CN108744044A - A kind of MEEK skin-grafting materials combined with allosome skin graft - Google Patents
A kind of MEEK skin-grafting materials combined with allosome skin graft Download PDFInfo
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- CN108744044A CN108744044A CN201810585073.XA CN201810585073A CN108744044A CN 108744044 A CN108744044 A CN 108744044A CN 201810585073 A CN201810585073 A CN 201810585073A CN 108744044 A CN108744044 A CN 108744044A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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Abstract
It makes skin graft material, including MEEK crapes piece and allosome skin graft the present invention relates to a kind of MEEK for being combined with allosome skin graft, the MEEK crapes piece includes metallic diaphragm and gauze layer stacked together, and the gauze layer is water-soluble tissue layer.The beneficial effects of the invention are as follows：Using the MEEK crape pieces with water-soluble tissue layer, burn wound is covered in conjunction with allosome skin graft, two kinds of burn treating methods is made to obtain perfect adaptation, significantly improves the therapeutic effect of MEEK skin-grafting.
Description
Technical field
The invention belongs to medical skin-grafting material more particularly to a kind of MEEK skin-grafting materials combined with allosome skin graft.
Background technology
MEEK skin-grafting technology is initiated by a kind of skin-grafting technology of Holland, is the micro skin piece that Continental Europe creates and develops
The surgical technic of transplanting, since researching and developing MEEK skin-grafting technologies, Dutch hospital is initially applied to burns unit clinic, especially answers
Patients with major full-thickness burn for skin donor site shortage.The core of MEEK skin-grafting technologies is MEEK skin-grafting crape pieces, crape piece
Including metallic diaphragm and gauze layer stacked together, crape piece is equipped with identical size and is spaced horizontal and vertical gauffer；It will use
Multiple rectangular micro skin pieces are cut into according to the size of space of gauffer in the skin graft of skin-grafting, crape is attached in a manner of corresponding with gauffer
On yarn sheet, the gauffer of crape piece is unfolded, the skin graft that total area coverage is raw hide piece several times area can be obtained, is transplanted in the surface of a wound,
It can be obtained good skin-grafting effect.Existing MEEK skin-grafting material is made of cork pad, aluminium foil, polyamide double pleats yarn, is being incited somebody to action
Self skin graft cuts and sticks on the surface of a wound surface cut scab or cut scab after being adhered to double pleats yarn, expansion, then again with multilayer gauze
Wrapping.At three weeks or so, self sword thickness micro skin piece gradually extended after surviving under double pleats yarn, and merged in blocks, Landfill covering
The surface of a wound.However, herein in three weeks or so time, before auto epidermis piece not yet extends fusion, do not covered by self skin graft
The surface of a wound of lid is only covered by polyamide double pleats yarn, and polyamide double pleats yarn does not have bioactivity, therefore as a kind of textile
It cannot play the role of reducing surface of a wound exudation, alien bacteria is prevented to invade the surface of a wound, therefore in this stage, patient is often in phase
When dangerous condition, the disability and the death rate of fire victim can be increased.
Invention content
The purpose of the present invention is to propose to a kind of technical solutions of the MEEK skin-grafting materials combined with allosome skin graft, improve MEEK
The therapeutic effect of skin-grafting.
To achieve the goals above, the technical scheme is that：A kind of MEEK skin-grafting materials combined with allosome skin graft,
Including MEEK crapes piece and allosome skin graft, the MEEK crapes piece includes metallic diaphragm and gauze layer stacked together, described
Gauze layer is water-soluble tissue layer.
Further, the water-soluble fabric is fabric caused by being knitted by pretreated viscose rayon.
Further, the water-soluble fabric is fabric caused by being knitted by pretreated pure cotton fiber.
Further, the water-soluble fabric is plain cloth.
Further, the water-soluble fabric is 60 plains cloth.
Further, the extension ratio of the MEEK crapes piece is 1 ︰ 5,1:8 or 1 ︰ 12.
