CN108654134A - Tetrahydrocannabinol extracting process in medical cannabis - Google Patents
Tetrahydrocannabinol extracting process in medical cannabis Download PDFInfo
- Publication number
- CN108654134A CN108654134A CN201810433372.1A CN201810433372A CN108654134A CN 108654134 A CN108654134 A CN 108654134A CN 201810433372 A CN201810433372 A CN 201810433372A CN 108654134 A CN108654134 A CN 108654134A
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- Prior art keywords
- tetrahydrocannabinol
- supercritical
- fluid
- extracting process
- medical cannabis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Abstract
Tetrahydrocannabinol extracting process in a kind of medical cannabis of offer of the embodiment of the present invention.Tetrahydrocannabinol extracting process includes in the medical cannabis：Using supercritical fluid, supercritical, high pressure extraction, the fluid containing tetrahydrocannabinol after being extracted are carried out to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol；Using tetrahydrocannabinol of the paraffin under default reaction temperature in fluid of the dissolving containing tetrahydrocannabinol, the paraffin solution containing tetrahydrocannabinol is obtained；The paraffin solution for being contained tetrahydrocannabinol using alcohol rinse is made the tetrahydrocannabinol in the paraffin solution containing tetrahydrocannabinol filter and is precipitated.This method can carry out tetrahydrocannabinol extraction, promote tetrahydrocannabinol purity.
Description
Technical field
The present embodiments relate to tetrahydrocannabinol in substance extractive technique field more particularly to a kind of medical cannabis to extract
Method.
Background technology
Hemp is Moraceae, Cannabis plant, and annual upright draft is 1-3 meters high.Medipot contains such as cannabinol
(Cannabinol, abbreviation CBN), cannabidiol (Cannabidiol, abbreviation CBD) and tetrahydrocannabinol
Substances such as (Tetrahydrocannabinol, abbreviation THC).Wherein, cannabidiol passes through to cyclooxygenase and lipoxygenase
Double inhibition plays analgesic and anti-inflammatory effect, has the effects that anti-epileptic, antipsychotic, antidepression, analgesic.Tetrahydrochysene hemp
Phenol can adjust immune system, diminish inflammation, stimulate appetite, and also have calm effect.It is controlled in addition, tetrahydrocannabinol can be used as
The potential drug for treating cancer makes the R and D of its medical value have wide space.
But the chemical substance for due to the more and different hemp plant of the chemical classes contained in hemp including
Type and component be not quite similar, to hemp carry out medical value research when, it is difficult to extract the single object of suitable purity
Matter so as to the research of the medical value of hemp there are obstacle, be unfavorable for fully excavating and using hemp medical value.
Invention content
In view of this, to be to provide tetrahydrochysene in a kind of medical cannabis big for one of the technical issues of embodiment of the present invention is solved
Numb phenol extraction method, to overcome, component is complicated in Cannador in the prior art, can not promote tetrahydrocannabinol purity
Problem.
Tetrahydrocannabinol extracting process in a kind of medical cannabis of offer of the embodiment of the present invention, including：Using supercritical fluid,
Supercritical, high pressure extraction is carried out to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol, contains four after being extracted
The fluid of hydrogen cannabinol；The tetrahydrochysene dissolved in the fluid containing tetrahydrocannabinol under default reaction temperature using paraffin is big
Numb phenol obtains the paraffin solution containing tetrahydrocannabinol；Using the paraffin solution containing tetrahydrocannabinol described in alcohol rinse, make
Tetrahydrocannabinol filtering in the paraffin solution containing tetrahydrocannabinol is precipitated.
Optionally, the supercritical fluid is carbon dioxide.
Optionally, using supercritical fluid, the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol is surpassed
Critical high pressure extraction, after being extracted the step of fluid containing tetrahydrocannabinol in, the pressure of the supercritical, high pressure extraction
Value range is：2.5atm~20atm.
Optionally, the supercritical fluid is nitrogen.
Optionally, using supercritical fluid, the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol is surpassed
Critical high pressure extraction, after being extracted the step of fluid containing tetrahydrocannabinol in, the pressure of the supercritical, high pressure extraction
Value range is：2.5atm~20atm.
Optionally, the value range of the default reaction temperature is 40 DEG C~80 DEG C.
Optionally, using supercritical fluid, the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol is carried out
Supercritical, high pressure extracts, and after being extracted before the fluid containing tetrahydrocannabinol, the method further includes：To hemp raw material into
Row pretreatment, obtains the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol.
Optionally, the pretreatment includes drying process and/or pulverization process.
