CN108721631A - A kind of sucrose fine grained and preparation method thereof, equipment and application - Google Patents
A kind of sucrose fine grained and preparation method thereof, equipment and application Download PDFInfo
- Publication number
- CN108721631A CN108721631A CN201810605041.1A CN201810605041A CN108721631A CN 108721631 A CN108721631 A CN 108721631A CN 201810605041 A CN201810605041 A CN 201810605041A CN 108721631 A CN108721631 A CN 108721631A
- Authority
- CN
- China
- Prior art keywords
- sucrose
- fine grained
- fluid bed
- fine
- mesh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
- F26B3/08—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed
- F26B3/084—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried so as to loosen them, e.g. to form a fluidised bed with heat exchange taking place in the fluidised bed, e.g. combined direct and indirect heat exchange
Abstract
The invention belongs to excipient substance fields, more particularly to a kind of sucrose fine grained and preparation method thereof, equipment and application, the sucrose fine grained grain includes at least 99.5% sucrose, grain size is 40-100 mesh, apparent density is 0.4-0.6g/ml, and angle of repose is 32 ° -35 °, and good fluidity, dissolubility are good, compressibility is good, it can be used as pharmaceutic adjuvant, be used for direct tablet compressing；The preparation method can prepare the above-mentioned sucrose fine grained that can be used for direct tablet compressing by ratio, the pressure of water jet pump and the hot blast rate of the volume and weight of material of control fluid bed.
Description
Technical field
The invention belongs to excipient substance fields, and in particular to a kind of sucrose fine grained and preparation method thereof, equipment and application.
Background technology
Sucrose is an important auxiliary material in pharmaceutical preparation, can be used as the filler of sweetener and solid pharmaceutical preparation tablet, is risen
The effects that flavoring, figuration, sucrose extensive use in pharmaceutical preparation, its current local and overseas application form have following several：
1, candy：That is sucrose crystal is used as sweetener, corrigent, filler, binder, sugar coated tablet in the formulation
Coating material.For in tablet, being generally unable to direct tablet compressing, and need to be ground into powdered sucrose use；
2, cane sugar powder：The cane sugar powder that USPNF20 is recorded is the mixture of sucrose (C12H22O11) and cornstarch, contains sugarcane
Sugar is not less than 95%.In preparation prescription, when seasoning or increasing sweet taste, sugarcane can be used when needing that sugar therein is made to dissolve rapidly
Icing Sugar.This product can be used for being used as diluent in solid pharmaceutical preparation prescription, can be used as binder, the filler of wet granulation.But
Cane sugar powder stickiness is big, poor fluidity, it is impossible to be used in the direct tablet compressing of tablet.Particle size range is 14~150 μm；
3, compressible sucrose：The compressible sucrose that USPNF20 is recorded contains 95.0%~98% sucrose (C12H22O11),
Starch, maltodextrin, inverted sugar and glidant appropriate can also be contained, can be used for tablet direct tablet compressing, particle size range is 75~
425μm；
4, sucrose spheric granules：The sucrose spheric granules that USPNF20 is recorded, epigranular, containing sucrose 62.5%~
91.5%, other components are mainly starch；PhEur records sucrose spheric granules and is not higher than 92% containing sucrose, remaining forms sediment for corn
Powder and starch hydrolysate and pigment, the inertia heart being used as in capsule and tablet, especially more particle slow release preparations first will
Drug be wrapped in in the heart, be then coated with polymeric material, the grain size of sucrose spheric granules is 200~2000 μm.On Product labelling
There is nominal particle size range；
On the one hand, common sucrose is crystal grain, and granularity is big, needs sucrose being ground into cane sugar powder use.Specifically
Usage is：Sucrose is ground into Icing Sugar and softwood is made in other raw and auxiliary materials, then wet granular processed, dry, whole grain, tabletting.It is general
The Icing Sugar of logical sucrose and crushing in tablet manufacturing all cannot direct step tabletting, i.e., it is all raw and auxiliary material mixed onces are equal
I.e. tabletting, reason are after even：Sucrose granules are big, although good fluidity, direct tablet compressing can exist with former particle in tablets, shadow
The performances such as the appearance of clicker agent and dissolving disintegration；And after sucrose is ground into Icing Sugar, although solubility property is improved, but Icing Sugar
Mobility is very poor, and mixing is poor, in tablet manufacturing can not smooth blanking, also can not just suppress uniform tablet.
