CN108714238A - A kind of porous based composite dressing for medical use of fibroin/titanium and preparation method thereof of load Anti-radiation Microbes - Google Patents
A kind of porous based composite dressing for medical use of fibroin/titanium and preparation method thereof of load Anti-radiation Microbes Download PDFInfo
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- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The present invention provides a kind of porous based composite dressing for medical use of fibroin/titanium and preparation method thereof of load Anti-radiation Microbes, includes the following steps：Using POROUS TITANIUM PLATE as backing material, thorough impregnation takes out in fibroin solutions through electric Gel Treatment, obtains the POROUS TITANIUM PLATE of fibroin gel cladding；The POROUS TITANIUM PLATE that fibroin gel coats is placed in -20~-80 DEG C of refrigerator after handling, it is composite porous to obtain fibroin/titanium for vacuum freeze-drying；It after the composite porous surface preparation of fibroin/titanium, is placed in Sabouraud dextrose enrichment liquid and cultivates 1d, be transferred to culture medium medium temperature chamber culture 1-7d, obtain the porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes.Medical dressing prepared by the present invention is porous structure, and flexible, breathable moisturizing, high mechanical strength, good biocompatibility also has biological radiation resistance, comprehensive good, particularly suitable as surface of a wound medical dressing.
Description
Technical field
The invention belongs to medical dressing field of material technology, and in particular to a kind of silk egg of load Anti-radiation Microbes
Porous based composite dressing for medical use of in vain/titanium and preparation method thereof.
Background technology
X-ray is also referred to as roentgen-ray, is by the transition between two energy levels that energy differs greatly of the electronics in atom
And the particle flux generated is excited, it is that there is very light penetration, electricity between gamma-rays and from a kind of electromagnetic wave between outer inspection
From effect, fluorescence, heat effect and interference, diffraction reflection and refraction action, therefore X-ray has extensively in every field
Application.But be chin while bringing convenient to our live and works also can harmful to human health, television tower,
The electromagnetic radiation that the electrical equipments such as mobile phone, electromagnetic wave, launching tower, computer, television set, micro-wave oven generate is full of space, can
It penetrates human body cell, destroy DNA, or even induce cancer cell, destroy red blood cell, it could even be possible to life security is threatened, therefore,
It reduces various radiation intensity and the control of its dosage within safety line, achievees the purpose that ensure health safety.
Medical dressing be it is a kind of can temporary protection wound, the medical material that prevents wound infection, promote healing, it is current
Medical dressing focus primarily upon research control wound fluid, avoid or control wound infection, removal or control wound stink,
Mitigate pain, promote wound healing etc., but the wound for being the absence of crust protection is easier directly to be endangered by electromagnetic radiation
Evil, it is easier to be compromised, therefore, it is very necessary study the medical dressing with radiation-resisting functional.Radiation resistance material is usually
Ionising radiation is handled by way of absorbing or dissipating, and mainly has the anti-spoke of metallic fiber using relatively broad radiation resistance material
Penetrate material and semimetal fiber radiation resistance material etc..A kind of functionality Medical face fabric disclosed in Chinese patent CN 104473365B
And preparation method thereof, which includes internal layer, outer layer and the base being placed between internal layer and outer layer, and the wherein warp of internal layer is to wash
Cotton blended fabric material, weft are terylene/alloy conductive yarn mixed yarn, and the warp of outer layer is chitosan fiber containing zinc, and weft is
Imbue fibers, base are organosilicon/polyvinyl alcohol/graphene oxide composite membrane of porous structure, and internal layer and outer layer all use one
On once plain weave, base be prepared by electrostatic spinning, internal layer, outer layer and link base layer are overpressurized heat treatment and bake system
Standby to form, multifunctional medical fabric prepared by this method has stronger bacteria resistance, radioresistance, anti-static effect, and face
Material is soft, moisture absorbing and sweat releasing effect is good, comfortable and easy to wear.A kind of Medical anti-radiation material disclosed in Chinese patent CN 106297928B,
The radiation proof material is multilayered structure, including radiation protective layer, buffer layer and protective layer, and wherein radiation protective layer includes that cupro lead is thin
The mixture of powder and coumarone indene resin fusing, buffer layer includes bamboo charcoal fiber, and protective layer includes containing super fine zinc oxide particle
The preparation method of textile material, wherein radiation protective layer is：Solid coumarone resin is added in the metal can of preheating, is slowly risen
Then cupro lead is added to melting in temperature, continue to stop heating after heating stirring, and stirring is to being uniformly mixed, after being cooled to room temperature
Broken to obtain granular substance, as radiation protective layer, radiation proof material prepared by this method is mainly used for radioexmination and treatment
Vest weaving and medical radioactive instrument security mask equipment in.By the above-mentioned prior art it is found that the doctor studied at present
Radiation proof material is used to be difficult to more work(as collection breathable moisture permeability, biocompatibility, Antimicrobial preservative and radiation resistance one
It can Medical wounded surface dressing.
