CN108742644A - Fetal hemoglobin saturation signal processing method, optical receiver apparatus and detection device - Google Patents

Fetal hemoglobin saturation signal processing method, optical receiver apparatus and detection device Download PDF

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CN108742644A
CN108742644A CN201810169917.2A CN201810169917A CN108742644A CN 108742644 A CN108742644 A CN 108742644A CN 201810169917 A CN201810169917 A CN 201810169917A CN 108742644 A CN108742644 A CN 108742644A
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signal
optical
optical signal
fetal
fetal hemoglobin
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CN108742644B (en
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黄汶
王义向
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Beijing Victor Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1464—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters specially adapted for foetal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Noninvasive fetal hemoglobin saturation detects signal processing method outside a kind of abdomen of present invention offer, and the relevant optical signal of multiple and fetal hemoglobin saturation of reception is synthesized optical signal summation, including step A：Reception is subjected to correlation analysis with fetal heart rate signal respectively with the relevant multiple optical signals of fetal hemoglobin saturation and obtains the relative coefficient of each optical signal；Step B：The corresponding weighting coefficient of each optical signal is obtained based on relative coefficient；Step C：By multiple optical signals according to respective weighting coefficient be overlapped to obtain with the relevant optical signal summation of fetal hemoglobin saturation, with improve receive with the relevant light signal strength of fetal hemoglobin saturation, removal noise signal interference improves signal-to-noise ratio；The present invention also provides noninvasive fetal hemoglobin saturation detection devices outside the optical receiver apparatus for using signal processing method of the present invention and abdomen.

Description

Fetal hemoglobin saturation signal processing method, optical receiver apparatus and detection device
Technical field
The present invention relates to the blood oxygen saturation detection technique fields in Medical Devices, more specifically to a kind of abdomen outside Noninvasive fetal hemoglobin saturation detection device outside noninvasive fetal hemoglobin saturation signal processing method, optical receiver apparatus and abdomen.
Background technology
Later stage of pregnancy, and can be a dangerous time phase to pregnant woman and fetus just before giving birth and the production phase.If tire Youngster's umbilical cord becomes disease of the distortion in unfavorable position, placenta premature disengagement or certain pregnant woman and fetus, is likely to lead It causes oxygen content in fetal blood insufficient, and then causes fetus cerebral injury or death.Detecting sphygmus and blood oxygen saturation is used on clinical medicine (SaO2) this physical signs comes indirect monitoring human body, including the oxygen content in fetal blood.
Currently, fetal heart frequency, heart sound patient monitor have been widely used in the monitoring of fetus physiological status.In view of the confession of fetus Oxygen is not obtained by fetus itself breathing, but is conveyed from placenta by parent, and the blood oxygen saturation of fetus more acurrate can reflect Oxygen concentration in blood, to be a physical signs for more directly reflecting fetal life state.Detect the SaO of fetus2Face Bed meaning is, directly reflects the oxygenation of fetus, life state of the fetus in parent is made a definite diagnosis with this, to reduce peri-natal infant The death rate and neonatal disability rate.2000 Nian You u s companies produced a kind of being placed in intrauterine to survey sensor The instrument of fetal hemoglobin saturation is measured, medical staff needs instrument to be goed deep into the intrauterine of pregnant woman, directly takes blood from fetus body surface To obtain the blood oxygen saturation index of fetus.These methods and instrument are not suitable for for a long time, continuously to fetal hemoglobin saturation Detection is less suitable for the perinatal monitoring of fetus.Since the blood oxygen for detecting fetus currently without effective non-intruding mode is full With the instrument and equipment of degree, medical staff can only often rely on fetal heart rate monitor device.And the fetal rhythm monitoring being widely used at present, Though the asphyxia of the sensitive detection fetus of energy, its specificity is relatively low, cannot reflect asphyxia omen in advance.Due to fetal rhythm monitoring it is special Property it is relatively low, cause doctor lack fetus integrality is fully realized, than such as whether need practise caesarean operation, when open Beginning practises caesarean operation, it is necessary to urgent medical decision making is made in the case of not abundant knowledge, thus on the one hand, doctor may Error diagnosis affects the opportunity for taking necessary means adversely；On the other hand, doctor is often too cautious, causes many unnecessary cut open Abdomen production surgical intervention increases, and not only increases operation risk and pregnant woman childbirth complication, but also the unnecessary great number of the thing followed Medical expense also add society and the financial burden of family.
Inventor herein is in Chinese patent ZL201310182965.2 (fetal hemoglobin saturation detecting system and method) In provide it is a kind of monitoring the detecting system and method for fetus detecting sphygmus and blood oxygen saturation in a manner of non-intruding, for the first time using setting It is placed on the external fetus detecting sphygmus and blood oxygen saturation photoelectric sensor of pregnant woman, is goed deep into pregnant woman's abdomen without any in detection process Operation, it is not necessary that photoelectric sensor to be applied to the privileged site of fetus, to be truly realized noninvasive fetal blood oxygen saturation outside abdomen Degree detection, the two important fetus physiological parameters can simultaneously be supplied to the blood oxygen saturation of heart rate and fetus to fetus Medical staff has very high Practical significance to fetus, pregnant woman and society.The present invention is to research and develop realization tool according to above-mentioned patent The new invention further generated in body product process.Applicants have discovered that since fetus is in the intrauterine position of mother (position of foetus) There are prodigious uncertainty, the position of foetus of different pregnant woman is different, and same pregnant woman changes very in the position of foetus of different stages of gestation Greatly, fetus can also change at any time in intrauterine posture, and the blood oxygen saturation of fetus different parts is also different, therefore, when adopting With the fetus SaO of Chinese patent (ZL201310182965.2)2The photoelectric sensor of detecting system is applied to one outside pregnant woman's abdomen When a privileged site, sense with fetus SaO2There are larger uncertainty, the uncertainties for relevant photosignal The specificity of testing result is directly influenced, i.e., when testing result shows positive (blood oxygen saturation is relatively low), fetus is actual Sa02 is normal.The consequence of such case may result in unnecessary human intervention or even surgical intervention, these interventions The increase of medical treatment cost and medical-risk can be caused, while can also increase the pain of mother and baby.It can be seen that noninvasive fetal blood outside abdomen A realistic problem facing of oxygen saturation detection be how to solve the problems, such as the uncertain influence to testing result of the position of foetus, then One problem is exactly the attenuation problem of light, and the optical signal that optical receiver receives must be intraperitoneal to its from pregnant woman's abdomen external exposure Fetus, then from fetus multigravida abdominal cavity back to the light of the specific wavelength outside pregnant woman's abdomen, it receives from being issued to, need to pass through very long Light path, and the decaying of light and light path is square directly proportional.In addition, optical receiver receive it is related to fetal hemoglobin saturation Optical signal, be organize (such as skin, fat, uterus, amniotic fluid) to absorb through fetal tissue, pregnant woman, reflection, the complicated mistake such as scattering Extremely faint light after journey, weak degrees are enough to threaten noninvasive fetal hemoglobin saturation detection outside the success and abdomen of detection Practicability.Therefore, the outer noninvasive blood oxygen saturation detection device of fetus of abdomen must solve optical receiver apparatus receives and fetal blood The problem of the problem of flowing relevant signal strength and signal interference, improves signal strength and removes noise jamming, improves noise Than.For this purpose, to research and develop successfully the noninvasive blood oxygen saturation detection device of the outer fetus of abdomen, it is necessary to while above-mentioned two problem is solved, in It is to shine and can optical receiver the problem of receiving signal strength relevant with fetus blood flow as solving the pass of the two problems Key.
