CN108721430A - A kind of Chinese medicine composition and its preparation method and application for treating mild acne - Google Patents
A kind of Chinese medicine composition and its preparation method and application for treating mild acne Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/748—Oldenlandia or Hedyotis
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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Abstract
The invention discloses a kind of Chinese medicine compositions and its preparation method and application for treating mild acne.The Chinese medicine composition includes：2~4 parts by weight of moutan bark, 1~3 parts by weight of cape jasmine, 1~2 parts by weight of rheum officinale, 2~4 parts by weight of radix rehmanniae recen, 5~7 parts by weight of dandelion, 5~7 parts by weight of Hedyotidis Diffusae, 2~4 parts by weight of Radix Salviae Miltiorrhizae.The present invention has preferable therapeutic effect to mild acne, and component is natural, without any irritation, while will not occur repeatedly, also without any side effects.
Description
Technical field
The invention belongs to field of traditional Chinese, more particularly, to a kind of Chinese medicine composition for treating mild acne and its
Preparation method and application.
Background technology
Acne is a kind of chronic inflammatory skin, is mainly apt to occur in teenager, to teen-age psychology and social influence
It is very big, but tend to nature after puberty and mitigate or fully recover.Clinical manifestation is to be apt to occur in facial acne, papule, warts, tubercle
Etc. with the characteristics of pleomorphism skin lesion.
The generation of acne mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.Adolesce androgen especially testosterone in descendant's body level it is rapid increase, promote sebaceous glands development
And generate a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia to form cutin simultaneously
Bolt, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes mass propagation in hair follicle, the lipase that propionibacterium acnes generate
It decomposes sebum and generates free fatty, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.
The treatment of acne mainly uses external application, for oral administration and physical method, wherein external used medicine includes mainly tretinoin
Drug, such as lincomycin, benzoyl peroxide etc.；Oral drugs include antibiotic, such as minocycline, azithromycin, Tai Er
Silk etc.；Physiotherapy includes red blue light photoradiation therapy and photodynamic therapy.
However, either external application or endo-medicine, can all have larger side effect, including hinders epidermal growth, draws
It sends out the tingling sensation of skin or leads to papule, and allergy etc. is occurred to antibiotic；Although physical therapy can be played and be controlled inflammation
Purpose, but need repeatedly treatment, and can only play symptom inhibition effect, can not fundamentally realize controlling for acne
It treats, not only medical expense is high, but also is easy to recur.
Invention content
It is an object of the invention to solve the above problems, provide it is a kind of to mild acne have preferable therapeutic effect, group
It is point natural, without any irritation while will not occur repeatedly, Chinese medicine composition without any side effects.
To achieve the goals above, the first aspect of the present invention provides a kind of Chinese medicine composition for treating mild acne, should
Chinese medicine composition includes：
2~4 parts by weight of moutan bark, 1~3 parts by weight of cape jasmine, 1~2 parts by weight of rheum officinale, 2~4 parts by weight of radix rehmanniae recen, Pu Gong
5~7 parts by weight of English, 5~7 parts by weight of Hedyotidis Diffusae, 2~4 parts by weight of Radix Salviae Miltiorrhizae.
As the further preferred embodiment of the present invention, the Chinese medicine composition includes：
2.5~3.5 parts by weight of moutan bark, 1.5~2.5 parts by weight of cape jasmine, 1~1.5 parts by weight of rheum officinale, radix rehmanniae recen 2.5~
3.5 parts by weight, 5.5~6.5 parts by weight of dandelion, 5.5~6.5 parts by weight of Hedyotidis Diffusae, 2.5~3.5 parts by weight of Radix Salviae Miltiorrhizae.
As the preferred embodiment of the present invention, the Chinese medicine composition further includes：25~35 parts by weight of Semen Juglandis, it is more excellent
28~32 parts by weight are selected as, the first purpose for adding Semen Juglandis is to be more prone to make pill, and the second purpose is to pass through shadow
The internal synthesis and its oxidation of cholesterol are rung, and then promotes the generation of insulin and insulin-like growth factor, finally reduces blood glucose
Concentration reduces the breaking-out and development of acne.
The second aspect of the present invention provides the preparation method of the Chinese medicine composition, and this method includes：By each component point
Not Fen Sui after uniformly mix.
The third aspect of the present invention provides the pharmaceutical composition and is preparing the application in treating mild acne drug.
As the preferred embodiment of the present invention, the dosage form of the treatment mild acne drug is pill.
In the present invention, mild acne refers to the I degree (slight) in Pillsbury classification, is generally clinically used
The severity of acne is divided into I-IV degree by Pillsbury classification.It is embodied in and distributes to multiple blackhead, it can companion
It is dispersed in the inflamed papules of distribution.