On the other hand, the Sucrose products such as compressible sucrose, sucrose spheric granules for being presently available for direct tablet compressing contains
At least 2% or more non-sucrose component, such as starch, dextrin, since these components can not dissolve in water, and effervescent tablet system
The quality requirement of agent is to be dissolved as clear liquid in water, so the Sucrose products of above-mentioned direct tablet compressing cannot be used for effervesce
In the prescription of piece.
Therefore, a kind of sucrose granules can be directly used for tabletting are developed, there is great application prospect.
Invention content
In view of the drawbacks of the prior art, it is an object of the present invention to provide a kind of sucrose fine grained, thin of the sucrose
Grain good fluidity, dissolubility is good, compressibility is good, can be used in direct tablet compressing.
It is a further object to provide the fine grain preparation methods of sucrose.
The present invention's a further object is the purposes for providing sucrose fine grained as pharmaceutic adjuvant.
It is also another object of the present invention to provide prepare the fine grain equipment of above-mentioned sucrose.
For achieving the above object, the present invention provides following technical scheme：
In a first aspect, the present invention provides a kind of sucrose fine grained, the sucrose fine grained includes at least 99.5% sucrose,
Grain size is 40-100 mesh, and apparent density 0.4-0.6g/ml, angle of repose is 32 ° -35 °.
In some preferred embodiments, sucrose fine grained provided by the invention, the sucrose fine grained include
99.5% sucrose and 0.5% dextrose syrup powder, grain size be 40-100 mesh, apparent density 0.4-0.6g/ml, angle of repose
It is 32 ° -35 °.
In some further preferred embodiments, sucrose fine grained provided by the invention, the sucrose fine grained packet
Dextrose syrup powder containing 99.5% sucrose and 0.5%, grain size be 60-80 mesh, apparent density 0.43-0.53g/ml, not
Angle till is about 32 °.
The present inventor the study found that the fine grain grain size of sucrose, apparent density and angle of repose to sucrose fine grained as medicine
It is very big with the performance influence of auxiliary material, when the fine grain grain size of sucrose is more than 40 mesh, apparent density is more than 0.6g/ml, angle of repose is small
In 32 ° of sucrose, poor compressibility, the tablet appearance and disintegration of preparation are bad；When grain size is less than 80 mesh, apparent density is less than
0.4g/ml, angle of repose are more than 35 ° of sucrose, and poor fluidity, mixing is poor, can not smooth blanking, and sucrose provided by the invention is thin
Particle, grain size 40-100 mesh, apparent density 0.4-0.6g/ml, angle of repose are 32 ° -35 °, and good fluidity, compressibility is good, can use
In direct tablet compressing.
Second aspect, the present invention provide the above-mentioned fine grain preparation method of sucrose, include the following steps：Sucrose is crushed and is made
Icing Sugar is obtained, is blown afloat gained Icing Sugar with thermal current in fluid bed, while spraying water to obtain the final product, the volume and weight of material of the fluid bed
Ratio be not less than 10.75L/KG, the pressure of water jet pump is 3~8 kilograms, and hot blast rate is 3000~8000 cubes ms/h.
Preferably, the fine grain preparation method of above-mentioned sucrose provided by the invention, includes the following steps：By 99.5% sugarcane
Sugared and 0.5% dextrose syrup powder mixes and crushes obtained Icing Sugar, is blown afloat gained Icing Sugar with thermal current in fluid bed, simultaneously
It sprays water to obtain the final product, the volume of the fluid bed and the ratio of weight of material are not less than 10.75L/KG, and the pressure of water jet pump is 3~8 public
Jin, hot blast rate are 3000~8000 cubes ms/h.
Preparation in accordance with the present invention, the Icing Sugar grain size obtained are no more than 50 mesh；Preferably, the sugar obtained
Powder diameter is no more than 40 mesh；It is further preferred that the Icing Sugar grain size obtained is 20-30 mesh.