Further, the allosome skin graft includes allogeneic skin graft and heterogenous allosome skin graft.
Further, the allogeneic skin graft include glycerine preserve allogeneic skin graft, profound hypothermia refrigerator preserves
Allogeneic skin graft, the allogeneic skin graft of Liquid nitrogen storage, de- Cell Allograft skin graft or fresh allogeneic skin graft；It is described
Heterogenous allosome skin graft includes acellular dermal matrix pigskin skin graft, acellular dermal matrix sheepskin skin graft, acellular dermal matrix
Frog skin skin graft and fresh porcine skin skin graft.
Further, the allogeneic skin graft is the allogeneic skin graft that glycerine preserves, and the heterogenous allosome skin graft is
Full thicker acellular dermal matrix pigskin skin graft.
The beneficial effects of the invention are as follows：Using the MEEK crape pieces with water-soluble tissue layer, covered in conjunction with allosome skin graft
Burn wound makes two kinds of burn treating methods obtain perfect adaptation, significantly improves the therapeutic effect of MEEK skin-grafting.
The present invention is described in detail with reference to the accompanying drawings and examples.
Description of the drawings
Fig. 1 is structure of the invention figure, and metallic diaphragm is on the upside of MEEK crape pieces；
Fig. 2 is structure of the invention figure, and water-soluble tissue layer is on the upside of MEEK crape pieces；
Fig. 3 is the A of Fig. 1 to partial enlarged view；
Fig. 4 is the skin graft schematic diagram that the present invention is sticked on cork disk and cut；
Fig. 5 is that self skin graft of the invention is posted the schematic diagram to water-soluble tissue layer from cork disk；
Fig. 6 is the schematic diagram that the present invention removes cork disk；
Fig. 7 is the schematic diagram of present invention expansion transversal fold；
Fig. 8 is the schematic diagram of the longitudinal gauffer of present invention expansion；
Fig. 9 is the schematic diagram that self skin graft, water-soluble tissue layer and allosome skin graft of the invention are applied to the surface of a wound.
Specific implementation mode
Referring to figs. 1 to Fig. 3, MEEK skin-grafting material is made of aluminium foil 10, gauze layer 20, cork pad 30, MEEK skin-grafting technologies
Core be MEEK crape pieces, MEEK crape pieces include aluminium foil 10 stacked together, gauze layer 20, and gauze layer uses polyamide
Double pleats yarn, MEEK crape pieces are equipped with identical size and interval transversal fold 11 and longitudinal gauffer 12；By the self skin for skin-grafting
Piece 40 is cut into multiple rectangular micro skin pieces according to the size of space of gauffer（As shown in Figure 4）, pasted in a manner of corresponding with gauffer
In crape on piece（As shown in Figure 5, Figure 6）, the gauffer of crape piece is unfolded（As shown in Figure 7, Figure 8）, total area coverage can be obtained
For the skin graft of raw hide piece several times area, the surface of a wound surface cut scab or cut scab is sticked on, larger cover is obtained with less self skin graft
The skin-grafting effect of lid efficiency.At three weeks or so, self sword thickness micro skin piece gradually extended after surviving under double pleats yarn, and is fused into
Piece, the Landfill covering surface of a wound.However, herein in three weeks or so time, before auto epidermis piece not yet extends fusion, the surface of a wound
It is almost only covered by polyamide double pleats yarn, polyamide double pleats yarn does not have bioactivity, therefore cannot as a kind of textile
Play the role of reducing surface of a wound exudation, alien bacteria is prevented to invade the surface of a wound, therefore in this stage, patient is often in quite danger
The condition of danger.