Optionally, the paraffin solution using containing tetrahydrocannabinol described in alcohol rinse makes described big containing tetrahydrochysene
After tetrahydrocannabinol filtering in the paraffin solution of numb phenol is precipitated, the method further includes：It is filtered using filter paper and collects analysis
The tetrahydrocannabinol gone out.
By above technical scheme as it can be seen that tetrahydrocannabinol extracting process in medical cannabis of the embodiment of the present invention, is faced by super
The mode of boundary's gas high pressure extraction is changed molten to supercritical fluid using supercritical fluid as extractant using pressure and other parameters
The influence of solution ability makes supercritical fluid contact to make with object to be extracted (such as tetrahydrocannabinol) in the supercritical state
Object to be extracted is dissolved in shooting flow body, forms the fluid containing tetrahydrocannabinol.By being obtained after the extraction of supercritical fluid
There may be the ingredients except tetrahydrocannabinol in the fluid containing tetrahydrocannabinol obtained, big in order to promote the tetrahydrochysene extracted
The purity of numb phenol dissolves tetrahydrocannabinol under predetermined reaction temperature using paraffin, makes tetrahydrocannabinol by containing four
It is transferred in paraffin in the fluid of hydrogen cannabinol, forms the paraffin solution containing tetrahydrocannabinol.Contained later using alcohol rinse
The paraffin solution for having tetrahydrocannabinol makes tetrahydrocannabinol filter precipitation from paraffin solution, obtains the higher solid of purity four
Hydrogen cannabinol.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments described in inventive embodiments can also obtain according to these attached drawings for those of ordinary skill in the art
Obtain other attached drawings.
Fig. 1 be the embodiment of the present invention medical cannabis in tetrahydrocannabinol extracting process flow chart.
Specific implementation mode
Certainly, implementing any technical solution of the embodiment of the present invention must be not necessarily required to reach simultaneously above all excellent
Point.
In order to make those skilled in the art more fully understand the technical solution in the embodiment of the present invention, below in conjunction with the present invention
Attached drawing in embodiment, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described reality
It is a part of the embodiment of the embodiment of the present invention to apply example only, instead of all the embodiments.Based on the implementation in the embodiment of the present invention
Example, the every other embodiment that those of ordinary skill in the art are obtained should all belong to the range of protection of the embodiment of the present invention.
Embodiment specific implementation is further illustrated the present invention with reference to attached drawing of the embodiment of the present invention.
According to an embodiment of the invention, tetrahydrocannabinol extracting process in a kind of medical cannabis is provided, this method include with
Lower step：
Step S101：Using supercritical fluid, the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol is carried out
Supercritical, high pressure extracts, the fluid containing tetrahydrocannabinol after being extracted；
Step S102：Use tetrahydrochysene hemp of the paraffin under default reaction temperature in fluid of the dissolving containing tetrahydrocannabinol
Phenol obtains the paraffin solution containing tetrahydrocannabinol；
Step S103：The paraffin solution for containing tetrahydrocannabinol using alcohol rinse, makes the paraffin containing tetrahydrocannabinol
Tetrahydrocannabinol filtering in solution is precipitated.
Tetrahydrocannabinol extracting process is made by way of supercritical, high pressure extraction with supercritical fluid in the medical cannabis
For extractant, the influence changed to supercritical fluid solvability using pressure and other parameters is made overcritical in the supercritical state
Fluid with object to be extracted (such as tetrahydrocannabinol) contacts that object to be extracted is made to be dissolved in shooting flow body, and formation contains four
The fluid of hydrogen cannabinol.By the way that there may be tetrahydrochysenes in the fluid containing tetrahydrocannabinol that is obtained after the extraction of supercritical fluid
Ingredient except cannabinol, it is right under predetermined reaction temperature using paraffin in order to promote the purity of the tetrahydrocannabinol extracted
Tetrahydrocannabinol is dissolved, and makes tetrahydrocannabinol by being transferred in paraffin in the fluid containing tetrahydrocannabinol, formation contains
The paraffin solution of tetrahydrocannabinol.The paraffin solution for containing tetrahydrocannabinol using alcohol rinse later, make tetrahydrocannabinol from
It filters and is precipitated in paraffin solution, obtain the higher solid tetrahydrocannabinol of purity.
The tetrahydrocannabinol that high-purity can be extracted using the extracting process, for subsequently carrying out medical research or drug
It produces and uses.Since the purity of the tetrahydrocannabinol extracted is higher, thus the medicinal of tetrahydrocannabinol can be applied to
In value research, the medical value of tetrahydrocannabinol is aided in determining whether, avoid containing other in tetrahydrocannabinol in the prior art
The problem that chemical composition causes medical value research inaccurate.
