CN1086592C - Antibiosis anticoagulative silica gel catheter - Google Patents
Antibiosis anticoagulative silica gel catheter Download PDFInfo
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- CN1086592C CN1086592C CN99113477A CN99113477A CN1086592C CN 1086592 C CN1086592 C CN 1086592C CN 99113477 A CN99113477 A CN 99113477A CN 99113477 A CN99113477 A CN 99113477A CN 1086592 C CN1086592 C CN 1086592C
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- silica gel
- solution
- gel catheter
- adds
- antibiosis
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Abstract
The present invention relates to an antibiosis anticoagulation silica gel catheter which is mainly used as a medical catheter for transfusion, which belongs to the technical field of medical sanitation. The silica gel catheter is dried after being respectively configured in a ciprofloxacin acetone solution and an antisepsis anticoagulation solution containing chlorhexidine, heparin quaternary ammonium ester and polyurethane resin for immersion, so that the treated medical silica gel catheter simultaneously has the efficacy of antibiosis and anticoagulation and is preferably suitable for clinical application. The present invention can also be used for urinary catheters, wound drainage tubes, in-vivo buried tubes, etc., and the present invention has a wide development future.
Description
A kind of silica gel catheter with antibiosis anticoagulative effect is mainly used in the medical infusion conduit, belongs to the medical and health technology field.
Clinically any critical patient's rescue and treatment are all be unable to do without transfusion catheter, for example to patient's vein fluid infusion or to gastrointestinal patient's nutrient, transfusion catheter is all indispensable.Past, used transfusion catheter all was to use plastic materials such as polyethylene or polrvinyl chloride to make, tube chamber stops up easily, easy infection, therefore the time that keeps in vivo is very short, this not only can influence finishing of therapeutic process, but also may cause suppurative phlebitis, suppurative thrombophlebitis, even develop into the possibility of fatal conduit septicemia.At present external many developed countries are without the plastic infusion conduit, and replace with silica gel tube.But silica gel tube itself there is no antibacterial action separately, though anticoagulation is stronger than plastic catheter, but still is difficult to satisfy clinical requirement.By literature search, abroad have and add antibiotic composition or anticoagulant composition in silicone rubber substrate, retention time is longer in vivo to make it, but does not see the report that has two kinds of compositions simultaneously concurrently.
The objective of the invention is to new prescription and new method that a kind of medical silica-gel catheter surface of research design is handled, make this treated medical silica-gel conduit have antibiotic, anticoagulant effect simultaneously, adapt to clinical practice better.
For realizing such goal of the invention, technical solution of the present invention is: dispose a kind of solution that has the antibiosis anticoagulative effect simultaneously, silica gel catheter is soaked surface treatment, concrete prescription and processing method are as follows:
1, configuration heparin quaternary ammonium lipoprotein solution
Heparin sodium 12500
μ20ml (1 * 10 of 2ml)
Quaternary ammonium chloride (bromo geramine) raw material 3-5 gram
With constantly stirring after above-mentioned two kinds of medicament mixed, make it into paste shape, remove supernatant after waiting to spend the night, also can remove supernatant after the centrifugation, with distillation washing several times, mainly remove Cl then
-, Na
+, the remaining white size pasty state in the back of anhydrating is exactly a chlorination quaternary ammonium fat; Chlorination quaternary ammonium fat adds isopropyl alcohol 5-10ml makes basic dissolving, and it is an amount of to add oxolane again, makes it whole dissolvings.This step total amount must not surpass 50ml.
2, configuration chlorhexidine acetate solution
Chlorhexidine acetate 1 gram, the cetomacrogol 1000 (mean molecule quantity 900-1100) that adds the 1-2 gram rises increases dissolution.Mix the back heating in 100 ℃ of water-baths about 10 minutes, constantly stir and make it into scattered paste shape, the cooling back adds oxolane with 2: 1 ratio and NN dimethyl methyl/acetamide makes dissolving.This step total amount must not surpass 50ml.
3, the heparin quaternary ammonium lipoprotein solutions of 1 and 2 configurations are mixed with chlorhexidine acetate solution and stir evenly, add polyurethane resin 24 grams, polyisocyanate resin 19 restrains, and adds oxolane again and dilutes and make it mobile; Above-mentioned component mixed add oxolane and shake up to 100ml and promptly get antibiosis anticoagulative solution.
Drain after 15 minutes with above antibiosis anticoagulative solution soaking silica gel catheter,, promptly finish surface treatment silica gel catheter at 55 ℃ of-60 ℃ of drying machine dryings.
Because the above-mentioned antibiosis anticoagulative solution that makes is to G
+Bacterium has efficiently, but to G
-The bacterium effect is poor, for strengthening G
-So the antibacterial action of bacterium is in steps 4.
4, configuration ciprofloxacin acetone solution, anti-G
-The bacterium effect
Ciprofloxacin 03 gram adds Polyethylene Glycol 1000 1-2 gram, suitably adds Polyethylene Glycol 4000, and heating about 10 minutes is gone up in water-bath (100 ℃), adds acetone solution after the cooling, constantly stirs and makes it whole dissolvings, to 100ml.
Must be noted that the ciprofloxacin acetone soln can not mix with the antibiosis anticoagulative solution that contains hibitane, heparin season ammonia ester, polyurethane resin, otherwise cause that precipitation lost efficacy.
Therefore the surface treatment to silica gel catheter is: soak the ciprofloxacin acetone solution earlier, take out oven dry, soak above antibiosis anticoagulative solution again and drain after 15 minutes, at 55 ℃ of-60 ℃ of drying machine dryings.
