CN108686129A - A kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia - Google Patents
A kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia Download PDFInfo
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- CN108686129A CN108686129A CN201810913638.2A CN201810913638A CN108686129A CN 108686129 A CN108686129 A CN 108686129A CN 201810913638 A CN201810913638 A CN 201810913638A CN 108686129 A CN108686129 A CN 108686129A
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Abstract
The present invention relates to a kind of sweet ginseng chrysanthemum essential oil eye stickers of Chinese medicine for treating xerophthalmia, are made of Hydrophillia Babu agent and sweet ginseng chrysanthemum essential oil, and the sweet ginseng chrysanthemum essential oil is by following volumes meter:Seed of feather cockscomb essential oil 4-6ml, butterflybush flower essential oil 4-6ml, chrysanthemum essential oil 8-12ml, Radix Salviae Miltiorrhizae essential oil 8-12ml, Radix Glycyrrhizae essential oil 8-12ml, henon bamboo leaf essential oil 4-6ml, sheathed flower essential oil 4-6ml, fruit of Chinese wolfberry essential oil 4-6ml and rose ethereal oil 4-6ml are uniformly mixed and are made.Each eye mask contains sweet ginseng chrysanthemum essential oil 0.1ml, and eye sticker containing essential oil is made;In use, eye sticker is attached to eye.Raw material of the present invention is commercial product, and abundant raw material, prescription is scientific and reasonable, preparation easy to produce, at low cost, and effect is good, easy to use, is the innovation treated on dry eye drugs, there is good economic and social benefit.
Description
Technical field
The present invention relates to Chinese medicine, especially a kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia.
Background technology
Xerophthalmia refers to that tear matter caused by any reason or amount exception or dynamics are abnormal, is caused under tear film stability
Drop, and with ophthalmic uncomfortable and (or) the general name of a variety of diseases of ocular lesion tissue feature.Also known as angle xerosis of conjunctiva.It is common
Symptom include eyes it is dry and astringent, be easy tired, eye itch, have sticky foreign body sensation, pain burning heat sensation, secretion, fear of wind, photophobia, externally
Boundary's stimulation is very sensitive;Sometimes eyes are too dry, basic oligodacrya, stimulate reflectivity lacrimal secretion instead, and cause usually to shed tears;
More severe case eyes can redness, hyperemia, keratinization, corneal epithelium broken skin and there is filiform to stick, with the passing of time this damage can then make
Angulation conjunctive disorder, and affecting vision, though the existing a variety of drugs for having treatment xerophthalmia, using and curative effect and unsatisfactory,
Therefore, the improvement on treatment dry eye drugs and innovation are imperative.
Invention content
For the above situation, to overcome the defect of the prior art, the purpose of the present invention, which is just to provide, a kind for the treatment of xerophthalmia
The sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine, can effectively solve the problems, such as the medication of dry eye treatment.
The technical solution that the present invention solves is a kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia, it is characterized in that:It is
It is made of Hydrophillia Babu agent and sweet ginseng chrysanthemum essential oil, the Hydrophillia Babu agent is by weight meter:Carbomer:Polyethylene
Alcohol:Gelatin:Polyacrylic acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil be by with
Lower volume meter:Seed of feather cockscomb essential oil 4-6ml, butterflybush flower essential oil 4-6ml, chrysanthemum essential oil 8-12ml, Radix Salviae Miltiorrhizae essential oil 8-12ml, Radix Glycyrrhizae
Essential oil 8-12ml, henon bamboo leaf essential oil 4-6ml, sheathed flower essential oil 4-6ml, fruit of Chinese wolfberry essential oil 4-6ml and rose ethereal oil 4-6ml are mixed
Conjunction is uniformly made;Each eye sticker (is prepared) containing sweet ginseng chrysanthemum essential oil 0.1ml when preparing eye sticker, and eye sticker containing essential oil is made;In use, will
Eye sticker is attached to eye;
The seed of feather cockscomb essential oil is that seed of feather cockscomb was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extracts
It takes, feed liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, extraction temperature 42~50
DEG C, 20~25MPa of extracting pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature,
Obtain seed of feather cockscomb essential oil;
The butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, sheathed flower essential oil, Chinese holly
Matrimony vine essential oil, rose ethereal oil preparation method are the same as seed of feather cockscomb essential oil.
