CN108686039A - For the anti-mixture containing plant component and the preparation method and application thereof to treat constipation - Google Patents
For the anti-mixture containing plant component and the preparation method and application thereof to treat constipation Download PDFInfo
- Publication number
- CN108686039A CN108686039A CN201810912900.1A CN201810912900A CN108686039A CN 108686039 A CN108686039 A CN 108686039A CN 201810912900 A CN201810912900 A CN 201810912900A CN 108686039 A CN108686039 A CN 108686039A
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- Prior art keywords
- tea
- plant component
- constipation
- mixture containing
- extraction
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention is provided to the anti-mixtures containing plant component and its preparation method and application to treat constipation.The mixture includes tea stem micro mist or tea stalk/tea stem extraction, tea stalk/tea stem tea is not only rich in plant fiber, simultaneously containing various actives compounds such as catechin, flavones, anthocyanidin, phenolic acid, enteral physiological environment can effectively be improved, promote enterocinesia, it is effectively anti-to treat constipation, it is of low cost, safe and reliable.The preparation process of the mixture is simple, energy consumption is low, pollution-free.
Description
Technical field
The invention belongs to the anti-plant extracts technical fields that treats constipation, and in particular to the extract of tea stalk/tea stem.
Background technology
Constipation is modern, especially the most common gastrointestinal symptom of the elderly, constipation can cause abdominal discomfort, apocleisis,
The symptoms such as weak, major complications are fecal impaction, and prolonged constipation also easily causes the illnesss such as intestinal obstruction, colonic ulcer, sternly
Ghost image rings people's health and quality of life.Constipation and diet, physiological status, social factor, the state of mind, physical disease etc. because
It is known as pass.Physical exertion reduction, digestive system function decline, Intestinal motility is poor, intestinal contents are long in the enteric cavity residence time
All easily cause constipation.
Epidemiological survey shows that constipation morbidity is in certain family's trend, it is also possible to related with heredity.Traditional Western medicine is controlled
It treats and is mostly used caccagogue, motivator drug, probiotics etc., but can not fully solve clinical problem.Especially chronic or habit
For the patient of inertia constipation after taking laxative for long periods of time and promoting defecation, enteron aisle forms the dependence to drug, loses voluntarily defecation
Function, cause constipation to deteriorate.As modern human diet refines increasingly, physical exertion is further reduced, while population is aged
Change increasingly sharpens, and the number of patients of China's constipation also will increasingly increase, and researching and developing effective constipation functional food or drug becomes people
The social concern paid close attention to.
Tea stem is the waste material of winter pruning tea tree, and crushing can make animal feeding-stuff additive;Tea stalk is useless after tealeaves makes
Material has certain health value.
In this specification, tea stalk/tea stem refers to tea stalk or tea stem.
Invention content
The present invention is provided to the anti-mixtures containing plant component and the preparation method and application thereof to treat constipation, it is intended to which solving will
Tea stalk/tea stem is for anti-the technical issues for the treatment of constipation.
One of technical solution of the present invention is a kind of for the anti-mixture containing plant component to treat constipation, including tea stalk/tea stem
Micro mist or tea stalk/tea stem extraction.Tea stalk/tea stem contains epigallocatechin gallate, epi-nutgall acid
The polyphenol compounds such as theine, L-Epicatechin gallate, epicatechin.
Further, further include antioxidant, preservative and sweetener, the antioxidant is sulphite or Vitamin C
The mixture of both acid or more, the preservative are the mixture of both dihydroxy acetic acid or methaform or more, the sweet tea
Taste agent is sucrose or the mixture of lactose or PEARLITOL 25C or more three.
Further, further include excipient and lubricant, the excipient is both starch or avicel cellulose or more
Mixture, the lubricant is magnesium stearate or the mixture of calcium stearate or talcum powder or more three.
Further, the dosage form of use is granule, tablet, capsule or pill.
Include that tea stem micro mist or tea stalk/tea stem carry provided by the present invention for the anti-mixture containing plant component to treat constipation
Object, tea stalk/tea stem tea is taken not only to be rich in plant fiber, while containing various actives chemical combination such as catechin, flavones, anthocyanidin, phenolic acid
Object can effectively improve enteral physiological environment, promote enterocinesia, effectively anti-to treat constipation, of low cost, safe and reliable.
Technical solution of the present invention second is that the above-mentioned preparation method for the anti-mixture containing plant component to treat constipation, including
Three steps below:S110 will trim tea stalk/tea stem mechanical crushing that tea tree obtains and be less than 0.85mm (20 mesh) at average grain diameter
Powder, to obtain the tea stalk/tea stem micro mist;The tea stalk/tea stem the micro mist obtained in S120, step S110 with it is described
Additive mixes;S130 is prepared into scheduled dosage form by mixture is obtained in step S120.The dosage form be granule, tablet,
The clinical applications dosage form such as capsule.
