CN108704391A - It is a kind of can on-line cleaning emulsion sample residues filter device - Google Patents
It is a kind of can on-line cleaning emulsion sample residues filter device Download PDFInfo
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- CN108704391A CN108704391A CN201810499586.9A CN201810499586A CN108704391A CN 108704391 A CN108704391 A CN 108704391A CN 201810499586 A CN201810499586 A CN 201810499586A CN 108704391 A CN108704391 A CN 108704391A
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- sample
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- bottles
- line cleaning
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D41/00—Regeneration of the filtering material or filter elements outside the filter for liquid or gaseous fluids
- B01D41/04—Regeneration of the filtering material or filter elements outside the filter for liquid or gaseous fluids of rigid self-supporting filtering material
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- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses it is a kind of can on-line cleaning emulsion sample residues filter device, including sample injection bottle, filter, ultrasonic vibrator, sample introduction needle, multi-path choice valve, syringe pump and backwash solvent bottle, filter is connected with away liquid pipeline, filtering sieve plate is installed, ultrasonic vibrator is installed on filter in filter；Sample injection bottle is connected to sample feeding pipe by sample introduction needle, and sample feeding pipe is connected to filter；Multi-path choice valve is equipped with injection pumping hole, backwash mouth and sample port, respectively corresponding connection syringe pump, backwash solvent bottle and caching pipe.Utilize backwashing technology, and the cavitation of ultrasonic wave cleans up the macromolecular filtered on sieve plate and fats residue, sieve plate can be cleaned and be reused automatically when having the function that for emulsion sample feedings such as milk, it reduces to solenoid valve, the damage of the electronics member device such as syringe pump, enhancing stability of instrument, consistency.
Description
Technical field
The present invention relates to analytical chemistry field more particularly to it is a kind of can on-line cleaning emulsion sample residues filtering dress
It sets.
Background technology
The emulsion sample such as milk is required for handling filtering, the then filtering through instrument before doing before entering analytical instrument
Enter back into analytical instrument after component, but the substances such as high molecular weight protein present in sample and fatty colloid, repeatedly to this sample
Be very easy to cause after product sample introduction the blocking of the fluid path electronic component of the filter assemblies of instrument and solenoid valve, syringe pump etc and
Damage, increases the failure rate of instrument.
There are mainly two types of the modes filtered at present to this kind of sample instrument side, and one is put filter element to sink in the sample
Entering sample bottle bottom, this is filtered for front end, and such filtering sieve plate also wants fixed time cleaning, but how long scavenging period is bad
It holds, there is also clean sordid situation.Second is that product filtering sieve plate is loaded in pipeline, and equally existing filtering sieve plate need to determine
Phase cleans, and is otherwise easy to block.Therefore, existing filter type generally existing troublesome maintenance, need to regularly replace filtering sieve plate
The drawbacks of, and the bad assurance of replacing construction.
Invention content
The present invention provides it is a kind of can on-line cleaning emulsion sample residues filter device, with solve filtering sieve plate it is clear
The problem of washing replacement.Specifically, current existing on-line filtration technology is unidirectional sample introduction, the emulsion such as multipass milk
Be easy to cause filtering sieve plate saturation after sample, lose filtration or even block pipeline, thus can not be permanent Reusability, portion
Blocking can only be perceived by dividing instrument to increase line-pressure sensor, reduced damage of the pipe blocking to instrument, needed dimension of visiting after sale
Shield or client oneself safeguard, increase corresponding cost.
It is provided by the invention it is a kind of can on-line cleaning emulsion sample residues filter device, including sample injection bottle, filtering
Device, ultrasonic vibrator, sample introduction needle, multi-path choice valve, syringe pump and backwash solvent bottle,
It is connected with away liquid pipeline in filter, filtering sieve plate is installed in screen pipe, ultrasonic vibrator is installed on filter；
Sample injection bottle is connected to sample feeding pipe by sample introduction needle, and sample feeding pipe is connected to filter；
Multi-path choice valve is equipped with injection pumping hole, backwash mouth and sample port, and corresponding connection syringe pump, backwash are molten respectively
Agent bottle and caching are managed.
Optionally, the backwash solvent bottle includes NaOH bottles, CH3COOH bottles and mobile phase bottle, wherein NaOH bottles described
In be 3moL/L NaOH solution, the CH3It is 0.6% CH in COOH bottles3COOH solution is in the mobile phase bottle
2.4mmoL/L Na2CO3、2.0mmoL/L NaHCO3With the mixed solution of 5% acetone.
Optionally, the backwash sequence of the backwash solvent bottle is NaOH bottles, CH3COOH bottles, mobile phase bottle.
