CN108766587B - Method and device for constructing drug administration database based on specified drugs - Google Patents
Method and device for constructing drug administration database based on specified drugs Download PDFInfo
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Abstract
The embodiment of the invention provides a method and a device for constructing a drug administration database based on specified drugs, wherein the method comprises the following steps: acquiring administration information aiming at a specified drug of a human body to be detected in a preset time period, and generating an administration strategy unit; evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; if the updating times are more than or equal to 1, combining the administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; acquiring all target administration strategy units, performing union set processing on the pre-administration detection items of each target administration strategy unit, and storing union set processing results to a first type administration database. The device performs the above method. The method and the device provided by the embodiment of the invention can improve the medication efficiency of the specified medicine and reduce the medical cost of taking medicine, detecting and the like.
Description
Technical Field
The embodiment of the invention relates to the technical field of data processing, in particular to a method and a device for constructing a drug administration database based on specified drugs.
Background
Certain first-line drugs for treating bacterial infections, such as vancomycin, have narrow treatment window and large individual difference in pharmacokinetics according to domestic and foreign diagnosis and treatment guidelines, and are commonly used for critically ill patients, so that the variability of the individual dose of vancomycin is large (10-20 mg/L). How to adopt the right dosage and the right frequency to let the patient take the vancomycin becomes a difficult problem.
In the prior art, the dosage and the frequency of administration of vancomycin are provided for different patients according to the experience of doctors, so that the efficiency is low, and the individual differences of different patients are large, so that repeated tests are required, and the medical costs of administration, detection and the like are increased.
Therefore, it is an urgent problem to avoid the above drawbacks, to improve the efficiency of medication, and to reduce the cost of medical treatment such as medication and examination.
Disclosure of Invention
Aiming at the problems in the prior art, the embodiment of the invention provides a method and a device for constructing a drug administration database based on specified drugs.
In a first aspect, embodiments of the present invention provide a method for building a drug administration database based on specified drugs, the method comprising:
acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information;
evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring;
if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information;
acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
In a second aspect, embodiments of the present invention provide an apparatus for building a drug administration database based on specified drugs, the apparatus comprising:
the device comprises a generating unit, a judging unit and a judging unit, wherein the generating unit is used for acquiring administration information of a human body to be detected aiming at a specified medicine in a preset time period and generating an administration strategy unit, and the administration strategy unit comprises the administration information and a detection item before and after administration and a detection item after administration corresponding to the administration information;
the evaluation unit is used for evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring;
the merging unit is used for merging the administration strategy units corresponding to the same administration information to acquire a target administration strategy unit if the updating times of the administration information are more than or equal to 1; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information;
and the storage unit is used for acquiring all target administration strategy units of all human bodies to be detected, performing union processing on the pre-administration detection items of each target administration strategy unit, and storing union processing results to the first type administration database.
In a third aspect, an embodiment of the present invention provides an electronic device, including: a processor, a memory, and a bus, wherein,
the processor and the memory are communicated with each other through the bus;
the memory stores program instructions executable by the processor, the processor invoking the program instructions to perform a method comprising:
acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information;
evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring;
if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information;
acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
In a fourth aspect, an embodiment of the present invention provides a non-transitory computer-readable storage medium, including:
the non-transitory computer readable storage medium stores computer instructions that cause the computer to perform a method comprising:
acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information;
evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring;
if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information;
acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
According to the method and the device for constructing the drug administration database based on the specified drugs, the target drug administration strategy units are obtained through the generated drug administration strategy units, the detection items before drug administration of each target drug administration strategy unit are subjected to union processing, the union processing result is stored, and the data in the constructed first type drug administration database are analyzed, so that the drug administration efficiency of the specified drugs can be improved, and the medical costs of drug administration, detection and the like can be reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.