The three of technical solution of the present invention are the above-mentioned preparation methods for the anti-mixture containing plant component to treat constipation, including
Three steps below:S210 will trim tea stalk/tea stem mechanical crushing of tea tree acquisition into powder;S220 obtains step S210
Raw material powder mixed with solvent, the solvent be water, ethyl alcohol or hydrous ethanol, the weight ratio of the raw material powder and solvent
1: (10~20) then obtain the tea stalk/tea stem extraction by heating extraction, Microwave Extraction or ultrasonic extraction;S230,
The tea stalk/tea stem extraction that step S220 is obtained is mixed with the additive, is then prepared into scheduled dosage form.
Further, step S220 include following three step by step:S221, the raw material powder that step S210 is obtained are mixed with water
It closes, first-time filtrate and a filter residue is obtained by filtration after heating extraction;S222 mixes a filter residue with water again, heating
Secondary filtrate is obtained by filtration after second of extraction;S223 merges the first-time filtrate and the secondary filtrate, is concentrated to give described
Tea stalk/tea stem extraction.
Provided by the present invention for the two above preparation method of the anti-mixture containing plant component to treat constipation, one is first
It prepares average grain diameter and is less than tea stalk/tea stem micro mist of 0.85mm, then mixed with additive, be then prepared into scheduled dosage form;Its
Second is that first making solvent using water, ethyl alcohol or hydrous ethanol, tea stalk/tea stem extraction is prepared, then mix with additive, then prepared
At scheduled dosage form.The form of micro mist or solvent extractable matter using grain size less than 0.85mm convenient for digesting and assimilating, and is prepared
It is simple for process, energy consumption it is low, pollution-free.
The four of technical solution of the present invention are above-mentioned for preventing that the mixture containing plant component to treat constipation is preparing anti-treat constipation
Application in health products.
The five of technical solution of the present invention are above-mentioned for preventing that the mixture containing plant component to treat constipation is preparing anti-treat constipation
Application in drug.
The six of technical solution of the present invention are above-mentioned for preventing that the mixture containing plant component to treat constipation is preparing anti-treat constipation
Application in food.
It is the constituent analysis of the tea stalk/tea stem extraction and tea extract of one embodiment below:
Experiment is analyzed using high performance liquid chromatography.DIONEX liquid phase analysis instrument is 3000 types of Ultimate, electronics
Balance is ten a ten thousandth types of Sartorius BP211D, and thermostatic drying chamber is Germany's Memmert types, and ultra-pure water instrument is Merck
Millipore companies, micromill are Hangzhou Xiong Huo Science and Technology Ltd.s, and acetonitrile is Fisher (chromatographically pure), and formic acid is wide
State chemical reagent factory (analysis is pure).Reference substance caffeine (Caffeine, Caff), theobromine (Theobromine, Tb), does not eat
Sub- catechin and gallate ((-)-Gallocatechin gallate, GCG), Epigallo-catechin gallate (EGCG)
((-)-Epigallocatechin gallate, EGCG) is purchased from Japanese Wako Pure Chemicals Co., Ltd.;Gallic acid (Gallic
Acid, GA), catechin ((+)-Catechin, C) is purchased from Sigma Co., USA;Nutgall catechin ((-)-
Gallocatechin, GC), epigallocatechin (Epigallocatechin, EGC), epicatechin (Epicatechin,
EC) it is purchased from Japanese Kurita Water Industries Ltd;L-Epicatechin gallate ((-)-Epicatechin-3-gallate, ECG)
Purchased from Shanghai Jing Chun biochemical technologies limited liability company.
Chromatographic condition, chromatographic column COSMOSIL5C18-AR-II (4.6*250mm, 5 μm, Nacalai tesque.Inc.,
Japan), flow velocity 1ml/min, quantitative Detection wavelength are 231nm, and column temperature is 35 DEG C, and sample size is 20 μ l.Mobile phase A:H2O
(containing 0.1% formic acid);Mobile phase B:CH3CN (contains 0.1% formic acid), and gradient elution program is shown in Table one.Test sample is through distilled water
It centrifuges, is analyzed through the laggard HPLC of 0.45 μm of water film filtering, each component content is shown in Table two in sample after dissolving.
It can be seen from table two in the extract of tea stalk/tea stem and tealeaves, the caffeine in tea extract
(Caffeine, Caff) content will be significantly larger than the extract of tea stalk/tea stem, may result in insomnia, excitement and palpitaition etc.