Optionally, further include six-way valve, six-way valve is equipped with six interfaces being connected to two-by-two, wherein the sample introduction of six-way valve
Liquid pipeline is walked in mouth connection, and one end of outlet connection caching pipe caches the other end connection sample port of pipe.
Optionally, it is additionally provided with quantitative loop on six-way valve.
Optionally, further include sample disc, several placement holes are offered in sample disc, sample injection bottle activity is positioned over placement hole
In.
Optionally, further include waste liquid tank.
The invention has the advantages that：
(1) using filtering sieve plate ultrasonic technique and multi-solvent back flushing, sample is stayed impurity by filtering sieve plate
In its sample introduction side, into complete sample after cut by syringe pump by drawing plurality of reagents, multi-path choice valve in backwash solvent bottle successively
The pipeline of sample introduction is changed to, reagent is reversely pushed into pipeline by syringe pump, is carried out back flush to pipeline and filtering sieve plate, was connected to
Ultrasonic vibrator on screen plate starts, and is cleaned up sieve plate is filtered using the cavitation of ultrasonic wave, is carried for later sample introduction
For good filtering environment, to reduce because sampling problems cause instrument failure rate, enhancing stability of instrument, consistency to reduce
The problems such as sample carryover, reduces the maintenance cost of instrument.Mainly solving impurity present in sample, repeatedly accumulation be easy to cause valve,
The damage of the fluid path electronic components such as pump and blockage problem, solve the problems, such as that fluid path sample segments filter need to regularly replace and reduce instrument
The maintenance cost of device enhances stability to reduce instrument failure rate, consistency, the problems such as reducing sample carryover.
(2) be directed to the emulsion sample such as milk, into complete sample after by syringe pump by being drawn successively in backwash solvent bottle
NaOH bottles, CH3COOH bottles and the 3moL/L in mobile phase bottle of NaOH solution, 0.6% CH3COOH solution and 2.4mmoL/L
Na2CO3、2.0mmoL/L NaHCO3With the mixed solution of 5% acetone.NaOH solution, CH3COOH solution is used for breasts such as milk
The substances such as high molecular weight protein and fat in the residue of turbid sample dissociate, and facilitate and rinse out residue；Under for convenience
Mobile phase is full of whole device, prevents sour interference by secondary sample introduction.
It should be understood that above general description and following detailed description is only exemplary and explanatory, not
It can the limitation present invention.
Description of the drawings
In order to illustrate more clearly of technical scheme of the present invention, letter will be made to attached drawing needed in the embodiment below
Singly introduce, it should be apparent that, for those of ordinary skills, without having to pay creative labor,
Other drawings may also be obtained based on these drawings.
Fig. 1 be it is provided by the invention it is a kind of can on-line cleaning emulsion sample residues filter device structural representation
Figure.
Label indicates in Fig. 1：1- sample injection bottles, 2- filters, 3- ultrasonic vibrators, 4- sample feeding pipes, 5- multi-path choice valves, 6- notes
Pump is penetrated, 7- backwashes solvent bottle, and 8- sample introduction needles, 9- six-way valves, 10-, which is cached, to manage, 11- sample discs, 12- waste liquid tanks, and 21- walks liquid pipe
Road, 22- filtering sieve plates, 51- injection pumping holes, 52- backwash mouths, 53- sample ports, 91- injection ports, 92- outlets, 93- are quantitative
Ring, 111- placement holes.
Specific implementation mode
The present invention provides it is a kind of can on-line cleaning emulsion sample residues filter device, for solving to filter
The problem of sieve plate cleaning replacement and solenoid valve, the damage problem of syringe pump.Following will be combined with the drawings in the embodiments of the present invention, right
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Go out the every other embodiment obtained under the premise of creative work, shall fall within the protection scope of the present invention.
Embodiment 1
As shown in Figure 1, for the embodiment of the present invention provide it is a kind of can on-line cleaning emulsion sample residues filter device
Structural schematic diagram.Including sample injection bottle 1, filter 2, ultrasonic vibrator 3, sample feeding pipe 4, multi-path choice valve 5, syringe pump 6 and recoil
Solvent bottle 7 is washed, filter 2 is connected with away liquid pipeline 21, and filtering sieve plate 22 is equipped in filter 2, and ultrasonic vibrator 3 was installed on
On filter 2；Sample injection bottle 1 is connected to sample feeding pipe 4 by sample introduction needle 8, and liquid pipeline 21 is walked in the connection of sample feeding pipe 4；Multi-path choice valve 5 is equipped with
Pumping hole 51, backwash mouth 52 and sample port 53 are injected, respectively corresponding connection syringe pump 6, backwash solvent bottle 7 and caching pipe 10.
