CN108653246A - A kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect - Google Patents
A kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect Download PDFInfo
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- CN108653246A CN108653246A CN201810744895.8A CN201810744895A CN108653246A CN 108653246 A CN108653246 A CN 108653246A CN 201810744895 A CN201810744895 A CN 201810744895A CN 108653246 A CN108653246 A CN 108653246A
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- China
- Prior art keywords
- preparation
- proof effect
- good water
- boron sieve
- vertical boron
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The invention discloses a kind of preparation methods of gram vertical boron sieve release membranes of good water-proof effect, are made of following raw material：Active constituent, plasticizer, filler, sorbefacient, suspending agent, binder.The frequency that present invention solution drug uses is excessively high and provides the longer skin residence time and reduces administration number of times, film is prepared using a variety of film forming supplementary product compatibilities, it complements each other, it is indispensable, plasticizer and filler enhance film forming, sorbefacient enhances Medicated Permeation ability, and suspending agent ensures that the dispersibility of raw material in a liquid state, binder enhance the laminating degree of film and skin.
Description
Technical field
The present invention relates to a kind of preparation methods of gram vertical boron sieve release membranes of good water-proof effect, belong to biomedical material neck
Domain.
Background technology
Gram vertical boron sieve (Crisaborole) is a kind of phosphodiesterase 4 (PDE4) inhibitor, and this inhibition causes intracellular
Cyclic adenosine monophosphate (cAMP) level increases, and for treating fungal infection, is in particular used to treat onychomycosis and/or dermatophyte
Infection.The drug obtains U.S. Food and Drug Administration (FDA) in December, 2016 and ratifies listing, public by Anacor pharmacy
Department researches and develops and is responsible in U.S.'s list marketing, and the chemical name of trade name Crisaborole is 5- (4- cyano-benzene oxygens) -1,
3- dihydro -1- hydroxyl -2,1- benzoxaborole heterocyclic pentylenes, English name are 4- ((1-hydroxy-1,3-
Dihydrobenzo [c] [1,2] oxaborol-5-yl) oxy) benzonitrile, shown in chemical structural formula such as formula (I)：
The characteristics of medicament slow release is to reach reduction poisonous side effect of medicine by effective control to drug medical dosage, subtract
Few human body drug resistance, improves the stability of drug and the purpose of effective rate of utilization.Since the high molecular material of selection is different, drug
The control releasing mechanism of molecule also differs, therefore the research of Polymer Drug Delayed Release Materials has a very important significance.Mesh
Before, gram vertical boron sieve preparation is largely that plaster needs fixed point to be administered, and be easier to be wiped without reference in terms of sustained release, cannot
Retain for a long time.
Invention content
In view of above-mentioned deficiency, the preparation method of gram vertical boron sieve release membranes of good water-proof effect provided by the invention solves medicine
The frequency that object uses is excessively high and provides the longer skin residence time and reduces administration number of times.
In order to solve the above-mentioned technical problem, technical scheme is as follows：
A kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect, carries out as follows：
A, prepared by membrane matrix：Using nano non-woven fabric material as host material, Nano waterproof paint is sprayed in front, i.e.,
Film forming matrix；
B, first layer is sustained film preparation：By active constituent, plasticizer, filler, sorbefacient, suspending agent, binder
Mixing is abundant, and the material of molten condition is uniformly applied on the back side of the above-mentioned membrane matrix prepared by melting；
C, second layer extended release film preparation：By active constituent, plasticizer, filler, sorbefacient, suspending agent, binder
Mixing is abundant, adds appropriate water dissolution, stirs evenly, it is uniformly applied in above-mentioned release membranes, and drying machine drying is not to bright
Aobvious moisture；
D, it cuts to obtain the final product.
The Nano waterproof paint is prepared by following methods：
A) it stocks up：40-50 parts of nano powder, 15-20 parts of styrene-acrylic emulsion, 5-10 parts of nanometer di-iron trioxide, titanium dioxide 5-8
Part, 2,2,4- 1-1.5 parts of trimethyl -1,3- pentanediol only son's acid esters take off 40-45 parts of aromatic hydrocarbon solvent；
B) organic nano micro mist, nanometer di-iron trioxide, titanium dioxide are mixed according to mass fraction, is then added to de- virtue
It is dissolved in fragrant hydrocarbon solvent, is stirred evenly under the rotating speed of 300-350r/min, then by styrene-acrylic emulsion and 2,2,4- front threes
Base -1,3- pentanediol only son's acid esters, which is added in said mixture, to be continued to stir evenly；Obtained mixture is sent to ultrasonic wave
In dispersing apparatus, under the frequency of 20-25kHz, with the rate of dispersion of 2500-3000r/min, ultrasonic wave decentralized processing 25-
30min obtains required Nano waterproof paint.
