CN108743819A - A kind of preparation method of gastrodia capsule - Google Patents
A kind of preparation method of gastrodia capsule Download PDFInfo
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- CN108743819A CN108743819A CN201810935513.XA CN201810935513A CN108743819A CN 108743819 A CN108743819 A CN 108743819A CN 201810935513 A CN201810935513 A CN 201810935513A CN 108743819 A CN108743819 A CN 108743819A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of preparation methods of gastrodia capsule,More particularly to one kind by Rhizoma Gastrodiae by passing through water extracting mode effective component extracting,Due to active ingredient Gastrodin in Rhizoma Gastrodiae,Solubility is big in water for the substances such as polysaccharide,Therefore it can fully extract the active ingredient of Rhizoma Gastrodiae,Acrylic resin is added in extraction process,It is combined with Rhizoma Gastrodiae active ingredient using its polyhydroxy structure,Improve the fat-soluble of Rhizoma Gastrodiae active ingredient,Increase and absorbs,Again by will be after Rhizoma Gastrodiae extract drying and crushing,It is pelletized using the lactic acid ethanol solution of certain concentration,It is combined into novel polymer using the characteristic and acrylic resin of lactic acid,Wrap up Rhizoma Gastrodiae dried cream powder,Reduce its hygroscopicity,Improve product stability,Therefore it is good to obtain a kind of stability through the invention,Dissolution is fast,The gastrodia capsule of good absorbing,Under severe conditions,Significant changes will not occur for the dissolution rate of gastrodia capsule,Stability is preferable.
Description
Technical field
The present invention relates to a kind of preparation methods of gastrodia capsule, belong to the field of Chinese medicines.
Background technology
Rhizoma Gastrodiae, Chinese medicine name.This product is the rhizome of orchid Rhizoma Gastrodiae.Winter, the excavation of two season of spring, the winter person's of adopting name winter fiber crops, matter
It measures excellent；The spring person's of adopting name spring fiber crops, quality are good not as good as winter fiber crops.After digging out, the aerial stem of plant and fibrous root are removed, soil is cleaned, is steeped with clear water,
Tertia is wiped in time, clear water is put into immediately or alum water impregnates, then boiling or steaming are thoroughly, until drying in the air for degree, taking-up when center is without white point
It is dry, it dries or dries.Major function is：Ceases wind, arresting convulsion.Control dizziness pupil, head wind headache, extremity numbness, hemiplegia, language
It is not smoothgoing puckery, infantile epilepsy and convulsions.
Modern pharmacy research shows that its active ingredient be Gastrodin, vanillic aldehyde, parahydroxyben-zaldehyde, polysaccharide etc. it is a variety of at
Point, have the effects that calm, analgesia, anticonvulsion, anti-inflammatory, improvement memory and slows down aging.During modern clinic in Rhizoma Gastrodiae
Patent medicine preparation is by extensively in treatment rheumatic joint disease, dizziness, headache, neural pain etc., the current domestic preparation to Rhizoma Gastrodiae
Study a lot of, but most of is that Rhizoma Gastrodiae is mixed combination with other Chinese medicines, is prepared into corresponding prescribed preparation, Rhizoma Gastrodiae
Drug effect is notable, and pharmacological research clearly certainly will generate other with the combination of other medicinal materials and react, and have for the pharmacology of itself certain
Influence, however less for the single formulation research of Rhizoma Gastrodiae at present, it is high to be primarily due to water soluble ingredient content in Rhizoma Gastrodiae, system
It is serious for the extract moisture absorption gone out, product quality is influenced, exploitation single preparations of ephedrine difficulty is big, I is opened by years of researches
Send out a kind of Rhizoma Gastrodiae single preparations of ephedrine of stable quality.
Invention content
To solve the above-mentioned problems of the prior art, the present invention provides a kind of preparation method of gastrodia capsule, the present invention
The gastrodia capsule preparation method of gained is simple controllably, is suitable for industrialization production, and stability is good, significant in efficacy, on realizing
Invention is stated, embodiment is as follows：
One, it takes Processed Product of Rhizoma Gastrodiae appropriate, acrylic resin is added and is equivalent to the water that 2-4 times of Rhizoma Gastrodiae quality is measured, it is small to be heated to reflux 2-4
When, filtering is extracted 1-3 times, merging filtrate, and it is 1.1-1.2 that filtrate, which is concentrated into relative density,（50-60 DEG C of detection）Stiff paste, do
It is dry at dry cream, crushed 80 mesh sieve.