The clinical treatment of another kind burn is allosome skin graft covering burn wound.Large-area burns, skin extension or
When infection causes large skin defect, it is necessary to which row skin grafting carrys out flap coverage, the exposed surface of a wound that no normal skin is covered
Narrow down to minimum limit.If the exposed surface of a wound is excessive, bacterium easily invades breeding, and internal water, electrolyte, protein easily ooze
Go out, cause water, electrolyte balance imbalance, heat loss, anaemia, Hypoproteinemia, high fever, pyemia, until multi-organ function
Failure and death.When defect of skin is more than the 30% of body surface area, not enough self skins carry out flap coverage；At this point, just must
Allosome skin graft flap coverage need to be used, the surface of a wound otherwise cannot be eliminated and improves systemic situation.Allosome skin graft has biology living
Property, surface of a wound exudation can be reduced, prevents alien bacteria from invading, the function of the protection surface of a wound, is had to the treatment of burn very positive
Effect.During treating the extensive deep burn surface of a wound, no matter post burn, has to use biological material covering will be exposed sooner or later
The surface of a wound temporarily cover.Currently, obtainable allosome skin graft（Including allogeneic skin graft and heterogenous allosome skin graft）Have：With work
The allosome skin graft of power；Applied chemistry or the processed unvital allosome skin graft of physical method；With cell culture or commercial run
The artificial skin graft obtained.
If can be by above two therapy R. concomitans, i.e.,：Miniature auto epidermis piece transplanting is completed in the surface of a wound
Afterwards, to have intact skin structure, biologically active allosome skin graft is covered on self skin and the surface of a wound.In this way, self
Before razor graft extension fusion in flakes, all surface of a wound are covered by allosome skin graft, without the exposed surface of a wound.Self skin is in allosome skin graft
Protection under grow；Under the covering of allosome skin graft, exudation is reduced the exposed surface of a wound, and extraneous bacterium is difficult to invade the surface of a wound, and the surface of a wound obtains
Effective protection is arrived.The therapeutic effect that burn can necessarily be significantly improved, the treatment of burn is reached a new high.But
Current technology obstacle is, existing MEEK skin-grafting crape piece uses polyamide double pleats yarn, and polyamide double pleats yarn be can not
Dissolving, unabsorbable material can not remove before self sword micro skin piece does not merge in flakes from the surface of a wound.It can not
Allosome skin graft is directly covered in polyamide double pleats external layer of yarn, hinders the application of the allosome skin graft of critical treatment effect.
In order to solve the above technical problems, the present invention proposes a kind of technical side of the MEEK skin-grafting materials combined with allosome skin graft
Case.
As shown in Figure 1, Figure 2, Fig. 9, a kind of MEEK skin-grafting materials combined with allosome skin graft, including MEEK crapes piece and allograft skin
Piece, the MEEK crapes piece include metallic diaphragm 10 and gauze layer 20 stacked together, and the gauze layer is water-soluble fabric
Layer.
The water solubility fabric is fabric caused by being knitted by pretreated viscose rayon.
It is described water solubility fabric can also be knitted by pretreated pure cotton fiber caused by fabric.
The water solubility fabric is plain cloth.
In order to obtain relatively thin water-soluble fabric, is folded convenient for MEEK crape pieces, also allow for dissolving as early as possible and be absorbed, institute
State the plain cloth that water-soluble fabric is 60.
In order to make full use of self skin graft, the extension ratio of the MEEK crapes piece is 1 ︰ 5,1:8 or 1 ︰ 12.
The allosome skin graft includes allogeneic skin graft and heterogenous allosome skin graft.Allogeneic skin graft refers to being derived from human body
Skin graft, including it is derived from the skin graft of corpse（Also commonly referred to as " allosome skin graft ", but " the allosome skin graft " in the present invention includes of the same race
Allosome skin graft also includes heterogenous allosome skin graft）, heterogenous allosome skin graft refers to the skin graft for being taken from animal.
The allogeneic skin graft include glycerine preserve allogeneic skin graft, profound hypothermia refrigerator preserve alloskin
Piece, the allogeneic skin graft of Liquid nitrogen storage, de- Cell Allograft skin graft or fresh allogeneic skin graft；The heterogenous allosome skin
Piece include acellular dermal matrix pigskin skin graft, acellular dermal matrix sheepskin skin graft, acellular dermal matrix frog skin skin graft and
Fresh porcine skin skin graft.
