CN108694380A - Droplet generates quality determining method, device, computer equipment and storage medium - Google Patents
Droplet generates quality determining method, device, computer equipment and storage medium Download PDFInfo
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Abstract
This application involves a kind of droplets to generate quality determining method, system, computer equipment and storage medium.The method includes:Obtain the scattering waveform signal of droplet to be detected;Scattering waveform signal is handled, the wave character of extraction scattering waveform signal;The generation quality testing information of droplet to be detected is obtained according to wave character.Using this method by extracting wave character from the scattering lightwave signal of droplet to be detected, and obtain generating quality testing information for when monitoring droplet generating process, the real time monitoring for generating quality to droplet can be realized while quick obtaining scatters lightwave signal, be effectively improved the efficiency that droplet generates quality testing.
Description
Technical field
This application involves microfluidic arts, and quality determining method, device, calculating are generated more particularly to a kind of droplet
Machine equipment and storage medium.
Background technology
Micro-fluidic (Microfluidics) is referred to using microchannel (size is tens of to hundreds of microns) processing or is manipulated
Science and Technology involved by the system of minute fluid.Droplet generation in micro-fluidic at present is all based on micro-fluidic generation chip
It carries out, it can generate the droplet unit largely disperseed and be used as microreactor in a short time, enhance micro-fluidic life significantly
The advantages that at the high sensitivity of chip, low consumption, high throughput and automation.
However, the droplet of micro-fluidic generation gives droplet matter since small, generating rate is fast, generates the features such as channel is narrow
The problem of amount detection brings many blind spots, can cause that quality of microdropletes in droplet generating process can not be effectively monitored.Have at present logical
It crosses high speed camera and carries out whole recording, then the data of storage are on a frame-by-frame basis played to quality of microdropletes in observation droplet generating process
Monitor mode, but be observed needs frame by frame and take a significant amount of time, the efficiency that droplet generates quality testing is low.
Invention content
Based on this, it is necessary to which in view of the above technical problems, droplet generation quality testing effect can be effectively improved by providing one kind
The droplet of rate generates quality determining method, device, computer equipment and storage medium.
A kind of droplet generation quality determining method, this method include:
Obtain the scattering waveform signal of droplet to be detected;
Scattering waveform signal is handled, the wave character of extraction scattering waveform signal;
The generation quality testing information of droplet to be detected is obtained according to wave character.
The step of scattering waveform signal for obtaining droplet to be detected in one of the embodiments, includes:
Acquire the scattered light signal of droplet to be detected;
Opto-electronic conversion is carried out to scattered light signal, obtains scattering photosignal;
Scattering photosignal is pre-processed, scattering waveform signal is obtained.
Scattering waveform signal is handled in one of the embodiments, the waveform of extraction scattering waveform signal
The step of feature includes:
The corresponding wave band of each droplet to be detected is divided according to the amplitude of scattering waveform signal;
Wave character is extracted according to the corresponding wave band of droplet to be detected, wave character includes in moment value, pulsewidth and amplitude
At least one.
The step of generation quality testing information of droplet to be detected is obtained according to wave character in one of the embodiments,
Including:
Quality testing parameter is obtained according to wave character, quality testing parameter characterization generates quality testing information.
Wave character includes moment value, pulsewidth and amplitude in one of the embodiments, is obtained according to wave character to be checked
Micrometer drop generation quality testing information the step of include:
According to the formation speed for being worth to droplet to be detected constantly;
Corresponding formation speed figure is drawn, pulsewidth figure is generated and generates amplitude figure according to formation speed, pulsewidth and amplitude, it is raw
At hodograph, generates pulsewidth figure and generate amplitude chart sign generation quality testing information.
Further include in one of the embodiments,:
When determining the abnormal quality of droplet to be detected according to generation quality testing information, abnormal prompt message is sent out.
A kind of droplet generation quality detection device, the device include:
Signal acquisition module, the scattering waveform signal for obtaining droplet to be detected;
Characteristic extracting module, for handling scattering waveform signal, the waveform of extraction scattering waveform signal is special
Sign;
Quality detection module, the generation quality testing information for obtaining droplet to be detected according to wave character.
