CN108693342A - Cervical carcinoma, the detection method of uterine cancer and system - Google Patents
Cervical carcinoma, the detection method of uterine cancer and system Download PDFInfo
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- CN108693342A CN108693342A CN201711414894.9A CN201711414894A CN108693342A CN 108693342 A CN108693342 A CN 108693342A CN 201711414894 A CN201711414894 A CN 201711414894A CN 108693342 A CN108693342 A CN 108693342A
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- 208000002495 Uterine Neoplasms Diseases 0.000 title claims abstract description 45
- 206010046766 uterine cancer Diseases 0.000 title claims abstract description 45
- 238000001514 detection method Methods 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 30
- 210000004291 uterus Anatomy 0.000 claims abstract description 28
- 230000003902 lesion Effects 0.000 claims abstract description 27
- 238000003708 edge detection Methods 0.000 claims abstract description 19
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- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
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- 210000001215 vagina Anatomy 0.000 claims description 2
- 230000008569 process Effects 0.000 abstract description 6
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
Abstract
The present invention provides a kind of cervical carcinoma, the detection method of uterine cancer and systems, are related to biology, microbiological analysis detection field, and method includes:Obtain the micro-image of vaginal fluid;Edge detection is carried out, and fills edge internal voids, to form complete cast-off cells shape;The micro-image in cast-off cells is obtained again and carries out edge detection, obtains nucleus;The area and curvature for calculating cast-off cells then can determine that as cervical carcinoma, uterine cancer;The ovality for calculating cast-off cells then can determine that when the ovality of cast-off cells is less than the first setting value as cervical carcinoma, uterus precancerous lesion;Cast-off cells long term voyage and cast-off cells area ratio are calculated, when cast-off cells long term voyage and cast-off cells area ratio are higher than the second setting value, then can determine that as cervical carcinoma, uterus precancerous lesion early period.Compared to the prior art, the complicated processes such as time of measuring is short, need not dye culture, it is easy, reliable.
Description
Technical field
The present invention relates to biology, microbiological analysis detection fields, more particularly, to the detection side of a kind of cervical carcinoma, uterine cancer
Method and system.
Background technology
Currently, progress cervical carcinoma, the method for uterine cancer detection be not many in clinic, almost without the side of through image identification
Method, it is cytolgical examination (i.e. cervical smear) that application is more at present:Cytolgical examination is that current clinical application is widest
Screening cervix cancer, the main method of uterine cancer.It is to diagnose the one of clinical disease to observe eucaryotic cell structure and metamorphosis
Door subject.TCT (ThinPrep liquid-based cytology test):Collected cell is put into the specimen bottle equipped with cell-preservation liquid by doctor
It is sent to laboratory, film-making process is controlled by computer program.Pathologist can be very clear, makes cervical carcinoma, uterine cancer especially
It is that the diagnosis of precancerous lesion significantly improves.HPV DNA detections:HPV DNA detections are a kind of genetic test modes, according to HPV
Parting predict the risk system of cervical carcinoma, uterus carcinogenesis.Method:Cell, patient are acquired at uterine neck with special small brushes
It is not damaged and painful.The accuracy rate of this method is quite high, but because costly, is usually only used in people at highest risk.Gynecatoptron
It checks:Gynecatoptron is the amplification endoscope between naked eyes and microscope, and cervical surface blood vessel is directly observed by amplifying
The morphosis of epithelium makes diagnosis, is a kind of clinical diagnosis method.When cervical smear inspection notes abnormalities, with regard to that need to do
Vaginoscopy takes several pieces of tissues to send pathologic finding, foundation is provided for operative treatment when necessary to determine lesion.It generally requires
DNA is surveyed in dyeing, measures complicated, long time period.Directly cervical carcinoma is carried out with image, the method for uterine cancer detection is to utilize cloth
Family name's microscope, only needs vaginal fluid, so that it may to carry out artificial detection.Certain Bu Shi microscopes can also be to everyone body
Present situation, disease risk and future trend are analyzed and are assessed, and most direct, clear, examining timely and accurately is provided to diagnosis person
Disconnected image and opinion, from see on color/graphics cell in blood, blood platelet, bacterium, fungi and parasite etc. solid shape,
The variations such as structure and quantity the case where by observing vivo oxidation free radical and trace existing for free radical, are judged with this