Optionally, in order to promote effect of extracting, the time required to reducing extraction, using supercritical fluid, to containing hemp
The mixture of phenol, cannabidiol and tetrahydrocannabinol carries out supercritical, high pressure extraction, and tetrahydrocannabinol is contained after being extracted
Before the step of fluid, hemp raw material can be pre-processed, acquisition contains cannabinol, cannabidiol and tetrahydrocannabinol
Mixture.
According to the difference of raw material, pretreatment may include different processing procedure, and the present embodiment is not construed as limiting this.Example
Such as, pretreatment includes but not limited to drying process and/or pulverization process.
If hemp raw material is the more hemp plant of moisture, pretreatment includes being dried.Specifically, at dry
Reason process can be：The part (such as marihuana, hemp pistil, big straw) that needs are removed from hemp plant, to what is removed
Processing is dried in part, and what will such as be removed is partially disposed in drying box, and the dry scheduled time, (the dry time can basis
The temperature of drying box is different specific determining), so that the moisture content for the part removed is reduced to suitable numerical value (for example, moisture content drops
As low as 7% or less).
After processing is dried to hemp raw material, processing can be crushed to the raw material after drying process and is obtained containing big
The mixture of numb phenol, cannabidiol and tetrahydrocannabinol makes raw material at powdered or tiny graininess by pulverization process, with
It is more preferable to continue effect of extracting when carrying out supercritical, high pressure extraction after an action of the bowels.
Using supercritical fluid, the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol is carried out overcritical
High pressure extraction, after being extracted the step of fluid containing tetrahydrocannabinol in, the ingredient that can be extracted as needed it is different and
Select different supercritical fluids.
For example, in the present embodiment, in order to promote effect of extracting, supercritical fluid is carbon dioxide.Made with carbon dioxide
For supercritical fluid, one side carbon dioxide is easy to prepare, and can reduce extraction cost；On the other hand, carbon dioxide has nothing
Color, tasteless, nontoxic, chemical property is stable, has the characteristics that incombustibility so that even if having two in extraction process or after extraction
Carbonoxide spill and leakage will not cause damages to environment.
Not according to the various chemical substance components in the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol
Together, it can select in suitable temperature and suitable pressure to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol
It is extracted.
Preferably, in order to promote extraction efficiency, ensure the purity of tetrahydrocannabinol extracted, make using carbon dioxide
For supercritical fluid, supercritical, high pressure extraction is carried out to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol, is obtained
After extraction the step of fluid containing tetrahydrocannabinol in, so that carbon dioxide is in Supercritical Conditions, Zhi Hou
Tetrahydrocannabinol is extracted in this pressure limit of 2.5atm (atmospheric pressure)~20atm, that is, carries out tetrahydrocannabinol extraction
When taking, the pressure value of supercritical, high pressure extraction is ranging from：2.5atm (atmospheric pressure)~20atm.In this pressure limit,
Carbon dioxide can remain liquid, and best to the supercritical extract effect of tetrahydrocannabinol, it can be ensured that higher extraction effect
Rate, effectively shortens extraction time.
It optionally, can be by supercritical, high pressure extracter to containing cannabinol, hemp when carrying out supercritical, high pressure extraction
Diphenol and the mixture of tetrahydrocannabinol are extracted.
Optionally, supercritical fluid can also be nitrogen.Nitrogen has stable chemical property, and nontoxic, will not be to ring
Border pollutes and damages, and uses nitrogen as supercritical fluid and may be implemented efficiently, steadily to the extraction of tetrahydrocannabinol.
When use nitrogen as supercritical fluid, to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol into
When row supercritical, high pressure extracts, the pressure value of supercritical, high pressure extraction is ranging from：2.5atm~20atm.In this pressure model
It is best to the supercritical extract effect of tetrahydrocannabinol in enclosing, it can be ensured that higher extraction efficiency, effectively shorten extraction when
Between.
After being extracted by supercritical, high pressure, the stream containing tetrahydrocannabinol is dissolved under default reaction temperature using paraffin
Tetrahydrocannabinol in body obtains the paraffin solution containing tetrahydrocannabinol.The higher tetrahydrochysene hemp of purity can be obtained in this way
Phenol can also make remaining tetrahydrocannabinol content in the fluid containing tetrahydrocannabinol lower, even if containing tetrahydrocannabinol
Fluid in remaining cannabidiol purity higher.Two kinds of substances can be extracted by single extraction process in this way, and made
The purity for obtaining two kinds of substances is higher, saves extraction cost, improves extraction efficiency.