Preferably, the Processed Product of Rhizoma Gastrodiae meets《Chinese Pharmacopoeia》2015 editions one regulation.
Preferably, the acrylic resin addition is the 0.5%-1.5% of Rhizoma Gastrodiae quality.
Two, Rhizoma Gastrodiae dried cream powder is mixed with diluent, lactic acid ethanol solution is added, granulation, after dry, whole grain pours into glue
Capsule.
Preferably, the diluent is made of starch, acrylic resin and microcrystalline cellulose；It is 1 to form mass ratio:
0.5:1。
Preferably, the acrylic resin and Rhizoma Gastrodiae dried cream powder mass ratio are 1:20-40.
Preferably, the lactic acid ethanol solution is made of lactic acid, ethyl alcohol, water, composition ratio 2:60：38.
Preferably, the granulation refers to being pelletized using the stainless steel mesh of certain mesh number, and the drying includes
Hot air circulation drying and fluidized drying；The whole grain refers to the stainless steel mesh by certain mesh number by the particle after drying,
Carry out whole grain.
Further, the granulation sieve mesh number is 16-24 mesh, and whole grain sieve mesh number is 16-24 mesh.
The method have the characteristics that：
The present invention is dried to obtain Rhizoma Gastrodiae dried cream powder, acrylic acid is added during boiling by the way that Processed Product of Rhizoma Gastrodiae is carried out boiling extraction
Resin is combined containing great amount of hydroxy group with active ingredients such as Gastrodin, polysaccharide, Gastrodines, and being formed has certain fat-soluble polymerization
Object reduces the hygroscopicity of medicinal extract, increases its assimilation effect.
For the present invention also by the way that Rhizoma Gastrodiae dried cream powder is pelletized by lactic acid ethanol solution, lactic acid has certain acid, reduction third
Olefin(e) acid resin dissolves in water, and lactic acid is a kind of carboxylic acid of small molecule, after self-polymerization, forms long-chain molecule and acrylic acid tree
Fat combines, and formation is not easy penetrating polymer, and pelletization is preferably wrapped up the water soluble ingredient in Rhizoma Gastrodiae, into one
Step reduces its moisture absorption, improves its stability.
The beneficial effects of the present invention are：
1, the present invention obtains a kind of gastrodia capsule of stable quality.
2, the gastrodia capsule good absorbing that the present invention obtains, it is significant in efficacy.
Preparation method of the present invention is simple, and raw material are easy to get, and is suitable for industrialization, large-scale production.
Specific implementation mode
Main points in order to better understand the present invention are now described in further detail foregoing invention by specific embodiment, but under
Embodiment is stated to should not be understood as to further limitation of the invention.
Following embodiment batches are 2000.
Embodiment 1
1, Processed Product of Rhizoma Gastrodiae 10kg as defined in meeting is taken, acrylic resin is added and is equivalent to the water of 3 times of amounts of Rhizoma Gastrodiae quality, acrylic acid
Resin amount is the 1.0% of Rhizoma Gastrodiae quality, is heated to reflux 3 hours, is filtered, and is extracted 2 times, merging filtrate, filtrate is concentrated into relatively
Density is 1.15（50-60 DEG C of detection）Stiff paste, be dried to dry cream, crushed 80 mesh sieve.
2, Rhizoma Gastrodiae dried cream powder is mixed with diluent, the diluent is by starch, acrylic resin and microcrystalline cellulose
Composition；It is 1 to form mass ratio:0.5:1；The acrylic resin is 1 with Rhizoma Gastrodiae dried cream powder mass ratio:30.Breast is added
Sour ethanol solution, the lactic acid ethanol solution are made of lactic acid, ethyl alcohol, water, composition ratio 2:60：38；Granulation, it is dry
Afterwards, whole grain pours into capsule.
Embodiment 2
1, Processed Product of Rhizoma Gastrodiae 10kg as defined in meeting is taken, acrylic resin is added and is equivalent to the water of 2 times of amounts of Rhizoma Gastrodiae quality, acrylic acid
Resin amount is the 0.5% of Rhizoma Gastrodiae quality, is heated to reflux 2 hours, is filtered, and is extracted 1 time, merging filtrate, filtrate is concentrated into relatively
Density is 1.1（50-60 DEG C of detection）Stiff paste, be dried to dry cream, crushed 80 mesh sieve.