Tumour, inflammation, Cardial or cerebral vascular diseases, endocrine system disease, allergy and cervical spondylosis etc., in a few minutes can be to the body shape of human body
Condition does an accurate, comprehensive assessment,
It is checked at present by microscopic system, is all that cervical carcinoma, uterine cancer are judged by artificialvision's observation
, this is because image automatic identification technology is also unqualified, cannot automatic decision, can only manually judge.Due to cell area
Artificial calculate is difficult accurate, as qualitative analysis, is also possible, but is used for quantitative analysis, and accuracy or difficulty are met the requirements
's.Front several method is used for analyzing detection cervical carcinoma, uterine cancer is effective, but for carrying out cervical carcinoma, uterus precancerosis
Become detection, then precision is relatively low, is primarily due to cervical carcinoma, uterus precancerous lesion, needs to detect cast-off cells core and cell face
The ratio between product, preceding several technologies can not also accurate measurement cell and nuclear area.Cervical carcinoma, uterus cancer morbidity rise year by year,
Having become influences a big killer of women's health, and more getting up early detects cervical carcinoma, uterus precancerous lesion, can more early therapeutic intervention,
Curative effect is better, and detects cervical carcinoma, uterus precancerous lesion, this is also a hard nut to crack, and cannot also in the prior art
Accomplish the method measured by MIcrosope image come automatic measurement, practical degree be also not achieved, can only indirect method measure, precision
It is low, process is complicated.
Invention content
The purpose of the present invention is to provide a kind of cervical carcinoma, the detection method of uterine cancer and systems, to solve the prior art
In manually observe cytological inspection method (i.e. cervical smear), it is existing with the naked eye to go to judge cast-off cells core and fall off thin
The difficulty of born of the same parents' area ratio, the low problem of process complexity, long time period, the accuracy of detection of detection.
A kind of cervical carcinoma provided by the invention, the detection method of uterine cancer, including:
Obtain the micro-image of vaginal fluid;
Edge detection is carried out, and fills edge internal voids, to form complete cast-off cells shape;
The micro-image in cast-off cells is obtained again and carries out edge detection, obtains nucleus;
The area and curvature for calculating cast-off cells then can determine that as cervical carcinoma, uterine cancer;
The ovality for calculating cast-off cells, when the ovality of cast-off cells be less than the first setting value when, then can determine that for
Cervical carcinoma, uterus precancerous lesion;
Cast-off cells long term voyage and cast-off cells area ratio are calculated, when cast-off cells long term voyage and cast-off cells area
The ratio between when being higher than the second setting value, then can determine that as cervical carcinoma, uterus precancerous lesion early period.
In the above-mentioned technical solutions, further, the method for obtaining the micro-image of vaginal fluid is:
Microscopic system obtains vaginal secretion object image;
Image is acquired by the video heads being fixed on microscopic system, after being converted into electric signal, is transmitted to analysis module.
In the above-mentioned technical solutions, further, image segmentation is carried out by the method for automatic correction threshold, improves side
The accuracy of edge detection.
In addition, the application also provides a kind of cervical carcinoma, the detecting system of uterine cancer, including:
Microscopic system, the microscopic system are used to obtain the micro-image of vaginal fluid;
Image information collecting module, described image information acquisition module are connect with microscopic system, for receiving and locating
Manage micro-image;
Analysis module, the analysis module are connect with image information collecting module and control module, for analyzing acquisition
Vaginal fluid micro-image;Edge detection is carried out to the vaginal fluid in micro-image, and fills edge internal voids, with
Form complete cast-off cells shape;The micro-image in cast-off cells is obtained again and carries out edge detection, obtains nucleus;Meter
The area and curvature for calculating cast-off cells, then can determine that as cervical carcinoma, uterine cancer;The ovality for calculating cast-off cells, when
When the ovality of cast-off cells is less than the first setting value, then it can determine that as cervical carcinoma, uterus precancerous lesion;Calculate cast-off cells
Long term voyage and cast-off cells area ratio, when cast-off cells long term voyage is higher than the second setting value with cast-off cells area ratio,
It is then cervical carcinoma, uterus precancerous lesion early period;
Output module, the output module are connect with analysis module, the analysis result for exporting analysis module.
In the above-mentioned technical solutions, further, the output module is printer.
In the above-mentioned technical solutions, further, the microscopic system further includes that can realize auto-translating and focusing
Three axis move objective table automatically.
