h~
25m3/ h, inlet air temperature are set as 80 DEG C~100 DEG C, carry out heating premix 7~15 minutes to material, obtain mixed material；In advance
After mixed, by adjusting air quantity and inlet air temperature so that mixed material temperature reaches 35 DEG C~40 DEG C, then multi-functional fluidisation
Bed starts to whitewash, and spouting velocity is set as 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, due to object after whitewashing
Material aggravates, and temperature reduces, and adjusts air quantity at any time and material is kept fully to jump, and adjusting inlet air temperature at any time makes temperature of charge keep
At 35 DEG C~40 DEG C, whitewashing is closed after the 15min~30min that whitewashes, completes granulation；Multifunctional fluidized bed inlet air temperature is set again
It is set to 100 DEG C material is dried, adjusts air quantity and material is kept fully to jump, when the moisture of material≤2.0%, will enter the wind
Temperature is down to 25 DEG C~45 DEG C, and the temperature of material is made to be reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
In above-mentioned steps 6, the dry particl that step 5 obtains is chosen into the particle between the mesh of 14 mesh~60 on shaking screen and is completed
Whole grain, then the dry particl of selection is fitted into bag complete it is filling.
The beneficial effects of the invention are as follows：It is clearing heat and detoxicating with swelling and pain relieving, promoting blood circulation to remove blood stasis, the work(of relaxing tendons and activating collaterals；It can make
The spur surrounding soft tissue inflammatory resolution of hyperplasia, repairs impaired bone tissue, and soften spur；Entire prescription scientific compatibility,
Pharmacological property is mild, integration of drinking and medicinal herbs, to human body stomach fanout free region, has no toxic and side effect to human body, can take for a long time.
Specific implementation mode
The present invention provides a kind of Chinese medicine composition for treating osteoproliferation, raw materials used by mass percentage by following
Group is grouped as：
Gingko 3%~5%, Semen sesami nigrum 7%~9%, Chinese yam 7%~9%, pawpaw 3%~5%, Chinese cassia tree 3%~5%, peach
Benevolence 3%~5%, coix seed 6%~8%, fructus alpiniae oxyphyllae 3%~5%, pueraria lobata 6%~8%, arillus longan 7%~9%, Radix Angelicae Sinensis 6%
~8%, mulberry fruit 6%~8%, raspberry 3%~5%, the fruit of Chinese wolfberry 7%~9%, sealwort 7%~9%, turmeric 6%~8%, with
The mass percent summation of upper each component is 100%.
The pharmacological action of Chinese medicine of the present invention is as follows：
Gingko：It is sweet, it is bitter, it is puckery, it puts down, toxic, return lung kidney channel astringing lung for relieving asthma, stop-band contracting urine is breathed with cough for abundant expectoration, with lower white
It is turbid, enuresis frequent micturition.
Semen sesami nigrum：Filling liver kidney, benefiting essence-blood, ease constipation is dry, be used for blood and essence asthenia, dizzy, Hiccough and deaf, poliosis,
Post disease alopecia, dry constipation of intestines.
Chinese yam：Sweet and neutral returns skin lung kidney channel tonifying spleen nourishing the stomach, engender liquid and benefic lung to be used for spleen eating less, endless diarrhea, deficiency syndrome of the lung asthma
Cough, emission due to the kidney deficiency, under, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea mistake
It is more.
Pawpaw：Acid, warm Return liver the spleen channel relaxing tendons and activating collaterals, stomach dampness elimination.For arthritis with fixed pain caused by dampness contraction, waist and knee joint acid weight pain, heat
Wet vomiting and diarrhoea, convulsion contraction pain, tinea pedis oedema.
Chinese cassia tree：Pungent, sweet, big heat returns kidney spleen conscience through mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, warming meridian, for sun
Impotence Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, deficient yang with upper manifestation, dizziness hot eyes, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold hernia stomachache, dysmenorrhoea are closed
Through.
Peach kernel：Promoting blood circulation relaxes bowel, relieving cough and asthma, is used for amenorrhoea dysmenorrhoea, lung carbuncle acute appendicitis, injury from falling down, intestinal dryness is just
It is secret, cough and asthma.