Characteristic extracting module includes in one of the embodiments,:
Band dividing unit, for dividing the corresponding wave band of each droplet to be detected according to the amplitude of scattering waveform signal;
Feature extraction unit, for extracting wave character according to the corresponding wave band of droplet to be detected, when wave character includes
Quarter value, at least one of pulsewidth and amplitude.
A kind of computer equipment, including memory, processor and storage can be run on a memory and on a processor
Computer program, processor realize following steps when executing computer program:
Obtain the scattering waveform signal of droplet to be detected;
Scattering waveform signal is handled, the wave character of extraction scattering waveform signal;
The generation quality testing information of droplet to be detected is obtained according to wave character.
A kind of computer readable storage medium is stored thereon with computer program, when computer program is executed by processor
Realize following steps:
Obtain the scattering waveform signal of droplet to be detected;
Scattering waveform signal is handled, the wave character of extraction scattering waveform signal;
The generation quality testing information of droplet to be detected is obtained according to wave character.
Above-mentioned droplet generates quality determining method, device, computer equipment and storage medium, by obtaining droplet to be detected
Scattering waveform signal, and from scattering waveform signal in extract wave character, obtain micrometer to be checked further according to wave character
The generation quality testing information of drop.By extracting wave character from the scattering lightwave signal of droplet to be detected, and generated
Quality testing information while quick obtaining scatters lightwave signal for that when monitoring droplet generating process, can realize to droplet
The real time monitoring for generating quality is effectively improved the efficiency that droplet generates quality testing.
Description of the drawings
Fig. 1 is the applied environment figure that droplet generates quality determining method in one embodiment;
Fig. 2 is the flow diagram that droplet generates quality determining method in one embodiment;
Fig. 3 is that waveform signal graph is scattered in one embodiment;
Fig. 4 is optical detecting module structural schematic diagram in one embodiment;
Fig. 5 is the flow diagram that droplet generates quality determining method in another embodiment;
Fig. 6 is that quality testing parameter schematic diagram is generated in one embodiment;
Fig. 7 is droplet formation speed statistical chart to be detected in one embodiment;
Fig. 8 is droplet formation speed statistical chart to be detected in another embodiment;
Fig. 9 is droplet pulsewidth statistical chart to be detected in one embodiment;
Figure 10 is droplet amplitude statistical chart to be detected in one embodiment;
Figure 11 is the structure diagram that droplet generates quality detection device in one embodiment;
Figure 12 is the application schematic diagram that droplet generates quality detection device in another embodiment;
Figure 13 is the internal structure chart of one embodiment Computer equipment.
Specific implementation mode
It is with reference to the accompanying drawings and embodiments, right in order to make the object, technical solution and advantage of the application be more clearly understood
The application is further elaborated.It should be appreciated that specific embodiment described herein is only used to explain the application, not
For limiting the application.
Fig. 1 is the schematic diagram of the droplet generating platform of one embodiment.As shown in Figure 1, droplet generating platform is by nitrogen cylinder
Output nitrogen carries out Isobarically Control and controls water phase and oil phase respectively, is generated by micro-fluidic droplet generation chip and exports droplet.
Droplet generating platform is an extensive platform of application field, such as the number for carrying out absolute quantitation to nucleic acid molecules number
In the fields such as PCR instrument and other high-flux sequences, cell separation and culture, can it use needed for the generation of droplet generating platform
Droplet.In the application, quality detection device is generated to droplet generation by the way that a droplet is arranged on existing droplet generating platform
Micro-fluidic droplet generates chip and generates the droplet progress quality testing of output in platform, and exports and generate quality testing information.
In one embodiment, as shown in Fig. 2, providing a kind of droplet generation quality determining method, this method can lead to
It crosses droplet shown in FIG. 1 and generates quality detection device execution, include the following steps:
Step S201 obtains the scattering waveform signal of droplet to be detected.
Scattering waveform signal is the laser waveform letter that micro-fluidic droplet generates the droplet to be detected reflection generated in chip
Number, scattering waveform signal can reflect the size of each droplet, formation speed and droplet generate whether the generating process such as uniform
Quality information can obtain the generation information of droplet to be detected in real time by obtaining the scattering waveform signal, when such as generating
Between, each moment amplitude etc..