Adverse reaction;And the extract of tea stalk/tea stem is conducive to prevent rich in Polyphenols antibacterial/antiviral activity ingredients such as catechins
Disease.
Table one, HPLC gradient elution program
Table two, alkaloid and polyphenol compound content (%) in tea stalk/tea stem and young tea leaves extract
| Extract component | Tealeaves | Tea stem | Tea stalk |
| GA | 0.15 | 0.17 | 0.20 |
| Tb | 0.26 | 0.05 | 0.03 |
| GC | 0.71 | 0.17 | 0.06 |
| EGC | 2.60 | 0.53 | - |
| C | 0.27 | 0.24 | 0.16 |
| Caff | 3.31 | 0.91 | 0.25 |
| EC | 0.85 | 0.58 | 0.17 |
| EGCG | 4.58 | 1.29 | - |
| GCG | 1.55 | 0.08 | - |
| ECG | 1.76 | 1.04 | 0.06 |
Note:Expression does not detect
Here is the influence that tea stalk/tea stem extraction inhibits compound diphenoxylate on mouse enterocinesia model.
The present invention inhibits the functions of loosening bowel relieving constipation of mouse enterocinesia model evaluation tea stalk, tea stem using compound diphenoxylate.
Experimental animal (is purchased from Guangdong Medical Lab Animal Center, animal licensing number is using 7 week old male mice in kunming
SCXK (Guangdong) 2013-0002).Experimental animal is raised in cleaning grade laminar-flow rack, and environment temperature is 23 ± 2 DEG C, and relative humidity is
75 ± 10%, lighting hours is 12 hours/day (7:00~19:00).Experimental animal adaptable fed after a week, carry out real
It tests.Experimental animal is randomly divided into Normal group, compound diphenoxylate model group, tea stalk, tea stem mechanical crushing micro mist 500mg/
Kg groups, tea stem extraction extract 500mg/kg groups and tea stalk extract 500mg/kg, totally 5 groups, every group 10.Tea stalk, tea stem
Mechanical crushing micro mist, tea stem extraction and the daily gastric infusion of tea stalk extract group 1 time, successive administration 1 week, Normal group and
Compound diphenoxylate model group gives equal capacity aqueous solution.It is deprived of food but not water before last dose 15 hours.Except Normal group,
Remaining each group gavage gives 5mg/kg compound diphenoxylates and induces mouse enterocinesia inhibition, and Normal group gives equivalent distilled water.
After compound diphenoxylate is administered 30 minutes, tea stalk, tea stem mechanical crushing micro mist, tea stem extraction and tea stalk extract group gavage are given
Drug containing charcoal end suspension is given, Normal group and compound diphenoxylate model group gavage 0.2ml/10g charcoals end suspension (contain 5%
Active powdered carbon, 10% gum arabic).Giving charcoal end suspension, cervical dislocation puts to death animal after twenty minutes, opens abdomen separation immediately
Mesenterium, clip upper end are placed in from the small intestine of pylorus, lower end to ileocecus on pallet, and small intestine is pulled into straight line, it is long to measure small intestine
Degree and pylorus calculate charcoal end propulsion rate to charcoal end forward position length.Charcoal end propulsion rate (%)=[Pylorus is to charcoal end forward position length
(em)/small intestinal length (em)s ]× 100%
For experimental result as shown in table 3., tea stalk, tea stem can significantly improve small intestine charcoal end propulsion rate, restore mouse by compound
The Intestinal motility that diphenoxylate inhibits.
Table three, the influence of tea stalk, tea stem micro mist and extract to mouse small intestine advancing movement
| Test group | Number of animals | Charcoal end propulsion rate (%) |
| Normal group | 10 | 57.2 soil 5.9 |
| Compound diphenoxylate model group | 10 | 34.3 soil 5.6 |
| Tea stem extraction | 10 | 53.0 soil 5.5* |
| Tea stalk extract | 10 | 54.1±6.0* |
| Tea stalk, tea stem micro mist | 10 | 51.1±5.1* |
With compound compared with fragrant promise group, * p < 0.05
Here is tea stalk/influence of the tea stem extraction to mouse enterocinesia.