Invention content
The technical problem to be solved in the present invention is to provide a kind of fibroin/titanium of load Anti-radiation Microbes is porous compound
Medical dressing and preparation method thereof, the present invention are porous on the surface of POROUS TITANIUM PLATE and internal formation using POROUS TITANIUM PLATE as carrier
Fibroin structure, then it is composite porous for substrate with fibroin/titanium, it cultivates to obtain the micro- life of radiation hardness on the surface of titanium plate
Object further enhances the radiation resistance of medical dressing, obtains the Medical coating for integrating comfortable, high-strength pro-skin and radioresistance
Material.
In order to solve the above technical problems, the technical scheme is that：
A kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes, the micro- life of the load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of object includes porous silk albumen, POROUS TITANIUM PLATE and Anti-radiation Microbes, described more
Hole silk is that fibroin is freeze-dried after electric Gel Treatment and obtains.
As a preferred embodiment of the above technical solution, the porous composite medical of fibroin/titanium of the load Anti-radiation Microbes
Dressing further includes cotton gauze.
As a preferred embodiment of the above technical solution, the porous compound doctor of fibroin/titanium of the load Anti-radiation Microbes
With the preparation method of dressing, include the following steps：
(1) using POROUS TITANIUM PLATE as backing material, thorough impregnation takes out in fibroin solutions through electric Gel Treatment,
Obtain the POROUS TITANIUM PLATE of fibroin gel cladding；
(2) POROUS TITANIUM PLATE of fibroin gel cladding prepared by step (1) is placed in -20~-80 DEG C of refrigerator
After reason, it is composite porous to obtain fibroin/titanium for vacuum freeze-drying；
(3) after the composite porous surface preparation of fibroin/titanium for preparing step (2), it is placed in Sabouraud dextrose
1d is cultivated in enrichment liquid, is transferred to culture medium medium temperature chamber culture 1-7d, and the fibroin/titanium for obtaining load Anti-radiation Microbes is more
Hole based composite dressing for medical use.
As a preferred embodiment of the above technical solution, in the step (1), POROUS TITANIUM PLATE is prepared by the printing of 3D printing powder
It arrives, the thickness of POROUS TITANIUM PLATE is 0.5-2mm, and porosity is more than 30%.
As a preferred embodiment of the above technical solution, in the step (1), the mass fraction of fibroin solutions is 4-6%.
As a preferred embodiment of the above technical solution, in the step (1), the voltage of coagulation glue is 15-30V, time 30-
90min。
As a preferred embodiment of the above technical solution, in the step (2), the time of vacuum freeze-drying is 2-3d, and vacuum degree is
0.01-0.05Pa。
As a preferred embodiment of the above technical solution, in the step (2), the composite porous middle silk egg of fibroin/titanium
White and titanium mass ratio is 0.6-0.8:1, porosity 35-55%.
As a preferred embodiment of the above technical solution, in the step (3), the temperature of hot-house culture is 37 DEG C, and culture medium is fine jade
Fat culture medium.
As a preferred embodiment of the above technical solution, it in the step (3), pre-processes as area load cotton gauze, it is described negative
Load mode is chemical crosslinking or physical adherence.
