CN108753219A - A kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, preparation method and applications - Google Patents
A kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, preparation method and applications Download PDFInfo
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- CN108753219A CN108753219A CN201810375886.6A CN201810375886A CN108753219A CN 108753219 A CN108753219 A CN 108753219A CN 201810375886 A CN201810375886 A CN 201810375886A CN 108753219 A CN108753219 A CN 108753219A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J153/00—Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/06—Non-macromolecular additives organic
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/08—Macromolecular additives
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J4/00—Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16
- C09J4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09J159/00 - C09J187/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
Abstract
The invention belongs to external use plaster technical field, a kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, preparation method and applications are provided.The invention is characterized in that framework material used is a kind of by can amphiphilic PEO-SIS-PEO copolymers of melt-processed and can be with the compound that form of polymer of non-covalent bond form and the interconnection of its ethylene oxide block at a lower temperature.Hot-fusible pressure-sensitive adhesive forms：PEO-SIS-PEO copolymers, polymer, tackifying resin, plasticizer and antioxidant that can be in the form of non-covalent bond with poly-ethylene oxide block interconnection.Effect and benefit of the present invention are：Using the amphiphilic PEO-SIS-PEO copolymers of energy low temperature moulding so that system can meet the requirement of the more drug including Thermo-sensitive drug and water-soluble row drug；The cross-linked structure constituted in the form of non-covalent bond can maintenance system watery fusion processing characteristic and assign system good cohesive force.
Description
Technical field
The invention belongs to external use plaster technical field, it is related to a kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, system
Preparation Method and its application.
Background technology
External use plaster is administered by skin surface, so that drug is passed through skin with nearly constant rate of speed and is entered body circulation, generates complete
Body or local therapeutic effects.It is avoided that it is oral bring do not accommodate liver first-pass effect；It can overcome because absorbing too fast generation blood
Adverse reaction caused by concentration is excessively high；Administration is flexible, steady, controllable, not by the shadow of the factors such as pH value, food in alimentary canal
It rings.It is mainly made of matrix and drug two parts, and drug is dispersed in matrix, and the effect of matrix is：One, as the object of drug
Provide carrier；Two, for drug channel is provided to skin surface conveying；Three, drug delivery system is effectively adhered to skin surface.
In recent years, by styrene-isoprene-styrene triblock copolymer (SIS), tackifying resin, plasticizer and anti-
The melt pressure sensitive gel matrix of the compositions such as old agent is shown one's talent with patch field outside, and drugloading rate is big, reusable, production effect
Rate is high, and of low cost, process is environmentally protective.However, the initial mesh of the structure design of SIS elastomers and its melt pressure sensitive gel matrix
Mark is only pressure-sensitive to be sticked, and there are still urgent problems to be solved when they are as external use plaster matrix：1) it is limited by its hard section glass
Change transition temperature (Tg, 100 DEG C or so), processing temperature is higher (150 DEG C or more), it is difficult to which the use for meeting Thermo-sensitive drug is wanted
It asks；2) intrinsic hydrophobic structure is not only difficult to meet the common drug release requirement of plurality of active ingredients, and gas permeability is low, is also easy to produce
Skin irritation, patient clinical poor compliance.In order to overcome the problems referred above, generally use physical compounding technology, in SIS melt pressure sensitives
The component that can reduce system processing temperature or introducing are introduced in gel matrix can improve the component of system hydrophily and gas permeability.Such as,
The processing temperature of patch is reduced to 80-90 DEG C by Wang Hao etc. using atoleine, systematically have developed testosterone patch (Ma Jianfang,
Luo Huafei, Wang Hao, Chinese Pharmaceutical Journal, 2012,47 (21), 1727)；Liang Wenquan etc. draws lanolin as hydrophily conditioning agent
Enter matrix, improve patch gas permeability and comfort (Yu Zhenwei, Liang Yi, Liang Wenquan, Chinese Pharmaceutical Journal, 2013,48 (6),
450)；It is total that Zhao Xu etc. introduces ethyl acrylate-methyl methacrylate-methacrylic acid trimethyl ammonium chloride base ethyl ester in system
Polymers and polyethylene glycol 400 (Zhao Xu, Wang Kun, Chinese medicine journal, 2015,30 (10), 1473).In order to fundamentally solve above-mentioned ask
Topic, the present invention is with ethylene oxide-five block copolymer of styrene-isoprene-phenylethene-ethylene oxide (PEO-SIS-PEO)
Compound skeleton material is formed with the polymer (crosslinking agent) that can be interconnected in non-covalent bond form with its ethylene oxide block, prepares one
Kind can suitable water solubility/fat-soluble medicine release of melt-processed at a lower temperature cross-linking type amphiphilic polystyrene hot melt
Pressure sensitive adhesive matrix.