Preparation in accordance with the present invention, the water spray are that two-way compressed air spray gun is sprayed water, and can make sugarcane obtained
Sugared fine grained size tunable degree higher；Preferably, the water spray is that two-way compressed air spray gun is sprayed water, two-way compressed air
The droplet that spray gun sprays is 0.5~20 micron.
This method is blown afloat gained Icing Sugar with thermal current, while being sprayed water so that Icing Sugar reassembles into new particle, and new
Grain collides in thermal current, dry, and sucrose fine grained boring obtained, surface be smooth, good fluidity, can be in tablet manufacturing
In be used for direct tablet compressing, greatly save tablet manufacturing cost.
The third aspect, the application the present invention also provides above-mentioned sucrose fine grained as pharmaceutic adjuvant, especially as solid
The purposes of body preparation excipient and/or flavoring agent.Sucrose fine grained raw material prepared by the present invention is at least 99.5% sucrose, seldom
It is on the one hand good with compatibility of drugs stability in use containing other reduced sugar ingredients, be conducive to the stabilization of the pharmaceutical preparation of its preparation
Property；On the other hand as auxiliary material preparation tablet can completely soluble formation clear solution, be particularly suitable for effervescent tablet.
Application according to the present invention, the solid pharmaceutical preparation include but not limited to tablet, granule, capsule, powder.
Application according to the present invention, the tablet include but not limited to ordinary tablet, lozenge, sublingual tablet, mouth paster, nozzle
Chew piece, dispersible tablet, fuse, effervescent tablet, vaginal tablets, vagina effervescence, sustained release tablets, controlled release tablet, enteric coatel tablets and oral disintegrating tablet；It is preferred that
Ground, the tablet are ordinary tablet and effervescent tablet.
Fourth aspect, the present invention also provides one kind being used to prepare the fine grain Fluidbedgranulatingdrier of above-mentioned sucrose, packet
Include sequentially connected blast pipe, fluid bed and discharge pipe, be equipped with successively in the blast pipe air filter, plate heat exchanger,
Adjusting air valve, hot air chamber, every in sieve, the fluid bed from bottom to top be equipped with several spray guns, effective boiling of the fluid bed
It rises volume and is not less than 10.75L/KG, the spray gun is two-way compressed air spray gun.
Further, the spray gun quantity of stating has 5.
Sucrose fine grained good fluidity provided by the invention can be used for a step tabletting in tablet manufacturing, be greatly saved
Production cost；Cane sugar content is high, is produced into the completely soluble formation clear solution of energy after tablet, is particularly suitable for effervesce
Piece produces, simultaneously because it is few even without containing other reduced sugar ingredients, it is more stable with the compatible use of drug, to formulation products
Medicine stability it is more advantageous.
The present invention, which provides, utilizes specific Fluidbedgranulatingdrier, on the one hand, by the effective boiling for controlling the fluid bed
It rises volume and is not less than 10.75L/KG, volume of effectively boiling when ensure that granulation；On the other hand, in fluid bed from top to bottom not
With multiple spray guns are highly arranged, the hollow degree of granulation can be adjusted by the spray gun of selection different height, grain size
Size, size of apparent density etc.；The spray gun of the third aspect, drying machine of the present invention uses two-way compressed air, atomization
Significant effect is better than single gas circuit spray gun of the prior art, can obtain the atomized drop of evenly thinner water, these atomizations
Small water droplet is exactly the aggregation center pelletized, and again by drying after granulation, hole is formed inside particle after moisture evaporation.So
Atomization is more uniform, and the adjustable range of atomization droplets diameter is bigger, higher to the controllable degree of the granulation of product.The spray gun is logical
0.5~20 micron of uniform droplet can be sprayed by overregulating the pressure size of compressed air.Fluidbedgranulatingdrier using the present invention,
The sucrose fine grained that good fluidity, dissolubility are good, compressibility is good can be produced.
Specifically, the present invention has advantage following prominent compared with the existing technology：
(1) cane sugar content is up to 99.5% in the sucrose granules：The sugar fine grained is by 99.5% sucrose (C12H22O11) and
0.5% spray drying dextrose syrup powder (value≤30 Spray-dried glucose syrup, DE) is constituted；
Currently, can be used for the Sucrose products such as compressible sucrose, sucrose spheric granules of direct tablet compressing contain at least 2% with
On non-sucrose component；On the one hand can not be dissolved in water due to these components, and the quality requirement of effervesce tablet preparation be
Clear liquid is dissolved as in water, so the Sucrose products of above-mentioned direct tablet compressing cannot be used in the prescription of effervescent tablet；It is another
Aspect, since there are the non-sucrose component of high level, especially content of reducing sugar is higher, and therefore, it is difficult to as oxidative drug
Auxiliary material.