2, Rhizoma Gastrodiae dried cream powder is mixed with diluent, the diluent is by starch, acrylic resin and microcrystalline cellulose
Composition；It is 1 to form mass ratio:0.5:1；The acrylic resin is 1 with Rhizoma Gastrodiae dried cream powder mass ratio:20.Breast is added
Sour ethanol solution, the lactic acid ethanol solution are made of lactic acid, ethyl alcohol, water, composition ratio 2:60：38；Granulation, it is dry
Afterwards, whole grain pours into capsule.
Embodiment 3
1, Processed Product of Rhizoma Gastrodiae 10kg as defined in meeting is taken, acrylic resin is added and is equivalent to the water of 4 times of amounts of Rhizoma Gastrodiae quality, acrylic acid
Resin amount is the 1.5% of Rhizoma Gastrodiae quality, is heated to reflux 4 hours, is filtered, and is extracted 3 times, merging filtrate, filtrate is concentrated into relatively
Density is 1.2（50-60 DEG C of detection）Stiff paste, be dried to dry cream, crushed 80 mesh sieve.
2, Rhizoma Gastrodiae dried cream powder is mixed with diluent, the diluent is by starch, acrylic resin and microcrystalline cellulose
Composition；It is 1 to form mass ratio:0.5:1；The acrylic resin is 1 with Rhizoma Gastrodiae dried cream powder mass ratio:40.Breast is added
Sour ethanol solution, the lactic acid ethanol solution are made of lactic acid, ethyl alcohol, water, composition ratio 2:60：38；Granulation, it is dry
Afterwards, whole grain pours into capsule.
Comparative example 1
1, Processed Product of Rhizoma Gastrodiae 10kg as defined in meeting is taken, the water for being equivalent to 3 times of amounts of Rhizoma Gastrodiae quality is added, is heated to reflux 3 hours, mistake
Filter is extracted 2 times, merging filtrate, and it is 1.15 that filtrate, which is concentrated into relative density,（50-60 DEG C of detection）Stiff paste, be dried to dry cream, powder
80 mesh of broken mistake sieves.
2, Rhizoma Gastrodiae dried cream powder is mixed with diluent, the diluent is by starch, acrylic resin and microcrystalline cellulose
Composition；It is 1 to form mass ratio:0.5:1；The acrylic resin is 1 with Rhizoma Gastrodiae dried cream powder mass ratio:30.Second is added
Alcoholic solution, the ethanol solution are made of ethyl alcohol, water, composition ratio 60：40；Granulation, after dry, whole grain pours into capsule
?.
Comparative example 2
1, Processed Product of Rhizoma Gastrodiae 10kg as defined in meeting is taken, the water for being equivalent to 2 times of amounts of Rhizoma Gastrodiae quality is added, is heated to reflux 2 hours, mistake
Filter is extracted 1 time, merging filtrate, and it is 1.1 that filtrate, which is concentrated into relative density,（50-60 DEG C of detection）Stiff paste, be dried to dry cream, powder
80 mesh of broken mistake sieves.
2, Rhizoma Gastrodiae dried cream powder is mixed with diluent, the diluent is by starch, acrylic resin and microcrystalline cellulose
Composition；It is 1 to form mass ratio:0.5:1；The acrylic resin is 1 with Rhizoma Gastrodiae dried cream powder mass ratio:20.Second is added
Alcoholic solution, the ethanol solution are made of ethyl alcohol, water, composition ratio 60：40；Granulation, after dry, whole grain pours into capsule
?.
Comparative example 3
1, Processed Product of Rhizoma Gastrodiae 10kg as defined in meeting is taken, the water for being equivalent to 4 times of amounts of Rhizoma Gastrodiae quality is added, is heated to reflux 4 hours, mistake
Filter is extracted 3 times, merging filtrate, and it is 1.2 that filtrate, which is concentrated into relative density,（50-60 DEG C of detection）Stiff paste, be dried to dry cream, powder
80 mesh of broken mistake sieves.
2, Rhizoma Gastrodiae dried cream powder is mixed with diluent, the diluent is by starch, acrylic resin and microcrystalline cellulose
Composition；It is 1 to form mass ratio:0.5:1；The acrylic resin is 1 with Rhizoma Gastrodiae dried cream powder mass ratio:40.Second is added
Alcoholic solution, the lactic acid ethanol solution are made of ethyl alcohol, water, composition ratio 60：40；Granulation, after dry, whole grain pours into
Capsule.