Raw material of the present invention is commercial product, and abundant raw material, prescription is scientific and reasonable, preparation easy to produce, at low cost, effect
It is good, it is easy to use, it is the innovation treated on dry eye drugs, there is good economic and social benefit.
Specific implementation mode
It elaborates with reference to embodiments to the specific implementation mode of the present invention with particular condition in use.
The present invention can be provided by following embodiment:
Embodiment 1:The technical solution that invention solves is a kind of sweet ginseng chrysanthemum essential oil eye of Chinese medicine that treating xerophthalmia
Patch, it is characterized in that:It is made of Hydrophillia Babu agent and sweet ginseng chrysanthemum essential oil, the Hydrophillia Babu agent is by weight meter:
Carbomer:Polyvinyl alcohol:Gelatin:Polyacrylic acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng
Chrysanthemum essential oil is by following volumes meter:Seed of feather cockscomb essential oil 5ml, butterflybush flower essential oil 5ml, chrysanthemum essential oil 10ml, Radix Salviae Miltiorrhizae essential oil 10ml,
Radix Glycyrrhizae essential oil 10ml, henon bamboo leaf essential oil 5ml, sheathed flower essential oil 5ml, fruit of Chinese wolfberry essential oil 5ml and rose ethereal oil 5ml are uniformly mixed
It is made;Each eye sticker (is prepared) containing sweet ginseng chrysanthemum essential oil 0.1ml when preparing eye sticker, and eye sticker containing essential oil is made;In use, eye sticker is pasted
In eye;
The seed of feather cockscomb essential oil is that seed of feather cockscomb was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extracts
It takes, feed liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, extraction temperature 42~50
DEG C, 20~25MPa of extracting pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature,
Obtain seed of feather cockscomb essential oil;
The butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, sheathed flower essential oil, Chinese holly
Matrimony vine essential oil, rose ethereal oil preparation method are the same as seed of feather cockscomb essential oil.
Embodiment 2:A kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia of the present invention, it is characterized in that:It is by hydrophily
Cataplasm and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:It is poly-
Acrylic acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:
Seed of feather cockscomb essential oil 4ml, butterflybush flower essential oil 4ml, chrysanthemum essential oil 8ml, Radix Salviae Miltiorrhizae essential oil 8ml, Radix Glycyrrhizae essential oil 8ml, henon bamboo leaf essential oil
4ml, sheathed flower essential oil 4ml, fruit of Chinese wolfberry essential oil 4ml and rose ethereal oil 4ml, which are uniformly mixed, to be made;Each eye sticker is containing sweet ginseng chrysanthemum essence
Oily 0.1ml (being prepared when preparing eye sticker), is made eye sticker containing essential oil;In use, eye sticker is attached to eye;
The seed of feather cockscomb essential oil, butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, rotation
Cover that flower essential oil, fruit of Chinese wolfberry essential oil, the preparation method is the same as that of Example 1 for rose ethereal oil.
Embodiment 3:A kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia of the present invention, it is characterized in that:It is by hydrophily
Cataplasm and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:It is poly-
Acrylic acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:
Seed of feather cockscomb essential oil 6ml, butterflybush flower essential oil 6ml, chrysanthemum essential oil 12ml, Radix Salviae Miltiorrhizae essential oil 12ml, Radix Glycyrrhizae essential oil 12ml, henon bamboo leaf essential oil
6ml, sheathed flower essential oil 6ml, fruit of Chinese wolfberry essential oil 6ml and rose ethereal oil 6ml, which are uniformly mixed, to be made;Each eye sticker is containing sweet ginseng chrysanthemum essence
Oily 0.1ml (being prepared when preparing eye sticker), is made eye sticker containing essential oil;In use, eye sticker is attached to eye;
The seed of feather cockscomb essential oil, butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, rotation
Cover that flower essential oil, fruit of Chinese wolfberry essential oil, the preparation method is the same as that of Example 1 for rose ethereal oil.
