CN108721275A - 一种腺花素和穿心莲内酯复方药物组合物及其用途 - Google Patents
一种腺花素和穿心莲内酯复方药物组合物及其用途 Download PDFInfo
- Publication number
- CN108721275A CN108721275A CN201810700618.7A CN201810700618A CN108721275A CN 108721275 A CN108721275 A CN 108721275A CN 201810700618 A CN201810700618 A CN 201810700618A CN 108721275 A CN108721275 A CN 108721275A
- Authority
- CN
- China
- Prior art keywords
- adenanthin
- andrographolide
- medicament composition
- compound medicament
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WQVYSFSBBFDGRG-UHFFFAOYSA-N Adenanthin Natural products CC(=O)OC1C(=O)C2C(C)(C)C(O)CC(OC(C)=O)C2(C)C2C(OC(=O)C)CC3C(=C)C(=O)C21C3 WQVYSFSBBFDGRG-UHFFFAOYSA-N 0.000 title claims abstract description 54
- WQVYSFSBBFDGRG-FYHXSELJSA-N adenanthin Chemical compound CC([C@H]1C(=O)[C@@H]2OC(C)=O)(C)[C@@H](O)C[C@H](OC(C)=O)[C@@]1(C)[C@@H]1[C@@H](OC(=O)C)C[C@H]3C(=C)C(=O)[C@]12C3 WQVYSFSBBFDGRG-FYHXSELJSA-N 0.000 title claims abstract description 54
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000003814 drug Substances 0.000 title claims abstract description 52
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- -1 andrographolide compound Chemical class 0.000 title claims abstract description 13
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 claims abstract description 40
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810700618.7A CN108721275B (zh) | 2018-06-29 | 2018-06-29 | 一种腺花素和穿心莲内酯复方药物组合物及其用途 |
Applications Claiming Priority (1)
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CN201810700618.7A CN108721275B (zh) | 2018-06-29 | 2018-06-29 | 一种腺花素和穿心莲内酯复方药物组合物及其用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108721275A true CN108721275A (zh) | 2018-11-02 |
CN108721275B CN108721275B (zh) | 2020-01-07 |
Family
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CN201810700618.7A Active CN108721275B (zh) | 2018-06-29 | 2018-06-29 | 一种腺花素和穿心莲内酯复方药物组合物及其用途 |
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CN (1) | CN108721275B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010003376A1 (en) * | 2008-07-09 | 2010-01-14 | The Chinese University Of Hong Kong | Methods for treatment and/or prevention of cancer with andrographolide (and) and use thereof |
CN102702147A (zh) * | 2012-06-18 | 2012-10-03 | 辽宁利锋科技开发有限公司 | 穿心莲内酯类似物及其治疗的应用 |
-
2018
- 2018-06-29 CN CN201810700618.7A patent/CN108721275B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010003376A1 (en) * | 2008-07-09 | 2010-01-14 | The Chinese University Of Hong Kong | Methods for treatment and/or prevention of cancer with andrographolide (and) and use thereof |
CN102702147A (zh) * | 2012-06-18 | 2012-10-03 | 辽宁利锋科技开发有限公司 | 穿心莲内酯类似物及其治疗的应用 |
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Publication number | Publication date |
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CN108721275B (zh) | 2020-01-07 |
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Application publication date: 20181102 Assignee: GUANGZHOU BANGBAO BIOTECHNOLOGY Co.,Ltd. Assignor: FOSHAN University Contract record no.: X2022980018389 Denomination of invention: Compound medical composition of adenosine and andrographolide and its application Granted publication date: 20200107 License type: Common License Record date: 20221014 |
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Application publication date: 20181102 Assignee: GUANGZHOU RANSHAO MEDICAL TECHNOLOGY DEVELOPMENT CO.,LTD. Assignor: FOSHAN University Contract record no.: X2022980018321 Denomination of invention: Compound medical composition of adenosine and andrographolide and its application Granted publication date: 20200107 License type: Common License Record date: 20221019 |
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Application publication date: 20181102 Assignee: GUANGZHOU DINGRAN MEDICINE TECHNOLOGY Co.,Ltd. Assignor: FOSHAN University Contract record no.: X2023980033463 Denomination of invention: A compound pharmaceutical composition of adenosine and andrographolide and its use Granted publication date: 20200107 License type: Common License Record date: 20230313 |
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Application publication date: 20181102 Assignee: Shenzhen Changyuan Biomedical Technology Co.,Ltd. Assignor: FOSHAN University Contract record no.: X2023980034532 Denomination of invention: A Compound Drug Composition of Adenosin and Andrographolide and Its Application Granted publication date: 20200107 License type: Common License Record date: 20230407 |
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Application publication date: 20181102 Assignee: GUANGZHOU JUENUO MEDICAL EQUIPMENT CO.,LTD. Assignor: FOSHAN University Contract record no.: X2023980037158 Denomination of invention: Compound medicine composition of adenosine and Andrographolide and its use Granted publication date: 20200107 License type: Common License Record date: 20230630 |
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Application publication date: 20181102 Assignee: Chongqing Zhixin Yicheng Biotechnology Co.,Ltd. Assignor: FOSHAN University Contract record no.: X2023980049750 Denomination of invention: A compound drug combination of adenosine and andrographolide and its use Granted publication date: 20200107 License type: Common License Record date: 20231204 |