Experimental animal (is purchased from Guangdong Medical Lab Animal Center, animal licensing using 7 week old male mice in kunming
Number is SCXK (Guangdong) 2013-0002).Experimental animal is raised in cleaning grade laminar-flow rack, and environment temperature is 23 2 DEG C of soil, relatively
Humidity is 75 soil 10%, and lighting hours is 12 hours/day (7:00~19:00), adaptable fed after a week, is tested.It is real
It tests animal and is randomly divided into Normal group, tea stalk, tea stem machinery micro mist 500mg/kg, 250mg/kg group, tea stem extraction
500mg/kg, 250mg/kg group and tea stalk extract 500mg/kg, 250mg/kg group, totally 7 groups, every group 10.Except normal right
Outer according to group, the daily gastric infusion of remaining each group 1 time, successive administration 1 week, Normal group gives equivalent distilled water.Last dose
Before be deprived of food but not water 15 hours.30 minutes equal gavages of each group give 0.2ml/10g charcoals end suspension and (live containing 5% after the last administration
Property powdered carbon, 10% gum arabic).Giving charcoal end suspension, cervical dislocation puts to death animal after twenty minutes, opens abdomen separation intestines immediately
Mesentery, small intestine of the clip from pylorus to ileocecus, is placed on pallet, and small intestine is gently pulled into straight line, measures small intestinal length and imprisons
Door calculates charcoal end propulsion rate to charcoal end forward position length.
Charcoal end propulsion rate (%)=[Pylorus is to charcoal end forward position length (cm)/small intestinal length (cm)s ]× 100%
As a result as shown in Table 4, the charcoal end advancing movement of small intestine can be remarkably reinforced in tea stalk, tea stem, promote small bowel peristalsis.
Table four, the influence of tea stalk, tea stem micro mist and extract to mouse small intestine advancing movement
| Test group | Number of animals | Charcoal end propulsion rate (%) |
| Normal group | 15 | 53.9±5.6 |
| 500mg/kg tea stem extractions | 15 | 73.4±6.2* |
| 250mg/kg tea stem extractions | 15 | 68.2±5.9* |
| 500mg/kg tea stalk extracts | 15 | 74.6±7.4* |
| 250mg/kg tea stem extractions | 15 | 72.7±6.8* |
| 500mg/kg tea stalks, tea stem micro mist | 15 | 70.1±6.4* |
| 250mg/kg tea stalks, tea stem micro mist | 15 | 67.3±6.1* |
Compared with Normal group, * P < 0.05
Specific implementation mode
The specific implementation mode of the present invention is described further below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but does not constitute limitation of the invention.In addition, invention described below
Involved technical characteristic can be combined with each other as long as they do not conflict with each other in each embodiment.
Tea stem and tea stalk used in following embodiment are provided by Guizhou Pu'an Hong Xin tea processing factories, have been cleaned and preliminary crushing.
Embodiment 1, the mixture containing tea stalk/tea stem micro mist for making the anti-food that treats constipation
Tea stem and tea stalk raw material are ground into the powder that average grain diameter is less than 0.85mm (20 mesh);Every above-mentioned tea of 100 parts by weight
1 part of ascorbic acid, 0.2 part of dihydroxy acetic acid, 2 parts of PEARLITOL 25C, 20 parts of cornstarch, stearic acid are added in stalk/tea stem micro mist
3 parts of calcium, 100 parts of water, is dried after mixing;
It is that average grain diameter is less than the particle of 0.85mm to get the mixture that dried object, which crushes,.The mixture adds as bread
Add agent in use, 1~5g is added in every 100 grams of bread wheat flour speciallies.
Embodiment 2 makees the mixture containing tea stalk/tea stem micro mist of the anti-health products that treat constipation
Tea stem and tea stalk raw material are ground into the powder that average grain diameter is less than 0.85mm (20 mesh);Every above-mentioned tea of 100 parts by weight
1 part of ascorbic acid, 0.2 part of dihydroxy acetic acid, 2 parts of PEARLITOL 25C, 10 parts of avicel cellulose, tristearin are added in stalk/tea stem micro mist
3 parts of sour calcium, 90 parts of water, are dried after mixing.
Dried object is tabletted or pill, or records as capsule.Tablet/the pill/capsule makees the anti-health products that treat constipation,
Warm water takes oral, takes 1~5g after the meal.
Embodiment 3, the preparation of tea stalk/tea stem extraction
Raw material is ground into coarse powder, 500g coarse powder is taken, sets in extractor, adds 20 times of amount water refluxing extractions, keeps boiling 8 small
When, filtering, filter residue adds 20 times of amount water refluxing extractions, and boiling 1 hour, filtering is kept to merge filtrate twice.Filtrate sets concentration
It is concentrated under reduced pressure into the liquid extract that relative density is 1.2 or so for 60 DEG C in tank, liquid extract, which takes out, is packed into pallet, so freeze-dried that carry
Take object about 50g.