Wherein, backwash solvent bottle 7 includes NaOH bottles, CH3COOH bottles and mobile phase bottle, wherein be in NaOH bottles described
The NaOH solution of 3moL/L, the CH3It is 0.6% CH in COOH bottles3COOH solution is 2.4mmoL/L in the mobile phase bottle
Na2CO3、2.0mmoL/L NaHCO3With the mixed solution of 5% acetone.Backwash sequence is NaOH bottles, CH3COOH bottles, mobile phase
Bottle.
In addition to this, further include six-way valve 9 according to the needs with the online sample introduction of other instruments, six-way valve 9 is equipped with two-by-two
Six interfaces of connection, and it is provided with quantitative loop 93, wherein liquid pipeline 21, outlet 92 are walked in the connection of injection port 91 of six-way valve 9
One end of connection caching pipe 10, the other end of caching pipe 10 are connected to sample port 53.
Further include sample disc 11 and waste liquid tank 12, several placement holes 111 are offered in sample disc 11, sample injection bottle 1 is placed
In placement hole 111.
Filtering sieve plate can also make filtration membrane into, and by taking autosampler as an example, syringe pump and multi-path choice valve install
After, sample introduction end connects sample introduction needle, and filter is mounted on fluid path electronic component front end and can play filtered sample while protect
The effect of electronic component.
It is provided in this embodiment it is a kind of can on-line cleaning emulsion sample residues filter device working mechanism it is as follows
It is described：
Sample introduction process：The emulsion sample such as milk in sample injection bottle 1 passes through sample introduction needle 8, and filter is connected by sample feeding pipe 4
2 sample introduction fittings walk liquid pipeline 21, are filtered to sample when flowing through filtering sieve plate 22, by the quantitative loop of six-way valve 9
93, pipe 10 is cached, into the sample port of multi-path choice valve 5, the quantitative loop 93 of six-way valve 9 is full of sample at this time, by logical to six
The switching of valve 9 makes the port of upside two and 93 unicom of quantitative loop, liquid chromatograph etc. access the inspection of 9 two ports in upside of six-way valve
Instrument is surveyed to take sample away.The filtering of complete paired samples and sample introduction process.Wherein filtering sieve plate can be replaced not according to filtration needs
With the sieve plate of aperture unlike material.
Backwash process：According to demand, specific different backwash reagent bottles are connected on the backwash mouth of multi-path choice valve 5
7 (being 4 in Fig. 1), for the emulsion sample such as milk, backwash solvent bottle 7 includes NaOH bottles, CH3COOH bottles and mobile phase
Bottle, wherein be the NaOH solution of 3moL/L, the CH in NaOH bottles described3It is 0.6% CH in COOH bottles3COOH solution, institute
State in mobile phase bottle is 2.4mmoL/L Na2CO3、2.0mmoL/L NaHCO3With the mixed solution of 5% acetone.Backwash sequence
For NaOH bottles, CH3COOH bottles, mobile phase bottle.NaOH bottles, CH are drawn successively by the syringe of syringe pump 63COOH bottles and flowing
After the reagent of phase bottle, multi-path choice valve 5 switches flow path, and the reagent of absorption is squeezed by injection port and caches pipe 11 by syringe, then into
Enter six-way valve 10, then enter to walk liquid pipeline 21, cocurrent opens ultrasonic vibrator 3, pass through ultrasonic vibrator 3 through sieves plate 22
The impurity for filtering sieve plate 22 is removed, while can also remove remaining impurity in six-way valve 9 and syringe pump 6 by effect, by sample introduction
Needle 8 flows into waste liquid tank, completes the flushing to filtering sieve plate.Wherein, NaOH solution, CH3COOH solution is used for milkiness such as milk
The substances such as high molecular weight protein and fat in the residue of liquid sample dissociate, and facilitate and rinse out residue；In order to facilitate next time
Mobile phase is full of whole device, prevents sour interference by sample introduction.
Invention described above embodiment is not intended to limit the scope of the present invention..
Those skilled in the art will readily occur to its of the present invention after considering specification and putting into practice the disclosure invented here
Its embodiment.The present invention is directed to cover the present invention any variations, uses, or adaptations, these modifications, purposes or
Person's adaptive change follows the general principle of the present invention and includes undocumented common knowledge in the art of the invention
Or conventional techniques.The description and examples are only to be considered as illustrative, and true scope and spirit of the invention are wanted by right
It asks and points out.
Claims (7)
1. it is a kind of can on-line cleaning emulsion sample residues filter device, which is characterized in that including sample injection bottle (1), filtering
Device (2), ultrasonic vibrator (3), sample introduction needle (8), multi-path choice valve (5), syringe pump (6) and backwash solvent bottle (7),
It is connected with away liquid pipeline (21) in the filter (2), filtering sieve plate (22) is installed in the filter (2), it is described
Ultrasonic vibrator (3) is installed on the filter (2)；
The sample injection bottle (1) is connected to sample feeding pipe (4) by sample introduction needle (8), and liquid pipeline is walked described in sample feeding pipe (4) connection
(21)；
The multi-path choice valve (5) is equipped with injection pumping hole (51), backwash mouth (52) and sample port (53), respectively corresponding connection
The syringe pump (6), backwash solvent bottle (7) and caching pipe (10).