The applicant also found that the outer noninvasive blood oxygen saturation monitoring system of fetus of abdomen must have enough power under study for action Light is radiated at the abdomen of pregnant woman, just can guarantee optical receiver receive effectively with the relevant optical signal of fetus, however if one Taste increase light source luminous power, be based on light-emitting component used at present (such as LED, laser), light-emitting area all very littles, and Usually it is close to the skin of pregnant woman, there is a possibility that skin of pregnant women feels under the weather or burnt in use.According to it is international it is non-from The sub- radiation protection committee (International Commission of Nob-Ionizing Radiation Protection, ICNIRP) publications in 2000 years file it is found that wavelength in 400nm to the LED light wave of 1400nm ranges, it is several The luminous power of milliwatt continues 100 seconds, can cause to burn to skin.Therefore, the practicability of the detection device and comfortable is improved Property, excluding the risk hidden danger of the ray radiation injury of topical burn is also very important.
Invention content
The purpose of the present invention is to provide it is a kind of improve receive with the relevant light signal strength of fetal hemoglobin saturation, It removes noise signal to interfere, noninvasive fetal hemoglobin saturation signal processing method outside the high abdomen of signal-to-noise ratio, and using the present invention Noninvasive fetal hemoglobin saturation detection dress outside the optical receiver apparatus of noninvasive fetal hemoglobin saturation signal processing method and abdomen outside abdomen It sets.
To achieve the above object, present invention employs following technical solutions：
Noninvasive fetal hemoglobin saturation detects signal processing method outside a kind of abdomen, by the multiple and fetal blood oxygen saturation of reception Relevant optical signal synthesis optical signal summation is spent, is included the following steps：
Step A：Reception is carried out with fetal heart rate signal respectively with the relevant multiple optical signals of fetal hemoglobin saturation Correlation analysis obtains the relative coefficient of each optical signal；
Step B：The corresponding weighting coefficient of each optical signal is obtained based on relative coefficient；
Step C：Multiple optical signals according to respective weighting coefficient are overlapped to obtain related to fetal hemoglobin saturation Optical signal summation.
Further, step B includes：If the relative coefficient of optical signal is less than preset relevance threshold, weight Coefficient is 0；If relative coefficient is higher than preset relevance threshold, weighting coefficient is obtained according to relative coefficient, it will be more A optical signal is overlapped to obtain optical signal summation according to respective weighting coefficient.
Further, step A includes：By each of reception and the relevant optical signal of fetal hemoglobin saturation time domain with connect The fetal heart rate signal of receipts carries out correlation analysis and obtains the relative coefficient of each optical signal.
Further, step A includes：Each of reception and the relevant optical signal of fetal hemoglobin saturation are gone to from time domain Frequency domain obtains optical signal spectrum, while the fetal heart rate signal of reception is gone to frequency domain from time domain and obtains fetus frequency domain luminous power frequency Optical signal spectrum is carried out correlation analysis with fetus frequency domain luminous power frequency spectrum in frequency domain and obtains the correlation system of each optical signal by spectrum Number.
Further, step A further includes：From the signal spectrum work(filtered out in optical signal spectrum other than fetus spectrum power Rate obtains filtered optical signal frequency spectrum, and filtered optical signal frequency spectrum from frequency domain is reverted back time domain, and to obtain filtered optical signal folded as weighting The optical signal added.
Further, further include step D：By the pregnant woman with the relevant optical signal summation of fetal hemoglobin saturation and acquisition Heart rate and/or pregnant woman's optical signal and/or fetal heart rate signal carry out the blood oxygen saturation that fetus is calculated in analysis.
The present invention also provides a kind of optical receiver apparatuses, are used for noninvasive fetal hemoglobin saturation detection device outside abdomen, including more A optical receiver 204, the signal primary processor 250 being connect with multiple optical receivers 204, signal primary processor 250 include The interface of fetal heart rate signal is received, noninvasive fetal hemoglobin saturation detects letter outside the abdomen of primary processor 250 through the invention The relevant optical signal of multiple and fetal hemoglobin saturation of reception is synthesized optical signal summation by number processing method.
Further, the signal primary processor 250 includes multiple signal analyzers 252 and is analyzed with multiple signals The addition selector 254 that device 252 connects, multiple signal analyzers 252 analyze multiple optical receivers 204 acquire and fetus respectively The relative coefficient of blood oxygen saturation relevant optical signal and fetal heart rate signal, addition selector 254 is according to signal analyzer Multi-path digital signal weight is superimposed to synthesize optical signal summation 256 by 252 analysis result.
Further, the signal analyzer 252 is time-domain signal analysis device or frequancy signal anaysis device.
Further, the addition selector 254 is linear superposition device, and linear superposition device will be at signal analyzer 252 The linear superposition of multi-path digital signal after reason is to synthesize optical signal summation 256；Alternatively, the addition selector 254 is light Signal selector, optical signal selector select to believe as light all the way from treated the multi-path digital signal of signal analyzer 252 Number summation 256, or therefrom select multi-path digital signal and be superimposed them to form optical signal summation 256.
Further, the signal primary processor 250 is microcontroller.
The present invention also provides noninvasive fetal hemoglobin saturation detection devices outside a kind of abdomen, including with signal processing controller The outer fetus BOLD contrast of 11 abdomen, illuminating source device 92 are used for acquisition and the relevant light of fetal hemoglobin saturation outside pregnant woman's abdomen The optical receiver apparatus 91 of signal, the fetal rhythm harvester for acquiring fetal heart rate signal, illuminating source device 92, light-receiving dress Set 91 and fetal rhythm harvester connect with signal processing controller 11, the illuminating source device 92 shines into pregnant woman's abdomen Penetrate the light of two or more different wave lengths；The optical receiver apparatus 91 includes multiple optical receivers 204, with multiple light The signal primary processor that receiver 204 connects, signal primary processor are connect with fetal rhythm harvester, and primary processor passes through Noninvasive fetal hemoglobin saturation detects signal processing method by the multiple and fetal hemoglobin saturation phase of reception outside the abdomen of the present invention The optical signal synthesis optical signal summation of pass is exported to signal processing controller 11, and the signal processing controller 11 is according to light The optical signal summation that reception device 91 exports, and fetus blood oxygen is calculated according to the fetal heart rate signal of fetal rhythm harvester acquisition and is satisfied And degree.
Noninvasive fetal hemoglobin saturation signal processing method outside the abdomen of the present invention, is acquired more by multiple optical receivers 204 A be superimposed with the relevant optical signal of fetal hemoglobin saturation synthesizes optical signal summation to improve the intensity of the optical signal received, and And the optical signal acquired based on multiple optical receivers 204 is carried out correlation analysis with the fetal heart rate signal acquired simultaneously and is added Power superposition is interfered with reducing noise signal unrelated with fetal hemoglobin saturation in optical signal, improves the letter of collected optical signal It makes an uproar and compares, to improve the accuracy and reliability of outer noninvasive fetal hemoglobin saturation detection device detection.In particular, by reception with When the relevant multiple optical signals of fetal hemoglobin saturation carry out correlation analysis with fetal heart rate signal respectively, by signal from time domain It goes to frequency domain and carries out correlation analysis, and from the signal spectrum work(filtered out in optical signal spectrum other than fetus spectrum power Rate greatly reduces noise jamming, improves the intensity of acquisition and the relevant optical signal of fetal hemoglobin saturation.In addition, this hair Another bright improvement is sensor and fetus blood oxygen detector host by using wireless communication connection her abdominal.