FIG. 1 is a flow chart illustrating a method for constructing a drug administration database based on specified drugs according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of an apparatus for constructing a drug administration database based on specified drugs according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of an electronic device according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Fig. 1 is a schematic flow chart of a method for constructing a drug administration database based on a specified drug according to an embodiment of the present invention, and as shown in fig. 1, the method for constructing a drug administration database based on a specified drug according to an embodiment of the present invention includes the following steps:
s101: the method comprises the steps of obtaining administration information aiming at a specified medicine of a human body to be detected in a preset time period, and generating an administration strategy unit, wherein the administration strategy unit comprises the administration information, and a detection item before administration and a detection item after administration, which correspond to the administration information.
Specifically, the device acquires administration information of a human body to be detected aiming at a specified drug within a preset time period, and generates an administration strategy unit, wherein the administration strategy unit comprises the administration information, and a detection item before administration and a detection item after administration corresponding to the administration information. The preset time interval can be set autonomously according to actual conditions, and the time interval from the time corresponding to the pre-administration detection item of the first administration information received by the human body to be detected to the time corresponding to the post-administration detection item of the last administration information can be used as the preset time interval. The designated drug may include vancomycin, but is not particularly limited. The administration information may include the dose and frequency of administration. It can be understood that: the administration information is in one-to-one correspondence with the administration strategy units. The detection item before administration can comprise a gene detection result item, and the individuation difference characteristics of the human body to be detected can be obtained through the gene detection result item; at least one of a blood routine test result and a urine routine test result may also be included. The test items after administration can refer to the description of the test items before administration, and are not repeated.
The method for acquiring the drug administration information of the human body to be detected for the specified drugs in the preset time period can adopt the following modes: non-specified administration information corresponding to the non-specified drugs is removed, and the remaining administration information is used as the administration information, and the specific implementation can be as follows: and for the preset zone bit 1 of the specified medicine and for the preset zone bit 0 of the non-specified medicine, acquiring the administration information of the specified medicine by retrieving the administration information with the preset zone bit of 1, or taking the residual administration information as the administration information of the specified medicine by retrieving and rejecting the administration information with the preset zone bit of 0.
S102: evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the therapeutic drug monitoring TDM.
Specifically, the device evaluates the administration effect of the administration information according to the detection results corresponding to the pre-administration detection item and the post-administration detection item respectively; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the therapeutic drug monitoring TDM. The preset index may be 15-20mg/L set based on TDM, more specifically, for children: 10-15 mg/L; adult: 15-20 mg/L. The specific numerical value of the preset index is not particularly limited. TDM can be calculated through detection results corresponding to the detection items before and after administration, and the specific calculation process is mature in the field and is not described again. If the TDM is in the range represented by the preset index, the medication effect reaches the preset index, and the administration is not required again; if the TDM is not in the range represented by the preset index, the medication effect does not reach the preset index, and the medication needs to be taken again, namely the medication information is updated (the dosage and/or frequency different from the last medication).
S103: if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information.
Specifically, if the device judges that the update times of the administration information are larger than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information. Since each update may produce administration information that may be different or the same, the same administration information includes the same dose and the same frequency, and administration information is considered to be different if one of the dose and the frequency is different. Examples are as follows: assuming that three administration strategy units are totally recorded as A, B, C in a preset time period, wherein administration information corresponding to A and administration information corresponding to B are completely the same, combining A and B, and if the detection items before administration of A are a gene detection result item E1, blood routine detection items C1-C4 and urine routine detection items D1-D4; if the pre-administration detection item of B is the gene detection result item E1 (namely the same gene detection result item of the same human body to be detected), the blood conventional detection items C3-C5 and the urine conventional detection items D3-D5. The pre-administration test items of the targeted administration strategy units are E1, C3-C4, D3-D4.
S104: acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
Specifically, the device acquires all target administration strategy units of all human bodies to be detected, performs union processing on the pre-administration detection items of each target administration strategy unit, and stores union processing results in a first type administration database. Examples are as follows: the kit comprises three human bodies to be detected, which are respectively marked as a, b and C, wherein the corresponding target administration strategy units are x, y and z, and the detection items before administration for x are E1, C3-C4 and D3-D4; pre-dose test items for y are E2, C3, C6, D3, D6; pre-dose test items for z are E3, C1, C6, D1, D6; the union processing result is E1, E2, E3, C1, C3-C4 and C6; d1, D3-D4 and D6.