And the sucrose granules of the present invention are produced into the completely soluble shape of energy after tablet since its cane sugar content is high
At clear solution, it is particularly suitable for effervescent tablet production；Simultaneously as sugar composition content is high, other compositions content is extremely low, because
This, the compatible use of the sucrose granules and drug is more stable, more advantageous to the medicine stability of formulation products.
(2) the sucrose granules grain size is in 40-80 mesh, and apparent density is in 0.4-0.6g/ml, and angle of repose is at 35 ° or less.
The inventors discovered that the fine grain grain size of sucrose, apparent density and angle of repose to sucrose fine grained as medicinal auxiliary
The performance of material influences very big；When sucrose of the grain size more than 40 mesh, apparent density more than 0.6g/ml, angle of repose less than 32 °, can press
Property is poor, and the tablet appearance and disintegration of preparation are bad；Grain size is less than 80 mesh, apparent density is less than 0.4g/ml, angle of repose is more than
35 ° of sucrose, poor fluidity, mixing is poor, can not smooth blanking.
The sucrose granules of the present invention, grain size 40-80 mesh, especially grain size 60-80 mesh, apparent density 0.4-0.6g/ml, not
Angle till is 32 ° -35 °, and good fluidity, disintegration is good, and compressibility is good, can be used for direct tablet compressing.
(3) preparation process of the sucrose：Commercially available sucrose is crushed, Icing Sugar is made；The interior thermal current of fluid bed is by gained Icing Sugar
It blows afloat, sprays water simultaneously, the white or off-white color particle of formation of pelletizing in thermal current；Water spray is that two-way compressed air spray gun sprays
Water can make sucrose fine grained size tunable degree higher obtained.
This method is blown afloat gained Icing Sugar with thermal current, while being sprayed water so that Icing Sugar reassembles into new particle, and new
Grain collides in the thermal current of fluid bed volume and the ratio of weight of material not less than 10.75L/KG, dry, and sucrose obtained is thin
Particle boring, surface be smooth, good fluidity, and direct tablet compressing can be used in tablet manufacturing, greatly save tablet manufacturing at
This.
Description of the drawings
Fig. 1 is the structural schematic diagram of Fluidbedgranulatingdrier.
Specific implementation mode
Sucrose fine grained of the present invention is further illustrated below.
The fine grain preparation of 1 sucrose of embodiment
Commercially available sucrose is crushed to the Icing Sugar for being made that grain size is 20-30 mesh, is blown afloat gained Icing Sugar with thermal current in fluid bed,
It sprays water simultaneously, the volume of the fluid bed and the ratio of weight of material are 10.75L/KG, and the pressure of water jet pump is 3 kilograms, hot wind
Amount is 8000 cubes ms/h.Sucrose fine grained grain size obtained is 60 mesh, apparent density 0.53g/ml, 32 ° of angle of repose.
The fine grain preparation of 2 sucrose of embodiment
Sucrose is crushed to the Icing Sugar for being made that grain size is 20-30 mesh, is blown afloat gained Icing Sugar with thermal current in fluid bed, simultaneously
Water spray, the volume of the fluid bed and the ratio of weight of material are 10.75L/KG, and the pressure of water jet pump is 5 kilograms, and hot blast rate is
8000 cubes ms/h.Sucrose fine grained grain size obtained is 70 mesh, apparent density 0.48g/ml, 32 ° of angle of repose.
The fine grain preparation of 3 sucrose of embodiment
Sucrose is crushed to the Icing Sugar for being made that grain size is 20-30 mesh, is blown afloat gained Icing Sugar with thermal current in fluid bed, simultaneously
Water spray, the volume of the fluid bed and the ratio of weight of material are 10.75L/KG, and the pressure of water jet pump is 8 kilograms, and hot blast rate is
5000 cubes ms/h.Sucrose fine grained grain size obtained is 80 mesh, apparent density 0.43g/ml, 32 ° of angle of repose.