Description of the drawings
Fig. 1 is the structure diagram of noninvasive fetal hemoglobin saturation detection device outside abdomen of the present invention；
Fig. 2 is the structural schematic diagram of noninvasive fetal hemoglobin saturation detection device outside abdomen of the present invention；
Fig. 3 is the structural schematic diagram of fetus blood oxygen light signal acquisition device of the present invention；
Fig. 4-5 is the structure chart of two embodiments of optical receiver apparatus of the present invention；
Fig. 6-11 is multiple optical receivers of fetus blood oxygen light signal acquisition device of the present invention and the layout knot of illuminating source The structure chart of six embodiments of structure；
Figure 12-14 is three embodiments of the layout structure of the luminescence unit of the illuminating source of optical receiver apparatus of the present invention Structure chart；
Figure 15 is the structural schematic diagram of illuminating source device of the present invention；
Figure 16 is the another example structure figure of optical receiver apparatus of the present invention；
Figure 17 is the block diagram of one embodiment of 250 signal processing flow of primary processor shown in Figure 16；
Figure 18 is the block diagram of another embodiment of 250 signal processing flow of primary processor shown in Figure 16；
Figure 19 is the block diagram of another embodiment of the signal processing flow of primary processor 250 shown in Figure 16；
Figure 20 is one embodiment of the addition selector of the optical receiver apparatus of Figure 16；
Figure 21 is another embodiment of the addition selector of the optical receiver apparatus of Figure 16.
Specific implementation mode
Below in conjunction with the embodiment that attached drawing 1 to 21 provides, noninvasive fetal blood oxygen saturation outside the abdomen further illustrated the present invention Spend the specific implementation mode of detection device.
As shown in Figure 1, noninvasive fetal hemoglobin saturation detection device generally includes the outer fetus of abdomen outside abdomen of the present invention BOLD contrast and the signal detection component being connect with fetus BOLD contrast outside abdomen.The outer fetus BOLD contrast of abdomen includes signal processing controller 11；The signal detection component includes shining for the light for irradiating two or more different wave lengths into pregnant woman's abdomen Light supply apparatus 92, for the optical receiver apparatus 91 of acquisition and the relevant optical signal of fetal hemoglobin saturation outside pregnant woman's abdomen, and For acquire fetal heart rate signal, acquisition maternal heart rate signal and pregnant woman's detecting sphygmus and blood oxygen saturation optical signal in any one or The reference signal detection device of multiple signals.The reference signal detection device includes for acquiring the fetus heart outside pregnant woman's abdomen The fetal rhythm harvester of rate signal, and/or the maternal heart rate harvester of maternal heart rate signal is acquired, and/or acquisition pregnant woman's pulse Pregnant woman's detecting sphygmus and blood oxygen saturation harvester of blood oxygen saturation optical signal, the optical receiver apparatus 91, illuminating source device 92, fetal rhythm harvester, maternal heart rate harvester and pregnant woman's detecting sphygmus and blood oxygen saturation harvester are controlled with signal processing Device 11 connects；Signal processing controller 11 is based on the fetus heart according to acquisition and the relevant optical signal of fetal hemoglobin saturation One or more of rate signal, maternal heart rate signal and pregnant woman's detecting sphygmus and blood oxygen saturation optical signal signal calculates fetus pulse Blood oxygen saturation.
The detection technique of the blood oxygen saturation of blood flow of the present invention in pregnant woman in-vitro measurements fetus, in detection process In be not necessarily to any operation goed deep into pregnant woman's abdomen, it is real in a creative way it is not necessary that photoelectric sensor to be applied to the privileged site of fetus The specific solution party for the problem of including how conversion process signal without noninvasive fetal hemoglobin saturation detection outside intrusive abdomen is showed Case discloses in the previous patent of invention CN201310182965.2 of the present inventor, is not repeating again.
As Figure 2-3, outside abdomen of the invention noninvasive fetal hemoglobin saturation detection device one embodiment, including abdomen Outer fetus BOLD contrast and the fetus blood oxygen light signal acquisition device 9 being connect with fetus BOLD contrast outside abdomen；The outer fetus BOLD contrast packet of abdomen Signal processing controller 11 is included, and the display module 12 and operation module 13 being connect with signal processing controller 11；The tire Youngster's blood oxygen light signal acquisition device 9 includes optical sensor installing mechanism 93,93 integrated installation of optical sensor installing mechanism There are illuminating source device 92 and the optical receiver apparatus 91 including multiple optical receivers 204, by illuminating source device 92 and light-receiving Device 91 integrates the harvester for constituting acquisition fetus blood oxygen optical signal.The fetus blood oxygen light signal acquisition device 9 can be wrapped tightly illuminating source device 92 and optical receiver apparatus 91 on her abdominal body surface in a manner of being close to, and can be by Fetus shift position is adjusted；Preferably, fetus blood oxygen light signal acquisition device 9 is that illuminating source device can be fixedly mounted 92 and the optical receiver apparatus 91 including multiple optical receivers 204 and it can be fixed on wrapping in pregnant woman's abdomen on her abdominal simultaneously The soft component in portion.Pregnant woman is tied up to as the optical sensor installing mechanism 93 of fetus blood oxygen light signal acquisition device 9 can be one The waistband of abdomen, a wearable abdomen scarf, stomacher or other illuminating source device 92 can be installed and including multiple light The optical receiver apparatus 91 of receiver 204 and the device that her abdominal can be fixed on.The fetus blood oxygen light signal collection Device 9 is connect by communication link 14 with fetus BOLD contrast outside abdomen, and it is wireless that communication link 14 can be that expired air can also be Link.WIFI, bluetooth and other wireless communication protocols can be used in wireless link.Display module 12 can be LED screen, LCD screen or Touch screen, operation module 13 can be keyboards.
Further, noninvasive fetal hemoglobin saturation detection device further includes fetal rhythm harvester (not shown) outside abdomen, Fetus blood oxygen light signal acquisition device 9 combines fetus blood oxygen probe or fetal rhythm outside composition abdomen together with fetal rhythm harvester and adopts Acquisition means, which are also integrated on the optical sensor installing mechanism 93 of fetus blood oxygen light signal acquisition device 9, constitutes the outer fetus blood oxygen spy of abdomen Head, the various signals needed for acquiring fetus BOLD contrast outside abdomen, the outer fetus blood oxygen probe of abdomen by communication link 14 and abdomen outside Fetus BOLD contrast 1 connects.Such as a kind of embodiment is fetus blood oxygen light signal acquisition device 9 and fetal rhythm harvester is two only Vertical harvester constitutes the outer fetus blood oxygen probe of abdomen, fetus blood oxygen light signal acquisition device 9 and fetal rhythm harvester point together It is not connect with fetus BOLD contrast 1 outside abdomen, fetus BOLD contrast 1 is equipped with the optical signal being connect with optical receiver apparatus 91 outside the abdomen Interface, the illuminating source interface being connect with illuminating source device 92, the fetal heart frequency detection interface being connect with fetal rhythm harvester, Illuminating source device 92, optical receiver apparatus 91 and fetal rhythm harvester pass through optical signal link, illuminating source link and tire respectively Youngster's heart rate signal link is connect with optical signal interface, illuminating source interface and fetal heart frequency detection interface, and optical signal link shines Optical source link and fetal heart rate signal link can be wired or wireless on-link mode (OLM)s, and WIFI, bluetooth can be used in wireless link With other wireless communication protocols.Such as the illuminating source device 92 that another embodiment is fetus blood oxygen light signal acquisition device 9 It is integrated on optical sensor installing mechanism 93 with optical receiver apparatus 91 and fetal rhythm harvester and constitutes the outer fetus blood oxygen spy of abdomen Head, the outer fetus BOLD contrast of the abdomen 1 are equipped with the first wireless transmitter receiver device, the optical signal interface of the outer fetus BOLD contrast of abdomen 1, Illuminating source interface and fetal heart frequency detection interface are connect with the first wireless transmitter receiver device respectively, optical sensor installing mechanism 93 It is equipped with the second wireless transmitter receiver device, illuminating source device 92, optical receiver apparatus 91 and fetal rhythm harvester are respectively with second Wireless transmitter receiver device connect, by the second wireless transmitter receiver device, the first wireless transmitter receiver device link and abdomen outside fetus BOLD contrast 1 connects.Further, the outer fetus blood oxygen probe of abdomen can also include maternal heart rate harvester and/or pregnant woman's pulse blood oxygen Saturation degree harvester (not shown).
