CN108720971A - A kind of controllable antibacterial trachea bracket - Google Patents
A kind of controllable antibacterial trachea bracket Download PDFInfo
- Publication number
- CN108720971A CN108720971A CN201810080529.7A CN201810080529A CN108720971A CN 108720971 A CN108720971 A CN 108720971A CN 201810080529 A CN201810080529 A CN 201810080529A CN 108720971 A CN108720971 A CN 108720971A
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- China
- Prior art keywords
- antibacterial
- trachea bracket
- controllable
- coat
- trachea
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
Abstract
The invention discloses a kind of controllable antibacterial trachea brackets, include the antibacterial coat of trachea bracket matrix and the covering trachea bracket matrix surface, and the antibacterial coat is the degradable host material of bio-compatible with antimicrobial component；Antimicrobial component is dispersed in the degradable host material of bio-compatible by the present invention, trachea bracket surface is attached to by method physically or chemically again, the controlled release of antimicrobial component, the efficiently controllable infection problems solved after trachea bracket merging human body are realized by adjusting the concentration of antimicrobial component and geometric parameter in degradable antibiotic layer.
Description
Technical field
The present invention relates to the manufacturing technology field of trachea bracket, more particularly to a kind of controllable antibacterial trachea bracket.
Background technology
Tracheae and bronchiostenosis can be caused by Different types of etiopathogenises, including：Inflammatory granuloma, wound, tracheomalacia, tumour
Deng.Tracheostenosis can cause obstructive pneumonia, atelectasis and expiratory dyspnea, serious to make patient that respiratory failure occur and jeopardize
Life.
Tracheal stent placing is one of the important means for the treatment of tracheostenosis, can release expiratory dyspnea rapidly.Improvement is faced
Bed symptom.Include clinically at present mainly metallic support and silicon stent etc. using more trachea bracket.Metal tracheae holder
Mostly be woven into netty circular tube shape using ti-ni shape memory alloy or stainless steel material, according to whether overlay film can be divided into again overlay film frame and
Bare bracket.Silicone trachea bracket can plant silicone material by medical grade and be made, and have two kinds of Y types and straight barrel type, it is possible to provide Duo Zhongzhi
Diameter and shape meet the needs of different patients, are removed compared to metallic support more convenient.
Trachea bracket can be placed in human body in short term or for a long time, clinical upper bracket merging after-poppet be in an open environment (with
Air is identical) in, the microorganism infection for being easy to be brought by respiratory movement does not have since rack surface does not have blood circulation yet
Cellular immune function, thus it is postoperative, and bacterium is easy to be colonized on holder and breeds and be difficult to clean off, gas after causing holder to place
Repeated infection in road, or even jeopardize patients ' lives.Therefore trachea bracket is improved, so that it is had antibacterial action has one
Fixed realistic meaning.In addition, different patient be placed in the period, implantation site the different demands for antibacterial coat also not to the utmost
It is identical.Therefore a kind of trachea bracket having controllable antibacterial coat is designed to have great importance.
Invention content
The present invention provides a kind of controllable antibacterial trachea brackets, gradually discharge antimicrobial component, efficient and controllable solution gas
Infection problems after pipe holder merging.
A kind of controllable antibacterial trachea bracket, including trachea bracket matrix and the covering trachea bracket matrix surface are anti-
Bacterium coat, the antibacterial coat are the degradable host materials of bio-compatible with antimicrobial component.
The antibacterial coat is degradable antibiotic layer, and the degradable host material of bio-compatible passes through physical agitation or change
The method for learning reduction is dispersed with antimicrobial component, after being placed in human body, with the gradual degradation of degradable antibacterial coat, gradually releases
Release antimicrobial component therein.
Antibiotic layer is applied on trachea bracket surface, what is be different from the prior art is " controllable ", is controlled by antimicrobial component content
Antimicrobial concentration controls releasing position by the Degradation Control rate of release of degradable matrix by structure and position.
The present invention by control the degradable antibacterial of trachea bracket matrix surface apply the mass fraction of shroud moderate resistance bacterium ingredient with
And geometric parameter controls the rate of release of antimicrobial component, releasing position, antibacterial time in antibacterial coat, so as to according to not
Same demand designs different controllable antibacterial trachea brackets, meets the rate of release after trachea bracket is placed in antimicrobial component, discharges
The controllable demand of position, antibacterial time, the efficiently controllable infection problems solved after trachea bracket merging.