Embodiment 4:A kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia of the present invention, it is characterized in that:It is by hydrophily
Cataplasm and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:It is poly-
Acrylic acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:
Seed of feather cockscomb essential oil 4ml, butterflybush flower essential oil 6ml, chrysanthemum essential oil 8ml, Radix Salviae Miltiorrhizae essential oil 12ml, Radix Glycyrrhizae essential oil 8ml, henon bamboo leaf essential oil
6ml, sheathed flower essential oil 4ml, fruit of Chinese wolfberry essential oil 6ml and rose ethereal oil 4ml, which are uniformly mixed, to be made;Each eye sticker is containing sweet ginseng chrysanthemum essence
Oily 0.1ml (being prepared when preparing eye sticker), is made eye sticker containing essential oil;In use, eye sticker is attached to eye;
The seed of feather cockscomb essential oil, butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, rotation
Cover that flower essential oil, fruit of Chinese wolfberry essential oil, the preparation method is the same as that of Example 1 for rose ethereal oil.
Embodiment 5:A kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia of the present invention, it is characterized in that:It is by hydrophily
Cataplasm and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:It is poly-
Acrylic acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:
Seed of feather cockscomb essential oil 6ml, butterflybush flower essential oil 4ml, chrysanthemum essential oil 12ml, Radix Salviae Miltiorrhizae essential oil 8ml, Radix Glycyrrhizae essential oil 12ml, henon bamboo leaf essential oil
4ml, sheathed flower essential oil 6ml, fruit of Chinese wolfberry essential oil 4ml and rose ethereal oil 6ml, which are uniformly mixed, to be made;Each eye sticker is containing sweet ginseng chrysanthemum essence
Oily 0.1ml (being prepared when preparing eye sticker), is made eye sticker containing essential oil;In use, eye sticker is attached to eye;
The seed of feather cockscomb essential oil, butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, rotation
Cover that flower essential oil, fruit of Chinese wolfberry essential oil, the preparation method is the same as that of Example 1 for rose ethereal oil.
Said medicine compatibility science supports there is moistening skin mutually, disappears and aches antipruritic, heat-clearing improving eyesight, the work(of dispelling fatigue
Effect is very beneficial for treating xerophthalmia, and achieves extraordinary advantageous effects through experiment, and relevant information is as follows:
One, animal experiment:
1 experiment material
1.1 pharmaceutical agent
Eye sticker of the present invention;Tween 80, Tianjin Fu Yu Fine Chemical Co., Ltd;Sodium hyaluronate eye drops, reach to the sky pharmacy
Co., Ltd;Tears detecting filter strip, Tianjin Jingming New Technological Development Co., Ltd.;Benzalkonium chloride, Shanghai Aladdin biochemistry section
Skill Co., Ltd.
1.2 experimental animal
SD rats, SPF grades, half male and half female, quality certification number 37009200008055 provides unit:Jinan friend is happy, and experiment is dynamic
Object breeds Co., Ltd.
1.3 test solutions are prepared
Benza prepares brief step and weighs 0.2g benzalkonium chloride powder, is added in 99.8ml distilled water, stirring
After place for 24 hours, after benzalkonium chloride powder is completely dissolved, with EP pipes dispense, be placed under room temperature and save backup.
Sweet ginseng chrysanthemum essential oil large dosage group is essential oil stoste;Sweet ginseng chrysanthemum essential oil small dose group, by sweet ginseng chrysanthemum essential oil and one times of agent
The atoleine of amount is diluted.