Invention content
For a kind of insufficient existing for styrene-series hot-melt pressure-sensitive adhesive matrix, amphiphilic styrene of low form of present invention offer
It is hot-fusible pressure-sensitive adhesive, preparation method and applications.
Technical scheme is as follows：
A kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, framework material are one kind by that can melt at a lower temperature
The amphiphilic PEO-SIS-PEO copolymers of processing and polymer group that can be in the form of non-covalent bond with the interconnection of its ethylene oxide block
At compound；The composition of the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form includes PEO-SIS-PEO copolymers, can be with
Crosslinking agent, tackifying resin, plasticizer and the antioxidant of non-covalent bond form and ethylene oxide block interconnection, the parts by weight of each component
Number is：
The PEO-SIS-PEO copolymers of (1) 20~100 parts by weight；
The crosslinking agent of (2) 10~50 parts by weight, the crosslinking agent are selected from butyl methacrylate two
Methylamino ethyl ester-methylmethacrylate copolymer, Dimethylaminoethyl Methacrylate, dimethylaminoethyl acrylate etc. contains
There is the copolymer of dimethylamino structure；
The tackifying resin of (3) 50~150 parts by weight, the tackifying resin are selected from Petropols, terpene resin, rosin
Or combinations thereof object；
The plasticizer of (4) 20~50 parts by weight, the plasticizer are selected from mineral oil, atoleine, white oil or its group
Close object；
The antioxidant of (5) 0.5~3.0 parts by weight, the antioxidant are selected from N, N- dibutylamino dithiocarbonic acids
Zinc, rubber accelerator or combinations thereof object；
The molecular weight of the PEO-SIS-PEO copolymers is 5~150,000；The benzene of the PEO-SIS-PEO copolymers
Ethylene block (PS) molecular weight is 1000~10000；The ethylene oxide block (PEO) of the PEO-SIS-PEO copolymers point
Son amount is 3000~12000.
The PEO-SIS-PEO copolymers preferably 50~80 parts by weight；The crosslinking agent preferably 30~40 weight
Number；The tackifying resin preferably 80~100 parts by weight；The plasticizer preferably 30~45 parts by weight；Described
Antioxidant preferably 1~2 parts by weight.
The preparation method of the above-mentioned amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, includes the following steps：
The first step, full of N2Closed container in, under the conditions of 80~100 DEG C, by PEO-SIS-PEO copolymers, antioxygen
Agent, plasticizer and tackifying resin press respective weight fraction melting mixing, prepare amphiphilic styrene-series hot-melt pressure-sensitive adhesive.
Second step is added crosslinking agent, improves system in the amphiphilic styrene-series hot-melt pressure-sensitive adhesive that the first step obtains
Cohesive force and drug release characteristics.
The above-mentioned amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form is used to prepare external use plaster main body, including 70~90 weight
The drug of the styrene-series hot-melt pressure-sensitive adhesive of number, the transdermal penetration enhancer of 5~10 parts by weight and 5~10 parts by weight；It is described
Transdermal penetration enhancer be ethyl alcohol, propylene glycol or combinations thereof object；The drug is disclosure satisfy that cutaneous penetration requirement single group
Point or multicomponent water solubility/fat-soluble medicine.The drug preferably 6~8 parts by weight, the transdermal penetration enhancer preferably 6
~8 parts by weight.
