CN108721502A - 一种用于治疗增生性瘢痕的外用贴膜 - Google Patents
一种用于治疗增生性瘢痕的外用贴膜 Download PDFInfo
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Abstract
本发明公开了一种用于治疗增生性瘢痕的外用贴膜，包括以下原料及重量分数：川芎15‑30g、茉莉花10‑30g、薄荷叶5‑15g、桃仁5‑10g、红花3‑10g、穿山甲7‑10g、五倍子10‑20g、苦参15‑30g、薰衣草10‑30g、没药5‑15g、山慈姑5‑15g、乳香5‑15g和5‑15丹参g，本发明采取不同的提取工艺提取中药的有效成分并制成适用的外用贴膜型，该贴膜对皮肤增生性瘢痕成纤维细胞具有明显的诱导凋亡作用，且对兔耳增生性瘢痕的治疗疗效显著，集活血解毒、渗湿止痒、淡化瘢痕等功效于一体，为瘢痕患者提供一种安全、方便、有效的治疗增生性瘢痕的新途径。
Description
技术领域
本发明涉及中药技术领域，尤其是一种用于治疗增生性瘢痕的外用贴膜。
背景技术
增生性瘢痕是创伤愈合留下的痕迹，也是组织修复愈合的最终结果，在某些个体，修复过程发生异常可以导致组织过度增生而形成增生性瘢痕。增生性瘢痕突出皮面，形状不规则，高低不平，潮红充血，质地实韧。有灼痛和瘙痒感，于环境温度增高，情绪激动，或进食辛辣刺激性食物时症状加剧。增生往往延续几月或几年后才逐渐发生退行性变化，表现为突起高度减低，颜色转暗，充血消退，变软。有些最终可以平复，痛痒症状也大为减轻或消失，增生性瘢痕，好发于损伤深度仅及真皮的创伤，偶尔亦见于较深的创伤和手术切口。
目前国内外治疗瘢痕多采用局部药物封闭，皮肤移植，手术切除植皮，晶体磨疤术，气囊扩张术，抗体注射，放射治疗，压迫疗法，激素疗法，硅酮类等疗法，在临床上都不是很成熟，疗效有待观察，而且有的所需时间长，痛苦大，容易反复，出现不良后果等，许多都不尽如人意。
针对以上这些问题，在这里我们提出一种用于治疗增生性瘢痕的外用贴膜。
发明内容
本发明针对现有的治疗增生性瘢痕等技术上的不足，提供了一种用于治疗增生性瘢痕的外用贴膜。
本发明为解决上述技术不足，采用改性的技术方案，一种用于治疗增生性瘢痕的外用贴膜，包括以下原料及重量分数：川芎15-30g、茉莉花10-30g、薄荷叶5-15g、桃仁5-10g、红花3-10g、穿山甲7-10g、五倍子10-20g、苦参15-30g、薰衣草10-30g、没药5-15g、山慈姑5-15g、乳香5-15g和5-15丹参g。
作为本发明的一种优选实施方式，包括以下原料及重量分数：川芎15g、茉莉花18g、薄荷叶12g、桃仁5g、红花3g、穿山甲7g、五倍子10g、苦参10g、薰衣草10g、没药5g、山慈姑5g、乳香5g和丹参5g。
作为本发明的一种优选实施方式，包括以下原料及重量分数：川芎20g、茉莉花10g、薄荷叶5g、桃仁6g、红花4g、穿山甲7g、五倍子10g、苦参15g、薰衣草13g、没药5g、山慈姑5g、乳香5g和丹参5g。
作为本发明的一种优选实施方式，制作工艺步骤如下：
a.将药品各组份粉碎成粗粉，按药品各组份比例及配方比例称取各组份；
b．将以上药粉用乙醇浸渍24小时后，以乙醇作溶剂，以2～5ml/分的速度渗漉，收集渗漉液至产品全量的300％，减压回收乙醇(50～60℃)，浓缩至相对密度为1.10～1.20(50～60℃热测)的清膏，加入乙醇至产品全量的50％，混匀；