In the above-mentioned technical solutions, further, the microscopic system includes that microscope and lens group are constituted, described
Microscope group is connect with microscope, and the video heads are fixed in lens group.
In the above-mentioned technical solutions, further, the lens group is formed by multiple lens gluings.
In the above-mentioned technical solutions, further, further include control module, the control module one side and analysis module
Connection, on the other hand connect with microscopic system.
In the above-mentioned technical solutions, further, described image information acquisition module is that digital video head or simulation regard
Frequency head.
Compared to the prior art, cervical carcinoma provided by the invention, the detection method of uterine cancer,
1. can more accurately directly be measured in vaginal fluid using image analysis method using method of direct observation
Ovality, curvature and the area of cast-off cells and the area of nucleus, to carry out cervical carcinoma, uterus precancerous lesion early period
With the judgement of cervical carcinoma, uterus precancerous lesion and cervical carcinoma, uterine cancer.It is equivalent to cervical carcinoma, the entire evolution of uterine cancer
Can whole identification records get off, the complicated process such as time of measuring is short, need not dye culture is easy, reliable;Especially palace
Neck cancer, the judgement of uterus precancerous lesion early period and cervical carcinoma, uterus precancerous lesion provide for the early stage of cancer, early early screening
Effective efficiently detection mode, can play early diagnosis, early treatment, early prevention, convenient for saving life with the time.
It is that image recognition technology is direct 2. the present invention is sampled using the micro-image to vaginal fluid
Cast-off cells are analyzed, are a kind of identification of through image to judge the method for cervical carcinoma, uterine cancer.Wherein adopted at uterine neck
Sample can analyze cervical carcinoma, be sampled at uterus, can analyze uterine cancer, distinguish only in the difference of sampling location.
The additional aspect and advantage of the present invention will become apparent in following description section, or practice through the invention
Recognize.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, other drawings may also be obtained based on these drawings.
The flow diagram of cervical carcinoma, the detection method of uterine cancer that Fig. 1 provides for some embodiments of the present application;
The structural schematic diagram of cervical carcinoma, uterine cancer detecting system that Fig. 2 provides for some embodiments of the present application;
The structure of the microscopic system of cervical carcinoma, uterine cancer detecting system that Fig. 3 provides for some embodiments of the present application
Schematic diagram.
Reference numeral:
1- microscopic systems;2- image information collecting modules;3- analysis modules;4- output modules;5- control modules;11-
Microscope;12- lens groups;Tri- axis of 13- moves objective table automatically.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
The every other embodiment that personnel are obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term "center", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for the description present invention and simplify description, do not indicate or imply the indicated device or element must have a particular orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for description purposes only, and is not understood to indicate or imply relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected;It can
Can also be electrical connection to be mechanical connection;It can be directly connected, can also indirectly connected through an intermediary, Ke Yishi
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.
Refering to fig. 1, the present invention provides a kind of cervical carcinoma, the detection method of uterine cancer, including:
In step 110, the micro-image of vaginal fluid is obtained.
Wherein, the equipment for obtaining micro-image is microscopic system 1 and video heads, and microscopic system 1 includes microscope 11
It is constituted with lens group 12, the lens group 12 is connect with microscope 11, and the video heads are fixed in lens group 12.
Wherein, observation object is human vagina's secretion.
In the step 120, edge detection is carried out, and fills edge internal voids, to form complete cast-off cells shape.
Because cast-off cells edge is very fuzzy, if carrying out image segmentation with fixed threshold value, it is difficult to accurately detect side
Edge.Therefore, the present embodiment is the segmentation that image is carried out by the method for automatic correction threshold in image recognition, to ensure to take off
Fall the accuracy of cell edges detection.The method of so-called automatic correction threshold exactly carries out image point with different threshold values
It cuts, different threshold values can obtain different cast-off cells area-graphs, and the selection wherein threshold value of number and area change minimum is average
As optimal threshold.The method that can also select fixed threshold pursues reliability.Select threshold value complete edge detection after, will in
The gap in face is filled up, and a complete cast-off cells shape is reformed into.
In step 130, it then obtains the micro-image in cast-off cells and carries out edge detection, obtain nucleus.
By cast-off cells carry out edge detection after, intramarginal cast-off cells image zooming-out is come out, reselection threshold value into
The edge detection of image obtains the shape of nucleus by existing filtering technique in row cast-off cells edge.