The present invention has tangible antibiosis anticoagulative effect.With the anti-microbial property of agar cavity test method(s) and the bacteriostatic activity test determination conduit in nutrient broth, the result shows that the antibacterial district of silica gel catheter of the present invention is big, and antibacterial effect is remarkable.In 10 rat acute arteriovenous shunt tests, the antibiosis anticoagulative drug solution is coated as circulation wire surface and silica gel tube inwall, after the extracorporeal circulation 30 minutes, the thrombus weight that adheres on the line is at 05-53mg, and the appended thrombus weight of control line (silk thread of uncoated antibiosis anticoagulative medicine) is at 295-917mg.In the test of rabbit external jugular vein bypass surgery, bury antibiosis anticoagulative silica gel pipe anatomic observation after 18 days, all stopped up by thrombosis fully in the contrast silica gel tube, the anticoagulative silica gel pipe has in the minority pipe a small amount of thrombosis adheres to, all basic maintenance is unimpeded, proves tangible blood coagulation resisting function.
Antibiosis anticoagulative medical silica-gel conduit of the present invention, its purposes is not limited to infuse one, can also be used for burying pipe etc. in catheter, wound drain, the body, has result of extraction.
Claims (2)
1, a kind of antibiosis anticoagulative silica gel catheter is characterized in that the surface processing solution prescription of silica gel catheter and processing method carry out as follows:
(1), with heparin sodium 12500
μStir into paste shape after 20ml and quaternary ammonium chloride raw material 3-5 gram mixes, remove supernatant, washing back one-tenth chlorination quaternary ammonium fat adds isopropyl alcohol 5-10ml and oxolane, makes it whole dissolvings, and total amount is no more than 50ml:
(2), chlorhexidine acetate 1 gram, add 1-2 gram cetomacrogol 1000, mix the back heating in 100 ℃ of water-baths about 10 minutes, stir into scattered paste shape, the cooling back adds oxolane with 2: 1 ratio and NN dimethyl methyl/acetamide makes dissolving, total amount is no more than 50ml;
(3), the heparin quaternary ammonium lipoprotein solution of (1) and (2) configuration is mixed stirring with chlorhexidine acetate solution, add polyurethane resin 24 and restrain, polyisocyanate resin 19 restrains, and adds oxolane and is diluted to 100ml and shakes up and promptly get antibiosis anticoagulative solution;
Silica gel catheter soaked in above antibiosis anticoagulative solution drain after 15 minutes, at 55 ℃ of-60 ℃ of drying machine dryings.
2, a kind of as the said antibiosis anticoagulative silica gel catheter of claim 1, its feature is that also the surface processing solution prescription of silica gel catheter and processing method increase following steps:
Configuration ciprofloxacin acetone solution with ciprofloxacin 03 gram, adds Polyethylene Glycol 1000 1-2 gram, adds in 4000,100 ℃ of water-baths of Polyethylene Glycol and heats about 10 minutes, adds acetone solution after the cooling, constantly stirs and makes it whole dissolvings, to 100ml;
Silica gel catheter is soaked the ciprofloxacin acetone solution earlier, take out oven dry, soak antibiosis anticoagulative solution again and drain after 15 minutes, at 55 ℃ of-60 ℃ of drying machine dryings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99113477A CN1086592C (en) | 1999-02-12 | 1999-02-12 | Antibiosis anticoagulative silica gel catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99113477A CN1086592C (en) | 1999-02-12 | 1999-02-12 | Antibiosis anticoagulative silica gel catheter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1225281A CN1225281A (en) | 1999-08-11 |
| CN1086592C true CN1086592C (en) | 2002-06-26 |
Family
ID=5276665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99113477A Expired - Fee Related CN1086592C (en) | 1999-02-12 | 1999-02-12 | Antibiosis anticoagulative silica gel catheter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1086592C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491768B2 (en) * | 2002-06-25 | 2009-02-17 | Woong-Sig Moon | Polymer resin formulation having anti-microbial or anti-coagulability and preparation method thereof |
| US7749529B2 (en) * | 2005-02-08 | 2010-07-06 | Ash Access Technology, Inc. | Catheter lock solution comprising citrate and a paraben |
| CN101987223B (en) * | 2009-07-29 | 2013-03-27 | 山东百多安医疗器械有限公司 | Multi-directional valve peripherally inserted central catheter with anticoagulant and antibacterial functions and preparation method thereof |
| US20140302113A1 (en) * | 2011-09-30 | 2014-10-09 | Sparkmed Research, Llc | Systems, devices, and methods for embedding drug molecules into medical catheters or tubes |
| CN110947056A (en) * | 2019-11-29 | 2020-04-03 | 河南驼人贝斯特医疗器械有限公司 | Inner and outer wall anti-infection anticoagulant remaining needle hose and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2220296Y (en) * | 1995-02-23 | 1996-02-21 | 山东省聊城地区人民医院 | Disposable oxygen inhalation pipe for clinic medical treatment |
-
1999
- 1999-02-12 CN CN99113477A patent/CN1086592C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2220296Y (en) * | 1995-02-23 | 1996-02-21 | 山东省聊城地区人民医院 | Disposable oxygen inhalation pipe for clinic medical treatment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1225281A (en) | 1999-08-11 |
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| PB01 | Publication | ||
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Granted publication date: 20020626 Termination date: 20110212 |