Coix seed：Clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, detoxicating and resolving a mass are used for oedema, tinea pedis, and difficult urination is good for
It is the splenic diarrhea to rush down, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis, cancerous swelling.
Fructus alpiniae oxyphyllae：Warming up astringent sperm contracting urine, it is warming spleen and stopping diarrha to take the photograph saliva, it is used for enuresis with renal asthenia, frequent urination, gonorrhoea of passing out semen, malaria
Diarrhea, the more salivas of crymodynia mouth in abdomen.
Pueraria lobata：Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, Shengyang Zhixie, clearing and activating the channels and collaterals, relieving alcoholism, is used for fever caused by exogenous pathogens head
Bitterly, stiff nape and back, it is thirsty, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea, dizziness and headache, hemiplegia, chest impediment and cardialgia, during wine poison is hindered.
Arillus longan：Sweet, warm, thoughts of returning home the spleen channel tonifying heart and spleen, nourishing blood and tranquilization；For insufficiency of vital energy and blood, palpitaition is seized with terror secondary, forgetful mistake
It sleeps, blood deficiency chlorosis.
Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, moistening dryness for relaxing bowels are used for blood deficiency chlorosis, and dizziness palpitaition, irregular menstruation, dysmenorrhoea closes
Through, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sore wound, dry constipation of intestines.
Mulberry fruit：Nourishing yin and supplementing blood, fluid dryness are used for the deficiency of liver-yin and kidney-yin, dizziness and tinnitus, palpitation and insomnia, poliosis, Tianjin wound
Yearningly, Heat Diabetes, dry constipation of intestines.
Raspberry：Supplementing the kidney to control the nocturnal contracting urine, nourishes the liver to improve visual acuity, and is used for emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, mesh is secretly dim-sighted.
The fruit of Chinese wolfberry：Nourishing liver and kidney, benefiting shrewd head is used for consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, interior heat
It quenches one's thirst, blood deficiency chlorosis, blurred vision.
Sealwort：Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing, be used for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food,
Deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.
Turmeric：Blood-breaking, it is inducing meastruation to relieve menalgia, it is used for sternal rib shouting pain, chest impediment and cardialgia, dysmenorrhoea amenorrhoea, rheumatism shoulder arm pain to fall
Flutter swelling and pain.
" the kidney being in charge of bone and marrow "《Plain Questions》.Essence in kidney is full, and can just supplement nutrition marrow；Marrow is full, could promote bone
Healthy development.According to《Chinese Pharmacopoeia》, Semen sesami nigrum, mulberry fruit, the fruit of Chinese wolfberry, sealwort, pawpaw in side, nourishing liver and kidney, Tianjing Busuiye medicinal, by force
Muscle strong bone, relaxing tendons and activating collaterals promote osteocyte newborn, delay degenerative bone；Gingko, Chinese cassia tree, fructus alpiniae oxyphyllae, raspberry, treating YIN within YANG,
Warming and invigorating kidney Yang, controlling nocturnal emission with astringent drugs are only lost；Chinese yam, arillus longan, blood of invigorating the spleen and benefiting qi, as a means of essence and blood of supplementing nutrition；Peach kernel, pueraria lobata, Radix Angelicae Sinensis, Huoxue San "
The stasis of blood, blood circulation promoting and enriching repair bone injury.Coix seed and turmeric, swelling and pain relieving are clearing heat and detoxicating；All medicines share plays tonifying kidney and benefiting sperm altogether,
The work(of raw marrow strong bone.
Chinese medicine composition of the present invention is 10 grams oral every time by the way of oral, 2 times a day, a month as a treatment course.