The fine grain preparation of 4 sucrose of embodiment
Sucrose is crushed to the Icing Sugar for being made that grain size is 20-30 mesh, is blown afloat gained Icing Sugar with thermal current in fluid bed, simultaneously
Water spray, the volume of the fluid bed and the ratio of weight of material are 10.75L/KG, and the pressure of water jet pump is 7 kilograms, and hot blast rate is
7000 cubes ms/h.Sucrose fine grained grain size obtained is 80 mesh, apparent density 0.43g/ml, 32 ° of angle of repose.
1 mobility of experimental example and dissolubility
The fine grain quality standard of sucrose is referring generally to current edition《Chinese Pharmacopoeia》,《European Pharmacopoeia》,《United States Pharmacopeia》In
" sucrose " quality standard.《Chinese Pharmacopoeia》2015 editions have been recorded " sucrose " and " compressible sucrose "；United States Pharmacopeia, European Pharmacopoeia,
Pharmacopeia of Japan has recorded " sucrose ", " compressible sucrose " " cane sugar powder " " sucrose spheric granules ".
It is write according to Chinese Pharmacopoeia Commission《Various countries' pharmaceutic adjuvant Comparison of standards handbook》It records, current sucrose both at home and abroad
The recent release that pharmacopeia is recorded is Chinese Pharmacopoeia (2015 editions), United States Pharmacopeia (the 38th edition), European Pharmacopoeia (8.5 editions), Japanese medicine
Office side's (the 16th edition).
The sucrose fine grained of the detection preparation of embodiment 4, commercially available sucrose crystal, the mobility of commercially available cane sugar powder, density, dissolving
Property, it the results are shown in Table 1.
Table 1
| Embodiment 4 | Commercially available sucrose crystal | Commercially available cane sugar powder (100 mesh) | |
| Angle of repose | 32° | 31.5° | 50° |
| Bulk density (g/ml) | 0.45 | 0.86 | 0.58 |
| Tap density (g/ml) | 0.52 | 0.90 | 0.68 |
| Dissolution time 10g:100ml | 1min | 2.5min | 1.5min |
As shown in Table 1, the sucrose fine grained angle of repose that prepared by the embodiment of the present invention 4 is suitable, and bulk density and tap density are low,
Good fluidity, disintegration is good, and compressibility is good, can be used for direct tablet compressing.
2 stability of experimental example
According to pharmaceutic adjuvant requirements of customs declaration, with reference to the finger in relation to bulk pharmaceutical chemicals stability test in 2015 editions annex of Chinese Pharmacopoeia
Principle is led, we have carried out accelerated test and the investigation for the experiment that keeps sample for a long time respectively.
2.1 accelerated test
According to pharmacopeia to the fine grain shelf appeal of sugar：Sealing preserves at drying.It will be according to the embodiment of the present invention 4
The sugared fine grained sample of homemade continuous three lot numbers of method is sealed in medicinal low density polyethylene (LDPE) bag (inner packing), is placed in phase
It is 75% ± 5% to humidity, temperature is stored 6 months under conditions of being 40 DEG C ± 2 DEG C, is carried out study on the stability, be the results are shown in Table 2.
Table 2
As can be seen from Table 2, sucrose fine grained of the invention is highly stable, is 75% ± 5% in relative humidity, temperature is
It is stored 6 months under conditions of 40 DEG C ± 2 DEG C, every Index for examination has no significant change.
The 2.2 long-term experiments that keep sample
Above-mentioned three batches of samples are sealed in medicinal low density polyethylene (LDPE) bag, it is 60% ± 10% to be placed in relative humidity, temperature
Degree is stored under conditions of being 25 DEG C ± 2 DEG C, is sampled respectively at 3,6,9, December, to the face of the character of test sample, specific rotation, solution
Seven color, reduced sugar, loss on drying, apparent density, color value factors are investigated, and detection data and the results are shown in Table 3.
Table 3
As can be seen from Table 2, it is 60% ± 5% in relative humidity, temperature is stored 12 months under conditions of being 25 DEG C ± 2 DEG C
Afterwards, every Index for examination has no that significant change, sucrose fine grained of the invention are relatively stablized.