In addition, scattering waveform signal can realize Quick Acquisition, a large amount of in droplet and high fast-growing by optical detector
Cheng Shi, it is ensured that acquire the real-time and reliability of signal.In the droplet generation system implemented at one, it can pass through
It is generated on chip if laser is got to micro-fluidic droplet by a laser, when droplet to be detected of Laser emission to micro-fluidic generation is sent out
Raw reflex, sends out scattered light signal, scattered light signal is carried out photoelectric processing and analog-to-digital conversion, is filtered etc. and is pre-
Smooth scattering waveform signal is obtained after processing.If Fig. 3 is the scattering waveform signal graph obtained in an embodiment, by figure
As can be seen that can reflect that generated time, volume size of each droplet to be detected etc. generate information in scattering waveform signal.
Step S202 handles scattering waveform signal, the wave character of extraction scattering waveform signal.
After obtaining scattering waveform signal, therefrom extraction characterizes the wave character that droplet to be detected generates information.Waveform is special
Sign can include but is not limited to amplitude, pulsewidth and the moment value etc. of the corresponding scattering waveform signal of droplet to be detected.Such as Fig. 3 institutes
The scattering waveform signal graph shown, wave character may include amplitude, pulsewidth and the moment value for scattering waveform signal, wherein
The volume size that amplitude and pulsewidth are used to characterize droplet to be detected then shows corresponding micrometer to be checked if amplitude is bigger with pulsewidth
The volume of drop is bigger;Moment value characterizes the time span of droplet to be detected, can further be obtained according to moment value to be detected
The formation speed of droplet.According to the wave character of scattering waveform signal, the generation quality of droplet to be detected can be quickly learnt
Information.
Step S203 obtains the generation quality testing information of droplet to be detected according to wave character.
After extraction obtains the wave character of scattering waveform signal, droplet to be detected is further obtained according to the wave character
Generation quality testing information.Specifically, quality testing parameter can be obtained according to wave character, quality testing parameter can be
Parameter after being counted according to the wave character such as can include but is not limited to stability bandwidth, the CV of wave character
The parameters such as (Coefficient of Variance, the coefficient of variation), mean value, intermediate value and standard deviation, wherein stability bandwidth reflects
The degree of stability of droplet generating process to be detected, CV are defined as the ratio between standard deviation and average value, reflect droplet waveform to be detected
The dispersion degree of feature, stability bandwidth and CV are bigger, then show that every wave character of droplet to be detected more disperses, generating process
It is more unstable.In one is specifically applied, if wave character is amplitude, then according to the amplitude obtain the stability bandwidth of amplitude, CV,
The quality testings parameter such as mean value, intermediate value and standard deviation, it is hereby achieved that the generation quality testing information of droplet amplitude to be detected,
The real-time monitoring to droplet amplitude is realized with this.
Above-mentioned droplet generates in quality determining method, by obtaining the scattering waveform signal of droplet to be detected, and from dissipating
It penetrates in waveform signal and extracts wave character, the generation quality testing information of droplet to be detected is obtained further according to wave character.It is logical
It crosses and extracts wave character from the scattering lightwave signal of droplet to be detected, and obtain generating quality testing information for monitoring droplet
When generating process, the real time monitoring that quality is generated to droplet can be realized while quick obtaining scatters lightwave signal, effectively
Ground improves the efficiency that droplet generates quality testing.
Further, the step of scattering waveform signal for obtaining droplet to be detected includes:Acquire dissipating for droplet to be detected
Penetrate optical signal;Opto-electronic conversion is carried out to scattered light signal, obtains scattering photosignal;Scattering photosignal is pre-processed,
Obtain scattering waveform signal.
The scattered light signal of droplet to be detected is acquired, micro-fluidic droplet can be arrived by installing optical detecting module additional setting
It generates on chip, adjusts the angle, so that micro-fluidic droplet is generated the droplet generated in chip and meet optical projection condition, by laser
When reaching micro-fluidic droplet generation chip, droplet reflects scattered light signal and is received by optical detecting module.
As shown in figure 4, optical detecting module includes mainly laser emitting module and detector for scattered light, droplet is micro-fluidic
When being moved in droplet generation chip, the laser of laser emitting module sends out laser, is reflected by half-reflection and half-transmission light splitting piece micro-
In drop, after laser is reflected by droplet, scattered light signal is received by light splitting piece by detector for scattered light.Collect scattered light signal
Afterwards, to scattered light signal carry out opto-electronic conversion, in the form of by electric signal by the generation information of the droplet to be checked of acquisition into
The remote transmission of row.Specifically, scattered light signal opto-electronic conversion can be obtained into scattering photoelectricity by photoelectric signal transforming module
Signal.Finally scattering photosignal is pre-processed, obtains smooth scattering waveform signal.Wherein, pretreatment includes AD
The processing such as conversion, filtering, so that scattering waveform signal is easier to extraction wave character.