The first type of dosing database may be a regulatory regimen database, as illustrated below:
adjusting a scheme database: after vancomycin is used for the first time for a plurality of days (can be 3 days), the TDM value is not between 15 and 20mg/L, the dose and/or frequency are continuously adjusted through trial and error iteration until the TDM value is between 15 and 20mg/L, the detection items before administration of all target administration strategy units are subjected to union processing, the union processing result is stored, and the detection items after administration of each administration strategy unit are reserved.
And if the updating times of the administration information are zero (only once administration is needed, the estimated administration effect reaches a preset index), directly storing the administration strategy unit corresponding to the administration information in a second type administration database.
The second type of administration database may be an initial regimen database, as illustrated below:
initial plan database: administration information with a TDM value between 15 and 20mg/L after the first administration of vancomycin for several days (which may be 3 days) and corresponding pre-administration and post-administration test items.
Data analysis and the like can be performed on the data in the drug administration database (including the first type drug administration database and the second type drug administration database), which is not specifically described.
According to the method for constructing the drug administration database based on the specified drugs, the target drug administration strategy units are obtained through the generated drug administration strategy units, the detection items before drug administration of each target drug administration strategy unit are subjected to union processing, the union processing result is stored, and the data in the constructed first type drug administration database are analyzed, so that the drug administration efficiency of the specified drugs can be improved, and the medical costs of drug administration, detection and the like can be reduced.
On the basis of the above embodiment, the method further includes:
and if the updating times of the administration information are zero, directly storing the administration strategy unit corresponding to the administration information in a second type administration database.
Specifically, if the device determines that the number of times of updating the administration information is zero, the device directly stores the administration strategy unit corresponding to the administration information in a second type administration database. Reference may be made to the above embodiments, which are not described in detail.
According to the method for constructing the drug administration database based on the specified drugs, which is provided by the embodiment of the invention, the drug administration strategy unit corresponding to the drug administration information which does not need to be updated is directly stored in the second type drug administration database, so that the data analysis, management and the like of different types of databases are facilitated.
On the basis of the above embodiment, the administration information includes administration dose and frequency; accordingly, the same administration information includes the same administration dose and the same frequency.
In particular, the same administration information in the device includes the same dose and the same frequency of administration. Reference may be made to the above embodiments, which are not described in detail.
The method for constructing the drug administration database based on the specified drugs provided by the embodiment of the invention ensures the smooth and reasonable operation of the method by adopting the same drug administration dosage and the same frequency to define the same drug administration information.
Based on the above examples, the specified drug comprises vancomycin.
In particular, the specified drug in the device comprises vancomycin.
According to the method for constructing the administration database based on the specified drugs, which is provided by the embodiment of the invention, the specified drugs are selected to be the vancomycin, so that the administration efficiency of the vancomycin can be improved, and the medical costs of administration, detection and the like can be reduced.
On the basis of the above embodiments, the pre-administration test item or the post-administration test item includes:
at least one of a gene test result item, a blood routine test result item, and a urine routine test result item.
Specifically, the pre-administration test item or the post-administration test item in the device comprises:
at least one of a gene test result item, a blood routine test result item, and a urine routine test result item. Reference may be made to the above embodiments, which are not described in detail.
The method for constructing the drug administration database based on the specified drugs provided by the embodiment of the invention can ensure the normal operation of the method by specifically defining the content of the detection item before drug administration or the content of the detection item after drug administration.
On the basis of the above embodiment, the acquiring, within the preset time period, the administration information of the human body to be detected for the specified drug includes:
and rejecting non-specified administration information corresponding to the non-specified drugs, and taking the residual administration information as the administration information.
Specifically, the device eliminates non-specified administration information corresponding to the non-specified drug, and takes the remaining administration information as the administration information. Reference may be made to the above embodiments, which are not described in detail.
According to the method for constructing the administration database based on the specified drugs, which is provided by the embodiment of the invention, the non-specified administration information corresponding to the non-specified drugs is removed, and the residual administration information is used as the administration information, so that the administration information can be effectively obtained.