Schirmer is tested:Using disposable lacrimal secretion ophthalmology Test paper, because of rat normal tear fluid secretory volume calibration
Ordinary person is few, so test paper is longitudinally cut into two halves, filter paper one end is bent 5mm, is clipped in conjunctival sac at 1/3 on the inside of rat lower eyelid
Interior, the other end is hung from above outside lower eyelid, is closed your eyes, and filter paper item is taken out after 5min, the length of observation filter paper moistening (does not include anti-
Folding).2. experimental method and result
Rat 60, half male and half female, 180~220g of weight are randomly divided into 5 groups:Blank group, model group, sodium hyaluronate drop
Ocular fluid group, the large and small sweet ginseng chrysanthemum essential oil group of dosage, except the mouse every of blank group every drips 5 μ L 2gL every time-1Benzalkonium chloride, often
It 2 times, the morning 9: 00 and at night 9: 00 each 1 time, continuous modeling 15 days are tested the 10th day assessment dry eyes situation, are tested the 11st day
Morning 9:00, positive controls give rat daily sodium hyaluronate eye drops, and the large and small sweet ginseng chrysanthemum essential oil group of dosage is to rat eye week
It encloses and applies sweet ginseng chrysanthemum essential oil (0.1ml/ is only), continuous use 12 days, in experiment the 22nd day, the morning 9:After 00 gastric infusion 1h, assessment
Dry eyes situation records lacrimal secretion, the results are shown in Table 1;Then rat is put to death, conjunctival tissue in upper eyelid is taken, with conjunctival tissue
(g):The ratio of physiological saline (ml)=1: 9 is homogenized with glass refiner at low temperature.4 DEG C, 3000r/min centrifugations
10min.It takes supernatant in -20 DEG C or less Cord bloods, measures TNF-α and IL-1 β, the results are shown in Table 2;Take intact eye, 4% first
Aldehyde is fixed, paraffin embedding, slice, and Hematoxylin-eosin (HE) dyeing observes cornea tissue morphological change, the results are shown in Table 3.
The sweet influence for joining chrysanthemum essential oil the 22nd day to rat lacrimal secretion of table 1
Compared with model group, * P<0.05, * * P<0.01
It can be seen that from upper table, compared with blank group, model group substantially reduces rat right and left eyes lacrimal secretion (p<0.01),
Illustrate to make xerophthalmia model success.With model group ratio, the sweet ginseng chrysanthemum essential oil group of large and small dosage and sodium hyaluronate eye drops group can be shown
It writes and increases rat right and left eyes lacrimal secretion (p<0.01).
Influence of the sweet ginseng chrysanthemum essential oil of table 2 to TNF-α, IL-1 β levels in cornea of rats tissue
Compared with model group, * P<0.05, * * P<0.01
It can be seen that from upper table, and blank group ratio, TNF-α and IL-1 β are horizontal significantly increases in model group rats cornea tissue
(p<0.01), illustrate local inflammation occur, modeling success.With model group ratio, the large and small dosage group of sweet ginseng chrysanthemum essential oil and sodium hyaluronate
Eye drops group can make IL-1 β in cornea of rats tissue, TNF-α level significantly reduce (p<0.01).
Influence of the sweet ginseng chrysanthemum essential oil of table 3 to rat corneal tissue form
Compared with model group, * P<0.05, * * P<0.01
"-" corneal epithelial cell level is normal, basal cell marshalling,;" ten " corneal epithelial cell level slightly increases
Adding, cells of superficial layer form is substantially neat,;" 10 " corneal epithelial cell level increases, and cells of superficial layer lacks on a small quantity, basal cell
Arrangement is not close;" 10 " corneal epithelial cell level obviously increases, and cells of superficial layer significantly lacks, increased vacuole sample denaturation
Cell, basal cell are disorganized.
It is examined through Ridit, with blank group ratio, notable pathological change (p< occurs in model group rats corneal tissue form;
0.01), illustrate the success of modeling type.With model group ratio, the large and small dosage group of sweet ginseng chrysanthemum essential oil and sodium hyaluronate eye drops group can be shown
Writing improves the pathological change (p< that rat cornea occurs;0.01).