In step 140, the area and curvature for calculating cast-off cells then can determine that as cervical carcinoma, uterine cancer.
In step 150, the ovality of cast-off cells is calculated, when the ovality of cast-off cells is less than the first setting value
When, then it can determine that as cervical carcinoma, uterus precancerous lesion.
In a step 160, cast-off cells long term voyage and cast-off cells area ratio are calculated, when cast-off cells long term voyage with
When cast-off cells area ratio is higher than the second setting value, then it can determine that as cervical carcinoma, uterus precancerous lesion early period.
Compared to the prior art, cervical carcinoma provided by the invention, the detection method of uterine cancer, using method of direct observation, profit
With image analysis method, more accurately the ovality of cast-off cells in vaginal fluid, curvature knead dough directly can be measured
The area of product and nucleus, to carry out cervical carcinoma, uterus precancerous lesion early period and cervical carcinoma, uterus precancerous lesion and uterine neck
The judgement of cancer, uterine cancer.Be equivalent to by cervical carcinoma, the entire evolution of uterine cancer can whole identification records get off, when measurement
Between short, the complicated process such as need not dye culture, it is easy, reliable;Especially cervical carcinoma, uterus precancerous lesion early period and uterine neck
The judgement of cancer, uterus precancerous lesion provides effective efficiently detection mode for the early stage of cancer, early early screening, can play
Early diagnosis, early treatment, early prevention, convenient for saving life with the time.
Referring to Fig.2, the present invention provides cervical carcinoma, the detecting system of uterine cancer, including microscopic system 1, image information are adopted
Collect module 2, analysis module 3 and output module 4.
Microscopic system 1, the microscopic system 1 are used to obtain the micro-image of vaginal fluid;
Refering to Fig. 3, microscopic system 1 includes that microscope 11 and lens group 12 are constituted, the lens group 12 and microscope 11
Connection.
Image information collecting module 2, described image information acquisition module 2 are connect with microscopic system 1, for receive and
Handle micro-image;
In some embodiments, described image information acquisition module 2 is video heads, and video heads are fixed in lens group 12.
Specifically there are two types of modes for video heads:
One is optical signallings to become analog electrical signal by analog video head, is sent in collecting image of computer card, becomes
At the picture signal in computer;Another kind is to be mounted directly digital video head, no longer directly becomes number by image pick-up card
Word signal enters computer, such image definition higher, the distorted signals that do not convert.
Analysis module 3, the analysis module 3 are connect with image information collecting module 2 and control module 5, are obtained for analyzing
The vaginal fluid micro-image taken;Edge detection is carried out to the vaginal fluid in micro-image, and is filled empty inside edge
Gap, to form complete cast-off cells shape;The micro-image in cast-off cells is obtained again and carries out edge detection, obtains cell
Core;The area and curvature for calculating cast-off cells then can determine that as cervical carcinoma, uterine cancer;Calculate the ellipse of cast-off cells
Degree then can determine that when the ovality of cast-off cells is less than the first setting value as cervical carcinoma, uterus precancerous lesion;It calculates de-
Nuclear area and cast-off cells area ratio are fallen, when cast-off cells long term voyage and cast-off cells area ratio are set higher than second
Then it is cervical carcinoma, uterus precancerous lesion early period when value.
Output module 4, the output module 4 are connect with analysis module 3, the analysis result for exporting analysis module 3.
In some embodiments, the output module 4 is printer, and printer prints out the result of analysis,
Including writings and image information.In some embodiments, the output module 4 is display screen, for showing analysis result.
In some embodiments, the microscopic system 1 further includes that can realize that three axis of auto-translating and focusing are automatic
Move objective table 13.
Objective table can be plain stage, can also be that three axis move objective table 13 automatically, objective table uses tri- axis of XYZ
Automatically the objective table moved is, it can be achieved that automatic focusing function of walking on stage automatically, the degree of automation higher.Specifically, XY axis controls
Stage surface moves, and automatic focusing function may be implemented in Z axis, and control Z axis variation acquires corresponding image, it is clear to analyze it
Degree, most clearly position is to focus optimum position.
In some embodiments, lens group 12 is formed by multiple lens gluings.
Cervical carcinoma, the detecting system of uterine cancer further include control module 5,5 one side of the control module and analysis module 3
Connection, on the other hand connect with microscopic system 1.Specifically, it is dynamic to move objective table 13 automatically for three axis of the control of control module 5
Make, realizes adjust automatically focusing.