The present invention has a wide range of application, especially suitable for existing trachea bracket structure, it is preferred that the trachea bracket matrix
For silicone trachea bracket or metal tracheae holder.It is applied widely, it is not necessary that original structure is transformed, reduce cost.
Preferably, the surface of the trachea bracket matrix is convex equipped with following closely, and the antibacterial coat is in trachea bracket matrix table
Face is convex to avoid the nail in the shape of a spiral.The important difference of trachea bracket and other holders is, asking there are expectoration in tracheae
Topic, so trachea bracket cannot influence expectoration, helical structure also minimizes the shadow to expectoration other than avoiding stud herein
It rings.
Follow closely convex effect：1. the fixing bracket between tracheae or bronchial cartilage ring structure prevents migration (main function)；
2. pressure is made to be uniformly distributed；3. reducing unnecessary between trachea bracket surface and tracheal mucosa contact.The antibacterial coat
The nail male structure of trachea bracket matrix is avoided using helical structure, while reducing the influence for expectoration.In addition, about for branch
It mounts and is easy infection into rear certain positions, so can have any should can the problem of antimicrobial component concentration is improved at those positions
To have plenty of tracheal injury or narrow caused by wound and tumour the reason of considering, place trachea bracket, so at these positions
Appropriate increasing antimicrobial component concentration, it is relatively reasonable.
Trachea bracket can be the structure of single supervisor, also there is y-type structure, it is preferred that the trachea bracket matrix includes
Supervisor and two branch pipes connected with supervisor, the surface of the supervisor, which is equipped with, follows closely convex, table of the antibacterial coat in the supervisor
Face is convex to avoid the nail in the shape of a spiral.
Preferably, the antibacterial coat the surface of the branch pipe in the shape of a spiral.Some holder branch pipes also have nail convex；?
In the presence of the holder of not branch pipe.
The antimicrobial component disperseed in the degradable antimicrobial coating should have antibacterial and antibacterial action, and to human body
Side effect is smaller.Preferably, the antimicrobial component of the antibacterial coat is using antibiotic, sulfamido, imidazoles, nitroimidazole
At least one of class, quinolones, silver ion and nano-Ag particles.
To realize controllable antibacterial effect, the base material of the degradable antimicrobial coating selects a kind of bio-compatible
Degradation material, and its degradation rate is stablized.The degradable antimicrobial coating passes through after being printed upon in trachea bracket substrate
Curing process makes antibiotic layer be attached to rest body surface.The host material of the degradable antimicrobial coating has certain
Elasticity will not be plastically deformed when as matrix deforms.Preferably, the bio-compatible of the antibacterial coat can drop
Host material is solved using in gelatin, methacrylate gelatin, chitosan, alginate and Poly(D,L-lactide-co-glycolide
At least one.It is at least one refer to can be single ingredient, can also be several mixture.
Preferably, the antimicrobial component uses Nano silver solution, the degradable host material of bio-compatible poly- using shell
The mixed solution of sugar and gelatin.Nano silver has broad-spectrum sterilization effect, has no toxic and side effect to human body, not will produce pharmacological dependence
Property；Chitosan and gelatin mixed solution, bio-compatible is degradable, and film forming and better mechanical property, can be more preferable in conjunction with after
Ground plays advantages of the present invention.
In order to realize the controllable of antimicrobial component rate of release, releasing position and antibacterial time, it is preferred that the antibacterial coating
Layer is coated in the trachea bracket matrix surface by 3D printing technique.
The antibacterial coat of the controllable antibacterial trachea bracket of the present invention is printed upon rami tracheales by extruded type 3D printing platform
On frame matrix.By controlling the rate of extrusion in two channels of extruder pump, control antimicrobial component and the degradable base of bio-compatible respectively
Thus the mass ratio of material controls the concentration of antimicrobial component in antibacterial coat.
By controlling the movement in three directions of 3D printing platform and being coated to control antibacterial for trachea bracket axial rotation
The geometric parameter of layer.When antibacterial coat uses helical structure, avoid the nail male structure on silicon stent surface, at the same reduce for
The influence of expectoration.
The geometric parameter that helical structure may be used in antibacterial coat can be by controlling tri- sides 3D printing platform X, Y, Z
It is controlled to movement and the rotation of trachea bracket axial direction, geometric parameter includes：Antibacterial layer thickness, width, screw pitch.