Further, as shown in figure 5, providing droplet in another embodiment generates quality determining method.Compared to Fig. 2
Illustrated embodiment in the present embodiment, is handled scattering waveform signal, the wave character of extraction scattering waveform signal
Step may include:
Step S501 divides the corresponding wave band of each droplet to be detected according to the amplitude of scattering waveform signal.
The scattering waveform signal of acquisition is the signal waveform of Time Continuous comprising the waveform of each droplet to be detected is believed
Number, so the corresponding wave band of each droplet to be detected is divided according to the amplitude of scattering waveform signal first, it is each to be checked to extract
Corresponding wave band is dripped in micrometer.Specifically, the range value of scattering waveform signal can be determined in no droplet, and is with this value
Reference value, when the range value of the scattering waveform signal acquired in detection process is more than the wave band of the reference value, you can divide
For a droplet.By taking scattering waveform signal graph shown in Fig. 3 as an example, when no droplet is scattered laser, amplitude
Value is about 2500 units, once may determine that figure includes 13 complete scattering waveforms, corresponds respectively to 13 and wait for
Droplet is detected, the wave band of each droplet to be detected is the wave band that range value is more than 2500 units.By being incited somebody to action according to range value
The corresponding wave band of each droplet to be detected marks off in scattering waveform signal, further to extract the waveform of each droplet to be detected
Feature.
Step S502 extracts wave character according to the corresponding wave band of droplet to be detected, and wave character includes moment value, pulsewidth
At least one of with amplitude.
After marking off the corresponding wave band of each droplet to be detected, the wave character of each droplet to be detected is extracted according to the wave band,
Wave character may include at least one of moment value, pulsewidth and amplitude.Wherein, moment value is the scattering light of droplet to be detected
Each amplitude of waveform signal corresponding time point is worth span, it may be determined that be detected at the time of according to the wave band of each droplet to be detected
The formation speed of droplet;Pulsewidth can reflect that the size of droplet to be detected, droplet to be detected generate chip in micro-fluidic droplet
When middle mobile, terminate from starting to reflect scattered light signal to reflection, as the pulsewidth size of the droplet to be detected;Amplitude reflects
The volume of droplet to be detected, that is, also reflect the size of droplet, laser is when being irradiated to droplet, due to the radian of laser surface
It is of different sizes, the waveform signal of different amplitudes is will produce, it is possible thereby to learn the volume size of droplet.The wave character of extraction can
To include simultaneously moment value, pulsewidth and amplitude, any of which or a variety of can also be obtained as required.
Further, the step of generation quality testing information that droplet to be detected is obtained according to wave character includes:According to
Wave character obtains quality testing parameter, and quality testing parameter characterization generates quality testing information.
Specifically, after obtaining wave character, quality testing parameter, quality testing ginseng are further obtained according to the wave character
Number can include but is not limited to the stability bandwidths of wave character, CV (Coefficient of Variance, the coefficient of variation), mean value,
The parameters such as intermediate value and standard deviation.Wherein, stability bandwidth reflects the degree of stability of droplet generating process to be detected, and CV is defined as standard
The ratio between difference and average value, reflect the dispersion degree of droplet waveform feature to be detected, stability bandwidth and CV are bigger, then show to be detected
Every wave character of droplet more disperses, and generating process is more unstable.Pass through quality testing parameter characterization droplet to be detected
Quality testing information is generated, the generation information quantification of droplet to be detected more efficient can accurately can be realized and be treated
The monitoring for detecting droplet compares to generate the longitudinal of different batches to droplet, can also play reference role.In concrete application
In, it can be calculated in real time or with a predetermined period and show quality testing parameter.As shown in Figure 6, it is shown that for pulsewidth and width
The stability bandwidth of value, the statistics of mean value, standard deviation and CV, wherein p are the abbreviation of pulsewidth, and expression is the relevant parameter of pulsewidth, and a is
The abbreviation of amplitude, expression is the relevant parameter of amplitude.