Each group rat corneal tissue morphologic observation is visible:Blank group:Show that corneal epithelium level is clear (5 layers) under mirror,
Cellular morphology is normal from basal layer to surface layer, anterior limiting lamina, corneal stroma, posterior limiting lamina and corneal endothelium marshalling, not
See apparent pathological change.Model group:Show that corneal epithelium level thickens (about 7-9 layers) under mirror, vacuoles within cells are denaturalized common, table
Confluent monolayer cells are reduced, it is seen that a large amount of karyorrhexis cells, accidental corneal stroma Mild edema and telangiectasis.Cornea prezone
Layer, corneal stroma, posterior limiting lamina and corneal endothelium marshalling.Positive group:Show that corneal epithelium level is clear (4-6 layers) under mirror,
Cellular morphology is normal from basal layer to surface layer, anterior limiting lamina, corneal stroma, posterior limiting lamina and corneal endothelium marshalling, not
See apparent pathological change.Large dosage of group:Show that corneal epithelium level is clear (4-6 layers) under mirror, cells of superficial layer karyon increases, vacuole
It is denaturalized accidental, basal layer cell arrangement is lax, and corneal epithelium, anterior limiting lamina, corneal stroma, posterior limiting lamina and corneal endothelium arrange base
This is normal.Small dose group:Show that corneal epithelium level increases under mirror, disorganized, vacuoles within cells are denaturalized common, slight surface layer
Leukopenia, accidental corneal stroma severe edema and inflammatory cell infiltration.Corneal epithelium, anterior limiting lamina, corneal stroma, rear boundary
Layer and corneal endothelium arrangement are normal.
3. brief summary
This research using benzalkonium chloride induced rat dry eye model success, sweet ginseng chrysanthemum essential oil to rat xerophthalmia model have compared with
Good intervention effect.
Two, clinical test:
On the basis of animal experiment ensures safety, essential oil of the present invention, which is clinically tested also to achieve, very satisfied to be had
Beneficial technique effect, data are as follows:
1, the standard of case is selected:
Xerophthalmia is since amount and matter or the fluid dynamics variation of tear cause tear film stability to decline, so as to cause eye
A kind of disease of the symptoms such as portion is dry and astringent, shed tears, foreign body sensation and blurred vision, lower asthenopia.The common eyes of clinical symptoms are dry
Astringent sense, foreign body sensation, burn feeling, gargalesthesia,Photophobia, furious, blurred vision,EyesightFluctuation, asthenopia etc., it is all that there is above-mentioned symptom
Person, the alternatively standard of case.
2, diagnostic criteria
It is all that there is above-mentioned symptom, and make a definite diagnosis after testing, you can it is diagnosed as xerophthalmia, and gives essential oil treatment of the present invention.
3, therapeutic scheme:In treatment, essential oil eye sticker of the present invention is given, daily applies essential oil eye sticker in eye, is divided early
Evening applies twice, 2 weeks 1 courses for the treatment of, and 2 courses for the treatment of count curative effect.
4, efficacy assessment standard:
It is effective:Patient symptom disappears, and the dyeing of cornea is reduced, and > is measured 15mm/5 minutes through multiple Schimer's test;
Effectively:Patient symptom mitigates, and the dyeing of cornea is reduced, and is measured 5~15mm/5 minutes through multiple Schimer's test;In vain:Suffer from
Person's symptom is not improved, and the dyeing of cornea is unchanged or increases, and measures < 5mm/5 minutes through multiple Schimer's test, very
And there is the trend of exacerbation.
5, statistical procedures:
Through the patients with dry eye 62 to making a definite diagnosis, wherein man 30, female 32,26~60 years old age, average 42.6 ±
8.9 year;After being statistically analyzed, effective 35, effective 23, invalid 4, total effective rate 93.5%, getting well for effect is not
Expect.