In order to not influence this body structure of trachea bracket and performance, it is preferred that the thickness of the antibacterial coat is less than
0.2mm.The influence to expectoration can be further decreased.
Beneficial effects of the present invention：
The controllable antibacterial trachea bracket of the present invention, antimicrobial component is dispersed in the degradable host material of bio-compatible, then
It is attached to trachea bracket surface by method physically or chemically, by adjusting the dense of antimicrobial component in degradable antibiotic layer
Degree and geometric parameter realize that the controlled release of antimicrobial component, the infection after efficiently controllable solution trachea bracket merging human body are asked
Topic.
Description of the drawings
Fig. 1 is the structural schematic diagram of the controllable antibacterial trachea bracket of the present invention.
Fig. 2 is the partial schematic sectional view of the controllable antibacterial trachea bracket of the present invention.
Fig. 3 is the partial schematic sectional view of the antibacterial coat of the controllable antibacterial trachea bracket of the present invention.
Fig. 4 is the printing principle schematic of the antibacterial coat of the controllable antibacterial trachea bracket of the present invention.
Fig. 5 is the schematic cross-sectional view of the mixing tube of the 3D printing equipment of the antibacterial coat of the printing present invention.
Each reference numeral is in figure：1. trachea bracket matrix, 2. degradable antibiotic layers, 3. silicone trachea brackets follow closely umbo
Structure, 4. degradable antibiotic layer screw pitch, 5. trachea bracket matrix outer diameters, 6. trachea bracket matrix internal diameters, 7. silicone trachea brackets nail
Convex height, 8. antibiotic layer width, the antimicrobial component in 9. antibiotic layers, 10. antibacterial layer thickness, 11. controllable antibacterial trachea brackets,
12. mixing tube, 13. trachea bracket axial rotation devices, 14. hold the syringe of the degradable host material of bio-compatible, and 15. contain
Put the syringe of the solution containing antimicrobial component, 16. binary channels syringe pumps, 17. mixing tube upper covers, 18. mixing pipe shells, 19. mixing
Pipe internal helical blades.
Specific implementation mode
As shown in Figures 1 to 3, the controllable antibacterial trachea bracket of the present embodiment includes：Trachea bracket matrix 1, degradable antibacterial
Layer 2 and silicone trachea bracket follow closely male structure 3.Degradable antibiotic layer 2 is printed upon rami tracheales by extruded type biology 3D printing platform
1 outer surface of frame can not fall off or be permanently deformed as certain deformation occurs for trachea bracket matrix 1.
Degradable antibiotic layer 2 in the present embodiment trachea bracket matrix surface in the shape of a spiral, the antibacterial of geometric parameter
Antimicrobial component 9 and antibacterial layer thickness 10 in slice width degree 8, antibiotic layer can be less than silicone gas taking human as adjusting, antibacterial layer thickness 10
Pipe holder follows closely convex height 8.It should be noted that being schematic diagram herein, the dimension scale in figure does not represent degradable antibiotic layer 2 and gas
The actual size ratio of pipe holder matrix 1, the actually thickness of degradable antibiotic layer 2 should be much smaller than the thickness of trachea bracket matrix 1
Degree.
It is uniformly dispersed with antimicrobial component particle 6 in degradable antibiotic layer 2 in the present embodiment, herein only schematic diagram,
In practice since the size of antimicrobial component particle 6 should in the micron-scale and hereinafter, the shape of antimicrobial component particle 6 may be not simultaneously
Rule, it is understood that there may be local agglomeration.
As shown in Figure 4, the degradable antibiotic layer 2 in the present embodiment can be printed upon trachea bracket base by diagramatic way
Body surface face, wherein controllable antibacterial trachea bracket 11 is mounted on trachea bracket axial rotation device 13, it can be around axial rotation, bilateral
There are two syringes for installation on road syringe pump 16, respectively hold the syringe 14 of the degradable host material of bio-compatible and hold
The syringe 15 of solution containing antimicrobial component (such as Nano silver solution), can be fast by controlling the feeding in 16 two channels of syringe pump
Degree controls the concentration of antimicrobial component in degradable antibiotic layer 2, and degradable host material is injected into the solution containing antimicrobial component
In mixing tube 12, mixing tube 12 includes mixing tube upper cover 17, mixes pipe shell 18 and mixing tube internal helical blades 19, utilizes mixing
Pipe internal helical blades 19 are sufficiently stirred two kinds of ingredients and obtain uniform degradable antibacterial mixing material, and mixing tube 12 is mounted on three-dimensional
On motion platform, three direction movements can be done, cooperation trachea bracket axial rotation device 13 prints on trachea bracket matrix
Helical structure avoids silicon stent surface nail male structure 3, while reducing the influence for expectoration, naturally it is also possible to print it
His shape.