One of the improvement of the present invention, the signal processing controller 11 control illuminating source device 92 to pregnant The light of the two or more different wave lengths of irradiation in woman's abdomen, the optical receiver apparatus 91 include being separately positioned on pregnant woman's abdomen Multiple optical receivers 204 of outer multiple and different positions, optical receiver apparatus 91 is acquired multiple from pregnant woman by multiple optical receivers 204 In abdomen scattering and be reflected back with the relevant optical signal of fetal hemoglobin saturation, and exported after being superimposed and fetal hemoglobin saturation phase The optical signal summation of pass is exported to signal processing controller 11.The optical receiver apparatus 91 of the present invention includes being separately positioned on pregnant woman's abdomen Multiple optical receivers 204 of outer multiple and different positions, optical receiver apparatus 91 acquire multiple returned out of pregnant woman abdomen and fetal bloods The relevant optical signal of oxygen saturation, and superposition is aggregated into optical signal summation and sends signal processing controller 11 to；The signal The optical signal summation that processing controller 11 is exported according to optical receiver apparatus 91, and according to the tire acquired from reference signal detection device Any one or more signals in youngster's heart rate signal, maternal heart rate signal and pregnant woman's detecting sphygmus and blood oxygen saturation optical signal calculate Fetal hemoglobin saturation.The optical receiver apparatus 91 of the present invention acquires multiple and fetal blood oxygen saturation by multiple optical receivers 204 Relevant optical signal is spent, multiple signals of acquisition are overlapped to summarize send signal processing controller 11 to, is effectively increased In the signal received with the intensity of the relevant optical signal of fetus blood flow.The optical receiver 204 is silicon photoelectric diode, snow Collapse formula photodiode, photomultiplier or other electrooptical devices；The luminous lighting module 12 includes at least two The light source of different wave length can be the feux rouges at 500 nanometers to 1000 nanometers of infrared lights, wherein preferably 660 nanometers, 740 receive Rice, 880 nanometers, 940 nanometers, illuminating source is LED or laser or other illuminating sources.
As illustrated in figures 4-5, the optical receiver apparatus 91 include multiple optical receivers 204 and with multiple optical receivers 204 The adder of connection, adder are connect with the signal processing controller 11 of the outer fetus BOLD contrast of abdomen.Each optical receiver 204 connects respectively Receive returned out of pregnant woman abdomen with the relevant optical signal of fetal hemoglobin saturation, and each optical signal is converted into multi-channel electric signal, Output is exported with the relevant optical signal summation of fetal hemoglobin saturation at signal after multi-channel electric signal is overlapped by adder Manage controller 11, optical receiver apparatus 91 is realized by multiple optical receivers 204 and adder, simple in structure at low cost, without pair The outer fetus BOLD contrast of existing abdomen is improved.
As shown in figure 4, one embodiment of optical receiver apparatus 91 of the present invention, optical receiver apparatus 91 includes multiple optical receivers 204, the multiple amplifiers being connect respectively with multiple optical receivers 204, multiple amplifiers are connect with adder, and adder passes through number Mode converter is connect with the signal processing controller 11 of the outer fetus BOLD contrast of abdomen.Each optical receiver 204 is received respectively from pregnant woman's abdomen Interior return with the relevant optical signal of fetal hemoglobin saturation, and each optical signal is converted into multi-channel electric signal, multi-channel electric signal After amplifier is put into after adder is superimposed together the optical signal summation Jing Guo digital analog converter digital signal export to Signal processing controller 11.
As shown in figure 5, another embodiment of optical receiver apparatus 91 of the present invention, optical receiver apparatus 91 includes multiple light-receivings Device 204, the multiple amplifiers being connect respectively with multiple optical receivers 204, the multiple digital-to-analogues being connect respectively with multiple amplifiers turn Parallel operation, multiple digital analog converters are connect with adder, and adder is connect with the signal processing controller 11 of the outer fetus BOLD contrast of abdomen. After each optical signal is converted into multi-channel electric signal by each optical receiver 204, respectively through amplifier amplifies signals and by digital-to-analogue conversion After device is converted to digital signal, then optical signal summation is superimposed as by adder and is exported to signal processing controller 11.
One of the improvement of the present invention, the fetus blood oxygen light signal acquisition device 9 is by 92 He of illuminating source device Optical receiver apparatus 91 including multiple optical receivers 204 integrates, not only so that its is easy to use, so that shining Layout before light supply apparatus 92 and multiple optical receivers 204 is more reasonable, and the path of acquisition scattering and reflection is closer, can Light source is reasonably utilized, the signal strength that optical receiver apparatus 91 acquires is improved.
As shown in fig. 6,9 one preferred embodiments of fetus blood oxygen light signal acquisition device of the present invention, the light-receiving The multiple optical receivers 204 and illuminating source device 92 of device 91 are mounted on sensor attachment mechanism 93, the light-receiving Surrounding one circle of composition in the illuminating source 921 of illuminating source device 92 is arranged in multiple optical receivers 204 of device 91.It is excellent Choosing, optical sensor installing mechanism 93 can form dome-shaped and be buckled in her abdominal, the illuminating source position of illuminating source device 92 It is located at her abdominal top central portion in the middle part of dome-shaped, multiple optical receivers 204 of optical receiver apparatus 91 are in her abdominal side Encompass a circle, illuminating source and multiple optical receivers 204 constitute dome-shaped, by by multiple light of optical receiver apparatus 91 921 rational deployment of illuminating source of receiver 204 and illuminating source device 92 can reasonably utilize light source, improve light-receiving The signal strength that device 91 acquires.
As shown in fig. 7,9 another preferred embodiment of fetus blood oxygen light signal acquisition device of the present invention, the light connect Multiple optical receivers 204 of receiving apparatus 91 be arranged illuminating source device 92 921 surrounding of illuminating source form one it is rectangular.
Multiple optical receivers 204 of several embodiments as illustrated in figs. 8-11, the optical receiver apparatus 91 constitute 1 i The array of row * j row and it is arranged in the side of the illuminating source 921 of illuminating source device 92, i and j are the integer more than 0；Or Multiple optical receivers 204 of optical receiver apparatus 91 described in person constitute the array of 2 i row * j row and are separately positioned on luminous light 921 both sides of illuminating source of source device 92, i and j are the integer more than 0.
Further, 9 another preferred embodiment of fetus blood oxygen light signal acquisition device of the invention, the fetus blood oxygen Light signal acquisition device 9 further includes the conducting switch of the signal control generated by the pulse sequence that illuminating source device 92 emits, The optical signal that each optical receiver 204 of optical receiver apparatus 91 receives switchs after being converted into electric signal by the conducting, with Make illuminating source device 92 shine with by be connected switch receive optical signal be it is synchronous, only with illuminating source device 92 Luminous synchronization the burst pulse time in optical signal can just be sent to the analog-digital converter of optical receiver apparatus 91 and be transformed into number Signal is further processed.