In short, clear above show that instant component abundant raw material, market are easily bought, compatibility is scientific and reasonable, props up mutually
It holds, with the effect of moistening skin, the pain that disappears is antipruritic, heat-clearing improving eyesight, dispelling fatigue, is very beneficial for treating xerophthalmia, user
Just, effect is good, and high efficiency has no toxic side effect up to 93% or more, and drug safety, curative effect is reliable and stable, is treatment xerophthalmia
Innovation on drug.
Claims (6)
1. a kind of sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine that treating xerophthalmia, it is characterized in that:It is by Hydrophillia Babu agent and sweet ginseng chrysanthemum essence
Oil is made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:Polyacrylic acid=1:1:4:0.1
The eye sticker matched with eye is made in mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:It is by following volumes meter:
Seed of feather cockscomb essential oil 4-6ml, butterflybush flower essential oil 4-6ml, chrysanthemum essential oil 8-12ml, Radix Salviae Miltiorrhizae essential oil 8-12ml, Radix Glycyrrhizae essential oil 8-12ml,
Henon bamboo leaf essential oil 4-6ml, sheathed flower essential oil 4-6ml, fruit of Chinese wolfberry essential oil 4-6ml and rose ethereal oil 4-6ml, which are uniformly mixed, to be made;
Each eye sticker contains sweet ginseng chrysanthemum essential oil 0.1ml, and eye sticker containing essential oil is made;In use, eye sticker is attached to eye;
The seed of feather cockscomb essential oil is that seed of feather cockscomb was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, feed liquid
W/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction pressure
20~25MPa of power, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain seed of feather cockscomb
Essential oil;
The butterflybush flower essential oil, chrysanthemum essential oil, Radix Salviae Miltiorrhizae essential oil, Radix Glycyrrhizae essential oil, henon bamboo leaf essential oil, sheathed flower essential oil, the fruit of Chinese wolfberry
Essential oil, rose ethereal oil preparation method are the same as seed of feather cockscomb essential oil.
2. the sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine for the treatment of xerophthalmia according to claim 1, it is characterized in that:By hydrophily bar cloth
Agent and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:Polypropylene
Acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:Celosia argentea
Sub- essential oil 5ml, butterflybush flower essential oil 5ml, chrysanthemum essential oil 10ml, Radix Salviae Miltiorrhizae essential oil 10ml, Radix Glycyrrhizae essential oil 10ml, henon bamboo leaf essential oil 5ml,
Sheathed flower essential oil 5ml, fruit of Chinese wolfberry essential oil 5ml and rose ethereal oil 5ml, which are uniformly mixed, to be made;Each eye sticker contains sweet ginseng chrysanthemum essential oil
Eye sticker containing essential oil is made in 0.1ml;In use, eye sticker is attached to eye.
3. the sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine for the treatment of xerophthalmia according to claim 1, it is characterized in that:By hydrophily bar cloth
Agent and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:Polypropylene
Acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:Celosia argentea
Sub- essential oil 4ml, butterflybush flower essential oil 4ml, chrysanthemum essential oil 8ml, Radix Salviae Miltiorrhizae essential oil 8ml, Radix Glycyrrhizae essential oil 8ml, henon bamboo leaf essential oil 4ml, rotation
Cover flower essential oil 4ml, fruit of Chinese wolfberry essential oil 4ml and rose ethereal oil 4ml be uniformly mixed be made;Each eye sticker contains sweet ginseng chrysanthemum essential oil
Eye sticker containing essential oil is made in 0.1ml;In use, eye sticker is attached to eye.