In conclusion the controllable antibacterial trachea bracket of the present embodiment, by print platform be blended with antimicrobial component can
Degradation biological compatible material is printed upon trachea bracket matrix surface, by being attached to gas after method dry solidification physically or chemically
Pipe holder matrix surface forms degradable antibiotic layer, by the concentration and antibiotic layer that adjust antimicrobial component in degradable antibiotic layer
Geometric parameter realize the controlled release of antimicrobial component, efficiently controllable solutions trachea bracket is placed in the infection after human body and asks
Topic.
Claims (10)
1. a kind of controllable antibacterial trachea bracket includes the antibacterial of trachea bracket matrix and the covering trachea bracket matrix surface
Coat, which is characterized in that the antibacterial coat is the degradable host material of bio-compatible with antimicrobial component.
2. controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the trachea bracket matrix is silicone tracheae
Holder or metal tracheae holder.
3. controllable antibacterial trachea bracket as claimed in claim 1 or 2, which is characterized in that the surface of the trachea bracket matrix
Convex equipped with following closely, the antibacterial coat is convex in the shape of a spiral to avoid the nail in trachea bracket matrix surface.
4. controllable antibacterial trachea bracket as claimed in claim 1 or 2, which is characterized in that the trachea bracket matrix includes master
The surface of pipe and two branch pipes connected with supervisor, the supervisor is convex equipped with following closely, and the antibacterial coat is on the surface of the supervisor
It is convex to avoid the nail in the shape of a spiral.
5. controllable antibacterial trachea bracket as claimed in claim 4, which is characterized in that the antibacterial coat is in the branch pipe
Surface is in the shape of a spiral.
6. controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the antimicrobial component of the antibacterial coat is adopted
With at least one of antibiotic, sulfamido, imidazoles, nitro glyoxaline, quinolones, silver ion and nano-Ag particles.
7. controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the bio-compatible of the antibacterial coat can
Matrix degradation material uses gelatin, methacrylate gelatin, chitosan, alginate and Poly(D,L-lactide-co-glycolide
At least one of.
8. controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the antimicrobial component is molten using nano silver
Liquid, the degradable host material of bio-compatible use the mixed solution of chitosan and gelatin.
9. controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the antibacterial coat passes through 3D printing skill
Art is coated in the trachea bracket matrix surface.
10. controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the thickness of the antibacterial coat is less than
0.2mm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810080529.7A CN108720971A (en) | 2018-01-28 | 2018-01-28 | A kind of controllable antibacterial trachea bracket |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810080529.7A CN108720971A (en) | 2018-01-28 | 2018-01-28 | A kind of controllable antibacterial trachea bracket |
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| CN108720971A true CN108720971A (en) | 2018-11-02 |
Family
ID=63940446
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| CN201810080529.7A Pending CN108720971A (en) | 2018-01-28 | 2018-01-28 | A kind of controllable antibacterial trachea bracket |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755678A (en) * | 2019-11-13 | 2020-02-07 | 中国矿业大学 | 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction |
Citations (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1649551A (en) * | 2002-04-24 | 2005-08-03 | 太阳生物医学有限公司 | Drug-delivery endovascular stent and method for treating restenosis |
| CN1883718A (en) * | 2006-06-08 | 2006-12-27 | 上海交通大学 | High molecular film coated scaffold |
| CN101171042A (en) * | 2005-05-05 | 2008-04-30 | 汉莫堤克股份有限公司 | A method for coating the whole surface of a built-in prothesis |
| US20080140176A1 (en) * | 2006-10-18 | 2008-06-12 | Krause Arthur A | Medical stent and devices for localized treatment of disease |
| CN101264351A (en) * | 2008-04-07 | 2008-09-17 | 易生科技(北京)有限公司 | Composite coating cardiovascular medicaments elution stent and preparation thereof |
| CN101636187A (en) * | 2007-01-30 | 2010-01-27 | 汉莫堤克股份有限公司 | Biodegradable vascular support |
| CN201524156U (en) * | 2009-11-16 | 2010-07-14 | 南京微创医学科技有限公司 | Y-shaped trachea stent and implantation device thereof |
| CN101785879A (en) * | 2010-01-26 | 2010-07-28 | 广东省人民医院 | Degradable airway stent and application thereof |
| CN201551421U (en) * | 2009-11-06 | 2010-08-18 | 易生科技(北京)有限公司 | Blood vessel bracket |
| CN201735407U (en) * | 2010-06-23 | 2011-02-09 | 东华大学 | Microfluidic control device for continuous high-throughput phosphopeptide enrichment and separation |
| US20110087319A1 (en) * | 2009-10-09 | 2011-04-14 | Hagaman Logan R | Bifurcated highly conformable medical device branch access |
| US20110230974A1 (en) * | 2010-03-17 | 2011-09-22 | National Jewish Health | Airway anchor suture to prevent airway stent migration |
| CN102551927A (en) * | 2011-11-29 | 2012-07-11 | 上海大学 | Embedded type graded drug release three-dimensional rack and preparation method thereof |
| CN103007345A (en) * | 2012-12-20 | 2013-04-03 | 深圳清华大学研究院 | Antibacterial biological activity stent and preparation method thereof |
| CN103349579A (en) * | 2010-11-12 | 2013-10-16 | 上海交通大学医学院附属新华医院 | Application of novel slide buckle bio-absorbable stent |
| CN103547238A (en) * | 2011-04-27 | 2014-01-29 | 百乐仕医疗器械有限公司 | Stent |
| CN103990182A (en) * | 2014-05-30 | 2014-08-20 | 东华大学 | Three-dimensional scaffold material for bone tissue repair and preparation method thereof |
| CN104470470A (en) * | 2012-04-06 | 2015-03-25 | 波士顿科学国际有限公司 | Anti-migration micropatterned stent coating |
| CN104874027A (en) * | 2015-05-12 | 2015-09-02 | 上海大学 | Preparation method of multi-medicine controllable load gradient regeneration bone scaffold |
| CN104908324A (en) * | 2015-06-10 | 2015-09-16 | 中国科学技术大学 | 3D printing device of biological tissue optical simulation |
| CN104970894A (en) * | 2015-07-09 | 2015-10-14 | 北京威控睿博科技有限公司 | 3D printing supplies forming method and device |
| CN105188790A (en) * | 2013-03-15 | 2015-12-23 | 波士顿科学国际有限公司 | Anti-migratory stent coating |
| CN204995614U (en) * | 2015-08-25 | 2016-01-27 | 王洪武 | Trachea support |
| CN105496615A (en) * | 2016-01-25 | 2016-04-20 | 张�杰 | Covered airway stent |
| CN106361476A (en) * | 2016-09-13 | 2017-02-01 | 郑州大学 | Woven fully-degradable magnesium alloy airway stent and preparation method thereof |
| CN106393679A (en) * | 2016-11-28 | 2017-02-15 | 贵州航天计量测试技术研究所 | Multi-material 3D printing sprayer and operating method thereof |
| CN106618817A (en) * | 2016-12-23 | 2017-05-10 | 首都医科大学附属北京儿童医院 | 3D printing endotracheal stent for babies and preparation method and application thereof |
| CN106691645A (en) * | 2017-02-05 | 2017-05-24 | 常州乐奥医疗科技股份有限公司 | Vascular drug stent |
| CN206455936U (en) * | 2016-12-27 | 2017-09-01 | 扬州大学 | A kind of multi-fluid mixing jetting pneumatic sprayhead structure |
| CN206623409U (en) * | 2016-12-12 | 2017-11-10 | 陈天润 | Color three-dimensional printer extrusion device |
-
2018
- 2018-01-28 CN CN201810080529.7A patent/CN108720971A/en active Pending
Patent Citations (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1649551A (en) * | 2002-04-24 | 2005-08-03 | 太阳生物医学有限公司 | Drug-delivery endovascular stent and method for treating restenosis |