Further, wave character includes moment value, pulsewidth and amplitude, and the life of droplet to be detected is obtained according to wave character
Include at the step of quality testing information:According to the formation speed for being worth to droplet to be detected constantly;According to formation speed, pulsewidth
Corresponding formation speed figure is drawn, pulsewidth figure is generated and generates amplitude figure with amplitude, formation speed figure generates pulsewidth figure and generation
Amplitude chart sign generates quality testing information.
Wherein, wave character includes moment value, pulsewidth and amplitude, at this point it is possible to be calculated according to moment value to be detected
The formation speed of droplet, and corresponding formation speed figure, generation pulsewidth figure and generation are drawn according to formation speed, pulsewidth and amplitude
Amplitude figure, formation speed figure generate pulsewidth figure and generate amplitude figure, generate quality testing information to characterize, make to droplet
Monitoring is more intuitive.
Specifically, as Figure 7-8, the droplet number of generation per second has been counted, wherein abscissa is time, ordinate
For droplet number.Phenomena such as whether droplet generating process blocks may determine that by the way that whether droplet formation speed is gentle etc.,
As occur in channel pressure it is unbalanced or due to block cause unstable situation.As shown in fig. 7, there is droplet generating rate
The case where shake, shows that unstable situation occurs for droplet generating process;And if droplet generating process is normal, droplet formation speed
Figure meeting image as shown in Figure 8 is smoother.
As shown in figure 9, abscissa is generated time, ordinate is pwm value.By uniting to the pulsewidth for generating droplet
Meter, it can be seen that whether uniform in size, micro- if generating process does not occur to block or situations such as impurity if generating droplet in generating process
Drop pulsewidth performance can concentrate very much, such as caused blockages in pressure transient in droplet generating process or generation chip, then can
There is the size droplet situation as shown in the front ends Fig. 9.
As shown in Figure 10, abscissa is generated time, and ordinate is amplitude.In figure, fore-end image is more concentrated, and is gone out
Existing magazine, droplet size is uneven, and the droplet size homogeneity of rear end part image is higher.By to generate droplet amplitude into
Row statistics, it can be seen that whether have impurity appearance, this Shen if being generated in generating process in the homogeneity and generating process of droplet size
What middle please be acquired is scattered light signal, therefore size droplet and impurity can be detected signal, by amplitude signal and pulsewidth
The comparison of signal, it can be determined that whether generating process is smooth.
Further, when generating chip progress droplet generation monitoring to micro-fluidic droplet, the application is not limited to simultaneously
Corresponding formation speed figure is drawn, pulsewidth figure is generated and generates amplitude figure according to wave character, and calculates quality testing parameter, with
Obtain the generation quality testing information of droplet.Wherein, the formation speed figure of drafting, generation pulsewidth figure and generation amplitude figure intuitive
By force, it is apparent to entirely monitor the droplet situation of process, quality testing parameter makes generation quality testing information quantization, can be more accurate
Really realize the monitoring to droplet to be detected.In general droplet generating process, to generating process parameter and quality results are generated
It compares and analyzes, you can judge that the set microfluidic system or micro-fluidic droplet generate the droplet that chip is generated and whether may be used
It takes, to accelerate to judge the result that droplet generates, realizes the feasibility of droplet Mass production.
Further, droplet generation quality determining method further includes:It is to be detected when being determined according to generation quality testing information
When the abnormal quality of droplet, abnormal prompt message is sent out.
After obtaining generating quality testing information, however, it is determined that when the abnormal quality of droplet to be detected, send out abnormal prompt and disappear
Breath, to prompt operating personnel to carry out related adjustment.Specifically, if when quality of microdropletes exception to be detected, prompt can be made a sound,
Or unusual part image is highlighted in the formation speed figure in drafting, generation pulsewidth figure and generation amplitude figure, such as normal portion
Partial image is black, and red display is then marked for unusual part image, can also be highlighted to quality detection parameters, as quality is examined
When surveying abnormal parameters, red display is marked, so that operating personnel can quickly grasp droplet and generate situation, realizes the prison generated to droplet
Control.