The preferred allogeneic skin graft is the allogeneic skin graft that glycerine preserves, the preferred heterogenous allosome skin graft
It is full thicker acellular dermal matrix pigskin skin graft.
Embodiment one：
As shown in Figure 1, Figure 2, Fig. 9, a kind of MEEK skin-grafting materials combined with allosome skin graft, including MEEK crapes piece and allosome skin graft
50, MEEK crape pieces include metallic diaphragm 10 and gauze layer 20 stacked together.Gauze layer is water-soluble tissue layer.
Metallic diaphragm is aluminium foil layer.
Water-soluble fabric is such as to use Chinese patent literature using cellulose as soluble fabric made of raw material
Soluble fabric is made in the method for CN1286329A, CN1143697A, CN1058342A description.Use cellulose is for raw material
Based on considered below：In a variety of absorbable materials such as gelatin, collagen, starch, cellulose, has only and take cellulose（Or regeneration is fine
Dimension element）Manufactured material has thin pliable, folding feature, and fabric is foldable, be prepare MEEK skin-grafting material must
Standby key feature.To currently form the SURGICEL of commodity（Speed is yarn）, for safe thin silk fabric, be with plant fiber or its processed goods
Prepared by raw material, appearance is closely similar with common fabric, is improved, and makes needed for adaptation MEEK skin-grafting.
Water-soluble fabric uses plain cloth.Cellulose hemostasis absorbable material made of fabric such as " safe thin silk fabric ", be
Using twill or the Weaving method of satin weave.Twills are that warp and weft at least just interweave once every two yarns, cloth feature
It is to have positive and negative, Density is higher, and product is more thick and solid；Satin fabric warp thread and weft yarn at least just interweave once every three, because
This this institutional framework makes Density higher, thus fabric is more thick and solid.Speed is that the products such as yarn, safe thin silk fabric take this weaving side
The advantages of method is fabric can be made more thick and solid, therefore can more absorb oozing of blood sepage after sticking on the surface of a wound, reaches quick-acting haemostatic powder
Purpose.But twill, satin fabric are not suitable for being used in the present invention.The present invention needs to turn self micro skin piece using fabric
It after moving on to the surface of a wound, dissolves and absorbs as early as possible, is not required to play anastalsis.The characteristics of used fabric of the invention is to need to have centainly
It is intensity, not damaged upon deployment, it is thin, can dissolve and absorb as early as possible, to allosome（Kind）The shadow of blood fortune is established between skin and the substrate surface of a wound
It rings minimum.Therefore, the present embodiment uses plain cloth.Tabby warp and weft just interweave once every one, feature
It is that quality is strong, surfacing, tow sides appearance is identical, more frivolous, and density is less high.Due to tabby latitude and longitude
Number is identical, thus two vertical direction when being adapted to unfolded firmly, so that the line of force is evenly distributed, keep micro skin piece
It is not shifted in fabric surface.The thickness for surveying commercially available " safe thin silk fabric " is about 0.18mm, blocked up for MEEK crape pieces, it is difficult to
It is folding, therefore cannot be used directly for making MEEK crape pieces.MEEK crapes piece is folding due to needing, it is necessary to sufficiently thin
It can just be used to prepare.The method for obtaining thin cloth is to weave using high grade cotton yarn, and the more high then cotton yarn of number is thinner, spins
Cloth it is thinner.In the present embodiment, using 60 high-count and high-density Weaving methods, plain weave that is thin and having enough intensity is obtained
Fabric prepares material as MEEK crape pieces.
In the present embodiment, MEEK crape pieces are equipped with transversal fold 11 and longitudinal gauffer 12；Between MEEK crape pieces are including 6 etc.