Preparation process is evaluated
Carry out preparing gastrodia capsule according to embodiment 1-3 and comparative example 1-3 respectively, according to the complexity of preparation process into
Row evaluation, record-keeping system are recorded a demerit as follows for phenomenon：
| Embodiment | Prepare phenomenon | Particle yield |
| Embodiment 1 | Preparation process is smooth, prepares that softwood controllability is strong, and mobility of particle is good, and hygroscopicity is preferably controlled, it is filling smoothly | 98.9% |
| Embodiment 2 | Preparation process is smooth, prepares that softwood controllability is strong, and mobility of particle is good, and hygroscopicity is preferably controlled, it is filling smoothly | 97.9% |
| Embodiment 3 | Preparation process is smooth, prepares that softwood controllability is strong, and mobility of particle is good, and hygroscopicity is preferably controlled, it is filling smoothly | 98.4% |
| Comparative example 1 | Softwood is difficult to control, and the particle moisture absorption is serious, and filling is difficult, and content uniformity is larger, and midway needs constantly cleaning mold. | 78.9% |
| Comparative example 2 | Softwood is difficult to control, and the particle moisture absorption is serious, and filling is difficult, and content uniformity is larger, and midway needs constantly cleaning mold. | 82.2% |
| Comparative example 3 | Softwood is difficult to control, and the particle moisture absorption is serious, and filling is difficult, and content uniformity is larger, and midway needs constantly cleaning mold. | 69.5% |
It analyzes from the above, the Rhizoma Gastrodiae particle that the present invention obtains is suitable for filling, and preparation process controllability is strong.
Study on the stability
Each 50g of gastrodia capsule obtained by Example 1-3 and comparative example 1-3, is respectively put into 10 low density polyethylene (LDPE) bottles
In, each bottled gastrodia capsule 5g of low density polyethylene (LDPE) covers tightly bottle cap, heat-sealing, by above-mentioned low density polyethylene bottle be put into 40 DEG C,
Under 75% damp condition, moisture and dissolution rate are detected respectively.
1, water content detection
According to《Chinese Pharmacopoeia》Embodiment 1-3 is detected about the oven drying method in moisture detecting method and comparison is real in 2015 editions four
The pellet moisture of a 1-3 is applied, it is as a result as follows：
| Date | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| 0 month（%） | 0.62 | 0.54 | 0.71 | 0.68 | 0.72 | 0.73 |
| January（%） | 0.68 | 0.81 | 0.72 | 2.56 | 2.86 | 2.77 |
| 2 months（%） | 0.75 | 0.82 | 0.83 | 7.86 | 7.01 | 7.99 |
| March（%） | 0.92 | 0.96 | 0.92 | 11.5 | 10.36 | 11.18 |
| April（%） | 1.05 | 1.08 | 1.04 | 13.52 | 12.99 | 13.08 |
| May（%） | 1.09 | 1.19 | 1.15 | 14.05 | 14.09 | 14.98 |
| June（%） | 1.22 | 1.24 | 1.38 | 14.69 | 15.02 | 15.78 |
It analyzes from the above, under severe conditions, moisture has no and rises appreciably gastrodia capsule of the invention within 6 months.