Fig. 2 is a schematic structural diagram of an apparatus for constructing a drug administration database based on a specified drug according to an embodiment of the present invention, and as shown in fig. 2, an apparatus for constructing a drug administration database based on a specified drug according to an embodiment of the present invention includes a generating unit 201, an evaluating unit 202, a combining unit 203, and a storing unit 204, where:
the generation unit 201 is configured to acquire administration information of a human body to be detected for a specified drug in a preset time period, and generate an administration strategy unit, where the administration strategy unit includes the administration information, and a pre-administration detection item and a post-administration detection item corresponding to the administration information; the evaluation unit 202 is configured to evaluate the medication effect of the medication information according to the detection results corresponding to the pre-medication detection item and the post-medication detection item respectively; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring; the merging unit 203 is configured to merge the medication strategy units corresponding to the same medication information to obtain a target medication strategy unit if the update frequency of the medication information is greater than or equal to 1; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information; the storage unit 204 is configured to acquire all target medication strategy units of all human bodies to be detected, perform union processing on the pre-medication detection items of each target medication strategy unit, and store union processing results in the first type medication database.
Specifically, the generating unit 201 is configured to acquire, within a preset time period, drug administration information of a human body to be detected for a specified drug, and generate a drug administration policy unit, where the drug administration policy unit includes the drug administration information, and a pre-drug administration detection item and a post-drug administration detection item corresponding to the drug administration information; the evaluation unit 202 is configured to evaluate the medication effect of the medication information according to the detection results corresponding to the pre-medication detection item and the post-medication detection item respectively; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring; the merging unit 203 is configured to merge the medication strategy units corresponding to the same medication information to obtain a target medication strategy unit if the update frequency of the medication information is greater than or equal to 1; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information; the storage unit 204 is configured to acquire all target medication strategy units of all human bodies to be detected, perform union processing on the pre-medication detection items of each target medication strategy unit, and store union processing results in the first type medication database.
According to the device for constructing the drug administration database based on the specified drugs, the target drug administration strategy units are obtained through the generated drug administration strategy units, the detection items before drug administration of each target drug administration strategy unit are subjected to union processing, the union processing result is stored, and the data in the constructed first type drug administration database are analyzed, so that the drug administration efficiency of the specified drugs can be improved, and the medical costs of drug administration, detection and the like can be reduced.
The device for constructing a drug administration database based on specified drugs provided by the embodiment of the present invention may be specifically configured to execute the processing procedures of the above method embodiments, and the functions thereof are not described herein again, and reference may be made to the detailed description of the above method embodiments.
Fig. 3 is a schematic structural diagram of an electronic device according to an embodiment of the present invention, and as shown in fig. 3, the electronic device includes: a processor (processor)301, a memory (memory)302, and a bus 303;
the processor 301 and the memory 302 complete communication with each other through a bus 303;
the processor 301 is configured to call program instructions in the memory 302 to perform the methods provided by the above-mentioned method embodiments, including: acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information; evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring; if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information; acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
The present embodiment discloses a computer program product comprising a computer program stored on a non-transitory computer readable storage medium, the computer program comprising program instructions which, when executed by a computer, enable the computer to perform the method provided by the above-mentioned method embodiments, for example, comprising: acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information; evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring; if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information; acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
The present embodiments provide a non-transitory computer-readable storage medium storing computer instructions that cause the computer to perform the methods provided by the above method embodiments, for example, including: acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information; evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring; if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information; acquiring all target administration strategy units of all human bodies to be detected, merging the detection items before administration of each target administration strategy unit, and storing the merging processing result to a first type administration database.
Those of ordinary skill in the art will understand that: all or part of the steps for implementing the method embodiments may be implemented by hardware related to program instructions, and the program may be stored in a computer readable storage medium, and when executed, the program performs the steps including the method embodiments; and the aforementioned storage medium includes: various media that can store program codes, such as ROM, RAM, magnetic or optical disks.
The above-described embodiments of the electronic device and the like are merely illustrative, where the units described as separate parts may or may not be physically separate, and the parts displayed as units may or may not be physical units, may be located in one place, or may also be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of the present embodiment. One of ordinary skill in the art can understand and implement it without inventive effort.