The preparation method of external use plaster main body, mainly includes the following steps that：
Drug and penetrating agent are added under the conditions of 80~100 DEG C in above-mentioned styrene-series hot-melt pressure-sensitive adhesive the first step,
Prepare the melt pressure sensitive gel matrix of drug containing；
Second step prepares and contains medicine plaster：Under the conditions of 80~100 DEG C, by hot melt coater by the drug containing of above-mentioned preparation
Melt pressure sensitive gel matrix to be coated on thickness be on 100 μm or so of polyester film, coating thickness is 120 ± 20 μm, to be cooled
After cover back lining materials, obtained hot-fusible pressure-sensitive adhesive patch is external use plaster main body.
The present invention is to made patch using adhesion property and medicine-releasing performance as the evaluation criterion of pressure sensitive adhesive characteristic.Adherency
Performance includes hold viscosity energy and peel strength, and national standard (GB/T4851-1998) and national standard (GB 2792- is respectively adopted
81) it tests.
Medicine-releasing performance measures：Using 40% ethanol water as the reception medium of drug release, drug release is carried out
Experiment, take preparation contains medicine plaster, removes patch protective film, medicated layer is towards reception tank, diffusion area 0.627cm2, reception tank
Volume 5ml；Ensure 37 ± 0.5 DEG C of reception tank temperature, mixing speed 700r/min.Start timing, is taken respectively at 1,3,6,9,12h
Sample 0.4ml in reception tank, while the blank for supplementing equality of temperature equivalent receives medium, test every time at least uses three groups of parallel realities
It tests.
The concentration that drug is measured according to liquid chromatograph calculates the accumulation of different time sections drug by formula (1) and (2)
Release rate Q,
Wherein, Mt：Unit area cumulative release amount；M∞：Drugloading rate in unit area patch；V：Receiving liquid volume；A：
Diffusion cell open area；Cn：The concentration of n-th sampling.Effect and benefit of the present invention are：Using the amphiphilic PEO- of energy low temperature moulding
SIS-PEO copolymers so that the use that system can meet the more drug including Thermo-sensitive drug and water-soluble row drug is wanted
It asks；The cross-linked structure constituted in the form of non-covalent bond can the processing of maintenance system watery fusion characteristic and to assign system good
Good cohesive force.
Description of the drawings
Fig. 1 is embodiment 1 to 3 hydrophilic medicament release performance figure of embodiment；
Fig. 2 is embodiment 4 to 6 lipophilic drugs release performance figure of embodiment；
Specific implementation mode
Following embodiment is merely illustrative, and is not limited the scope of the invention in any way.
Embodiment 1
First, full of N280 DEG C of closed containers in, sequentially add 80 parts by weight Petropols, 30 parts by weight mines
Object oil, 1 parts by weight, four [β-(3,5- di-tert-butyl-hydroxy phenyl) propionic acid] pentaerythritol ester and 50 parts by weight PEO-
SIS-PEO copolymers (PEO-SIS-PEO molecular weight 50,000；PS molecular weight 10000；PEO molecular weight 3000), melting mixing 15 is divided
30 parts by weight butyl methacrylate dimethylamino ethyl esters-methyl methacrylate copolymer is added in Zhong Hou
Object continues mixing after ten minutes, 6 parts by weight Gardenosides of addition and 6 parts by weight ethyl alcohol, melting mixing 10 minutes, finally,
At a temperature of 100 DEG C, the drug containing hot-fusible pressure-sensitive adhesive of above-mentioned preparation is coated on by the polyester that thickness is 100 μm by hot melt coater
On film, 120 ± 20 μm of coating thickness covers back lining materials after cooling, and adhesion property is shown in Table 1, and medicine-releasing performance is shown in attached drawing
1。
Embodiment 2
First, full of N290 DEG C of closed containers in, sequentially add 90 parts by weight terpene resins, 40 parts by weight liquid
Body paraffin, 1.5 parts by weight rubber accelerators and 65 parts by weight PEO-SIS-PEO copolymer (PEO-SIS-PEO molecular weight 10
Ten thousand；PS molecular weight 5000；PEO molecular weight 10000), 35 parts by weight dimethylaminoethyl acrylate methyls are added after 15 minutes in melting mixing
Aminoethyl continues mixing after ten minutes, and 7 parts by weight Gardenosides are added and 7 parts by weight propylene glycol, melting mixing 10 are divided
Clock, finally, at a temperature of 100 DEG C, it is 100 that the drug containing hot-fusible pressure-sensitive adhesive of above-mentioned preparation, which is coated on thickness, by hot melt coater
μm polyester film on, 120 ± 20 μm of coating thickness covers back lining materials after cooling, and adhesion property is shown in Table 1, drug release
Performance is shown in attached drawing 1.