Compared with prior art, the invention has the advantages that：
The porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes prepared by the present invention includes porous silkworm
POROUS TITANIUM PLATE prepared by three-dimensional printing technology is impregnated in fibroin solutions, makes by silk, POROUS TITANIUM PLATE and Anti-radiation Microbes
Fibroin solutions are full of the inside and surface of POROUS TITANIUM PLATE, recycle electric gel technique, make inside POROUS TITANIUM PLATE and surface
Fibroin forms gel, and composite porous, the porous composite wood is finally prepared using Vacuum Freezing & Drying Technology
Porous silk albumen and POROUS TITANIUM PLATE, which interpenetrate, in material entwines, and forms dual network porous structure, not only contributes to microorganism
Attachment and breeding, and ensure that the breathable moisture permeability of functional material, then again with composite porous for substrate, porous
The surface of titanium plate is grown and microbial material of the breeding with radiation resistance, and the silk adhered to around POROUS TITANIUM PLATE, into one
Step improves composite porous biocompatibility, further promotes the growth of Anti-radiation Microbes, is conducive to improve work(
The radiation resistance of energy material.In addition the porous composite medical of fibroin/titanium for the load Anti-radiation Microbes that prepared by the present invention
Dressing further includes cotton gauze, the cladding of cotton gauze does not influence other than containing composite porous conduct functional material
The ventilative comfort of medical dressing also reduces external environment to composite porous influence, and prepared due to the present invention
Contain sheet metal, therefore excellent in mechanical performance in porous based composite dressing for medical use, durability is good.
(2) preparation method of the invention is simple, is combined by coagulation glue, vacuum freeze drying and biological culture technigue,
Porous metal material, multiporous biological protein material and microbial material are organically combined, mechanical property, gas permeability, parent is prepared
The all good medical dressing of skin, radiation resistance is used particularly suitable as Medical wounded surface dressing, can be effectively promoted being cured for the surface of a wound
It closes.
Specific implementation mode
Below in conjunction with specific embodiment, the present invention will be described in detail, herein illustrative examples and explanation of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1：
(1) it is 0.5mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as support
Material, thorough impregnation is in the fibroin solutions of 4wt%, and electric Gel Treatment 30min, takes out, obtain silkworm under the pressure of 15V
The POROUS TITANIUM PLATE of silk-fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -20 DEG C of refrigerator after handling, in 0.01P a vacuum
Degree is lower to be lyophilized 2d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle fibroin of fibroin/titanium
Mass ratio with titanium is 0.6:1, porosity 35%.
(3) it after area load cotton gauze, is placed in by way of chemical crosslinking by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 1 d is cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 2：
(1) it is 2mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as fid
Material, thorough impregnation is in the fibroin solutions of 6wt%, and electric Gel Treatment 90min, takes out, obtain silkworm under the pressure of 30V
The POROUS TITANIUM PLATE of silk-fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -80 DEG C of refrigerator after handling, in 0.05P a vacuum
Degree is lower to be lyophilized 3d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle fibroin of fibroin/titanium
Mass ratio with titanium is 0.8:1, porosity 35-55%.
(3) it after area load cotton gauze, is placed in by way of physical adherence by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 7 d are cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 3：
(1) it is 1mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as fid
Material, thorough impregnation is in the fibroin solutions of 4-6wt%, and electric Gel Treatment 60min, takes out, obtain silkworm under the pressure of 25V
The POROUS TITANIUM PLATE of silk-fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -60 DEG C of refrigerator after handling, in 0.03P a vacuum
Degree is lower to be lyophilized 2.5d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle silk egg of fibroin/titanium
White and titanium mass ratio is 0.7:1, porosity 45%.
(3) it after area load cotton gauze, is placed in by way of chemical crosslinking by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 4 d are cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 4：
(1) it is 1.5mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as support
Material, thorough impregnation is in the fibroin solutions of 4.5wt%, and electric Gel Treatment 45min, takes out, obtain under the pressure of 25V
The POROUS TITANIUM PLATE of fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -60 DEG C of refrigerator after handling, in 0.03P a vacuum
Degree is lower to be lyophilized 2.5d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle silk egg of fibroin/titanium
White and titanium mass ratio is 0.65:1, porosity 50%.