Preferably, each raw material proportioning is as follows：Active constituent 15-25%, plasticizer 20-30%, filler 20-30% inhale
Receive accelerating agent 5-10%, suspending agent 5-10%, binder 6-15%.
Preferably, active constituent includes gram vertical boron sieve and/or gram vertical boron sieve analog derivative.
Preferably, the one kind or several of plasticizer in glycerine, propenyl, polyethylene glycol and/or glyceryl triacetate
Kind.
Preferably, the one kind or several of filler in microcrystalline cellulose, D-sorbite, converted starch and/or dextrin
Kind.
Preferably, sorbefacient is selected from one or more of propylene glycol, polysorbate and/or menthol.
Preferably, suspending agent is selected from one or more of carragheen, guar gum and/or sodium carboxymethylcellulose.
Preferably, binder in polyvinylpyrrolidone, polycarbophil, chitosan and/or polyvinyl alcohol one
Kind is several.
Preferably, in step C, dryer temperature is 60-80 DEG C.
Preferably, the preparation method of the nano powder is：By dimethyldichlorosilane, phenyl trichlorosilane, trimethyl
Four kinds of ingredients of one chlorosilane and ethyl trichlorosilane, wait the amount of substances to mix, and the water-soluble of 5-8 times of mixture quality is then added
Solution, into solution be added sulfuric acid adjust pH value be 3-4,0.5-1h is then stirred under the rotating speed of 250-300r/min, then to
Isometric 40%NaOH solution is added in solution, and solution is heated to 85-90 DEG C, and stirring 1- is continued with same rotational speed
Finally insoluble polymer is obtained by filtration in reactant by 1.5h, and polymer is adjusted to neutrality, and it is dry to reuse strong drying machine
It is dry, and by filter cake rapid dispersion, obtain nano powder.
In the present invention, film is prepared using a variety of film forming supplementary product compatibilities, complemented each other, it is indispensable, it plasticizer and fills out
Agent enhancing film forming is filled, sorbefacient enhances Medicated Permeation ability, and suspending agent ensures the dispersibility of raw material in a liquid state,
Binder enhances the laminating degree of film and skin.
Membrane matrix provided by the invention, nano non-woven fabric material spray Nano waterproof paint as host material, in front,
On the one hand, nano non-woven fabric material is good waterproof cloth, and on the other hand, coating is by various nm waterproof materials and solvent
Composition has good water resistance, and hydrophobicity is good, the film layer smooth even of formation, and caking property is strong.
Bilayer film provided by the invention, first layer release membranes are prepared using the raw material of molten condition, second layer extended release film
Using aqueous solution of raw material brushing, when in use, second layer extended release film is labelled on skin, waits for that water composition is slowly absorbed into disease
In stove, the fused raw material of first layer will continue to discharge drug, and due to being diluted without solvent, concentration higher can be constant
Carry out treat, reach extraordinary slow release treatment effect.
Description of the drawings
Fig. 1 is the infiltration situation of embodiment 1, embodiment 2, comparative example 1 and comparative example 2.
Specific implementation mode
Said program is described further below in conjunction with specific embodiment；It should be understood that these embodiments are for illustrating
The basic principles, principal features and advantages of the present invention, and the present invention is not by the scope limitation of following embodiment；It is used in embodiment
Implementation condition further adjustment can be done according to specific requirement, the implementation condition being not specified is usually the item in routine experiment
Part.