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1
Preparation method for treating osteoproliferation Chinese medicine composition, including following operating procedure：
Step 1,
Weigh gingko 4kg, Semen sesami nigrum 9kg, Chinese yam 7kg, pawpaw 3kg, Chinese cassia tree 5kg, peach kernel 4kg, coix seed 8kg, intelligence development
Benevolence 4kg, pueraria lobata 6kg, arillus longan 7kg, Radix Angelicae Sinensis 6kg, mulberry fruit 8kg, raspberry 5kg, fruit of Chinese wolfberry 7kg, sealwort 9kg, turmeric 8kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts decoct 2 hours, add for the second time
The water of 6 times of amounts decocts 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.35 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is spare；
Step 4,
Weigh thick paste 20.5kg, maltodextrin 61.5kg and potassium sorbate 20g；Thick paste and water are uniformly mixing to obtain spray
The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set as 20m3/ h, inlet air temperature setting
It is 90 DEG C, heating premix is carried out 10 minutes to material, obtains mixed material；After premix, by adjusting air quantity and into wind-warm syndrome
Degree so that mixed material temperature reaches 36 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is set as 17rpm, atomization
Pressure is 1.70bar, and since material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and material is kept fully to jump, and at any time
Adjusting inlet air temperature makes temperature of charge be maintained at 36 DEG C, closes whitewashing after the 20min that whitewashes, completes granulation；Again by multi-functional fluidisation
The inlet air temperature of bed is set as 100 DEG C material is dried, and adjusts air quantity and material is kept fully to jump, when material moisture≤
When 2.0%, inlet air temperature is down to 25 DEG C, the temperature of material is made to be reduced to 25 DEG C, finally discharging shutdown；
Step 6,
The dry particl that step 5 obtains is chosen into the particle between the mesh of 14 mesh~60 on shaking screen and completes whole grain, then will
The dry particl of selection be fitted into bag complete it is filling.
Embodiment 2
Preparation method for treating osteoproliferation Chinese medicine composition, including following operating procedure：
Step 1,
Weigh gingko 3kg, Semen sesami nigrum 8kg, Chinese yam 9kg, pawpaw 5kg, Chinese cassia tree 4kg, peach kernel 3kg, coix seed 7kg, intelligence development
Benevolence 4kg, pueraria lobata 7kg, arillus longan 9kg, Radix Angelicae Sinensis 7kg, mulberry fruit 6kg, raspberry 3kg, fruit of Chinese wolfberry 8kg, sealwort 9kg, turmeric 8kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts decoct 2 hours, add for the second time
The water of 6 times of amounts decocts 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.20 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is spare；
Step 4,
Weigh thick paste 24kg, maltodextrin 75.97kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing,
The weight ratio of thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set as 25m3/ h, inlet air temperature setting
It is 80 DEG C, heating premix is carried out 7 minutes to material, obtains mixed material；After premix, by adjusting air quantity and into wind-warm syndrome
Degree so that mixed material temperature reaches 40 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is set as 15rpm, atomization
Pressure is 1.50bar, and since material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and material is kept fully to jump, and at any time
Adjusting inlet air temperature makes temperature of charge be maintained at 40 DEG C, closes whitewashing after the 15min that whitewashes, completes granulation；Again by multi-functional fluidisation
The inlet air temperature of bed is set as 100 DEG C material is dried, and adjusts air quantity and material is kept fully to jump, when material moisture≤
When 2.0%, inlet air temperature is down to 35 DEG C, the temperature of material is made to be reduced to 35 DEG C, finally discharging shutdown；
Step 6,
The dry particl that step 5 obtains is chosen into the particle between the mesh of 14 mesh~60 on shaking screen and completes whole grain, then will
The dry particl of selection be fitted into bag complete it is filling.
Embodiment 3
Preparation method for treating osteoproliferation Chinese medicine composition, including following operating procedure：
Step 1,
Weigh gingko 4kg, Semen sesami nigrum 8kg, Chinese yam 9kg, pawpaw 4kg, Chinese cassia tree 4kg, peach kernel 3kg, coix seed 7kg, intelligence development
Benevolence 5kg, pueraria lobata 8kg, arillus longan 8kg, Radix Angelicae Sinensis 7kg, mulberry fruit 6kg, raspberry 4kg, fruit of Chinese wolfberry 9kg, sealwort 8kg, turmeric 6kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts decoct 2 hours, add for the second time
The water of 6 times of amounts decocts 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.30 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is spare；
Step 4,
Weigh thick paste 26.97kg, maltodextrin 73kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing,
The weight ratio of thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set as 15m3/ h, inlet air temperature setting
It is 100 DEG C, heating premix is carried out 12 minutes to material, obtains mixed material；After premix, by adjusting air quantity and into wind-warm syndrome
Degree so that mixed material temperature reaches 38 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is set as 18rpm, atomization
Pressure is 2.0bar, and since material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and material is kept fully to jump, and at any time
Adjusting inlet air temperature makes temperature of charge be maintained at 38 DEG C, closes whitewashing after the 30min that whitewashes, completes granulation；Again by multi-functional fluidisation
The inlet air temperature of bed is set as 100 DEG C material is dried, and adjusts air quantity and material is kept fully to jump, when material moisture≤
When 2.0%, inlet air temperature is down to 30 DEG C, the temperature of material is made to be reduced to 30 DEG C, finally discharging shutdown；
Step 6,
The dry particl that step 5 obtains is chosen into the particle between the mesh of 14 mesh~60 on shaking screen and completes whole grain, then will
The dry particl of selection be fitted into bag complete it is filling.