4. the sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine for the treatment of xerophthalmia according to claim 1, it is characterized in that:By hydrophily bar cloth
Agent and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:Polypropylene
Acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:Celosia argentea
Sub- essential oil 6ml, butterflybush flower essential oil 6ml, chrysanthemum essential oil 12ml, Radix Salviae Miltiorrhizae essential oil 12ml, Radix Glycyrrhizae essential oil 12ml, henon bamboo leaf essential oil 6ml,
Sheathed flower essential oil 6ml, fruit of Chinese wolfberry essential oil 6ml and rose ethereal oil 6ml, which are uniformly mixed, to be made;Each eye sticker contains sweet ginseng chrysanthemum essential oil
Eye sticker containing essential oil is made in 0.1ml;In use, eye sticker is attached to eye.
5. the sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine for the treatment of xerophthalmia according to claim 1, it is characterized in that:By hydrophily bar cloth
Agent and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:Polypropylene
Acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:Celosia argentea
Sub- essential oil 4ml, butterflybush flower essential oil 6ml, chrysanthemum essential oil 8ml, Radix Salviae Miltiorrhizae essential oil 12ml, Radix Glycyrrhizae essential oil 8ml, henon bamboo leaf essential oil 6ml, rotation
Cover flower essential oil 4ml, fruit of Chinese wolfberry essential oil 6ml and rose ethereal oil 4ml be uniformly mixed be made;Each eye sticker contains sweet ginseng chrysanthemum essential oil
Eye sticker containing essential oil is made in 0.1ml;In use, eye sticker is attached to eye.
6. the sweet ginseng chrysanthemum essential oil eye sticker of Chinese medicine for the treatment of xerophthalmia according to claim 1, it is characterized in that:By hydrophily bar cloth
Agent and sweet ginseng chrysanthemum essential oil are made, and the Hydrophillia Babu agent is by weight meter:Carbomer:Polyvinyl alcohol:Gelatin:Polypropylene
Acid=1:1:4:The eye sticker matched with eye is made in 0.1 mixing;The sweet ginseng chrysanthemum essential oil is by following volumes meter:Seed of feather cockscomb
Essential oil 6ml, butterflybush flower essential oil 4ml, chrysanthemum essential oil 12ml, Radix Salviae Miltiorrhizae essential oil 8ml, Radix Glycyrrhizae essential oil 12ml, henon bamboo leaf essential oil 4ml, rotation
Cover flower essential oil 6ml, fruit of Chinese wolfberry essential oil 4ml and rose ethereal oil 6ml be uniformly mixed be made;Each eye sticker contains sweet ginseng chrysanthemum essential oil
Eye sticker containing essential oil is made in 0.1ml;In use, eye sticker is attached to eye.
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Citations (4)
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|---|---|---|---|---|
| CN101766695A (en) * | 2009-01-06 | 2010-07-07 | 天津奥克莱斯生物技术有限公司 | Point eye mask and preparation method and application thereof |
| CN104274601A (en) * | 2013-07-03 | 2015-01-14 | 郑州市新视明科技工程有限公司 | External traditional Chinese medicinal composition for treating xerophthalmia and preparation method thereof |
| CN105687296A (en) * | 2016-01-31 | 2016-06-22 | 杭州睩客科技有限公司 | Volatile medicine with eye health-care effect |
| CN107213014A (en) * | 2017-05-26 | 2017-09-29 | 李笑涵 | A kind of walnut moxibustion eye box and its preparation technology |
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2018
- 2018-08-13 CN CN201810913638.2A patent/CN108686129A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766695A (en) * | 2009-01-06 | 2010-07-07 | 天津奥克莱斯生物技术有限公司 | Point eye mask and preparation method and application thereof |
| CN104274601A (en) * | 2013-07-03 | 2015-01-14 | 郑州市新视明科技工程有限公司 | External traditional Chinese medicinal composition for treating xerophthalmia and preparation method thereof |
| CN105687296A (en) * | 2016-01-31 | 2016-06-22 | 杭州睩客科技有限公司 | Volatile medicine with eye health-care effect |
| CN107213014A (en) * | 2017-05-26 | 2017-09-29 | 李笑涵 | A kind of walnut moxibustion eye box and its preparation technology |
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Application publication date: 20181023 |