Claims (10)
1. a kind of sucrose fine grained, it is characterised in that：The sucrose fine grained includes at least 99.5% sucrose, grain size 40-
100 mesh, apparent density 0.4-0.6g/ml, angle of repose are 32 ° -35 °.
2. sucrose fine grained according to claim 1, it is characterised in that：The sucrose fine grained includes 99.5% sucrose
With 0.5% dextrose syrup powder, grain size is 40-100 mesh, and apparent density 0.4-0.6g/ml, angle of repose is 32 ° -35 °.
3. sucrose fine grained according to claim 1, it is characterised in that：The sucrose fine grained includes 99.5% sucrose
With 0.5% dextrose syrup powder, grain size is 60-80 mesh, and apparent density 0.43-0.53g/ml, angle of repose is about 32 °.
4. the fine grain preparation method of sucrose described in claim 1, includes the following steps：Sucrose is crushed, Icing Sugar is made, fluidisation
Gained Icing Sugar is blown afloat with thermal current in bed, while being sprayed water to obtain the final product, the volume of the fluid bed and the ratio of weight of material be not small
It it is 3~8 kilograms in the pressure of 10.75L/KG, water jet pump, hot blast rate is 3000~8000 cubes ms/h.
5. the fine grain preparation method of sucrose described in claim 1, includes the following steps：By 99.5% sucrose and 0.5%
Dextrose syrup powder mixes and crushes obtained Icing Sugar, is blown afloat gained Icing Sugar with thermal current in fluid bed, while spraying water to obtain the final product, institute
The ratio of the volume and weight of material of stating fluid bed is not less than 10.75L/KG, and the pressure of water jet pump is 3~8 kilograms, and hot blast rate is
3000~8000 cubes ms/h.
6. the fine grain preparation method of sucrose according to claim 4 or 5, it is characterised in that：The Icing Sugar grain obtained
Diameter is no more than 50 mesh.
7. the fine grain preparation method of sucrose according to claim 4 or 5, it is characterised in that：The water spray is two-way pressure
Contracting air atomizing burner is sprayed water, and sucrose fine grained size tunable degree higher obtained can be made.
8. application of the claim 1-3 any one of them sucrose fine graineds as pharmaceutic adjuvant.
9. application as claimed in claim 8, it is characterised in that：The sucrose fine grained is as solid formulation excipients and/or tune
Taste agent.
10. preparing the fine grain Fluidbedgranulatingdrier of claims 1 to 3 any one of them sucrose, including sequentially connected
Blast pipe (1), fluid bed (2) and discharge pipe (3), the blast pipe (1) is interior to be equipped with air filter (11), plate-type heat-exchange successively
Device (12), adjusting air valve (13), hot air chamber (14), every sieve (15), several sprayings are equipped in the fluid bed (2) from bottom to top
Rifle (21), it is characterised in that：Effective boiling volume of the fluid bed (2) is 10.75L/KG, and the spray gun (21) is two-way
Compressed air spray gun.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810605041.1A CN108721631A (en) | 2018-06-13 | 2018-06-13 | A kind of sucrose fine grained and preparation method thereof, equipment and application |
| CN202210536048.9A CN114796508A (en) | 2018-06-13 | 2019-04-04 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN201910268426.8A CN110585437B (en) | 2018-06-13 | 2019-04-04 | Sugar fine particles and preparation method, equipment and application thereof |
| CN202210532006.8A CN114949232A (en) | 2018-06-13 | 2019-04-04 | Sugar fine particles and preparation method, equipment and application thereof |
| CN201910268415.XA CN110585436B (en) | 2018-06-13 | 2019-04-04 | Sucrose fine particles and preparation method, equipment and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810605041.1A CN108721631A (en) | 2018-06-13 | 2018-06-13 | A kind of sucrose fine grained and preparation method thereof, equipment and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108721631A true CN108721631A (en) | 2018-11-02 |
Family