Every the transversal fold and 6 equally spaced longitudinal gauffers, in the present embodiment, the interval B1 between transversal fold is
6mm, it is described longitudinal direction gauffer between interval B2 be 6mm.The length of run of every transversal fold is all mutually S1=7.4mm, and every vertical
Length of run to gauffer is identical, is S2=7.4mm, as shown in Figure 8.
Longitudinal gauffer is the gauffer for being folded in metallic diaphragm one side, and transversal fold is by MEEK crapes piece together with longitudinal gauffer
The gauffer folded together, transversal fold protrude metallic diaphragm and perpendicular to metallic diaphragms.I.e. whole gauffers are all to metallic diaphragm one
Side folds, and is a smooth plane in water-soluble tissue layer side.
In the laminated positioning salient angle 13 for being equipped with protrusion of the gauze of MEEK crape pieces；Edge positions one including positioning salient angle is
42mm×42mm（As shown in Fig. 2, L × L）The positioning salient angle of square.
Cork disk is a 42mm × 42mm（As shown in Figure 1, L × L）Square disk body, the positioning with MEEK crape pieces
Salient angle size is corresponding.
During skin-grafting, according to surface of a wound size, the self skin graft 40 of corresponding amount is taken with dermatome, be cut into length of side 42mm ×
The square skin graft of 42mm is affixed on an equal amount of cork disk of size, is cut in length and breadth with dermatome 2 times, and joint-cutting 41 is by skin graft
It is 6mm × 6mm to be divided into 49 block sizes（As shown in figure 4, C1 × C2）Micro skin piece, the area of every micro skin piece is 36
Square millimeter.To the skin graft glue spraying being attached on cork disk, then it is posted in water-soluble tissue layer, as shown in Figure 5.It is posted
When, the positioning salient angle of MEEK crape pieces can make cork disk accurately be put into the position of setting, make the joint-cutting in length and breadth of self skin graft
The accurately seam of corresponding longitudinal gauffer and transversal fold.
Cork disk is removed later（As shown in Figure 6）.MEEK crape pieces are pulled with hand, horizontal expansion transversal fold is unfolded（Such as Fig. 7
It is shown）, pull the longitudinal gauffer of crape piece expansion again later（As shown in Figure 8）, the micro skin piece array that is expanded.Due to described
Transversal fold and the length of run of longitudinal gauffer are 7.4mm, and the area after expansion corresponding to a piece of micro skin piece is 13.4mm
× 13.4mm=180 square millimeter are equivalent to the skin-grafting area of self skin graft expanding 5 times, the i.e. ratio of MEEK crapes piece
Example is 1 ︰ 5.The water-soluble tissue layer for being covered with micro skin piece is detached with metallic diaphragm finally, micro skin piece is transplanted in the surface of a wound
60。
Such as Fig. 9, then allosome skin graft 50 is used to cover burn wound.Allosome skin graft is covered on water-soluble tissue layer.Such as
It has ready conditions, allosome skin graft answers the allogeneic skin graft that preferred glycerine preserves, and the allogeneic skin graft antigenicity that glycerine preserves is smaller,
Anti-infection property is strong, and adhesion is strong, can improve surface of a wound condition, reduces surface of a wound necrosis and secondary necrosis.According to clinical experience, glycerine is protected
The allogeneic skin graft deposited is used in combination with the MEEK crape pieces using water-soluble tissue layer has best skin-grafting effect.