Embodiment 1
A, prepared by membrane matrix：Using nano non-woven fabric material as host material, Nano waterproof paint is sprayed in front, i.e.,
Film forming matrix；
B, first layer is sustained film preparation：By gram vertical boron sieve 20%, glycerine 25%, microcrystalline cellulose 25%, propylene glycol 7%,
Carragheen 8%, polyvinylpyrrolidone 15% mixes fully, and the material of molten condition is uniformly applied to above-mentioned preparation by melting
On the back side of good membrane matrix；
C, second layer extended release film preparation：By gram vertical boron sieve 20%, propenyl 25%, D-sorbite 25%, polysorbate
7%, guar gum 8%, polycarbophil 15% mixes fully, adds appropriate water dissolution, stirs evenly, it is uniformly applied to above-mentioned slow
It releases on film, drying machine drying to unapparent moisture；
D, it cuts to obtain the final product.
The Nano waterproof paint is prepared by following methods：
A) it stocks up：40 parts of nano powder, 15 parts of styrene-acrylic emulsion, 5 parts of nanometer di-iron trioxide, 5 parts of titanium dioxide, 2,2,4- tri-
Methyl-1,1 part of 3- pentanediol only son acid esters take off 40 parts of aromatic hydrocarbon solvent；
B) organic nano micro mist, nanometer di-iron trioxide, titanium dioxide are mixed according to mass fraction, is then added to de- virtue
It is dissolved in fragrant hydrocarbon solvent, is stirred evenly under the rotating speed of 300r/min, then by styrene-acrylic emulsion and 2,2,4- trimethyl -1,
3- pentanediol only son's acid esters, which is added in said mixture, to be continued to stir evenly；Obtained mixture is sent to ultrasonic wave dispersion and sets
In standby, under the frequency of 20kHz, with the rate of dispersion of 2500r/min, it is anti-to obtain required nanometer by ultrasonic wave decentralized processing 25min
Water paint.
Embodiment 2
A, prepared by membrane matrix：Using nano non-woven fabric material as host material, Nano waterproof paint is sprayed in front,
That is film forming matrix；
B, first layer is sustained film preparation：By gram vertical boron sieve 25%, polyethylene glycol 23%, converted starch 22%, menthol
8%, sodium carboxymethylcellulose 7%, chitosan 15% mixes fully, and the material of molten condition is uniformly applied to above-mentioned by melting
On the back side of the membrane matrix prepared；
C, second layer extended release film preparation：By gram vertical boron sieve 25%, glyceryl triacetate 23%, dextrin 22%, menthol
8%, sodium carboxymethylcellulose 7%, polyvinyl alcohol 15% mixes fully, adds appropriate water dissolution, stirs evenly, it is uniformly smeared
In above-mentioned release membranes, drying machine drying to unapparent moisture；
D, it cuts to obtain the final product.
The Nano waterproof paint is prepared by following methods：
A) it stocks up：50 parts of nano powder, 20 parts of styrene-acrylic emulsion, 10 parts of nanometer di-iron trioxide, 8 parts of titanium dioxide, 2,2,4-
1.5 parts of trimethyl -1,3- pentanediol only son acid esters takes off 45 parts of aromatic hydrocarbon solvent；
B) organic nano micro mist, nanometer di-iron trioxide, titanium dioxide are mixed according to mass fraction, is then added to de- virtue
It is dissolved in fragrant hydrocarbon solvent, is stirred evenly under the rotating speed of 350r/min, then by styrene-acrylic emulsion and 2,2,4- trimethyl -1,
3- pentanediol only son's acid esters, which is added in said mixture, to be continued to stir evenly；Obtained mixture is sent to ultrasonic wave dispersion and sets
In standby, under the frequency of 25kHz, with the rate of dispersion of 3000r/min, it is anti-to obtain required nanometer by ultrasonic wave decentralized processing 30min
Water paint.
Embodiment 3
The preparation method of the nano powder is：By dimethyldichlorosilane, phenyl trichlorosilane, tri-methyl-chlorosilane
With four kinds of ingredients of ethyl trichlorosilane, the amount of substances is waited to mix, the water dissolution of 5 times of mixture quality is then added, into solution
It is 3 that sulfuric acid, which is added, and adjusts pH value, and 0.5h is then stirred under the rotating speed of 250r/min, is then added in equal volume into solution
40%NaOH solution, and solution is heated to 85 DEG C, and stirring 1h is continued with same rotational speed, finally reactant is obtained by filtration not
Polymer is adjusted to neutrality by soluble polymer, reuses the drying of strong drying machine, and by filter cake rapid dispersion, obtain nanometer
Micro mist.