ID=63929567
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810605041.1A Pending CN108721631A (en) | 2018-06-13 | 2018-06-13 | A kind of sucrose fine grained and preparation method thereof, equipment and application |
| CN201910268426.8A Active CN110585437B (en) | 2018-06-13 | 2019-04-04 | Sugar fine particles and preparation method, equipment and application thereof |
| CN201910268415.XA Active CN110585436B (en) | 2018-06-13 | 2019-04-04 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN202210536048.9A Pending CN114796508A (en) | 2018-06-13 | 2019-04-04 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN202210532006.8A Pending CN114949232A (en) | 2018-06-13 | 2019-04-04 | Sugar fine particles and preparation method, equipment and application thereof |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910268426.8A Active CN110585437B (en) | 2018-06-13 | 2019-04-04 | Sugar fine particles and preparation method, equipment and application thereof |
| CN201910268415.XA Active CN110585436B (en) | 2018-06-13 | 2019-04-04 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN202210536048.9A Pending CN114796508A (en) | 2018-06-13 | 2019-04-04 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN202210532006.8A Pending CN114949232A (en) | 2018-06-13 | 2019-04-04 | Sugar fine particles and preparation method, equipment and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (5) | CN108721631A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148280A (en) * | 2015-07-07 | 2015-12-16 | 深圳国源国药有限公司 | Innovative drug excipient compressible sucrose and preparation method thereof |
| CN110578020A (en) * | 2019-09-24 | 2019-12-17 | 广西南宁万宇科技有限公司 | Method for preparing compressible sucrose from sucrose syrup |
| CN110585437A (en) * | 2018-06-13 | 2019-12-20 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114100508A (en) * | 2021-11-11 | 2022-03-01 | 北京亚东生物制药(安国)有限公司 | Spray granulation equipment |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1168692A (en) * | 1966-02-28 | 1969-10-29 | Ogilvie Flour Mills Company Lt | Process and Apparatus for Preparing Free-Flowing and Readily Dispersible Products from Finely Powdered Materials. |
| GB1240691A (en) * | 1968-09-26 | 1971-07-28 | Tate & Lyle Refineries Ltd | Improvements in the production of sugar |
| GB2008920B (en) * | 1977-11-29 | 1982-05-26 | Ingredient Technology Corp | Agglomeration process |
| JPH0633306B2 (en) * | 1988-01-22 | 1994-05-02 | 第一工業製薬株式会社 | Method for producing sucrose fatty acid ester granules |
| FI104787B (en) * | 1989-06-07 | 2000-04-14 | Xyrofin Oy | Granulated product based on fructose and process for its preparation |
| FR2826290B1 (en) * | 2001-06-26 | 2003-09-12 | Beghin Say Eridania | PROCESS FOR DRYING A SUCROSE SOLUTION, PRODUCT AS OBTAINED AND USE THEREOF |
| CN100451130C (en) * | 2006-07-11 | 2009-01-14 | 广西南宁化学制药有限责任公司 | Production method of granular compressible sugar |
| FR2925499B1 (en) * | 2007-12-20 | 2010-02-12 | Roquette Freres | MALTITOL GRANULE FOR DIRECT COMPRESSION AND PROCESS FOR PREPARING THE SAME |
| CN102485216A (en) * | 2010-12-03 | 2012-06-06 | 中山市中健药物研究所有限公司 | Taste-modifying medicine tablets |
| CN102091566A (en) * | 2010-12-17 | 2011-06-15 | 常州市鹏多干燥设备有限公司 | One-step granulating and drying equipment with fluidized bed |
| CN103820583B (en) * | 2014-03-06 | 2015-12-02 | 济南百诺医药科技开发有限公司 | A kind of preparation method of granular compressible sugar |
| CN104014278A (en) * | 2014-06-07 | 2014-09-03 | 张家港市进润彩印包装有限公司 | Fluid bed granulating drier and drying process thereof |
| CN104014277A (en) * | 2014-06-07 | 2014-09-03 | 张家港市进润彩印包装有限公司 | Fluid bed granulating drying process |
| WO2015198483A1 (en) * | 2014-06-27 | 2015-12-30 | フロイント産業株式会社 | Excipient granules, and tablet |
| CN105833280B (en) * | 2016-04-28 | 2018-03-06 | 湖南尔康制药股份有限公司 | A kind of preparation method of compressible sucrose |
| CN105890288B (en) * | 2016-06-16 | 2018-01-02 | 江苏宇通干燥工程有限公司 | A kind of spraying granulation drying device |