Through the above description of the embodiments, those skilled in the art will clearly understand that each embodiment can be implemented by software plus a necessary general hardware platform, and certainly can also be implemented by hardware. With this understanding in mind, the above-described technical solutions may be embodied in the form of a software product, which can be stored in a computer-readable storage medium such as ROM/RAM, magnetic disk, optical disk, etc., and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the methods described in the embodiments or some parts of the embodiments.
Finally, it should be noted that: the above embodiments are only used for illustrating the technical solutions of the embodiments of the present invention, and are not limited thereto; although embodiments of the present invention have been described in detail with reference to the foregoing embodiments, those skilled in the art will understand that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (8)
1. A method of building a drug administration database based on specified drugs, comprising:
acquiring drug administration information of a human body to be detected aiming at a specified drug in a preset time period, and generating a drug administration strategy unit, wherein the drug administration strategy unit comprises the drug administration information, and a detection item before drug administration and a detection item after drug administration which correspond to the drug administration information;
evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring;
if the updating times of the administration information are more than or equal to 1, combining administration strategy units corresponding to the same administration information to obtain a target administration strategy unit; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information;
acquiring all target administration strategy units of all human bodies to be detected, performing union processing on pre-administration detection items of each target administration strategy unit, and storing union processing results to a first type administration database;
and if the updating times of the administration information are zero, directly storing the administration strategy unit corresponding to the administration information in a second type administration database.
2. The method of claim 1, wherein the administration information includes dose and frequency of administration; accordingly, the same administration information includes the same administration dose and the same frequency.
3. The method of claim 1, wherein the specified drug comprises vancomycin.
4. The method of claim 1, wherein the pre-dose or post-dose test item comprises:
at least one of a gene test result item, a blood routine test result item, and a urine routine test result item.
5. The method according to claim 1, wherein the obtaining of the administration information of the human body to be detected for the specified drug within the preset time period comprises:
and rejecting non-specified administration information corresponding to the non-specified drugs, and taking the residual administration information as the administration information.
6. An apparatus for building a drug administration database based on specified drugs, comprising:
the device comprises a generating unit, a judging unit and a judging unit, wherein the generating unit is used for acquiring administration information of a human body to be detected aiming at a specified medicine in a preset time period and generating an administration strategy unit, and the administration strategy unit comprises the administration information and a detection item before and after administration and a detection item after administration corresponding to the administration information;
the evaluation unit is used for evaluating the medication effect of the medication information according to the detection results respectively corresponding to the pre-medication detection item and the post-medication detection item; if the medication effect does not reach a preset index, updating the medication information; the preset index is set according to the TDM of the therapeutic drug monitoring;
the merging unit is used for merging the administration strategy units corresponding to the same administration information to acquire a target administration strategy unit if the updating times of the administration information are more than or equal to 1; the pre-administration detection items of the target administration strategy unit are obtained by performing intersection processing on the pre-administration detection items respectively corresponding to all the same administration information;
the storage unit is used for acquiring all target administration strategy units of all human bodies to be detected, performing union processing on the pre-administration detection items of each target administration strategy unit, and storing union processing results to the first type administration database; and if the updating times of the administration information are zero, directly storing the administration strategy unit corresponding to the administration information in a second type administration database.
7. An electronic device, comprising: a processor, a memory, and a bus, wherein,
the processor and the memory are communicated with each other through the bus;
the memory stores program instructions executable by the processor, the processor invoking the program instructions to perform the method of any of claims 1 to 5.
8. A non-transitory computer-readable storage medium storing computer instructions that cause a computer to perform the method of any one of claims 1 to 5.