Embodiment 4
Preparation method for treating osteoproliferation Chinese medicine composition, including following operating procedure：
Step 1,
Weigh gingko 5kg, Semen sesami nigrum 7kg, Chinese yam 8kg, pawpaw 5kg, Chinese cassia tree 3kg, peach kernel 5kg, coix seed 6kg, intelligence development
Benevolence 3kg, pueraria lobata 8kg, arillus longan 9kg, Radix Angelicae Sinensis 8kg, mulberry fruit 7kg, raspberry 4kg, fruit of Chinese wolfberry 8kg, sealwort 7kg, turmeric 7kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts decoct 2 hours, add for the second time
The water of 6 times of amounts decocts 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.40 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is spare；
Step 4,
Weigh thick paste 24.02kg, maltodextrin 75.97kg and potassium sorbate 10g；Thick paste and water are uniformly mixing to obtain spray
The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set as 20m3/ h, inlet air temperature setting
It is 95 DEG C, heating premix is carried out 15 minutes to material, obtains mixed material；After premix, by adjusting air quantity and into wind-warm syndrome
Degree so that mixed material temperature reaches 35 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is set as 20rpm, atomization
Pressure is 1.70bar, and since material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and material is kept fully to jump, and at any time
Adjusting inlet air temperature makes temperature of charge be maintained at 35 DEG C, closes whitewashing after the 25min that whitewashes, completes granulation；Again by multi-functional fluidisation
The inlet air temperature of bed is set as 100 DEG C material is dried, and adjusts air quantity and material is kept fully to jump, when material moisture≤
When 2.0%, inlet air temperature is down to 45 DEG C, the temperature of material is made to be reduced to 45 DEG C, finally discharging shutdown；
Step 6,
The dry particl that step 5 obtains is chosen into the particle between the mesh of 14 mesh~60 on shaking screen and completes whole grain, then will
The dry particl of selection be fitted into bag complete it is filling.
Clinical data
1, case selection：
In order to verify the effect of pharmaceutical composition of the present invention, in June, 2016, in December, -2017, selected the hyperostosis made a definite diagnosis
200 clinical observations of raw patient, male 88, women 112, age 34-70 Sui, average age 48 years old, the course of disease are most 2 short
Month, longest 17 years；Cervical vertebra hyperplasia person 59, hyperosteogeny person 72, knee joint increase survivor 48, calcaneal hyperplasia person 21.
Make a definite diagnosis standard：
(1) cervical vertebra hyperplasia person shows as：Neck, shoulder, back pain, when neck activity, aggravate, and neck limitation of activity is unilateral or double
The side numbness of fingers；Piece prompt is taken the photograph through x-ray or CT：Stenosis of disc space and asymmetry, lesion joint vertebral rim lip sample become, front and rear edge
Spur is formed.
(2) hyperosteogeny person shows as：The tired pain of waist, swollen pain bend over to turn over limited, unilateral or bilateral numbness of lower limbs pain
Bitterly, tired postemphasis；Piece prompt is taken the photograph through x-ray or CT：Stenosis of disc space and asymmetry, lesion joint vertebral rim lip sample becomes, preceding
Rear spur is formed.
(3) knee joint increases survivor and shows as：Knee pain, with the most apparent when stair activity, joint flexion-extension motion is limited；
Piece prompt is taken the photograph through x-ray or CT：The intercondylar and periarticular marginal bone in outside has spur sample hyperplasia in visible shin bone when knee joint hyperplasia.