Although it should be understood that Fig. 2,5 flow chart in each step shown successively according to the instruction of arrow,
These steps are not that the inevitable sequence indicated according to arrow executes successively.Unless expressly stating otherwise herein, these steps
Execution there is no stringent sequences to limit, these steps can execute in other order.Moreover, at least one in Fig. 2,5
Part steps may include that either these sub-steps of multiple stages or stage are not necessarily in synchronization to multiple sub-steps
Completion is executed, but can be executed at different times, the execution sequence in these sub-steps or stage is also not necessarily successively
It carries out, but can either the sub-step of other steps or at least part in stage be in turn or alternately with other steps
It executes.
In one embodiment, as shown in figure 11, a kind of droplet generation quality detection device is provided, including:Signal obtains
Modulus block, characteristic extracting module and quality detection module, wherein:
Signal acquisition module 111, the scattering waveform signal for obtaining droplet to be detected;
Characteristic extracting module 112, for handling scattering waveform signal, the waveform of extraction scattering waveform signal
Feature;
Quality detection module 113, the generation quality testing information for obtaining droplet to be detected according to wave character.
Further, signal acquisition module 111 includes:Light signal collection unit, the scattering for acquiring droplet to be detected
Optical signal;Photoelectric conversion unit obtains scattering photosignal for carrying out opto-electronic conversion to scattered light signal;Pretreatment unit,
For being pre-processed to scattering photosignal, scattering waveform signal is obtained.
Further, characteristic extracting module 112 includes:Band dividing unit, for the width according to scattering waveform signal
Degree divides the corresponding wave band of each droplet to be detected;Feature extraction unit, for extracting wave according to the corresponding wave band of droplet to be detected
Shape feature, wave character include at least one of moment value, pulsewidth and amplitude.
Further, quality detection module 113 includes:Detection parameters unit, for obtaining quality inspection according to wave character
Parameter is surveyed, quality testing parameter characterization generates quality testing information.
Further, wave character includes moment value, pulsewidth and amplitude, and quality detection module 113 includes:Speed obtains single
Member, for according to the formation speed for being worth to droplet to be detected constantly;Image-drawing unit, for according to formation speed, pulsewidth and width
Value draws corresponding formation speed figure, generates pulsewidth figure and generates amplitude figure, and formation speed figure generates pulsewidth figure and generates amplitude
Chart sign generates quality testing information.
Further, further include:Abnormal prompt unit determines droplet to be detected for working as according to generation quality testing information
Abnormal quality when, send out abnormal prompt message.
Further, as shown in figure 12, droplet generates quality detection device and is applied in droplet generating platform, is given birth to droplet
Quality testing is carried out at the droplet that platform generates.Wherein, droplet generating platform carries out Isobarically Control point by nitrogen cylinder output nitrogen
Not Kong Zhi water phase and oil phase, chip is generated by micro-fluidic droplet and generates and exports droplet.Further, signal acquisition module
111 settings are generated in micro-fluidic droplet on chip, so that quality detection device is had mobility, miniflow can be followed to generate
Platform movement setting.Wherein, the scattered light signal of droplet to be detected is acquired by light signal collection unit, photoelectric conversion unit is used
In carrying out opto-electronic conversion to scattered light signal, scattering photosignal is obtained, pretreatment unit is used to carry out scattering photosignal
Pretreatment obtains scattering waveform signal.Obtained scattering waveform signal is sent to characteristic extracting module by pretreatment unit
112, scattering waveform signal is handled by characteristic extracting module 112, the wave character of extraction scattering waveform signal.Most
The generation quality of droplet to be detected is obtained according to the wave character that characteristic extracting module 112 is sent by quality detection module 113 afterwards
Detection information, to realize the efficient monitoring to droplet generating process in droplet generating platform.
The specific restriction that quality detection device is generated about droplet may refer to generate quality testing above for droplet
The restriction of method, details are not described herein.Above-mentioned droplet generates the modules in quality detection device can be fully or partially through
Software, hardware and combinations thereof are realized.Above-mentioned each module can be embedded in or in the form of hardware independently of the place in computer equipment
It manages in device, can also in a software form be stored in the memory in computer equipment, in order to which processor calls execution or more
The corresponding operation of modules.