Beneficial effects of the present invention：
The present invention is using moutan bark, cape jasmine, rheum officinale, radix rehmanniae recen, dandelion, Hedyotidis Diffusae, Radix Salviae Miltiorrhizae as primary raw material, to slight
Acne has preferable therapeutic effect, and component is natural, without any irritation, while will not occur repeatedly, also without any side effects.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Specific implementation mode
The preferred embodiment of the present invention is described in more detail below.Although the following describe the preferred implementations of the present invention
Mode, however, it is to be appreciated that may be realized in various forms the present invention without should be limited by embodiments set forth herein.Phase
Instead, these embodiments are provided so that the present invention is more thorough and complete, and can be by the scope of the present invention completely
It is communicated to those skilled in the art.
Embodiment 1
15 parts by weight of moutan bark, 10 parts by weight of cape jasmine, 5 parts by weight of rheum officinale, 15 parts by weight of radix rehmanniae recen, dandelion are weighed respectively
Then 30 parts by weight, 30 parts by weight of Hedyotidis Diffusae, 15 parts by weight of Radix Salviae Miltiorrhizae crush respectively, by the raw material as above and 180 after crushing
Parts by weight Semen Juglandis mixes, and smashs to pieces, the drug for treating mild acne is made.
Embodiment 2
10 parts by weight of moutan bark, 15 parts by weight of cape jasmine, 5 parts by weight of rheum officinale, 15 parts by weight of radix rehmanniae recen, dandelion are weighed respectively
Then 30 parts by weight, 30 parts by weight of Hedyotidis Diffusae, 15 parts by weight of Radix Salviae Miltiorrhizae crush respectively, by the raw material as above and 180 after crushing
Parts by weight Semen Juglandis mixes, and smashs to pieces, the drug for treating mild acne is made.
Embodiment 3
10 parts by weight of moutan bark, 15 parts by weight of cape jasmine, 5 parts by weight of rheum officinale, 10 parts by weight of radix rehmanniae recen, dandelion are weighed respectively
Then 30 parts by weight, 30 parts by weight of Hedyotidis Diffusae, 20 parts by weight of Radix Salviae Miltiorrhizae crush respectively, by the raw material as above and 180 after crushing
Parts by weight Semen Juglandis mixes, and smashs to pieces, the drug for treating mild acne is made.
Embodiment 4
10 parts by weight of moutan bark, 15 parts by weight of cape jasmine, 5 parts by weight of rheum officinale, 15 parts by weight of radix rehmanniae recen, dandelion are weighed respectively
Then 25 parts by weight, 25 parts by weight of Hedyotidis Diffusae, 25 parts by weight of Radix Salviae Miltiorrhizae crush respectively, by the raw material as above and 180 after crushing
Parts by weight Semen Juglandis mixes, and smashs to pieces, the drug for treating mild acne is made.
Embodiment 5
The difference is that, it is added without Semen Juglandis, i.e., with embodiment 4：By the moutan bark after crushing, cape jasmine, rheum officinale, life
Glutinous rehmannia, dandelion, Hedyotidis Diffusae and Radix Salviae Miltiorrhizae are directly prepared into the drug for treating mild acne.
Comparative example 1
30 parts by weight of moutan bark, 30 parts by weight of cape jasmine, 30 parts by weight of radix rehmanniae recen, 30 parts by weight of dandelion are weighed respectively, so
Afterwards, it crushes respectively, the raw material as above after crushing is mixed with 180 parts by weight Semen Juglandis, smashs to pieces, is made for treating mild acne
Drug.
Comparative example 2
30 parts by weight of moutan bark, 30 parts by weight of cape jasmine, 30 parts by weight of radix rehmanniae recen, 30 parts by weight of Hedyotidis Diffusae are weighed respectively,
Then, it crushes respectively, the raw material as above after crushing is mixed with 180 parts by weight Semen Juglandis, smashs to pieces, is made for treating slight Cuo
The drug of sore.
Comparative example 3
The difference is that, the moutan bark after crushing, cape jasmine, radix rehmanniae recen, dandelion are directly prepared into use with comparative example 1
In the drug for the treatment of mild acne.
Comparative example 4
The difference is that, moutan bark, cape jasmine, radix rehmanniae recen, the Hedyotidis Diffusae after crushing are directly prepared into comparative example 2
Drug for treating mild acne.
Test case 1：Mild acne Experiment on therapy
Case-data：Patient 240, age were the clinical acne patient to see and treat patients at 16~50 years old, and the course of disease is 1
- 3 years moons.It is divided into 6 groups using randomized double-blind principle, every group of 40 patients；Each group patient age structure and gender are substantially suitable, nothing
Significant difference.
Diagnosis and criterion of therapeutical effect：Diagnostic criteria is with reference to the 8th edition《Diagnostics》, tcm diagnosis and dialectical and parting reference《In
Cure diagnoses and treatment standard》；Criterion of therapeutical effect reference《New Chinese medicine guideline of clinical investigations》In card marquis's curative effect determinate standard.Its
In, it is effective：It totally disappeared mistake or significantly mitigate, symptom integral reduces >=70%；Effectively：Original symptom is improved or is mitigated, symptom
Integral reduce >=30% but<70%；In vain：Original symptom reduces < 30% without improvement, symptom integral.