One of the improvement of the present invention, illuminating source device 92 of the invention include illuminating source 921 and with shine The light source drive that light source 921 connects.The light source drive is connect with signal processing controller, and light source drive is at signal It manages driving illuminating source 921 under the control of controller and sends out the pulsed light that frequency is higher than 20Hz, and the duty ratio of its pulse is small In 40%.The frequency range of the preferred pulsed light is 400Hz to 5000Hz, but not comprising 50Hz, 60Hz and theirs is whole The frequency of several times.The illuminating source device 92 of the present invention is using the pulsed optical signals with smaller duty ratio so that human body is connect The average light power received is significantly smaller than moment maximum luminous power to ensure human-body safety, is improving the same of signal strength When, solve the problems, such as that excessive luminous power may damage pregnant woman and fetus.The light source drive of the present embodiment can be with For the illuminating source 921 with single first luminescence unit and single second luminescence unit, it can be used for having multiple The illuminating source 921 of one luminescence unit and multiple second luminescence units.
One of the improvement of the present invention, illuminating source device of the invention include illuminating source 921 and with luminous light The light source drive that source 921 connects, the illuminating source 921 include multiple first luminescence units and multiple second luminous lists Member, multiple first luminescence units can send out the feux rouges or infrared light of first wave length, and multiple second luminescence units can be sent out Go out the feux rouges or infrared light of second wave length, first wave length is different from second wave length, the first luminescence unit and the second luminescence unit Quantity is identical, and multiple first luminescence units and multiple second luminescence units are arranged to ranks light source battle array, and multiple first is luminous single First and multiple second luminescence units are alternately lighted under the control of light source drive.Multiple first luminescence units in ranks light source battle array It can be equidistant with multiple second luminescence units, can also be not equidistant, it is preferable that each luminous list in ranks light source battle array The spacing of member is equal.The illuminating source device 92 of the present invention is shone single using multiple first luminescence units and multiple second Member, and multiple first luminescence units and multiple second luminescence units are arranged as equidistant ranks light source battle array, it realizes a wide range of Multichannel is to increase the luminous power of light source, while illumination is not a bit, make to receive with the relevant light of fetal hemoglobin saturation Signal is greatly reinforced than original device, but the true very little of luminous power received by her abdominal skin unit area or is not increased.It is excellent Choosing, the illuminating source device 92 includes the second luminescence unit of the first luminescence unit of at least two and at least two.It is described The first luminescence unit and the second luminescence unit be the LED, laser or other light sources that can send out feux rouges or infrared light, it is excellent Choosing can send out 600 nanometers of feux rouges to the LED or laser of 950 nanometers of infrared lights, the if first wave length is feux rouges Two wavelength are infrared light, if first wave length is infrared light, second wave length is feux rouges.Multiple first luminescence units send out red The first wave length of light or infrared light is preferably identical, but is actually extremely difficult to, therefore, what multiple first luminescence units were sent out The feux rouges or infrared light of the first wave length of feux rouges or infrared light refer to essentially identical, in smaller deviation range, Belong to the protection domain of the application.Equally, the second wave length for the feux rouges or infrared light that multiple second luminescence units are sent out is also similar.
As shown in figure 12, the illuminating source 921 of illuminating source device 92 include multiple first luminescence units equidistantly or not Arrangement constitutes the first ranks light source battle array of a m*n at equal intervals, and multiple second luminescence units are equidistant or not equidistant cloth The the second ranks light source battle array for constituting a m*n is set, n is the integer more than 1, and m is the integer more than or equal to 1.Wherein first shines Unit is red-light LED 102, and R indicates feux rouges in figure, and the first ranks light source battle array is the red LED array that red-light LED is constituted, second Luminescence unit is infrared light LED 104, and IR indicates infrared light in figure, and it is infrared that the second ranks light source battle array is that infrared light LED is constituted Light LED array.
As shown in figure 13, the illuminating source of illuminating source device includes multiple first luminescence units and multiple second luminous lists First equidistantly or not arrangement constitutes the ranks light source battle array that a m rows 2*n is arranged at equal intervals, and each column of ranks light source battle array is by the first hair The first luminescence unit row that light unit is constituted or the second luminescence unit row for thering is the second luminescence unit to constitute, the first luminescence unit Row and the second luminescence unit row are arranged alternately, and n is the integer more than 1, and m is the integer more than or equal to 1, but make two different waves The mode that long feux rouges or infrared light reaches light path ratio Figure 12 of fetus by her abdominal is more nearly.Obviously, it first shines Also possible, i.e., multiple first luminescence units and multiple second are arranged in unit and the alternate mode of the second luminescence unit sampling row Luminescence unit is equally spaced or does not constitute at equal intervals the ranks light source battle array of a 2*m rows n row, ranks light source battle array often go by The first luminescence unit row that first luminescence unit is constituted or the second luminescence unit row for thering is the second luminescence unit to constitute, the first hair Light unit row and the second luminescence unit row are arranged alternately, and n is the integer being equal to more than 1, and m is the integer more than 1.
As shown in figure 14, the preferred embodiment of illuminating source device of the present invention, in multiple first luminescence units and multiple In the ranks light source battle array that two luminescence units are constituted, the first luminescence unit and the second luminescence unit are arranged alternately so that ranks light source First luminescence unit and the second luminescence unit is arranged alternately and the first luminescence unit in each column of ranks light source battle array in often the going of battle array It is also arranged alternately with the second luminescence unit, the feux rouges of two different wave lengths or infrared light is made to reach the light of fetus by her abdominal Road ratio Figure 13 is more nearly, and substantially increases intensity and precision that optical receiver apparatus 91 acquires signal.
Further, as shown in figure 15, the preferred embodiment of illuminating source device of the present invention, in the multiple of illuminating source 921 The light diffusion that the ranks light source battle array that first luminescence unit and multiple second luminescence units are arranged to is externally provided with diffusion irradiated area is saturating Mirror 922, can not increase the light radiation on unit illuminated area when increasing the luminous power of luminescence unit.Preferably, described Light diverging lens 922 be concavees lens, concavees lens and the distance between the first luminescence unit and the second luminescence unit are more than 0；Or Person, the light diverging lens are convex lens, and concavees lens and the distance between the first luminescence unit and the second luminescence unit are more than 0 And less than or equal to the focal length of convex lens.
Further, the preferred embodiment of fetus blood oxygen light signal acquisition device of the invention, what it is by the present invention includes multiple The optical receiver apparatus 91 of optical receiver 204 is combined with the illuminating source device 92 that ranks light source battle array is laid out.A kind of such as preferred embodiment, The illuminating source device 92 of 91 sum of optical receiver apparatus is mounted on optical sensor installing mechanism 93, and illuminating source device 92 shines Light source includes the ranks light source battle array that multiple first luminescence units and multiple second luminescence units are constituted, in ranks light source battle array, first Luminescence unit and the second luminescence unit are arranged alternately so that in often the going of ranks light source battle array the first luminescence unit and second shine it is single Member is arranged alternately and the first luminescence unit and the second luminescence unit are also arranged alternately in each column of ranks light source battle array, and the light Surrounding one circle of composition in illuminating source device 92, optical sensor peace is arranged in multiple optical receivers 204 of reception device 91 Mounting mechanism 93 can form dome-shaped and be buckled in her abdominal, and the illuminating source of illuminating source device 92, which is located in the middle part of dome-shaped, to be located at Her abdominal top central portion, multiple optical receivers 204 of optical receiver apparatus 91 in her abdominal side surrounding at a circle, Illuminating source and multiple optical receivers 204 constitute dome-shaped.This so that the illumination of light source and the acquisition of optical receiver 204 are more It point and does not require to correspond yet, so that unit area is increased, and the feux rouges of two different wave lengths or infrared light are by pregnant The light path that woman's abdomen reaches fetus is close, substantially increases strong with the relevant optical signal of fetus blood flow in the signal received Degree.