| CN101171042A (en) * | 2005-05-05 | 2008-04-30 | 汉莫堤克股份有限公司 | A method for coating the whole surface of a built-in prothesis |
| CN1883718A (en) * | 2006-06-08 | 2006-12-27 | 上海交通大学 | High molecular film coated scaffold |
| US20080140176A1 (en) * | 2006-10-18 | 2008-06-12 | Krause Arthur A | Medical stent and devices for localized treatment of disease |
| CN101636187A (en) * | 2007-01-30 | 2010-01-27 | 汉莫堤克股份有限公司 | Biodegradable vascular support |
| CN101264351A (en) * | 2008-04-07 | 2008-09-17 | 易生科技(北京)有限公司 | Composite coating cardiovascular medicaments elution stent and preparation thereof |
| US20110087319A1 (en) * | 2009-10-09 | 2011-04-14 | Hagaman Logan R | Bifurcated highly conformable medical device branch access |
| CN201551421U (en) * | 2009-11-06 | 2010-08-18 | 易生科技(北京)有限公司 | Blood vessel bracket |
| CN201524156U (en) * | 2009-11-16 | 2010-07-14 | 南京微创医学科技有限公司 | Y-shaped trachea stent and implantation device thereof |
| CN101785879A (en) * | 2010-01-26 | 2010-07-28 | 广东省人民医院 | Degradable airway stent and application thereof |
| US20110230974A1 (en) * | 2010-03-17 | 2011-09-22 | National Jewish Health | Airway anchor suture to prevent airway stent migration |
| CN201735407U (en) * | 2010-06-23 | 2011-02-09 | 东华大学 | Microfluidic control device for continuous high-throughput phosphopeptide enrichment and separation |
| CN103349579A (en) * | 2010-11-12 | 2013-10-16 | 上海交通大学医学院附属新华医院 | Application of novel slide buckle bio-absorbable stent |
| CN103547238A (en) * | 2011-04-27 | 2014-01-29 | 百乐仕医疗器械有限公司 | Stent |
| CN102551927A (en) * | 2011-11-29 | 2012-07-11 | 上海大学 | Embedded type graded drug release three-dimensional rack and preparation method thereof |
| CN104470470A (en) * | 2012-04-06 | 2015-03-25 | 波士顿科学国际有限公司 | Anti-migration micropatterned stent coating |
| CN103007345A (en) * | 2012-12-20 | 2013-04-03 | 深圳清华大学研究院 | Antibacterial biological activity stent and preparation method thereof |
| CN105188790A (en) * | 2013-03-15 | 2015-12-23 | 波士顿科学国际有限公司 | Anti-migratory stent coating |
| CN103990182A (en) * | 2014-05-30 | 2014-08-20 | 东华大学 | Three-dimensional scaffold material for bone tissue repair and preparation method thereof |
| CN104874027A (en) * | 2015-05-12 | 2015-09-02 | 上海大学 | Preparation method of multi-medicine controllable load gradient regeneration bone scaffold |
| CN104908324A (en) * | 2015-06-10 | 2015-09-16 | 中国科学技术大学 | 3D printing device of biological tissue optical simulation |
| CN104970894A (en) * | 2015-07-09 | 2015-10-14 | 北京威控睿博科技有限公司 | 3D printing supplies forming method and device |
| CN204995614U (en) * | 2015-08-25 | 2016-01-27 | 王洪武 | Trachea support |
| CN105496615A (en) * | 2016-01-25 | 2016-04-20 | 张�杰 | Covered airway stent |
| CN106361476A (en) * | 2016-09-13 | 2017-02-01 | 郑州大学 | Woven fully-degradable magnesium alloy airway stent and preparation method thereof |
| CN106393679A (en) * | 2016-11-28 | 2017-02-15 | 贵州航天计量测试技术研究所 | Multi-material 3D printing sprayer and operating method thereof |
| CN206623409U (en) * | 2016-12-12 | 2017-11-10 | 陈天润 | Color three-dimensional printer extrusion device |
| CN106618817A (en) * | 2016-12-23 | 2017-05-10 | 首都医科大学附属北京儿童医院 | 3D printing endotracheal stent for babies and preparation method and application thereof |
| CN206455936U (en) * | 2016-12-27 | 2017-09-01 | 扬州大学 | A kind of multi-fluid mixing jetting pneumatic sprayhead structure |
| CN106691645A (en) * | 2017-02-05 | 2017-05-24 | 常州乐奥医疗科技股份有限公司 | Vascular drug stent |
Non-Patent Citations (2)
| Title |
|---|
| 何小维等: "《功能性碳水化合物及其应用技术丛书 医药用碳水化合物》", 31 January 2016, 北京：中国轻工业出版社 * |
| 樊瑜波等: "《生物力学建模仿真与应用》", 31 December 2017, 上海：上海交通大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755678A (en) * | 2019-11-13 | 2020-02-07 | 中国矿业大学 | 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction |
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