In addition to allogeneic skin graft, as microparticle skin covering, xenogenesis skin graft has to be come the xenogenesis micromicro such as pigskin, sheepskin
The abundant advantage in source.Especially pigskin is with extensive.More early, exposed wound after solution-off occurs for the common fresh porcine skin rejection time
Face is more.Compared with fresh porcine skin, acellular dermal matrix pigskin skin graft only remains dermis scaffold, and antigenicity is weak, tool
There is good histocompatbility, while there is favorable elasticity, flexibility and toughness, it is each can be applicable in human body with bodily form flap coverage
A position, can room temperature preserve, transport, it is easy to use.The model of acellular dermal matrix pigskin skin graft is divided into full thicker, middle thickness
Type, ultrathin type.Due to needing by chemical treatment, the epidermis of skin is removed, medium-thick type and extra-thin de- cell pigskin
Permeability increases, and dehydration and drying is easy, to lose the protective effect to the surface of a wound and micro skin piece.According to clinical experience, with complete
Thicker acellular dermal matrix pigskin skin graft is another preferable selection as the covering from body minisize skin grafting dermepenthesis.
Embodiment two：
A kind of MEEK skin-grafting materials combined with allosome skin graft, the present embodiment are that the structure of embodiment one is replaced.
In the present embodiment, the length of run of every transversal fold of MEEK crape pieces is identical, is S1=11.0mm, and every vertical
Length of run to gauffer is identical, is S2=11.0mm, as shown in Figure 8.
Since the length of run of transversal fold and longitudinal gauffer is 11.0mm, after expansion corresponding to a piece of micro skin piece
Area is 17mm × 17mm=289 square millimeter, is equivalent to the skin-grafting area of self skin graft expanding 8 times, i.e. MEEK crapes piece
Extension ratio be 1 ︰ 8.
Embodiment three：
A kind of MEEK skin-grafting materials combined with allosome skin graft, the present embodiment are that the structure of embodiment one is replaced.
In the present embodiment, the length of run of every transversal fold of MEEK crape pieces is identical, is S1=14.8mm, and every vertical
Length of run to gauffer is identical, is S2=14.8mm, as shown in Figure 8.
Since the length of run of transversal fold and longitudinal gauffer is 14.8mm, after expansion corresponding to a piece of micro skin piece
Area is 20.8mm × 20.8mm=432.6 square millimeter, is equivalent to the skin-grafting area of self skin graft expanding 12 times, i.e.,
The extension ratio of MEEK crape pieces is 1 ︰ 12.
The extension ratio of common MEEK crapes piece is not less than 1 ︰ 4.In above-described embodiment, uses and combined with allosome skin graft
MEEK make skin graft material, according to clinical experience, the extension ratio of MEEK crape pieces can reach 1 ︰ 12, significantly extend grafting for burns
Efficiency is covered, the utilization rate of self skin graft is greatly improved, ratio appropriate can be selected according to the case where fire victim.
Currently, MEEK crape piece Skin autografts and the allosome skin graft surface of a wound cover the extensive use in burn treating,
With good therapeutic effect, become the technical way of burn treating, and ripe day by day.But it further increases burn to control
Therapeutic effect needs new technological break-through.Water-soluble fabric is also applicable in medical field in recent years, is typically used as hemostatic material.
MEEK crape piece Skin autografts and the covering of the allosome skin graft surface of a wound are realized and organically combined using water-soluble fabric, can get
MEEK crape piece Skin autografts and the allosome skin graft surface of a wound cover the Overlay of two kinds of burn treating methods, may be implemented to burn
Hinder a new breakthrough for the treatment of technology.