Therapy：Each group patient is treated with the Chinese medicine composition of embodiment 1-5 and comparative example 1-4 respectively, is controlled
The treatment time is 30d, and the Chinese medicine composition in 1 each embodiment/comparative example is taken rear observing effect by 9 groups of patients daily morning and evening.
Each group therapeutic effect is as shown in table 1：
Table 1
It can be seen from the Contrast on effect of embodiment 1-5 and comparative example 1-4 drug is carried out according to raw material of the embodiment of the present invention
Proportioning can effectively improve the therapeutic effect for mild acne, also, the effect of embodiment 1 is better than other embodiment, can
See, raw material proportioning has large effect for the therapeutic effect of Chinese medicine composition of the present invention.
It is compared by the therapeutic effect of embodiment 1-4 and embodiment 5 it is found that Semen Juglandis is added also has shadow for therapeutic effect
It rings, it is preferred embodiment that Semen Juglandis, which is added,.
The effective patient of each group is being paid a return visit after two months, patient feeds back the drug during treatment and skin is had no
Irritation, and do not occur repeatedly substantially after treating.
Test case 2：Typical case Experiment on therapy
Lee, man, 17 years old, suffers from acne 1 year, applies and uses Western medicine Ointment in Treatment, ineffective；Acne is carried out with embodiment 1 to control
It treats, after 1 month, acne obviously fades away；After 2 months, acne disappear substantially, are not recurred after treatment.
It should be noted that the present invention will be described rather than limits the invention for above-described embodiment, and ability
Field technique personnel can design alternative embodiment without departing from the scope of the appended claims.To solve same skill
Art problem, even if some made in the present invention are without substantive change or polishing, the essence of used technical solution is still
So as the present invention, therefore it should also be as within the scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating mild acne, which is characterized in that the Chinese medicine composition includes：
2~4 parts by weight of moutan bark, 1~3 parts by weight of cape jasmine, 1~2 parts by weight of rheum officinale, 2~4 parts by weight of radix rehmanniae recen, dandelion 5~
7 parts by weight, 5~7 parts by weight of Hedyotidis Diffusae, 2~4 parts by weight of Radix Salviae Miltiorrhizae.
2. Chinese medicine composition according to claim 1, wherein the Chinese medicine composition includes：
2.5~3.5 parts by weight of moutan bark, 1.5~2.5 parts by weight of cape jasmine, 1~1.5 parts by weight of rheum officinale, 2.5~3.5 weight of radix rehmanniae recen
Measure part, 5.5~6.5 parts by weight of dandelion, 5.5~6.5 parts by weight of Hedyotidis Diffusae, 2.5~3.5 parts by weight of Radix Salviae Miltiorrhizae.
3. Chinese medicine composition according to claim 1 or 2, wherein the Chinese medicine composition further includes：Semen Juglandis 25~35
Parts by weight.
4. Chinese medicine composition according to claim 3, wherein the Chinese medicine composition further includes：28~32 weight of Semen Juglandis
Measure part.
5. the preparation method of the Chinese medicine composition described in any one of claim 1-4, which is characterized in that this method includes：
It is uniformly mixed after each component is crushed respectively.
6. the pharmaceutical composition described in any one of claim 1-4 is preparing the application in treating mild acne drug.
7. application according to claim 6, wherein the dosage form of the treatment mild acne drug is pill.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810727351.0A CN108721430A (en) | 2018-07-05 | 2018-07-05 | A kind of Chinese medicine composition and its preparation method and application for treating mild acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810727351.0A CN108721430A (en) | 2018-07-05 | 2018-07-05 | A kind of Chinese medicine composition and its preparation method and application for treating mild acne |
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| Publication Number | Publication Date |
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| CN108721430A true CN108721430A (en) | 2018-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810727351.0A Pending CN108721430A (en) | 2018-07-05 | 2018-07-05 | A kind of Chinese medicine composition and its preparation method and application for treating mild acne |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526519A (en) * | 2012-01-09 | 2012-07-04 | 付吉星 | Chinese medicinal composition for treating acne |
| CN104739925A (en) * | 2015-04-17 | 2015-07-01 | 史建平 | Composition for treating acnes and preparation method for composition |
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2018
- 2018-07-05 CN CN201810727351.0A patent/CN108721430A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526519A (en) * | 2012-01-09 | 2012-07-04 | 付吉星 | Chinese medicinal composition for treating acne |
| CN104739925A (en) * | 2015-04-17 | 2015-07-01 | 史建平 | Composition for treating acnes and preparation method for composition |
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Application publication date: 20181102 |