Finally it should be noted that:The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations;To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that:Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement;And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of cervical carcinoma, the detection method of uterine cancer, which is characterized in that including:
Obtain the micro-image of vaginal fluid;
Edge detection is carried out, and fills edge internal voids, to form complete cast-off cells shape;
The micro-image in cast-off cells is obtained again and carries out edge detection, obtains nucleus;
The area and curvature for calculating cast-off cells then can determine that as cervical carcinoma, uterine cancer;
The ovality for calculating cast-off cells then can determine that when the ovality of cast-off cells is less than the first setting value as uterine neck
Cancer, uterus precancerous lesion;
Cast-off cells long term voyage and cast-off cells area ratio are calculated, when cast-off cells long term voyage and cast-off cells area ratio
When higher than the second setting value, then it can determine that as cervical carcinoma, uterus precancerous lesion early period.
2. cervical carcinoma according to claim 1, the detection method of uterine cancer, which is characterized in that obtain vaginal fluid
The method of micro-image is:
Microscopic system obtains vaginal secretion object image;
Image is acquired by the video heads being fixed on microscopic system, after being converted into electric signal, is transmitted to analysis module.
3. cervical carcinoma according to claim 1, the detection method of uterine cancer, which is characterized in that pass through automatic correction threshold
Method carry out image segmentation, improve the accuracy of edge detection.
4. a kind of cervical carcinoma, the detecting system of uterine cancer, which is characterized in that including:
Microscopic system, the microscopic system are used to obtain the micro-image of vaginal fluid;
Image information collecting module, described image information acquisition module are connect with microscopic system, aobvious for receiving and handling
Micro- image;
Analysis module, the analysis module are connect with image information collecting module and control module, for analyzing the vagina obtained
Secretion micro-image;Edge detection is carried out to the vaginal fluid in micro-image, and fills edge internal voids, to be formed
Complete cast-off cells shape;The micro-image in cast-off cells is obtained again and carries out edge detection, obtains nucleus;It calculates
The area and curvature of cast-off cells then can determine that as cervical carcinoma, uterine cancer;The ovality for calculating cast-off cells, when falling off
When the ovality of cell is less than the first setting value, then it can determine that as cervical carcinoma, uterus precancerous lesion;Calculate cast-off cells core face
Product and cast-off cells area ratio, when cast-off cells long term voyage and cast-off cells area ratio are higher than the second setting value, then for
Cervical carcinoma, uterus precancerous lesion early period;
Output module, the output module are connect with analysis module, the analysis result for exporting analysis module.
5. cervical carcinoma according to claim 4, the detecting system of uterine cancer, which is characterized in that the output module is to beat
Print machine.
6. cervical carcinoma according to claim 4, the detecting system of uterine cancer, which is characterized in that the microscopic system is also
Including that can realize that three axis of auto-translating and focusing move objective table automatically.
7. cervical carcinoma according to claim 4, the detecting system of uterine cancer, which is characterized in that the microscopic system packet
It includes microscope and lens group is constituted, the lens group is connect with microscope, and the video heads are fixed in lens group.
8. cervical carcinoma according to claim 7, the detecting system of uterine cancer, which is characterized in that the lens group is by multiple
Lens gluing forms.
9. cervical carcinoma according to claim 4, the detecting system of uterine cancer, which is characterized in that further include control module, institute
It states control module on the one hand to connect with analysis module, on the other hand be connect with microscopic system.
10. cervical carcinoma according to claim 4, the detecting system of uterine cancer, which is characterized in that described image information collection
Module is digital video head or analog video head.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109975196A (en) * | 2019-03-01 | 2019-07-05 | 深圳大学 | A kind of granulophilocyte detection method and its system |
| CN112378727A (en) * | 2020-12-14 | 2021-02-19 | 湖南莱博赛医用机器人有限公司 | DNA ploid quantitative analysis device based on machine vision and application method thereof |
| CN112378837A (en) * | 2020-09-15 | 2021-02-19 | 深圳市华中生物药械有限公司 | Cervical exfoliated cell detection method and related device |
| CN113570655A (en) * | 2021-06-22 | 2021-10-29 | 厦门理工学院 | Method, device, equipment and storage medium for identifying tumor deterioration degree |
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