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972631A (en) * | 2004-05-04 | 2007-05-30 | 达尔豪斯大学 | Method of assessment of airway variability in airway hyperresponsiveness |
| CN102497847A (en) * | 2009-07-20 | 2012-06-13 | 达雅医疗股份有限公司 | Pharmaceutical packaging and method for delivery of same |
| CN103354929A (en) * | 2010-11-23 | 2013-10-16 | 商业法律支持有限责任公司 | System for differentiation and analysis of recorded clinical data |
| CN103782299A (en) * | 2011-07-01 | 2014-05-07 | 百特恩格伍德公司 | Systems and methods for intelligent patient interface device |
| CN104392085A (en) * | 2014-09-05 | 2015-03-04 | 上海卫生信息工程技术研究中心有限公司 | Drug effect evaluation method based on kernel principal component TOPSIS |
| CN104615904A (en) * | 2015-02-28 | 2015-05-13 | 领智控股有限公司 | Antibacterial medicament clinical application decision support system and constructing method thereof |
| CN105658134A (en) * | 2013-03-15 | 2016-06-08 | 塞罗拉公司 | Multi-modal pharmaco-diagnostic assessment of brian helath |
| CN106126886A (en) * | 2008-03-26 | 2016-11-16 | 赛拉诺斯股份有限公司 | Computer system |
| CN106897549A (en) * | 2017-01-25 | 2017-06-27 | 浙江大学 | Cancer Individual treatment policy selection method based on molecular physiology group |
| CN107066826A (en) * | 2017-05-11 | 2017-08-18 | 杭州逸曜信息技术有限公司 | Medication information processing method based on test rating |
| CN107111673A (en) * | 2014-09-29 | 2017-08-29 | 周格尼克斯国际有限公司 | Control the control system of medicine distribution |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003232406A1 (en) * | 2002-06-14 | 2003-12-31 | Pfizer Inc. | Metabolic phenotyping |
| GB0213786D0 (en) * | 2002-06-14 | 2002-07-24 | Imp College Innovations Ltd | Metabolic phenotyping |
| US20040193446A1 (en) * | 2003-03-27 | 2004-09-30 | Mayer Steven Lloyd | System and method for managing a patient treatment program including a prescribed drug regimen |
| WO2012023680A1 (en) * | 2010-08-16 | 2012-02-23 | Ajou University Industry-Academic Cooperation Foundation | Method of detecting adverse reaction to drug using electronic medical record, method of detecting adverse reaction to intervention, and method of detecting adverse reaction to drug or intervention using electronic medical record and electrocardiogram data |
| US20140297199A1 (en) * | 2011-11-11 | 2014-10-02 | Cold Spring Harbor Laboratory | Drug screening method and uses thereof |
| EP3298519A1 (en) * | 2015-04-09 | 2018-03-28 | Diane R. Mould | Systems and methods for patient-specific dosing |
-
2018
- 2018-05-11 CN CN201810449795.2A patent/CN108766587B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972631A (en) * | 2004-05-04 | 2007-05-30 | 达尔豪斯大学 | Method of assessment of airway variability in airway hyperresponsiveness |
| CN106126886A (en) * | 2008-03-26 | 2016-11-16 | 赛拉诺斯股份有限公司 | Computer system |
| CN102497847A (en) * | 2009-07-20 | 2012-06-13 | 达雅医疗股份有限公司 | Pharmaceutical packaging and method for delivery of same |
| CN103354929A (en) * | 2010-11-23 | 2013-10-16 | 商业法律支持有限责任公司 | System for differentiation and analysis of recorded clinical data |
| CN103782299A (en) * | 2011-07-01 | 2014-05-07 | 百特恩格伍德公司 | Systems and methods for intelligent patient interface device |
| CN105658134A (en) * | 2013-03-15 | 2016-06-08 | 塞罗拉公司 | Multi-modal pharmaco-diagnostic assessment of brian helath |
| CN104392085A (en) * | 2014-09-05 | 2015-03-04 | 上海卫生信息工程技术研究中心有限公司 | Drug effect evaluation method based on kernel principal component TOPSIS |
| CN107111673A (en) * | 2014-09-29 | 2017-08-29 | 周格尼克斯国际有限公司 | Control the control system of medicine distribution |
| CN104615904A (en) * | 2015-02-28 | 2015-05-13 | 领智控股有限公司 | Antibacterial medicament clinical application decision support system and constructing method thereof |
| CN106897549A (en) * | 2017-01-25 | 2017-06-27 | 浙江大学 | Cancer Individual treatment policy selection method based on molecular physiology group |
| CN107066826A (en) * | 2017-05-11 | 2017-08-18 | 杭州逸曜信息技术有限公司 | Medication information processing method based on test rating |
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