As shown in figure 16, another improvement of the invention, optical receiver apparatus 91 of the invention include multiple optical receivers 204, the signal primary processor 250 being connect with multiple optical receivers 204, signal primary processor 250 includes receiving the fetus heart The interface of rate signal, for being connect with fetal rhythm harvester, primary processor 250 is received by multiple optical receivers 204 and tire The relevant multiple optical signals of youngster's blood oxygen saturation, the fetal heart rate signal for being obtained while being acquired by fetal rhythm harvester are primary Reception is carried out correlation by processor 250 with fetal heart rate signal respectively with the relevant multiple optical signals of fetal hemoglobin saturation Analysis obtains the relative coefficient of each optical signal；The corresponding weighting coefficient of each optical signal is obtained based on relative coefficient；It will be multiple Optical signal is overlapped to obtain optical signal summation according to respective weighting coefficient.
The present invention also provides noninvasive fetal hemoglobin saturations outside a kind of abdomen to detect signal processing method, and what it is by reception includes tire Multiple optical signals of youngster's blood oxygen saturation information synthesize optical signal summation, to improve and the relevant optical signal of fetal hemoglobin saturation Intensity, removal noise jamming can be used for optical receiver apparatus 91 comprising following steps to improve signal-to-noise ratio：
Reception is subjected to correlation with fetal heart rate signal respectively with the relevant multiple optical signals of fetal hemoglobin saturation Analysis obtains the relative coefficient of each optical signal；The corresponding weighting coefficient of each optical signal is obtained based on relative coefficient；It will be multiple Optical signal is overlapped to obtain optical signal summation according to respective weighting coefficient.Wherein, each light letter is obtained based on relative coefficient The step of number corresponding weighting coefficient is：If the relative coefficient of optical signal is less than preset relevance threshold, give up this Optical signal, i.e. weighting coefficient are 0；If relative coefficient is higher than preset relevance threshold, obtained according to relative coefficient Weighting coefficient, the more big then weighting coefficient of relative coefficient is bigger, 0 < weighting coefficients < 1；Then, by multiple optical signals according to each From weighting coefficient be overlapped to obtain optical signal summation, after such as multiple optical signals are multiplied with respective weighting coefficient respectively fold Add to obtain optical signal summation.Noninvasive fetal hemoglobin saturation signal processing method outside the abdomen of the present invention, passes through multiple optical receivers The multiple synthesis optical signal summations that are superimposed with the relevant optical signal of fetal hemoglobin saturation of 204 acquisitions are to improve the optical signal received Intensity, and based on multiple optical receivers 204 acquire optical signal and acquire simultaneously fetal heart rate signal progress correlation Analysis is weighted superposition and is interfered with removing noise signal unrelated with fetal hemoglobin saturation in optical signal, improves collected The signal-to-noise ratio of optical signal, to improve the accuracy and reliability of outer noninvasive fetal hemoglobin saturation detection device detection.
Noninvasive fetal hemoglobin saturation detects signal processing method outside the abdomen of the present invention, can be used for noninvasive fetus blood oxygen outside abdomen In the optical receiver apparatus 91 of saturation degree detection device, reception and the relevant multiple optical signals of fetal hemoglobin saturation are selected Optical signal summation is obtained after selecting superposition, removes noise jamming, improves signal-to-noise ratio, then will believe with the relevant light of fetal hemoglobin saturation Number summation is sent to the signal processing controller 11 of the outer fetus BOLD contrast of abdomen 1, by signal processing controller 11 by optical signal summation The blood oxygen saturation that fetus is calculated in analysis is carried out with fetal heart rate signal.It certainly, can be with by signal processing controller 11 It is based further on optical signal summation, and the maternal heart rate of acquisition and/or pregnant woman's optical signal and/or fetal heart rate signal divide The blood oxygen saturation of fetus is calculated in analysis, and the calculation of the blood oxygen saturation of fetus is in another patent of inventor Described in CN201310182965.2, details are not described herein.It should be noted that noninvasive fetal blood oxygen saturation outside the abdomen of the present invention Degree detection signal processing method can also be handled by signal processing controller 11, be received by signal processing controller 11 multiple Optical signal summation is synthesized after optical signal, but will greatly increase the complexity of system in this way.
As shown in figure 16, optical receiver apparatus 91 of the invention include multiple optical receivers 204, respectively with multiple optical receivers 204 connection multiple amplifiers, the multiple digital analog converters being connect respectively with multiple amplifiers, and with multiple digital analog converters The signal primary processor 250 of connection, signal primary processor 250 are connect with the output end of fetal rhythm harvester.Each light-receiving Device 204 receives the optical signal in pregnant woman's abdomen and converts thereof into multi-channel electric signal respectively, through amplifier and analog-digital converter It is processed into multi-path digital signal, then is synthesized after the processing of signal primary processor 250 and receives optical signal summation 256.
A kind of embodiment of the signal primary processor 250 is as shown in figure 16, including 252 He of multiple signal analyzers The addition selector 254 being connect with multiple signal analyzers 252, multiple signal analyzers 252 carry out correlation analysis, The addition selector 254 carries out the selective stacking of signal.Certainly, the signal primary processor 250 can be monolithic Machine, noninvasive fetal hemoglobin saturation detection signal processing method passes through software realization, including signal analyzer outside abdomen of the invention 252 and addition selector 254 corresponding function pass through software realization, microcontroller execute corresponding software, to multiple optical signals carry out The synthesis of optical signal summation is realized in analyzing processing and superposition.The fetal heart frequency sensor of fetal rhythm harvester can be that Doppler is super The Fetal ECG sensor or other fetal heart frequency sensors of sound wave fetal heart sound sensor or electrode composition.As another implementation Example, the signal primary processor 250 can be microcontroller, substitute the adder of embodiment as illustrated in figures 4-5, realize figure Embodiment shown in 4-5 directly carries out the superposition of signal by software.
Figure 17 is the flow instance that a signal analyzer 252 carries out signal analysis in time domain, the signal analyzer 252 be time-domain signal analysis device, by each of reception and the relevant optical signal of fetal hemoglobin saturation time domain and reception tire Youngster's heart rate signal carries out correlation analysis and obtains the relative coefficient of each optical signal.It is noninvasive outside abdomen of the present invention referring specifically to Figure 17 The digital signal weighted superposition synthesis reception optical signal that fetal hemoglobin saturation detects multipath light signal in signal processing method is total Flow with 256 includes the following steps：
(620) optical signal that optical receiver receives is obtained, is passed through after the optical signal that optical receiver receives is converted to electric signal Digital signal is converted to after amplifier and digital analog converter processing, is obtained and the relevant optical signal of fetal hemoglobin saturation；
(630) concurrently with step (620), the fetal heart rate signal that fetal rhythm harvester receives is obtained；
(622) by optical signal, the correlation analysis with fetal heart rate signal, the algorithm category of correlation analysis are carried out in time domain In the prior art, by record in general mathematics handbook, details are not described herein；
(624) relative coefficient A is calculated through correlation analysis；
(626) judge whether relative coefficient A is more than preset threshold value X, if relative coefficient A is higher than predetermined threshold X then goes to step 628, and step 632 is gone to if relative coefficient A is less than predetermined threshold X；
(628) weighting coefficient M, 0 < weighting coefficient M < 1 are obtained according to relative coefficient A and then goes to the step under it 634；
(632) weighting coefficient M is set as 0, then goes to the step 634 under it；
(634) will be multiplied with the relevant optical signal of fetal hemoglobin saturation with weighting coefficient M weighting, the data E after weighting It makes a gift to someone addition selector 254.