(3) it after area load cotton gauze, is placed in by way of chemical crosslinking by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 5 d are cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 5：
(1) it is 2mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as fid
Material, thorough impregnation is in the fibroin solutions of 5.5wt%, and electric Gel Treatment 75min, takes out, obtain silkworm under the pressure of 25V
The POROUS TITANIUM PLATE of silk-fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -50 DEG C of refrigerator after handling, in 0.02P a vacuum
Degree is lower to be lyophilized 3d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle fibroin of fibroin/titanium
Mass ratio with titanium is 0.7:1, porosity 40%.
(3) it after area load cotton gauze, is placed in by way of physical adherence by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 6 d are cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 6：
(1) it is 0.5mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as support
Material, thorough impregnation is in the fibroin solutions of 6wt%, and electric Gel Treatment 90min, takes out, obtain silkworm under the pressure of 15V
The POROUS TITANIUM PLATE of silk-fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -20 DEG C of refrigerator after handling, in 0.05P a vacuum
Degree is lower to be lyophilized 2d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle fibroin of fibroin/titanium
Mass ratio with titanium is 0.8:1, porosity 35%.
(3) it after area load cotton gauze, is placed in by way of physical adherence by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 1 d is cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 7：
(1) it is 2mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as fid
Material, thorough impregnation is in the fibroin solutions of 4wt%, and electric Gel Treatment 30min, takes out, obtain silkworm under the pressure of 30V
The POROUS TITANIUM PLATE of silk-fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -80 DEG C of refrigerator after handling, in 0.01P a vacuum
Degree is lower to be lyophilized 3d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle fibroin of fibroin/titanium
Mass ratio with titanium is 0.6:1, porosity 55%.
(3) it after area load cotton gauze, is placed in by way of chemical crosslinking by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 7 d are cultivated at 37 DEG C, it is micro- to obtain load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of biology.
Embodiment 8：
(1) it is 1.3mm by thickness, POROUS TITANIUM PLATE prepared by 3D printing powder printing of the porosity more than 30% is as support
Material, thorough impregnation is in the fibroin solutions of 4-6wt%, and electric Gel Treatment 65min, takes out, obtain under the pressure of 23V
The POROUS TITANIUM PLATE of fibroin gel cladding.
(2) POROUS TITANIUM PLATE that fibroin gel coats is placed in -75 DEG C of refrigerator after handling, in 0.04P a vacuum
Degree is lower to be lyophilized 2-3d, it is composite porous to obtain fibroin/titanium, wherein the composite porous middle silk egg of fibroin/titanium
White and titanium mass ratio is 0.75:1, porosity 45%.
(3) it after area load cotton gauze, is placed in by way of chemical crosslinking by fibroin/titanium is composite porous
1d is cultivated in Sabouraud dextrose enrichment liquid, is transferred in agar medium, 3. 5d are cultivated at 37 DEG C, obtains load radiation hardness
The porous based composite dressing for medical use of fibroin/titanium of microorganism.
After testing, the porous based composite dressing for medical use of fibroin/titanium for the load Anti-radiation Microbes that prepared by embodiment 1-8
The result of gas permeability, mechanical property and radiation resistance is as follows：
As seen from the above table, the porous based composite dressing for medical use of fibroin/titanium for the load Anti-radiation Microbes that prepared by the present invention
Good permeability, mechanical property and elasticity are excellent, also have good radiation resistance.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
1. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes, it is characterised in that：The load is resistance to
The porous based composite dressing for medical use of fibroin/titanium for radiating microorganism includes porous silk albumen, POROUS TITANIUM PLATE and the micro- life of radiation hardness
Object, the porous silk are that fibroin is freeze-dried after electric Gel Treatment and obtains.
2. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 1,
It is characterized in that：The porous based composite dressing for medical use of fibroin/titanium of the load Anti-radiation Microbes further includes cotton gauze.
3. the preparation of the porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes described in claims 1 or 2
Method, which is characterized in that include the following steps：
(1) using POROUS TITANIUM PLATE as backing material, thorough impregnation takes out through electric Gel Treatment, obtains in fibroin solutions
The POROUS TITANIUM PLATE of fibroin gel cladding；
(2) POROUS TITANIUM PLATE of fibroin gel cladding prepared by step (1) is placed in -20~-80 DEG C of refrigerator after handling,
It is composite porous to obtain fibroin/titanium for vacuum freeze-drying；
(3) it after the composite porous surface preparation of fibroin/titanium for preparing step (2), is placed in Sabouraud dextrose and increases bacterium
1d is cultivated in liquid, is transferred to culture medium medium temperature chamber culture 1-7d, and the fibroin/titanium for obtaining load Anti-radiation Microbes is porous multiple
Close medical dressing.
4. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：In the step (1), POROUS TITANIUM PLATE is prepared by the printing of 3D printing powder, POROUS TITANIUM PLATE
Thickness is 0.5-2mm, and porosity is more than 30%.
5. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：In the step (1), the mass fraction of fibroin solutions is 4-6%.
6. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：In the step (1), the voltage of coagulation glue is 15-30V, time 30-90min.
7. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：In the step (2), the time of vacuum freeze-drying is 2-3d, vacuum degree 0.01-0.05Pa.
8. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：In the step (2), the quality of fibroin/titanium composite porous middle fibroin and titanium
Than for 0.6-0.8:1, porosity 35-55%.
9. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：In the step (3), the temperature of hot-house culture is 37 DEG C, and culture medium is agar medium.
10. a kind of porous based composite dressing for medical use of fibroin/titanium of load Anti-radiation Microbes according to claim 3
Preparation method, it is characterised in that：It in the step (3), pre-processes as area load cotton gauze, the mode of loading is chemistry
Crosslinking or physical adherence.
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| CN201810624336.3A CN108714238A (en) | 2018-06-16 | 2018-06-16 | A kind of porous based composite dressing for medical use of fibroin/titanium and preparation method thereof of load Anti-radiation Microbes |
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| CN201810624336.3A CN108714238A (en) | 2018-06-16 | 2018-06-16 | A kind of porous based composite dressing for medical use of fibroin/titanium and preparation method thereof of load Anti-radiation Microbes |
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| CN103805797A (en) * | 2014-01-17 | 2014-05-21 | 西北工业大学 | Preparation method of medical porous titanium/porous titanium alloy |
| CN105664225A (en) * | 2016-02-24 | 2016-06-15 | 苏州思彬纳米科技有限公司 | Nano-silver, chitosan and fibroin compound biological dressing and preparation method thereof |
| CN105859294A (en) * | 2016-03-31 | 2016-08-17 | 青岛百瑞吉生物工程有限公司 | Method for preparing biomedical porous titanium-based composite material |
| CN107501961A (en) * | 2017-09-17 | 2017-12-22 | 钱景 | Titanium dioxide/Nano Silver/silk magnetic porous composite material and preparation method thereof |
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2018
- 2018-06-16 CN CN201810624336.3A patent/CN108714238A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103805797A (en) * | 2014-01-17 | 2014-05-21 | 西北工业大学 | Preparation method of medical porous titanium/porous titanium alloy |
| CN105664225A (en) * | 2016-02-24 | 2016-06-15 | 苏州思彬纳米科技有限公司 | Nano-silver, chitosan and fibroin compound biological dressing and preparation method thereof |
| CN105859294A (en) * | 2016-03-31 | 2016-08-17 | 青岛百瑞吉生物工程有限公司 | Method for preparing biomedical porous titanium-based composite material |
| CN107501961A (en) * | 2017-09-17 | 2017-12-22 | 钱景 | Titanium dioxide/Nano Silver/silk magnetic porous composite material and preparation method thereof |
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Application publication date: 20181030 |