Embodiment 4, the preparation of tea stalk/tea stem extraction
Raw material is ground into coarse powder, 500g coarse powder is taken, sets in extractor, 10 times of amount 50% ethanol water reflux is added to carry
It takes, boiling 2 hours, filtering, filter residue is kept to add 10 times of amount 50% alcohol reflux extractions, keep boiling 1 hour, filter, close
And filtrate twice.Filtrate sets in concentration tank and is concentrated under reduced pressure into the liquid extract that relative density is 1.0 or so for 60 DEG C, freeze-dried to obtain
Extract about 50g.
The extract, the tea extract prepared in aforementioned manners, be used for more than test analysis.
Embodiment 5 is used to prepare the mixture containing tea stalk/tea stem extraction of prevention constipation drug
The above tea stalk/tea stem extraction is prepared into a variety of pharmaceutical preparations, adds conventional excipient, lubricant, anti-oxidant
The additives such as agent, preservative, colorant, sweetener;Wherein, preferred excipient has lactose, white sugar, PEARLITOL 25C, starch, knot
Crystalline cellulose etc.;Preferred lubricant has magnesium stearate, calcium stearate, talcum powder etc.;Preferred antioxidant have sulphite,
Ascorbic acid etc.;Preferred preservative has dihydroxy acetic acid, methaform etc..Tea stalk/tea stem extraction is mixed evenly with additive
Afterwards, granule, tablet, capsule or pill etc. is made.The mode of taking of said medicine preparation is postprandial oral, each taking agent
Tea stalk/tea stem extraction content is 0.2~0.6g in amount.
Embodiments of the present invention are explained in detail above, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (10)
1. a kind of for the anti-mixture containing plant component to treat constipation, characterized in that including tea stalk/tea stem micro mist or tea stalk/tea
Stem extraction.
2. according to claim 1 for the anti-mixture containing plant component to treat constipation, characterized in that further include anti-oxidant
Agent, preservative and sweetener, the antioxidant are the mixture of both sulphite or ascorbic acid or more, the anti-corrosion
Agent is the mixture of both dihydroxy acetic acid or methaform or more, the sweetener be sucrose or lactose or PEARLITOL 25C or with
The mixture of upper three.
3. according to claim 2 for the anti-mixture containing plant component to treat constipation, characterized in that further include excipient
And lubricant, the excipient are the mixtures of both starch or avicel cellulose or more, the lubricant is magnesium stearate
Or the mixture of calcium stearate or talcum powder or more three.
4. according to claim 2 or 3 for the anti-mixture containing plant component to treat constipation, characterized in that the agent of use
Type is granule, tablet, capsule or pill.
5. a kind of preparing the method described in claim 1 for the anti-mixture containing plant component to treat constipation, characterized in that packet
Include following three steps:Tea stalk/tea stem mechanical crushing is less than the powder of 0.85mm, to obtain by S110 at average grain diameter
State tea stalk/tea stem micro mist;The tea stalk/tea stem the micro mist obtained in S120, step S110 is mixed with the additive;S130,
It is prepared into scheduled dosage form by mixture is obtained in step S120.
6. a kind of preparing the method described in claim 1 for the anti-mixture containing plant component to treat constipation, characterized in that packet
Include following three steps:
S210 will trim tea stalk/tea stem mechanical crushing of tea tree acquisition into powder;
S220 mixes the step S210 raw material powders obtained with solvent, the solvent be water, ethyl alcohol or hydrous ethanol, it is described
Raw material powder and solvent weight ratio 1:(1~20) then obtains institute by heating extraction, Microwave Extraction or ultrasonic extraction
State tea stalk/tea stem extraction;
S230, the tea stalk/tea stem extraction that step S220 is obtained are mixed with the additive, are then prepared into scheduled dose
Type.
7. the preparation method according to claim 6 for the anti-mixture containing plant component to treat constipation, characterized in that step
Rapid S220 include following three step by step:S221, the powder that step S210 is obtained are mixed with water, and one is obtained by filtration after heating extraction
Secondary filtrate and a filter residue;S222 remixes a filter residue with water, and secondary filter is obtained by filtration after second of extraction of heating
Liquid;S223 merges the first-time filtrate and secondary filtrate, is concentrated to give the tea stalk/tea stem extraction.
8. according to claim 1 for preventing the mixture containing plant component to treat constipation in preparing the anti-health products that treat constipation
Application.
9. containing the plant component mixture according to claim 1 for preventing treating constipation is in preparing prevention constipation drug
Using.
10. according to claim 1 for preventing the mixture containing plant component to treat constipation in preparing the anti-food that treats constipation
Application.
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Application publication date: 20181023 |