Figure 18 is the flow instance that a signal analyzer 252 carries out signal analysis in frequency domain, the signal analyzer 252 be frequancy signal anaysis device, and each of reception is gone to frequency domain from time domain with the relevant optical signal of fetal hemoglobin saturation and is obtained To optical signal spectrum, while the fetal heart rate signal of reception is gone into frequency domain from time domain and obtains fetus frequency domain luminous power frequency spectrum, it will Optical signal spectrum carries out correlation analysis in frequency domain and fetus frequency domain luminous power frequency spectrum and obtains the relative coefficient of each optical signal.Tool Body is referring to Figure 18, and multi-path digital signal weight is superimposed in noninvasive fetal hemoglobin saturation detection signal processing method outside abdomen of the present invention The flow that synthesis receives optical signal summation 256 includes the following steps：
(720) optical signal that optical receiver receives is obtained, is passed through after the optical signal that optical receiver receives is converted to electric signal Amplifier and digital analog converter processing after be converted to digital signal, obtain with the relevant optical signal of fetal hemoglobin saturation, then Go to the step 722 under it；
(722) frequency domain will be gone to from time domain with the relevant optical signal of fetal hemoglobin saturation and obtain optical signal spectrum, then Go to step 724；
(740) concurrently with step 720, the fetal heart rate signal that fetal rhythm harvester receives is obtained, it is then gone to Under step 742；
(742) fetal heart rate signal of input is gone into frequency domain from time domain and obtains fetus frequency domain luminous power frequency spectrum, then turned Step 724 under to it；
(724) will with the relevant optical signal spectrum of fetal hemoglobin saturation, frequency domain and fetus frequency domain luminous power frequency spectrum into Row correlation analysis；
(726) it is calculated in frequency domain, the relative value B of optical signal spectrum and fetus frequency domain luminous power frequency spectrum through correlation analysis As relative coefficient；
(728) judge whether relative value B is more than preset threshold value Y, turn it if relative value B is higher than predetermined threshold Y Under step 730, if relative value B less than turning following step 744 if predetermined threshold Y；
(730) optical signal spectrum is reverted back time domain from frequency domain, then goes to the step 732 under it；
(732) weighting coefficient M is obtained according to relative value B weightings, 0 < weighting coefficient M < 1 then go to the step under it 734；
(744) optical signal spectrum signal is reverted back time domain from frequency domain, then goes to the step 746 under it, certain step 744 can also omit；
(746) weighting coefficient M is set as 0, then goes to the step 734 under it；
(734) it will be weighted with the relevant optical signal of fetal hemoglobin saturation and weighting coefficient M, the data F after weighting makes a gift to someone Addition selector 254.
Figure 19 is another flow instance that a signal analyzer 252 carries out signal analysis in frequency domain, by the every of reception It is a to go to frequency domain from time domain with the relevant optical signal of fetal hemoglobin saturation and obtain optical signal spectrum, while by the fetus heart of reception Rate signal goes to frequency domain from time domain and obtains fetus frequency domain luminous power frequency spectrum, by optical signal spectrum in frequency domain and fetus frequency domain luminous power Frequency spectrum carries out correlation analysis and obtains the relative coefficient of each optical signal, and fetus spectrum power is filtered out from optical signal spectrum Signal spectrum power in addition obtains filtered optical signal frequency spectrum, to remove noise unrelated with fetal hemoglobin saturation in optical signal Signal interference, then filtered optical signal frequency spectrum is reverted back time domain from frequency domain and obtains filtered optical signal as the light of weighted superposition letter Number.Specifically, referring to Figure 19, multi-path digital signal in noninvasive fetal hemoglobin saturation detection signal processing method outside abdomen of the present invention The flow that weighted superposition synthesis receives optical signal summation 256 includes the following steps：
(720) optical signal that optical receiver receives is obtained, is passed through after the optical signal that optical receiver receives is converted to electric signal Amplifier and digital analog converter processing after be converted to digital signal, obtain with the relevant optical signal of fetal hemoglobin saturation, then Go to the step 722 under it；
(722) frequency domain will be gone to from time domain obtain optical signal frequency with the relevant optical signal optical signal of fetal hemoglobin saturation Spectrum, then goes to step 724 below；
(740) concurrently with step 720, the fetal heart rate signal that fetal rhythm harvester receives is obtained, it is then gone to Under step 742；
(742) fetal heart rate signal of input is gone into frequency domain from time domain and obtains fetus frequency domain luminous power frequency spectrum, then turned Step 724 under to it；
(724) will with the relevant optical signal spectrum of fetal hemoglobin saturation, frequency domain and fetus frequency domain luminous power frequency spectrum into Row correlation analysis and compare；
(726) it is calculated in frequency domain, the relative value B of optical signal spectrum and fetus frequency domain luminous power frequency spectrum through correlation analysis As relative coefficient；
(728) judge whether relative value B is more than preset threshold value Y, turn it if relative value B is higher than predetermined threshold Y Under step 750, if relative value B less than turning following step 744 if predetermined threshold Y；
(750) it is filtered from the signal spectrum power filtered out in optical signal spectrum other than fetus frequency domain luminous power frequency spectrum Frequency domain filter may be used in optical signal spectrum, can also be realized by software mode, then goes to the step 730 under it
(730) filtered optical signal frequency spectrum is reverted back time domain from frequency domain and obtains filtered optical signal as the light of weighted superposition letter Number, then go to the step 734 under it；
(744) optical signal spectrum is reverted back time domain from frequency domain, then goes to the step 746 under it；
(746) it is 0 to be multiplied by weighting coefficient M, then goes to the step 734 under it；
(734) it will be weighted with the relevant filtered optical signal of fetal hemoglobin saturation and weighting coefficient M, the data F after weighting It makes a gift to someone addition selector 254.
It should be noted that Figure 18 and Figure 19's except that frequency-region signal step 728 judgement be more than preset After threshold value Y, Figure 18 directly carries out inverse conversion in step 730 and restores time-domain signal.Figure 19 is then handle and fetus frequency domain luminous power frequency It composes after incoherent target signal filter falls, then input step 730 carries out inverse conversion and restores time-domain signal.
Signal is converted into the mathematics conversion formula of frequency domain from time domain and quick Fu may be used by step 722 in Figure 18, Figure 19 In leaf conversion formula or transform formula, in addition, Laplace transform can be used for the conversion from time domain to frequency domain, time domain turns The mode for changing frequency domain into belongs to the prior art and is not repeating.
Signal is reversed the mathematics conversion formula for gaining time domain that can correspond to use by step 730 from frequency domain in Figure 18, Figure 19 Inverse Fast Fourier conversion formula and Z anti transform formula or inverse laplace transform, frequency domain reverse the mode for gaining time domain to belong to The prior art is not repeating.
Referring to Figure 16,20-21, signal primary processor 250 further includes for digital signal to be converted to frequency domain from time domain Time-frequency convert device and/or time-frequency inverse converter for digital signal to be reduced to time domain from frequency domain.The signal is primary The signal analyzer 252 of processor 250 based on fetal heart rate signal with digital signal in frequency domain or the correlation of time domain, to each road Digital signal marks weighting coefficient respectively, and the addition selector 254 is overlapped processing according to weighting coefficient, described Addition selector 254 can be linear superposition device or optical signal selector.
Figure 20 is a flow instance of addition selector 254 in Figure 16.The signal primary processor 250 includes Addition selector 254, the addition selector 254 are linear superposition device, it exports optical receiver 204 and process letter The linear superposition of multi-path digital signal after number 252 analyzing processing of analyzer receives optical signal summation 256 with synthesis.Specifically It says, the signal 802,804,806 that each signal analyzer 252 generates imports linear superposition device and carries out linear superposition, and generation connects Receive optical signal summation 256.Fetus BOLD contrast 1 outside abdomen will be sent by communication link 14 by receiving optical signal summation 256.Described The input signal of the linear superposition device of signal primary processor 250 is the data E generated by time-domain signal analysis device, or by The data F that frequancy signal anaysis device generates.