In one embodiment, a kind of computer equipment is provided, which can be server, internal junction
Composition can be as shown in figure 13.The computer equipment include the processor connected by system bus, memory, network interface and
Database.Wherein, the processor of the computer equipment is for providing calculating and control ability.The memory packet of the computer equipment
Include non-volatile memory medium, built-in storage.The non-volatile memory medium is stored with operating system, computer program and data
Library.The built-in storage provides environment for the operation of operating system and computer program in non-volatile memory medium.The calculating
The database of machine equipment generates quality testing data for storing droplet.The network interface of the computer equipment is used for and outside
Terminal is communicated by network connection.To realize that a kind of droplet generates quality testing side when the computer program is executed by processor
Method.
It will be understood by those skilled in the art that structure shown in Figure 13, only with the relevant part of application scheme
The block diagram of structure, does not constitute the restriction for the computer equipment being applied thereon to application scheme, and specific computer is set
Standby may include either combining certain components than more or fewer components as shown in the figure or being arranged with different components.
In one embodiment, a kind of computer equipment is provided, including memory, processor and storage are on a memory
And the computer program that can be run on a processor, processor realize following steps when executing computer program:It obtains to be detected
The scattering waveform signal of droplet;Scattering waveform signal is handled, the wave character of extraction scattering waveform signal;Root
The generation quality testing information of droplet to be detected is obtained according to wave character.
Further, following steps are also realized when processor executes computer program:Acquire the scattering light of droplet to be detected
Signal;Opto-electronic conversion is carried out to scattered light signal, obtains scattering photosignal;Scattering photosignal is pre-processed, is obtained
Scatter waveform signal.
Further, following steps are also realized when processor executes computer program:According to the width of scattering waveform signal
Degree divides the corresponding wave band of each droplet to be detected;Wave character, wave character packet are extracted according to the corresponding wave band of droplet to be detected
Include at least one of moment value, pulsewidth and amplitude.
Further, following steps are also realized when processor executes computer program:Quality inspection is obtained according to wave character
Parameter is surveyed, quality testing parameter characterization generates quality testing information.
Further, wave character includes moment value, pulsewidth and amplitude, processor also realized when executing computer program with
Lower step:According to the formation speed for being worth to droplet to be detected constantly;Corresponding life is drawn according to formation speed, pulsewidth and amplitude
It at hodograph, generates pulsewidth figure and generates amplitude figure, formation speed figure, generation pulsewidth figure and generation amplitude chart sign generate quality
Detection information.
Further, following steps are also realized when processor executes computer program:When according to generation quality testing information
When determining the abnormal quality of droplet to be detected, abnormal prompt message is sent out.
In one embodiment, a kind of computer readable storage medium is provided, computer program is stored thereon with, is calculated
Machine program realizes following steps when being executed by processor:Obtain the scattering waveform signal of droplet to be detected;To scattering waveform
Signal is handled, the wave character of extraction scattering waveform signal;The generation matter of droplet to be detected is obtained according to wave character
Measure detection information.
Further, following steps are also realized when computer program is executed by processor:Acquire the scattering of droplet to be detected
Optical signal;Opto-electronic conversion is carried out to scattered light signal, obtains scattering photosignal;Scattering photosignal is pre-processed, is obtained
To scattering waveform signal.
Further, following steps are also realized when computer program is executed by processor:According to scattering waveform signal
Amplitude divides the corresponding wave band of each droplet to be detected;Wave character, wave character are extracted according to the corresponding wave band of droplet to be detected
Including at least one of moment value, pulsewidth and amplitude.
Further, following steps are also realized when computer program is executed by processor:Quality is obtained according to wave character
Detection parameters, quality testing parameter characterization generate quality testing information.
Further, wave character includes moment value, pulsewidth and amplitude, is also realized when computer program is executed by processor
Following steps:According to the formation speed for being worth to droplet to be detected constantly;It is drawn according to formation speed, pulsewidth and amplitude corresponding
Formation speed figure generates pulsewidth figure and generates amplitude figure, and formation speed figure, generation pulsewidth figure and generation amplitude chart sign generate matter
Measure detection information.
Further, following steps are also realized when computer program is executed by processor:When according to generation quality testing letter
When breath determines the abnormal quality of droplet to be detected, abnormal prompt message is sent out.