2. it is according to claim 1 can on-line cleaning emulsion sample residues filter device, which is characterized in that it is described
It includes NaOH bottles, CH to backwash solvent bottle (7)3COOH bottles and mobile phase bottle, wherein be the NaOH of 3moL/L in NaOH bottles described
Solution, the CH3It is 0.6% CH in COOH bottles3COOH solution is 2.4mmoL/L Na in the mobile phase bottle2CO3、
2.0mmoL/L NaHCO3With the mixed solution of 5% acetone.
3. it is according to claim 2 can on-line cleaning emulsion sample residues filter device, which is characterized in that it is described
The backwash sequence for backwashing solvent bottle (7) is NaOH bottles, CH3COOH bottles, mobile phase bottle.
4. it is according to claim 1 can on-line cleaning emulsion sample residues filter device, which is characterized in that also wrap
Six-way valve (9) is included, the six-way valve (9) is equipped with six interfaces being connected to two-by-two, wherein the injection port of the six-way valve (9)
(91) liquid pipeline (21) is walked described in connection, one end of outlet (92) connection caching pipe (11) is described to cache the another of pipe (10)
End is connected to the sample port (53).
5. it is according to claim 4 can on-line cleaning emulsion sample residues filter device, which is characterized in that it is described
Quantitative loop (93) is additionally provided on six-way valve (9).
6. it is according to claim 1 can on-line cleaning emulsion sample residues filter device, which is characterized in that also wrap
Sample disc (11) is included, several placement holes (111) are offered on the sample disc (11), the sample injection bottle (1) is positioned over described
In placement hole (111).
7. it is according to claim 1 can on-line cleaning emulsion sample residues filter device, which is characterized in that also wrap
Include waste liquid tank (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810499586.9A CN108704391A (en) | 2018-05-23 | 2018-05-23 | It is a kind of can on-line cleaning emulsion sample residues filter device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810499586.9A CN108704391A (en) | 2018-05-23 | 2018-05-23 | It is a kind of can on-line cleaning emulsion sample residues filter device |
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| Publication Number | Publication Date |
|---|---|
| CN108704391A true CN108704391A (en) | 2018-10-26 |
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ID=63869290
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810499586.9A Pending CN108704391A (en) | 2018-05-23 | 2018-05-23 | It is a kind of can on-line cleaning emulsion sample residues filter device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113588612A (en) * | 2021-07-27 | 2021-11-02 | 中国科学院成都生物研究所 | ATP (adenosine triphosphate) online detection method and device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204116276U (en) * | 2014-09-18 | 2015-01-21 | 上海通微分析技术有限公司 | The liquid conveying system of full-automatic capillary electrophoresis apparatus |
| CN104690047A (en) * | 2013-12-10 | 2015-06-10 | 中国科学院大连化学物理研究所 | Liquid chromatographic sampling passage cleaning device |
| CN206252900U (en) * | 2016-12-15 | 2017-06-16 | 东北石油大学 | A kind of new type ultrasonic back purge system |
| CN208372645U (en) * | 2018-05-23 | 2019-01-15 | 青岛盛瀚色谱技术有限公司 | It is a kind of can multi-solvent back flush pipeline on-line filtration device |
-
2018
- 2018-05-23 CN CN201810499586.9A patent/CN108704391A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104690047A (en) * | 2013-12-10 | 2015-06-10 | 中国科学院大连化学物理研究所 | Liquid chromatographic sampling passage cleaning device |
| CN204116276U (en) * | 2014-09-18 | 2015-01-21 | 上海通微分析技术有限公司 | The liquid conveying system of full-automatic capillary electrophoresis apparatus |
| CN206252900U (en) * | 2016-12-15 | 2017-06-16 | 东北石油大学 | A kind of new type ultrasonic back purge system |
| CN208372645U (en) * | 2018-05-23 | 2019-01-15 | 青岛盛瀚色谱技术有限公司 | It is a kind of can multi-solvent back flush pipeline on-line filtration device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113588612A (en) * | 2021-07-27 | 2021-11-02 | 中国科学院成都生物研究所 | ATP (adenosine triphosphate) online detection method and device |
| CN113588612B (en) * | 2021-07-27 | 2023-08-01 | 中国科学院成都生物研究所 | ATP (adenosine triphosphate) on-line detection method and equipment |
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