Figure 21 is another flow instance of addition selector 254 in Figure 16.The signal primary processor 250 includes Addition selector 254, the addition selector 254 are optical signal selector, it will be exporting and pass through from optical receiver 204 It is selected in multi-path digital signal after 252 analyzing processing of signal analyzer all the way as reception optical signal summation 256；Or therefrom It selects multi-path digital signal and is superimposed to be formed by them to receive optical signal summation 256.Specifically, each signal analyzer produces Raw signal 802,804,806 imports optical signal selector and further screen and be superimposed.Optical signal selector 810 is according to institute Comparison, the cognition to the position of each optical receiver 204 in Fig. 6, Fig. 7, Figure 16 for having signal 802,804,806, Yi Jiqi He judges with the relevant knowledge of fetal hemoglobin saturation, selects one or more signals to generate and receives optical signal summation 256. Fetus BOLD contrast 1 outside abdomen will be sent by communication link 14 by receiving optical signal summation 256.The signal primary processor 250 The input signal of optical signal selector be the data E generated by time-domain signal analysis device, or by frequancy signal anaysis device The data F of generation, the optical signal selector alternative condition of signal primary processor 250 include oxygen saturation signal state and/ Or position signal state.
The present invention both can be used for the undesirable fetus of anoxic heart rate, equally can be used for the fetus of normal cardiac rate, both may be used To be detected in hospital, it can also be transplanted and expand to the long-range perinatal monitor supported with mobile Internet, such as by remotely existing Family is detected.The present invention can be tied with existing electronic fetal monitoring (Electronic Fetal Monitor, EFM) Altogether, the signal processing to more fully novel fetal monitoring equipment is realized.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that The specific implementation of the present invention is confined to these explanations.For those of ordinary skill in the art to which the present invention belongs, exist Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to the present invention's Protection domain.

Claims (12)

1. noninvasive fetal hemoglobin saturation detects signal processing method outside a kind of abdomen, which is characterized in that by the multiple and tire of reception The relevant optical signal of youngster's blood oxygen saturation synthesizes optical signal summation, includes the following steps：
Step A：Reception is related with fetal heart rate signal progress respectively to the relevant multiple optical signals of fetal hemoglobin saturation Property is analyzed to obtain the relative coefficient of each optical signal；
Step B：The corresponding weighting coefficient of each optical signal is obtained based on relative coefficient；
Step C：Multiple optical signals are overlapped to obtain and the relevant light of fetal hemoglobin saturation according to respective weighting coefficient Signal summation.
2. noninvasive fetal hemoglobin saturation detects signal processing method outside abdomen according to claim 1, which is characterized in that step Suddenly B includes：
If the relative coefficient of optical signal is less than preset relevance threshold, weighting coefficient 0；If relative coefficient is high In preset relevance threshold, then weighting coefficient is obtained according to relative coefficient, is according to respective weighting by multiple optical signals Number is overlapped to obtain optical signal summation.
3. noninvasive fetal hemoglobin saturation detects signal processing method outside abdomen according to claim 1, which is characterized in that step Suddenly A includes：By each of reception and the relevant optical signal of fetal hemoglobin saturation time domain and the fetal heart rate signal of reception into Row correlation analysis obtains the relative coefficient of each optical signal.
4. noninvasive fetal hemoglobin saturation detects signal processing method outside abdomen according to claim 1, which is characterized in that step Suddenly A includes：
Each of reception and the relevant optical signal of fetal hemoglobin saturation are gone into frequency domain from time domain and obtain optical signal spectrum, simultaneously The fetal heart rate signal of reception is gone into frequency domain from time domain and obtains fetus frequency domain luminous power frequency spectrum, by optical signal spectrum frequency domain with Fetus frequency domain luminous power frequency spectrum carries out correlation analysis and obtains the relative coefficient of each optical signal.
5. noninvasive fetal hemoglobin saturation detects signal processing method outside abdomen according to claim 4, which is characterized in that step Suddenly A further includes：
Filtered optical signal frequency spectrum is obtained from the signal spectrum power filtered out in optical signal spectrum other than fetus spectrum power, filter Wave optical signal frequency spectrum reverts back the optical signal that time domain obtains filtered optical signal as weighted superposition from frequency domain.
6. detecting signal processing method, feature according to noninvasive fetal hemoglobin saturation outside any abdomens of claim 1-5 It is, further includes step D：By with the maternal heart rate of the relevant optical signal summation of fetal hemoglobin saturation and acquisition and/or pregnant Woman's optical signal and/or fetal heart rate signal carry out the blood oxygen saturation that fetus is calculated in analysis.
7. a kind of optical receiver apparatus, for noninvasive fetal hemoglobin saturation detection device outside abdomen, it is characterised in that：Including multiple light Receiver, the signal primary processor being connect with multiple optical receivers, signal primary processor include receiving fetal heart rate signal Interface, primary processor passes through noninvasive fetal hemoglobin saturation outside any abdomens of claim 1-5 and detects signal processing The relevant optical signal of multiple and fetal hemoglobin saturation of reception is synthesized optical signal summation by method.
8. optical receiver apparatus according to claim 7, it is characterised in that：The signal primary processor includes multiple letters Number analyzer and the addition selector being connect with multiple signal analyzers, multiple signal analyzers analyze multiple optical receivers respectively The relative coefficient with fetal hemoglobin saturation relevant optical signal and fetal heart rate signal of acquisition, addition selector is according to letter Multi-path digital signal weight is superimposed to synthesize optical signal summation by the analysis result of number analyzer.
9. optical receiver apparatus according to claim 8, it is characterised in that：The signal analyzer is time-domain signal analysis Device or frequancy signal anaysis device.
10. optical receiver apparatus according to claim 8, it is characterised in that：The addition selector is linear superposition device, Linear superposition device is by the linear superposition of signal analyzer treated multi-path digital signal to synthesize optical signal summation；Alternatively, institute The addition selector stated is optical signal selector, and optical signal selector is selected from signal analyzer treated multi-path digital signal It selects and is used as optical signal summation all the way, or therefrom select multi-path digital signal and be superimposed them to form optical signal summation.
11. optical receiver apparatus according to claim 7, it is characterised in that：The signal primary processor is microcontroller.
12. noninvasive fetal hemoglobin saturation detection device outside a kind of abdomen, includes fetal blood outside the abdomen with signal processing controller Oxygen instrument, illuminating source device, for the acquisition outside pregnant woman's abdomen and the optical receiver apparatus of the relevant optical signal of fetal hemoglobin saturation, Fetal rhythm harvester for acquiring fetal heart rate signal, illuminating source device, optical receiver apparatus and fetal rhythm harvester with Signal processing controller connects, it is characterised in that：
The illuminating source device irradiates the light of two or more different wave lengths into pregnant woman's abdomen；
The optical receiver apparatus includes multiple optical receivers, the signal primary processor being connect with multiple optical receivers, signal Primary processor is connect with fetal rhythm harvester, and primary processor passes through noninvasive fetus outside any abdomens of claim 1-5 The relevant optical signal of multiple and fetal hemoglobin saturation of reception is synthesized optical signal by blood oxygen saturation detection signal processing method Summation is exported to signal processing controller,
The optical signal summation that the signal processing controller is exported according to optical receiver apparatus, and acquired according to fetal rhythm harvester Fetal heart rate signal calculate fetal hemoglobin saturation.
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