| CN108553645A (en) * | 2018-03-27 | 2018-09-21 | 天津信诚康达药业有限公司 | A kind of innovative auxiliary material sucrose and preparation method thereof |
| CN108721631A (en) * | 2018-06-13 | 2018-11-02 | 沈惠 | A kind of sucrose fine grained and preparation method thereof, equipment and application |
| CN111202244A (en) * | 2020-01-20 | 2020-05-29 | 浙江华康药业股份有限公司 | Granular arabinose and preparation method and application thereof |
-
2018
- 2018-06-13 CN CN201810605041.1A patent/CN108721631A/en active Pending
-
2019
- 2019-04-04 CN CN201910268426.8A patent/CN110585437B/en active Active
- 2019-04-04 CN CN201910268415.XA patent/CN110585436B/en active Active
- 2019-04-04 CN CN202210536048.9A patent/CN114796508A/en active Pending
- 2019-04-04 CN CN202210532006.8A patent/CN114949232A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148280A (en) * | 2015-07-07 | 2015-12-16 | 深圳国源国药有限公司 | Innovative drug excipient compressible sucrose and preparation method thereof |
| CN110585437A (en) * | 2018-06-13 | 2019-12-20 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
| CN110585436A (en) * | 2018-06-13 | 2019-12-20 | 南京紫鸿生物科技有限公司 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN110585436B (en) * | 2018-06-13 | 2022-05-27 | 南京紫鸿生物科技有限公司 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN114796508A (en) * | 2018-06-13 | 2022-07-29 | 南京紫鸿生物科技有限公司 | Sucrose fine particles and preparation method, equipment and application thereof |
| CN114949232A (en) * | 2018-06-13 | 2022-08-30 | 南京紫鸿生物科技有限公司 | Sugar fine particles and preparation method, equipment and application thereof |
| CN110578020A (en) * | 2019-09-24 | 2019-12-17 | 广西南宁万宇科技有限公司 | Method for preparing compressible sucrose from sucrose syrup |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114796508A (en) | 2022-07-29 |
| CN110585436B (en) | 2022-05-27 |
| CN110585437A (en) | 2019-12-20 |
| CN110585436A (en) | 2019-12-20 |
| CN114949232A (en) | 2022-08-30 |
| CN110585437B (en) | 2022-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108721631A (en) | A kind of sucrose fine grained and preparation method thereof, equipment and application | |
| US4835187A (en) | Spray dried ibuprofen | |
| KR101324898B1 (en) | Orally disintegrating tablets | |
| CA2734847C (en) | Novel excipient for mannitol tableting | |
| US4835186A (en) | Spray dried ibuprofen | |
| PL207953B1 (en) | Tablets quickly disintegrating in the oral cavity and process for producing the same | |
| EP0322137A1 (en) | Spray dried ibuprofen | |
| US6039813A (en) | Fructose-based granulated product and a process for the production thereof | |
| CN102058480B (en) | Oral effervescent tablet and preparation method thereof | |
| CN100546571C (en) | Sangju effervescent tablet for treating common cold | |
| CN103920157B (en) | A kind of medicinal modified starch type celphere | |
| CN101138554A (en) | Effervescence dispersible tablet | |
| CN101224211B (en) | Entecavir solid dispersoid, medicine compounds and preparing method and applications thereof | |
| CN101375838B (en) | Fizzy formulation and preparation method thereof | |
| CN108553645A (en) | A kind of innovative auxiliary material sucrose and preparation method thereof | |
| CN100389750C (en) | Pharmaceutical composition with improved solubility and fluidity | |
| Kumar et al. | Dispersible Tablets: An Overview | |
| JPH1135486A (en) | Solid pharmaceutical preparation | |
| US7326427B2 (en) | Tablet composition containing Kampo medicinal extract and its manufacturing process | |
| EP0636023B1 (en) | Aminoguanidine spray drying process | |
| WO2022227116A1 (en) | Method for preparing roxithromycin capsule | |
| CN101491677A (en) | Method for preparing medicine composite with reduced bitter | |
| CN109316459A (en) | A kind of preparation method of curcumin effervescent tablet | |
| CN100531741C (en) | Magnesium isoglycyrrhetate oral preparation and its making method | |
| CN105435144A (en) | Raw ginger micro-pill and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181102 |