Embodiment 4
The preparation method of the nano powder is：By dimethyldichlorosilane, phenyl trichlorosilane, tri-methyl-chlorosilane
With four kinds of ingredients of ethyl trichlorosilane, the amount of substances is waited to mix, the water dissolution of 8 times of mixture quality is then added, into solution
It is 4 that sulfuric acid, which is added, and adjusts pH value, and 1h is then stirred under the rotating speed of 300r/min, isometric 40% is then added into solution
NaOH solution, and solution is heated to 90 DEG C, and stirring 1.5h is continued with same rotational speed, finally reactant is obtained by filtration insoluble
Property polymer, polymer is adjusted to neutrality, the drying of strong drying machine is reused, and by filter cake rapid dispersion, it is micro- to obtain nanometer
Powder.
Comparative example 1
A, prepared by membrane matrix：Using common cloth material as host material, Nano waterproof paint is sprayed in front,
Membrane matrix；
B, first layer is sustained film preparation：By gram vertical boron sieve 20%, glycerine 25%, microcrystalline cellulose 25%, propylene glycol 7%,
Carragheen 8%, polyvinylpyrrolidone 15% mixes fully, and the material of molten condition is uniformly applied to above-mentioned preparation by melting
On the back side of good membrane matrix；
C, second layer extended release film preparation：By gram vertical boron sieve 20%, propenyl 25%, D-sorbite 25%, polysorbate
7%, guar gum 8%, polycarbophil 15% mixes fully, adds appropriate water dissolution, stirs evenly, it is uniformly applied to above-mentioned slow
It releases on film, drying machine drying to unapparent moisture；
D, it cuts to obtain the final product.
The Nano waterproof paint is prepared by following methods：
A) it stocks up：40 parts of nano powder, 15 parts of styrene-acrylic emulsion, 5 parts of nanometer di-iron trioxide, 5 parts of titanium dioxide, 2,2,4- tri-
Methyl-1,1 part of 3- pentanediol only son acid esters take off 40 parts of aromatic hydrocarbon solvent；
B) organic nano micro mist, nanometer di-iron trioxide, titanium dioxide are mixed according to mass fraction, is then added to de- virtue
It is dissolved in fragrant hydrocarbon solvent, is stirred evenly under the rotating speed of 300r/min, then by styrene-acrylic emulsion and 2,2,4- trimethyl -1,
3- pentanediol only son's acid esters, which is added in said mixture, to be continued to stir evenly；Obtained mixture is sent to ultrasonic wave dispersion and sets
In standby, under the frequency of 20kHz, with the rate of dispersion of 2500r/min, it is anti-to obtain required nanometer by ultrasonic wave decentralized processing 25min
Water paint.
Comparative example 2
A, prepared by membrane matrix：Using nano non-woven fabric material as host material, Nano waterproof paint is sprayed in front, i.e.,
Film forming matrix；
B, first layer is sustained film preparation：By gram vertical boron sieve 20%, glycerine 25%, microcrystalline cellulose 25%, propylene glycol 7%,
Carragheen 8%, polyvinylpyrrolidone 15% mixes fully, and the material of molten condition is uniformly applied to above-mentioned preparation by melting
On the back side of good membrane matrix；
C, second layer extended release film preparation：By gram vertical boron sieve 20%, propenyl 25%, D-sorbite 25%, polysorbate
7%, guar gum 8%, polycarbophil 15% mixes fully, adds appropriate water dissolution, stirs evenly, it is uniformly applied to above-mentioned slow
It releases on film, drying machine drying to unapparent moisture；
D, it cuts to obtain the final product.