(4) calcaneal hyperplasia person shows as：Heel is ached, shouting pain, is carried out ground and is aggravated, fixed pain；Piece is taken the photograph through x-ray or CT to carry
Show：The visible spur sample hyperplasia of calcaneal hyperplasia.
2, medicament selection：
Patient takes drug of the present invention, and 2 times a day, each 10g, warm water delivery service in half an hour after meal is treated for 30 days for one
Journey, continuously takes 1 to 3 courses for the treatment of, and serious patient increases the amount of discretion.
3, efficacy determination：
(1) it cures：Pain numbness disappear, activity freely, without recurrence after half a year；
(2) effective：Pain numbness disappears, and Changes in weather or overwork fashion have secret anguish, functional activity to return to normal；
(3) effectively：Subjective symptoms sign has exacerbation when having different degrees of mitigation, Changes in weather or overwork；
(4) invalid：Pain relief when treatment, but stop treatment after pain as before.
4, result：
It takes in 200 patients of drug of the present invention,
In 59 cervical vertebra hyperplasia patients：Cure 28, effective 18, effective 9, invalid 4；
In 72 hyperosteogeny patients：Cure 34, effective 22, effective 10, invalid 6；
In 48 knee joint hyperplasia patients：Cure 24, effective 12, effective 8, invalid 4；
In 21 calcaneal hyperplasia patients：Cure 10, effective 6, effective 3, invalid 2.
Case 1
Zhang, female, 53 years old, Xi'an Gaoling people from area；Patient's readme：Its waist distending pain, which has 2 years, has a surplus, sick from the beginning of this year
Feelings obviously aggravate, and flank pain takes place frequently, and waist body cannot be upright when violent, day and night tosses about in bed.It is aobvious to clap lumbar X anterioposterior and lateral film result
Show：Lumbar physiological-curvature straightens, L2~5Preceding upper limb side and tail bone are shown in lip sample osteoproliferation, L3~5Narrowing of intervertebral space, remaining vertebra
Body no abnormality seen.It is diagnosed as L2、3、4、5And the hypertrophy hyperplasia of tail bone.Patient took drug of the present invention after 2 months, carried out here further consultation：
The state of an illness is effectively controlled, and flank pain slows down.Continue to take drug of the present invention 2 months, carrys out here further consultation：Patient's waist pain
Symptom disappears substantially, and when only doing waist activity, still some stiff discomforts have mild pain.To consolidate curative effect, continue to take this
Invention drug 1 month.
Case 2
Week certain, female, 49 years old, Shaanxi Province Weinan City people.Patient's readme：Pain 3 years, nearly 2 years pairs of knees close double knee joint repeatedly
Section pain gradually aggravates, on foot when pain obviously aggravate, cannot squat down and stair activity, seriously affect daily life, weather becomes
Pain aggravates when change, ineffective through multi-treatment.Patient body is fat, double knee joint swelling, tenderness, audible and rubs when movable
Fricative.X ray photograph prompts articulatio genus hyperosteogeny, is diagnosed as double knee joint hyperostosis.Continuously take drug 2 of the present invention
After month, double knee joint pain relief, and continue to take 3 months, double knee joint feeling of pain disappears, can slowly stair activity and under
It squats, stair activity and while squatting down have secret anguish.
Case 3
Perhaps certain, male, 60 years old, Baoji, Shaanxi province people from city.Because occurring pain in the back, right lower extremity radiation after fatigue of suffering from cold before patient's half a year
Pain is turned over difficult to heel, cannot be walked, and when action helps by people's back of the body.Once it massaged, drawn, being fumigated, acupuncture and moxibustion therapy is without apparent
Effect.CT is prompted：L4/5、L5S1Disc herniation oppresses dural sac to spinal canal stenosis；X-ray prompts：L4/5Narrowing of intervertebral space；Diagnosis
For：The protrasion of the lumbar intervertebral disci, lumbar spinal stenosis.Drug of the present invention is continuously taken after 2 months, pain in the back is alleviated, right lower extremity Rediating Pain
Also be relieved, on foot when slightly feeling of pain.Continuing to take drug of the present invention 2 months again, pain in the back disappears, and patient stretches one's legs freely,
It does not feel very well when walking, right lower extremity can be raised.