The present invention is with pretreated viscose rayon（Viscose rayon is natural regeneration cellulose fibre）Or it is pretreated
Pure cotton fiber is raw material, is made according to the method for Chinese patent literature CN1286329A, CN1143697A, CN1058342A description
Soluble plain cloth.This plain cloth is replaced into nonabsorable material polyamide double pleats used in existing MEEK crapes piece
Yarn.Still retain the original cork pad of MEEK skin-grafting materials, aluminium foil.Soluble plain cloth is made of soluble cellulose, sticks
It is combined, can also be drenched, material water swelling subsequently becomes clear gel sample, is pasted on wound fluid after on the surface of a wound
The surface of a wound, it is last all to dissolve.It when carrying out skin-grafting operation, still presses general flow and carries out, a small amount of self sword sheet is cut, in MEEK
It rolls Pi Jishang and is cut into micro skin piece, be pasted onto above the soluble fabric of folding after self skin graft epidermis side glue spraying, it can
After insoluble fabric expansion, micro skin piece is scattering for rule, is distributed in fabric surface, fabric is directly attached to wound at this time
Face.Soluble fabric is combined rear transparent gel sample with surface of a wound moisture.At this point, in outer fabric layer, allosome skin graft is transplanted.In fabric
Before dissolving, the serosity exudation of the surface of a wound can pass through, and the survival of allosome skin graft provides nutrient.After the broken absorption of soluble fabric, wound
Face is in direct contact with allosome skin graft, establishes blood fortune.Soluble fabric does not use twill weave used in usual MEEK crapes piece
Object, and use plain cloth.The reason is that, through fabric used in MEEK crape pieces folding, it need to be mutual during expansion
It is firmly pulled in two perpendicular horizontal directions, folding and expanding, twills is made to be unfavorable for balancing in power, and it is tabby
Latitude and longitude direction is mutually perpendicular to, drawing force preferably.It further can get using 60 plains cloth relatively thin solvable
Property tissue layer, be convenient for MEEK crape pieces folding, it is often more important that convenient for dissolving and being absorbed by the surface of a wound as early as possible, make allosome skin graft more
It plays a role well.
Technical scheme of the present invention have extremely strong practicability and application prospect, can make burn treating technology obtain it is great into
Step.
Claims (9)
1. a kind of MEEK skin-grafting materials combined with allosome skin graft, including MEEK crapes piece and allosome skin graft, which is characterized in that institute
Metallic diaphragm and gauze layer that MEEK crape pieces include stacked together are stated, the gauze layer is water-soluble tissue layer.
2. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 1, which is characterized in that described water-soluble
Property fabric is fabric caused by being knitted by pretreated viscose rayon.
3. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 1, which is characterized in that described water-soluble
Property fabric is fabric caused by being knitted by pretreated pure cotton fiber.
4. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 1, which is characterized in that described water-soluble
Property fabric is plain cloth.
5. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 4, which is characterized in that described water-soluble
Property fabric is 60 plains cloth.
6. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 1, which is characterized in that the MEEK
The extension ratio of crape piece is 1 ︰ 5,1:8 or 1 ︰ 12.
7. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 1, which is characterized in that the allosome
Skin graft includes allogeneic skin graft and heterogenous allosome skin graft.
8. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 7, which is characterized in that described of the same race
Allosome skin graft include glycerine preserve allogeneic skin graft, profound hypothermia refrigerator preserve allogeneic skin graft, Liquid nitrogen storage it is same
Kind allosome skin graft, de- Cell Allograft skin graft or fresh allogeneic skin graft；The heterogenous allosome skin graft includes that de- cell is true
Scytoblastema matter pigskin skin graft, acellular dermal matrix sheepskin skin graft, acellular dermal matrix frog skin skin graft and fresh porcine skin skin graft.
9. a kind of MEEK skin-grafting materials combined with allosome skin graft according to claim 8, which is characterized in that described of the same race
Allosome skin graft is the allogeneic skin graft that glycerine preserves, and the heterogenous allosome skin graft is full thicker acellular dermal matrix pigskin skin
Piece.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664512A (en) * | 2019-10-08 | 2020-01-10 | 重庆大学 | Structural flexible electronic skin |
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| CN110664512A (en) * | 2019-10-08 | 2020-01-10 | 重庆大学 | Structural flexible electronic skin |
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Effective date of registration: 20210409 Address after: 100037, Fu Cheng Road, Beijing, Haidian District, No. 51 Patentee after: Fourth Medical Center, General Hospital of the Chinese PLA Address before: 100037 Department of burn and plastic surgery, the First Affiliated Hospital of PLA General Hospital, 51 Fu Cheng Road, Beijing, Haidian District Patentee before: Li Feng |
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