Embodiment 3
First, full of N2100 DEG C of closed containers in, it is white to sequentially add 100 parts by weight rosin, 45 parts by weight
Oil, 2 parts by weight, four [β-(3,5- di-tert-butyl-hydroxy phenyl) propionic acid] pentaerythritol ester and 80 parts by weight PEO-SIS-
PEO copolymers (PEO-SIS-PEO molecular weight 150,000；PS molecular weight 10000；PEO molecular weight 12000, melting mixing 15 minutes
Afterwards, 40 parts by weight dimethylaminoethyl acrylates etc. are added and contain dimethylamino structure, continue mixing after ten minutes, be added 8
Parts by weight Gardenoside and 8 parts by weight propylene glycol, melting mixing 10 minutes finally at a temperature of 100 DEG C, are applied by heating
The drug containing hot-fusible pressure-sensitive adhesive of above-mentioned preparation is coated on the polyester film that thickness is 100 μm by cloth machine, 120 ± 20 μ of coating thickness
M covers back lining materials after cooling, and adhesion property is shown in Table 1, and medicine-releasing performance is shown in attached drawing 1.
Embodiment 4
First, full of N280 DEG C of closed containers in, sequentially add 80 parts by weight Petropols, 30 parts by weight mines
Object oil, 1 parts by weight, four [β-(3,5- di-tert-butyl-hydroxy phenyl) propionic acid] pentaerythritol ester and 50 parts by weight PEO-
SIS-PEO copolymers (PEO-SIS-PEO molecular weight 50,000；PS molecular weight 1000；PEO molecular weight 12000), melting mixing 15 is divided
30 parts by weight butyl methacrylate dimethylamino ethyl esters-methyl methacrylate copolymer is added in Zhong Hou
Object continues mixing after ten minutes, 6 parts by weight oleanolic acids of addition and 6 parts by weight ethyl alcohol, melting mixing 10 minutes, finally,
At a temperature of 100 DEG C, the drug containing hot-fusible pressure-sensitive adhesive of above-mentioned preparation is coated on by the polyester that thickness is 100 μm by hot melt coater
On film, 120 ± 20 μm of coating thickness covers back lining materials after cooling, and adhesion property is shown in Table 1, and medicine-releasing performance is shown in attached
Fig. 2.
Embodiment 5
First, full of N290 DEG C of closed containers in, sequentially add 90 parts by weight terpene resins, 40 parts by weight liquid
Body paraffin, 1.5 parts by weight rubber accelerators and 65 parts by weight PEO-SIS-PEO copolymer (PEO-SIS-PEO molecular weight 10
Ten thousand；PS molecular weight 5000；PEO molecular weight 10000), 35 parts by weight dimethylaminoethyl acrylate methyls are added after 15 minutes in melting mixing
Aminoethyl continues mixing after ten minutes, and 7 parts by weight oleanolic acids are added and 7 parts by weight propylene glycol, melting mixing 10 are divided
Clock, finally, at a temperature of 100 DEG C, it is 100 that the drug containing hot-fusible pressure-sensitive adhesive of above-mentioned preparation, which is coated on thickness, by hot melt coater
μm polyester film on, 120 ± 20 μm of coating thickness covers back lining materials after cooling, and adhesion property is shown in Table 1, drug release
Performance is shown in attached drawing 2.