Claims (4)
1. the Chinese medicine composition for treating osteoproliferation, which is characterized in that raw materials used by mass percentage by following components
Composition：
Gingko 3%~5%, Semen sesami nigrum 7%~9%, Chinese yam 7%~9%, pawpaw 3%~5%, Chinese cassia tree 3%~5%, peach kernel
3%~5%, coix seed 6%~8%, fructus alpiniae oxyphyllae 3%~5%, pueraria lobata 6%~8%, arillus longan 7%~9%, Radix Angelicae Sinensis 6%~
8%, mulberry fruit 6%~8%, raspberry 3%~5%, the fruit of Chinese wolfberry 7%~9%, sealwort 7%~9%, turmeric 6%~8%, it is above
The mass percent summation of each component is 100%.
2. for treating the preparation method of osteoproliferation Chinese medicine composition described in a kind of claim 1, which is characterized in that including with
Lower operating procedure：
Step 1,
By mass percentage, gingko 3%~5%, Semen sesami nigrum 7%~9%, Chinese yam 7%~9%, pawpaw 3%~5%, meat are weighed
Osmanthus 3%~5%, peach kernel 3%~5%, coix seed 6%~8%, fructus alpiniae oxyphyllae 3%~5%, pueraria lobata 6%~8%, arillus longan 7%
~9%, Radix Angelicae Sinensis 6%~8%, mulberry fruit 6%~8%, raspberry 3%~5%, the fruit of Chinese wolfberry 7%~9%, sealwort 7%~9%, ginger
The mass percent summation of Huang 6%~8%, the above each component is 100%；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, add the water of 10 times of amounts for the first time, are decocted 2 hours, second plus 6 times
The water of amount decocts 2 hours, merges decocting liquid twice, filtering, it is the thick of 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density,
Cream；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is spare；
Step 4,
By mass percentage, thick paste 24%~26.97%, maltodextrin 73%~75.97% and sorb that step 2 obtains are weighed
The mass percent summation of sour potassium 0.01%~0.03%, the above each component is 100%；Thick paste and water are uniformly mixing to obtain spray
The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating premix, obtain mixed material, it is then past
Whitewashing is pelletized on mixed material, is finally dried, is cooled down, discharging, shutting down；
Step 6,
Last whole grain and it is filling to get.
3. being used to treat the preparation method of osteoproliferation Chinese medicine composition according to claim 2, it is characterised in that：The step
In rapid 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set as 15m3/ h~25m3/ h, inlet air temperature
80 DEG C~100 DEG C are set as, heating premix is carried out 7~15 minutes to material, obtains mixed material；After premix, pass through tune
Save air quantity and inlet air temperature so that mixed material temperature reaches 35 DEG C~40 DEG C, then multifunctional fluidized bed to start to whitewash, whitewashing
Speed is set as 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, and since material aggravates after whitewashing, temperature reduces,
Adjusting air quantity at any time keeps material fully to jump, and adjusting inlet air temperature at any time makes temperature of charge be maintained at 35 DEG C~40 DEG C, spray
Whitewashing is closed after starching 15min~30min, completes granulation；Multifunctional fluidized bed inlet air temperature is set as 100 DEG C to material again
Be dried, adjust air quantity and material is kept fully to jump, when the moisture of material≤2.0%, by inlet air temperature be down to 25 DEG C~
45 DEG C, the temperature of material is made to be reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
4. being used to treat the preparation method of osteoproliferation Chinese medicine composition according to claim 2, it is characterised in that：The step
In rapid 6, the dry particl that step 5 obtains is chosen into the particle between the mesh of 14 mesh~60 on shaking screen and completes whole grain, it then will choosing
The dry particl taken be fitted into bag complete it is filling.
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| CN110870570A (en) * | 2019-11-25 | 2020-03-10 | 类红缨 | Edible granule for strengthening tendons and bones and preparation method thereof |
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| CN106474410A (en) * | 2016-12-28 | 2017-03-08 | 陕西红顶名医堂药业有限公司 | For treating Chinese medicine composition of chronic prostatitiss and preparation method thereof |
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