2. dissolution rate is investigated
Respectively detect 0 month, March, June gastrodia capsule dissolve out situation, reference《Chinese Pharmacopoeia》About molten in versions four in 2015
Out-degree detection method takes gastrodia capsule 6, is put into stripping rotor, using water as dissolution medium, respectively 5min, 10min,
15min, 30min sample 5ml, reference《Chinese Pharmacopoeia》The middle Rhizoma Gastrodiae detection method of version one in 2015 detects the content in sample,
Solubility is calculated, the mean value of 6 dissolution rates is calculated, it is as a result as follows：
0 month testing result
| Time | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| 5min（%） | 75.5 | 78.6 | 79.5 | 60.7 | 62.8 | 55.9 |
| 10min（%） | 89.5 | 90.5 | 91.4 | 75.9 | 72.9 | 70.4 |
| 15min（%） | 94.8 | 96.2 | 96.8 | 84.5 | 86.5 | 81.5 |
| 30min（%） | 98.5 | 96.4 | 99.5 | 90.2 | 91.4 | 89.9 |
March testing result
| Time | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| 5min（%） | 72.5 | 76.8 | 71.5 | 32.5 | 30.4 | 28.9 |
| 10min（%） | 86.3 | 88.4 | 84.9 | 54.6 | 51.8 | 48.9 |
| 15min（%） | 95.6 | 94.8 | 96.4 | 60.4 | 59.6 | 57.2 |
| 30min（%） | 99.5 | 97.8 | 99.6 | 62.8 | 64.5 | 68.2 |
June testing result
| Time | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| 5min（%） | 69.8 | 65.9 | 75.8 | 10.5 | 9.5 | 11.4 |
| 10min（%） | 84.5 | 89.3 | 88.4 | 20.1 | 23.5 | 24.2 |
| 15min（%） | 94.5 | 93.6 | 92.8 | 30.2 | 29.8 | 26.5 |
| 30min（%） | 95.9 | 94.7 | 96.8 | 33.4 | 34.3 | 30.7 |
It analyzes from the above, the gastrodia capsule dissolution rate of present invention gained is very fast, and under severe conditions, dissolution speed
Degree has no that significant change, stability are preferable.
Claims (5)
1. a kind of preparation method of gastrodia capsule, it is characterised in that including following steps：
（1）It takes Processed Product of Rhizoma Gastrodiae appropriate, acrylic resin is added and is equivalent to the water that 2-4 times of Rhizoma Gastrodiae quality is measured, it is small to be heated to reflux 2-4
When, filtering is extracted 1-3 times, merging filtrate, and it is 1.1-1.2 that filtrate, which is concentrated into relative density,（50-60 DEG C of detection）Stiff paste, do
It is dry at dry cream, crushed 80 mesh sieve；
（2）Rhizoma Gastrodiae dried cream powder is mixed with diluent, lactic acid ethanol solution is added, granulation, after dry, whole grain pours into capsule i.e.
It can.
2. gastrodia capsule preparation method according to claim 1, it is characterised in that：The acrylic resin addition is
The 0.5%-1.5% of Rhizoma Gastrodiae quality.
3. gastrodia capsule preparation method according to claim 1, it is characterised in that：The diluent is by starch, propylene
Acid resin and microcrystalline cellulose composition；It is 1 to form mass ratio:0.5:1.
4. gastrodia capsule preparation method according to claim 3, it is characterised in that：The acrylic resin is dry with Rhizoma Gastrodiae
Cream powder mass ratio is 1:20-40.
5. gastrodia capsule preparation method according to claim 1, it is characterised in that：The lactic acid ethanol solution is by breast
Acid, ethyl alcohol, water composition, composition ratio 2:60：38.
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| CN201810935513.XA CN108743819A (en) | 2018-08-16 | 2018-08-16 | A kind of preparation method of gastrodia capsule |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640443A (en) * | 2004-01-15 | 2005-07-20 | 苏少宁 | Rhizome gastrodiae preparation and its preparing method |
| CN101015656A (en) * | 2007-02-16 | 2007-08-15 | 周湘平 | Method for preparation of pure gastrodia elata capsule with sleeping improving and hypoxia resistant functions |
| CN101396377A (en) * | 2007-09-29 | 2009-04-01 | 上海中医药大学 | Moisture protection method of traditional Chinese medicine extract |
| CN102499890A (en) * | 2011-09-30 | 2012-06-20 | 沈阳药科大学 | Preparation method of hot melt extrusion moisture-proof preparation for medicaments |
-
2018
- 2018-08-16 CN CN201810935513.XA patent/CN108743819A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640443A (en) * | 2004-01-15 | 2005-07-20 | 苏少宁 | Rhizome gastrodiae preparation and its preparing method |
| CN101015656A (en) * | 2007-02-16 | 2007-08-15 | 周湘平 | Method for preparation of pure gastrodia elata capsule with sleeping improving and hypoxia resistant functions |
| CN101396377A (en) * | 2007-09-29 | 2009-04-01 | 上海中医药大学 | Moisture protection method of traditional Chinese medicine extract |
| CN102499890A (en) * | 2011-09-30 | 2012-06-20 | 沈阳药科大学 | Preparation method of hot melt extrusion moisture-proof preparation for medicaments |
Non-Patent Citations (1)
| Title |
|---|
| 狄留庆等: "粉体表面改性技术降低中药全浸膏制剂引湿性的应用研究", 《南京中医药大学学报》 * |
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