c．在方形条状模具槽中放入医用压敏胶，在50-100℃下成膜；
d．闭合方形条状模具槽，向内部注入b中液体混合均匀利用真空或者震动排气。
e.排气完成后，二次加热在50-100℃成膜，贴防粘纸密封包装后放射消毒得到成品。
作为本发明的一种优选实施方式，步骤a，在粉碎加工成成细粉，可以经过50-100目筛，均匀筛选细粉末，步骤b，乙醇的浓度取75%-85%之间。
本发明所达到的有益效果是：采用上述的技术方案，原料采用常用的中草药，来源广、价格低，从疾病根源治疗，通过辨证论治，本发明是以中国传统医药“清热凉血、祛瘀软坚、镇痛止痒”理论为指导，筛选具有较强作用的中药方剂，采取不同的提取工艺提取中药的有效成分并制成适用的外用贴膜型，该贴膜对皮肤增生性瘢痕成纤维细胞具有明显的诱导凋亡作用，且对兔耳增生性瘢痕的治疗疗效显著，集活血解毒、渗湿止痒、淡化瘢痕等功效于一体，为瘢痕患者提供一种安全、方便、有效的治疗增生性瘢痕的新途径。
具体实施方式
一种用于治疗增生性瘢痕的外用贴膜，包括以下原料及重量分数：川芎15-30g、茉莉花10-30g、薄荷叶5-15g、桃仁5-10g、红花3-10g、穿山甲7-10g、五倍子10-20g、苦参15-30g、薰衣草10-30g、没药5-15g、山慈姑5-15g、乳香5-15g和5-15丹参g。
制作工艺步骤如下：
a.将药品各组份粉碎成粗粉，按药品各组份比例及配方比例称取各组份；
b．将以上药粉用乙醇浸渍24小时后，以乙醇作溶剂，以2～5ml/分的速度渗漉，收集渗漉液至产品全量的300％，减压回收乙醇(50～60℃)，浓缩至相对密度为1.10～1.20(50～60℃热测)的清膏，加入乙醇至产品全量的50％，混匀；
c．在方形条状模具槽中放入医用压敏胶，在50-100℃下成膜；
d．闭合方形条状模具槽，向内部注入b中液体混合均匀利用真空或者震动排气。
e.排气完成后，二次加热在50-100℃成膜，贴防粘纸密封包装后放射消毒得到成品。
川芎：行气开郁，法风燥湿，活血止痛。治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。
茉莉花：茉莉花的花、叶、根均可入药。花性温，味甘、辛。叶性凉，味辛。根性温，味苦。花能理气，开郁，安神，辟秽，和中。主治头晕、头痛、下痢腹腹痛。结膜炎、疮毒。叶能清热解毒，消肿止痛。主治外感发热、腹胀腹泻。根有麻醉、安神、止痛。主治跌损筋骨、龋齿、头顶疼、失眠。
薄荷叶：薄荷是中国常用中药，肌肉疼痛，皮肤风疹搔痒，麻疹不透等症，此外对痈、疽、疥、癣、漆疮亦有效。
桃仁：具有活血祛瘀，润肠通便，止咳平喘的功效，用于经闭痛经，瘕瘕痞块，肺痈肠痈，跌扑损伤，肠燥便秘，咳嗽气喘。
红花：活血通经，散瘀止痛，有助于治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛疗效。有活血化瘀，散湿去肿的功效。
穿山甲：中医常以其走窜之性无所不至，用于宣通脏腑，疏畅经络，透达关窍，开血凝，散血聚，消肿排脓，活血下乳。
苦参：治筋骨拘挛，不可屈伸，久风湿痹，下气。
薰衣草：薰衣草提取液有明显的消解脂肪的作用，薰衣草精油还能通过嗅觉降低动脉压的平均水平。
没药：治各种瘀血阻滞之痛症，如跌打损伤，症见伤处疼痛，伤筋动骨或麻木酸胀，或内伤瘀血，心腹疼痛，肢臂疼痛等症。
山慈姑：具有清热解毒，消肿散结之功效。