Extraction purity as needed is different, and default reaction temperature can be different, for example, in the present embodiment, presetting anti-
It is 40 DEG C~80 DEG C to answer the value range of temperature.It is preset in range of reaction temperature at this, paraffin can keep fluid state, and
It is best to the solute effect of tetrahydrocannabinol.
After being dissolved to tetrahydrocannabinol by paraffin, the paraffin of tetrahydrocannabinol is contained using alcohol rinse, it can
So that the tetrahydrocannabinol filtering in the paraffin solution containing tetrahydrocannabinol is precipitated, and then obtain the higher tetrahydrochysene hemp of purity
Phenol particle and/or powder.The tetrahydrocannabinol particle and/or powder of precipitation can be collected by filter paper.
Optionally, alcohol can be high-purity alcohol or 95% or more purity alcohol.
Tetrahydrocannabinol extracting process can isolate the tetrahydrocannabinol (THC) in medical cannabis in the medical cannabis
Come, obtains the higher tetrahydrocannabinol of purity.
Embodiment of above is merely to illustrate the embodiment of the present invention, and is not the limitation to the embodiment of the present invention, related skill
The those of ordinary skill in art field can also make various in the case where not departing from the spirit and scope of the embodiment of the present invention
Variation and modification, therefore all equivalent technical solutions also belong to the scope of the embodiment of the present invention, the patent of the embodiment of the present invention
Protection domain should be defined by the claims.
Claims (9)
1. tetrahydrocannabinol extracting process in a kind of medical cannabis, which is characterized in that including：
Using supercritical fluid, supercritical, high pressure extraction is carried out to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol
It takes, the fluid containing tetrahydrocannabinol after being extracted；
Using tetrahydrocannabinol of the paraffin under default reaction temperature in the dissolving fluid containing tetrahydrocannabinol, contained
There is the paraffin solution of tetrahydrocannabinol；
Using the paraffin solution containing tetrahydrocannabinol described in alcohol rinse, make in the paraffin solution containing tetrahydrocannabinol
Tetrahydrocannabinol filtering be precipitated.
2. tetrahydrocannabinol extracting process in medical cannabis according to claim 1, which is characterized in that the shooting flow
Body is carbon dioxide.
3. tetrahydrocannabinol extracting process in medical cannabis according to claim 2, which is characterized in that use shooting flow
Body carries out supercritical, high pressure extraction to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol, contains after being extracted
In the step of fluid of tetrahydrocannabinol, the pressure value of the supercritical, high pressure extraction is ranging from：2.5atm~20atm.
4. tetrahydrocannabinol extracting process in medical cannabis according to claim 1, which is characterized in that the shooting flow
Body is nitrogen.
5. tetrahydrocannabinol extracting process in medical cannabis according to claim 4, which is characterized in that use shooting flow
Body carries out supercritical, high pressure extraction to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol, contains after being extracted
In the step of fluid of tetrahydrocannabinol, the pressure value of the supercritical, high pressure extraction is ranging from：2.5atm~20atm.
6. tetrahydrocannabinol extracting process in medical cannabis according to any one of claims 1-5, which is characterized in that institute
The value range for stating default reaction temperature is 40 DEG C~80 DEG C.
7. tetrahydrocannabinol extracting process in medical cannabis according to any one of claims 1-5, which is characterized in that
Using supercritical fluid, supercritical, high pressure extraction is carried out to the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol, is obtained
After must extracting before the fluid containing tetrahydrocannabinol, the method further includes：
Hemp raw material is pre-processed, the mixture containing cannabinol, cannabidiol and tetrahydrocannabinol is obtained.
8. tetrahydrocannabinol extracting process in medical cannabis according to claim 7, which is characterized in that the pretreatment packet
Include drying process and/or pulverization process.
9. tetrahydrocannabinol extracting process in medical cannabis according to claim 1, which is characterized in that described to use alcohol
The paraffin solution containing tetrahydrocannabinol is rinsed, the tetrahydrocannabinol in the paraffin solution containing tetrahydrocannabinol is made
After filtering is precipitated, the method further includes：
The tetrahydrocannabinol of precipitation is filtered and collected using filter paper.
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| CN201810433372.1A CN108654134A (en) | 2018-05-08 | 2018-05-08 | Tetrahydrocannabinol extracting process in medical cannabis |
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| CN201810433372.1A CN108654134A (en) | 2018-05-08 | 2018-05-08 | Tetrahydrocannabinol extracting process in medical cannabis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
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