One of ordinary skill in the art will appreciate that realizing all or part of flow in above-described embodiment method, being can be with
Relevant hardware is instructed to complete by computer program, the computer program can be stored in a non-volatile computer
In read/write memory medium, the computer program is when being executed, it may include such as the flow of the embodiment of above-mentioned each method.Wherein,
Any reference to memory, storage, database or other media used in each embodiment provided herein,
Including non-volatile and/or volatile memory.Nonvolatile memory may include read-only memory (ROM), programming ROM
(PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM) or flash memory.Volatile memory may include
Random access memory (RAM) or external cache.By way of illustration and not limitation, RAM is available in many forms,
Such as static state RAM (SRAM), dynamic ram (DRAM), synchronous dram (SDRAM), double data rate sdram (DDRSDRAM), enhancing
Type SDRAM (ESDRAM), synchronization link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM
(RDRAM), direct memory bus dynamic ram (DRDRAM) and memory bus dynamic ram (RDRAM) etc..
Each technical characteristic of above example can be combined arbitrarily, to keep description succinct, not to above-described embodiment
In each technical characteristic it is all possible combination be all described, as long as however, the combination of these technical characteristics be not present lance
Shield is all considered to be the range of this specification record.
The several embodiments of the application above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, under the premise of not departing from the application design, various modifications and improvements can be made, these belong to the protection of the application
Range.Therefore, the protection domain of the application patent should be determined by the appended claims.
Claims (10)
1. a kind of droplet generates quality determining method, the method includes:
Obtain the scattering waveform signal of droplet to be detected;
The scattering waveform signal is handled, the wave character of the scattering waveform signal is extracted;
The generation quality testing information of the droplet to be detected is obtained according to the wave character.
2. according to the method described in claim 1, it is characterized in that, the scattering waveform signal for obtaining droplet to be detected
Step includes:
Acquire the scattered light signal of the droplet to be detected;
Opto-electronic conversion is carried out to the scattered light signal, obtains scattering photosignal;
The scattering photosignal is pre-processed, the scattering waveform signal is obtained.
3. according to the method described in claim 1, it is characterized in that, described handle the scattering waveform signal, carry
Take it is described scattering waveform signal wave character the step of include:
The corresponding wave band of each droplet to be detected is divided according to the amplitude of the scattering waveform signal;
According to the corresponding wave band extraction of the droplet to be detected wave character, the wave character includes moment value, pulsewidth
At least one of with amplitude.
4. according to the method described in claim 1, it is characterized in that, described obtain the micrometer to be checked according to the wave character
The step of generation quality testing information of drop includes:
Quality testing parameter is obtained according to the wave character, quality testing letter is generated described in the quality testing parameter characterization
Breath.
5. according to the method described in claim 1 to 2 any one, which is characterized in that the wave character includes moment value, arteries and veins
The step of wide and amplitude, the generation quality testing information that the droplet to be detected is obtained according to the wave character includes:
The formation speed of the droplet to be detected is worth to according to the moment;
Corresponding formation speed figure is drawn according to the formation speed, the pulsewidth and the amplitude, generates pulsewidth figure and generation
Amplitude figure, the formation speed figure, the generation pulsewidth figure and the generation amplitude chart levy the generation quality testing information.
6. method according to any one of claims 1 to 4, which is characterized in that further include:
When determining the abnormal quality of the droplet to be detected according to the generation quality testing information, sends out abnormal prompt and disappear
Breath.
7. a kind of droplet generates quality detection device, which is characterized in that described device includes:
Signal acquisition module, the scattering waveform signal for obtaining droplet to be detected;
Characteristic extracting module extracts the wave of the scattering waveform signal for handling the scattering waveform signal
Shape feature;
Quality detection module, the generation quality testing information for obtaining the droplet to be detected according to the wave character.
8. droplet according to claim 7 generates quality detection device, which is characterized in that the characteristic extracting module packet
It includes:
Band dividing unit, for dividing the corresponding wave of each droplet to be detected according to the amplitude of the scattering waveform signal
Section;
Feature extraction unit, for according to the corresponding wave band extraction of the droplet to be detected wave character, the waveform to be special
Sign includes at least one of moment value, pulsewidth and amplitude.
9. a kind of computer equipment, including memory and processor, the memory are stored with computer program, feature exists
In when the processor executes the computer program the step of any one of realization claim 1 to 6 the method.
10. a kind of computer readable storage medium, is stored thereon with computer program, which is characterized in that the computer program
The step of method according to any one of claims 1 to 6 is realized when being executed by processor.
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