乳香：活血行气止痛，消肿生肌。
丹参：具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效。
实施例 1
张某，男性，39岁，白领，患有增生性瘢痕3年，手臂年轻时因烫伤做过小型手术，术后手臂上出现瘢痕，表现为突起高度减低，颜色转暗，充血消退，变软，西医治疗2年，效果较差，患处大小约6.74cm²。用本配方治疗三个疗程后，每日一贴，三周为一疗程，患处明显出现脱落，正常皮肤开始增生，病情稳定。
实施例 2
黄某，女性，29岁，公务员，发现增生性瘢痕2年，怀孕采用剖腹产，产后刀疤处出现增生性瘢痕，患处大小面积约8.32cm²，西医治疗，长期用药导致了患处经常出现红肿，用本发明治疗五个疗程后，患处得到明显恢复，患处大小面积缩小至3.26cm²，病情得到缓解。
本发明是以中国传统医药“清热凉血、祛瘀软坚、镇痛止痒”理论为指导，筛选具有较强作用的中药方剂，采取不同的提取工艺提取中药的有效成分并制成适用的外用贴膜型，该贴膜对皮肤增生性瘢痕成纤维细胞具有明显的诱导凋亡作用，且对兔耳增生性瘢痕的治疗疗效显著，集活血解毒、渗湿止痒、淡化瘢痕等功效于一体，为瘢痕患者提供一种安全、方便、有效的治疗增生性瘢痕的新途径。
最后应说明的是：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (5)
1.一种用于治疗增生性瘢痕的外用贴膜，其特征在于，包括以下原料及重量分数：川芎15-30g、茉莉花10-30g、薄荷叶5-15g、桃仁5-10g、红花3-10g、穿山甲7-10g、五倍子10-20g、苦参15-30g、薰衣草10-30g、没药5-15g、山慈姑5-15g、乳香5-15g和5-15丹参g。
2.根据权利要求1所述的一种用于治疗增生性瘢痕的外用贴膜，其特征在于，包括以下原料及重量分数：川芎15g、茉莉花18g、薄荷叶12g、桃仁5g、红花3g、穿山甲7g、五倍子10g、苦参10g、薰衣草10g、没药5g、山慈姑5g、乳香5g和丹参5g。
3.根据权利要求1所述的一种用于治疗增生性瘢痕的外用贴膜，其特征在于，包括以下原料及重量分数：川芎20g、茉莉花10g、薄荷叶5g、桃仁6g、红花4g、穿山甲7g、五倍子10g、苦参15g、薰衣草13g、没药5g、山慈姑5g、乳香5g和丹参5g。
4.一种制备权利要求1至3之一所述的一种用于治疗增生性瘢痕的外用贴膜的加工工艺，其特征在于，制作工艺步骤如下：
a.将药品各组份粉碎成粗粉，按药品各组份比例及配方比例称取各组份；
b．将以上药粉用乙醇浸渍24小时后，以乙醇作溶剂，以2～5ml/分的速度渗漉，收集渗漉液至产品全量的300％，减压回收乙醇(50～60℃)，浓缩至相对密度为1.10～1.20(50～60℃热测)的清膏，加入乙醇至产品全量的50％，混匀；
c．在方形条状模具槽中放入医用压敏胶，在50-100℃下成膜；
d．闭合方形条状模具槽，向内部注入b中液体混合均匀利用真空或者震动排气；
e.排气完成后，二次加热在50-100℃成膜，贴防粘纸密封包装后放射消毒得到成品。
5.根据权利要求4所述的一种用于治疗增生性瘢痕的外用贴膜的加工工艺，其特征在于：步骤a，在粉碎加工成成细粉，可以经过50-100目筛，均匀筛选细粉末，步骤b，乙醇的浓度取75%-85%之间。
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