Embodiment 6
First, full of N2100 DEG C of closed containers in, it is white to sequentially add 100 parts by weight rosin, 45 parts by weight
Oil, 2 parts by weight, four [β-(3,5- di-tert-butyl-hydroxy phenyl) propionic acid] pentaerythritol ester and 80 parts by weight PEO-SIS-
PEO copolymers (PEO-SIS-PEO molecular weight 150,000；PS molecular weight 10000；PEO molecular weight 12000, melting mixing 15 minutes
Afterwards, 40 parts by weight dimethylaminoethyl acrylates etc. are added and contain dimethylamino structure, continue mixing after ten minutes, be added 8
Parts by weight oleanolic acid and 8 parts by weight propylene glycol, melting mixing 10 minutes finally at a temperature of 100 DEG C, pass through hot melt
The drug containing hot-fusible pressure-sensitive adhesive of above-mentioned preparation is coated on the polyester film that thickness is 100 μm by coating machine, coating thickness 120 ± 20
μm, back lining materials are covered after cooling, and adhesion property is shown in Table 1, and medicine-releasing performance is shown in attached drawing 2.
The adhesion property of 1 embodiment hot-fusible pressure-sensitive adhesive of table
Embodiments of the present invention above described embodiment only expresses, but therefore can not be interpreted as special to the present invention
The limitation of the range of profit, it is noted that for those skilled in the art, without departing from the inventive concept of the premise,
Various modifications and improvements can be made, these are all belonged to the scope of protection of the present invention.
Claims (9)
1. a kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form, which is characterized in that the amphiphilic styrene of the low form
The composition for being hot-fusible pressure-sensitive adhesive is included PEO-SIS-PEO copolymers, can be interconnected with ethylene oxide block in the form of non-covalent bond
The parts by weight of crosslinking agent, tackifying resin, plasticizer and antioxidant, each component are：
The PEO-SIS-PEO molecular weight of copolymer is in 5~150,000, PS block molecules amount in 1000~10000, PEO blocks
Molecular weight is 3000~12000.
2. the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of a kind of low form according to claim 1, which is characterized in that described
PEO-SIS-PEO copolymers preferably 50~80 parts by weight；The crosslinking agent preferably 30~40 parts by weight；The thickening
Resin preferably 80~100 parts by weight；The plasticizer preferably 30~45 parts by weight；The antioxidant preferably 1~2 weight
Measure number.
3. the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of a kind of low form according to claim 1 or 2, which is characterized in that institute
The crosslinking agent stated is selected from butyl methacrylate dimethylamino ethyl ester-methylmethacrylate copolymer, methyl
Dimethylamino ethyl acrylate, dimethylaminoethyl acrylate contain the copolymer of dimethylamino structure；The tackifying resin
Selected from Petropols, terpene resin, rosin or combinations thereof object；The plasticizer be selected from mineral oil, atoleine, white oil or its
Composition；The antioxidant is selected from four [β-(3,5- di-tert-butyl-hydroxy phenyl) propionic acid] pentaerythritol esters, rubber promotes
Agent or combinations thereof object.
4. a kind of preparation method of the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form as claimed in claim 1 or 2, feature exist
In following steps：
The first step, full of N2Closed container in, under the conditions of 80~100 DEG C, by PEO-SIS-PEO copolymers, antioxidant, increasing
It moulds agent and tackifying resin presses respective weight fraction melting mixing, prepare amphiphilic styrene-series hot-melt pressure-sensitive adhesive；
Second step is added crosslinking agent, improves the cohesion of system in the amphiphilic styrene-series hot-melt pressure-sensitive adhesive that the first step obtains
Power and drug release characteristics.
5. a kind of preparation method of the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form described in claim 3, it is characterised in that
Following steps：
The first step, full of N2Closed container in, under the conditions of 80~100 DEG C, by PEO-SIS-PEO copolymers, antioxidant, increasing
It moulds agent and tackifying resin presses respective weight fraction melting mixing, prepare amphiphilic styrene-series hot-melt pressure-sensitive adhesive；
Second step is added crosslinking agent, improves the cohesion of system in the amphiphilic styrene-series hot-melt pressure-sensitive adhesive that the first step obtains
Power and drug release characteristics.
6. a kind of amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form as claimed in claim 1 or 2 is used to prepare external use plaster master
Body, which is characterized in that the external use plaster main body includes the styrene-series hot-melt pressure-sensitive adhesive of 70~90 parts by weight, 5~10
The drug of the transdermal penetration enhancer of parts by weight and 5~10 parts by weight；The transdermal penetration enhancer is ethyl alcohol, propylene glycol or its group
Close object；The drug is the one-component or multicomponent water solubility/fat-soluble medicine that disclosure satisfy that cutaneous penetration requirement；
The preparation method of the external use plaster main body includes the following steps：
Drug and penetrating agent under the conditions of 80~100 DEG C, are added in styrene-series hot-melt pressure-sensitive adhesive, prepare drug containing by the first step
Melt pressure sensitive gel matrix；
Second step prepares and contains medicine plaster
Under the conditions of 80~100 DEG C, the melt pressure sensitive gel matrix of the drug containing of above-mentioned preparation is coated on by thickness by hot melt coater
Degree is on 100 μm or so of polyester film, coating thickness is 120 ± 20 μm, covers back lining materials after cooling, obtained hot melt
Pressure sensitive adhesive patch is external use plaster main body.
7. the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form described in a kind of claim 3 is used to prepare external use plaster main body,
It is characterized in that, the external use plaster main body includes the styrene-series hot-melt pressure-sensitive adhesive of 70~90 parts by weight, 5~10 weight
The drug of the transdermal penetration enhancer of number and 5~10 parts by weight；The transdermal penetration enhancer is ethyl alcohol, propylene glycol or combinations thereof
Object；The drug is the one-component or multicomponent water solubility/fat-soluble medicine that disclosure satisfy that cutaneous penetration requirement；
The preparation method of the external use plaster main body includes the following steps：
Drug and penetrating agent under the conditions of 80~100 DEG C, are added in styrene-series hot-melt pressure-sensitive adhesive, prepare drug containing by the first step
Melt pressure sensitive gel matrix；
Second step prepares and contains medicine plaster
Under the conditions of 80~100 DEG C, the melt pressure sensitive gel matrix of the drug containing of above-mentioned preparation is coated on by thickness by hot melt coater
Degree is on 100 μm or so of polyester film, coating thickness is 120 ± 20 μm, covers back lining materials after cooling, obtained hot melt
Pressure sensitive adhesive patch is external use plaster main body.
8. the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form according to claim 6 is used to prepare external use plaster main body,
It is characterized in that, the drug preferably 6~8 parts by weight, the transdermal penetration enhancer preferably 6~8 parts by weight.
9. the amphiphilic styrene-series hot-melt pressure-sensitive adhesive of low form according to claim 7 is used to prepare external use plaster main body,
It is characterized in that, the drug preferably 6~8 parts by weight, the transdermal penetration enhancer preferably 6~8 parts by weight.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115449341A (en) * | 2022-10-08 | 2022-12-09 | 上海方田粘合剂技术有限公司 | Plasticizer-free hot-melt pressure-sensitive adhesive capable of being coated at low temperature and preparation method thereof |
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| CN115449341A (en) * | 2022-10-08 | 2022-12-09 | 上海方田粘合剂技术有限公司 | Plasticizer-free hot-melt pressure-sensitive adhesive capable of being coated at low temperature and preparation method thereof |
Also Published As
| Publication number | Publication date |
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| CN108753219B (en) | 2019-06-21 |
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