The Nano waterproof paint is prepared by following methods：
A) it stocks up：30 parts of nano powder, 10 parts of styrene-acrylic emulsion, 2 parts of nanometer di-iron trioxide, 5 parts of titanium dioxide, 2,2,4- tri-
Methyl-1,1 part of 3- pentanediol only son acid esters take off 40 parts of aromatic hydrocarbon solvent；
B) organic nano micro mist, nanometer di-iron trioxide, titanium dioxide are mixed according to mass fraction, is then added to de- virtue
It is dissolved in fragrant hydrocarbon solvent, is stirred evenly under the rotating speed of 300r/min, then by styrene-acrylic emulsion and 2,2,4- trimethyl -1,
3- pentanediol only son's acid esters, which is added in said mixture, to be continued to stir evenly；Obtained mixture is sent to ultrasonic wave dispersion and sets
In standby, under the frequency of 20kHz, with the rate of dispersion of 2500r/min, it is anti-to obtain required nanometer by ultrasonic wave decentralized processing 25min
Water paint.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
Scholar cans understand the content of the present invention and implement it accordingly, and it is not intended to limit the scope of the present invention, all according to the present invention
Equivalent change or modification made by Spirit Essence, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect, which is characterized in that carry out as follows：
A, prepared by membrane matrix：Using nano non-woven fabric material as host material, Nano waterproof paint is sprayed in front, that is, is formed a film
Matrix；
B, first layer is sustained film preparation：Active constituent, plasticizer, filler, sorbefacient, suspending agent, binder are mixed
Fully, it melts, the material of molten condition is uniformly applied on the back side of the above-mentioned membrane matrix prepared；
C, second layer extended release film preparation：Active constituent, plasticizer, filler, sorbefacient, suspending agent, binder are mixed
Fully, add appropriate water dissolution, stir evenly, it is uniformly applied in above-mentioned release membranes, drying machine drying to unapparent water
Point；
D, it cuts to obtain the final product.
The Nano waterproof paint is prepared by following methods：
A) it stocks up：40-50 parts of nano powder, 15-20 parts of styrene-acrylic emulsion, 5-10 parts of nanometer di-iron trioxide, 5-8 parts of titanium dioxide,
2,2,4- 1-1.5 parts of trimethyl -1,3- pentanediol only son's acid esters take off 40-45 parts of aromatic hydrocarbon solvent；
B) organic nano micro mist, nanometer di-iron trioxide, titanium dioxide are mixed according to mass fraction, is then added to de- aromatic hydrocarbon
It is dissolved in solvent, is stirred evenly under the rotating speed of 300-350r/min, then by styrene-acrylic emulsion and 2,2,4- trimethyl -1,
3- pentanediol only son's acid esters, which is added in said mixture, to be continued to stir evenly；Obtained mixture is sent to ultrasonic wave dispersion and sets
In standby, under the frequency of 20-25kHz, with the rate of dispersion of 2500-3000r/min, ultrasonic wave decentralized processing 25-30min is obtained
To required Nano waterproof paint.
2. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Each raw material proportioning is as follows：Active constituent 15-25%, plasticizer 20-30%, filler 20-30%, sorbefacient 5-10%,
Suspending agent 5-10%, binder 6-15%.
3. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Its active constituent includes gram vertical boron sieve and/or gram vertical boron sieve analog derivative.
4. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Its plasticizer is selected from one or more of glycerine, propenyl, polyethylene glycol and/or glyceryl triacetate.
5. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Its filler is selected from one or more of microcrystalline cellulose, D-sorbite, converted starch and/or dextrin.
6. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Its sorbefacient is selected from one or more of propylene glycol, polysorbate and/or menthol.
7. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Its suspending agent is selected from one or more of carragheen, guar gum and/or sodium carboxymethylcellulose.
8. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect according to claim 1, which is characterized in that
Its binder is selected from one or more of polyvinylpyrrolidone, polycarbophil, chitosan and/or polyvinyl alcohol.
9. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect as described in claim 1, which is characterized in that C
In step, dryer temperature is 60-80 DEG C.
10. a kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect as described in claim 1, which is characterized in that
The preparation method of the nano powder is：By dimethyldichlorosilane, phenyl trichlorosilane, tri-methyl-chlorosilane and ethyl three
Four kinds of ingredients of chlorosilane wait the amount of substances to mix, and the water dissolution of 5-8 times of mixture quality is then added, sulphur is added into solution
It is 3-4 that acid, which adjusts pH value, and 0.5-1h is then stirred under the rotating speed of 250-300r/min, is then added in equal volume into solution
40%NaOH solution, and solution is heated to 85-90 DEG C, and stirring 1-1.5h is continued with same rotational speed, finally by reactant mistake
Filter obtains insoluble polymer, and polymer is adjusted to neutrality, and reuses the drying of strong drying machine, and by filter cake rapid dispersion,
Obtain nano powder.
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| CN201810744895.8A CN108653246A (en) | 2018-07-09 | 2018-07-09 | A kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect |
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| CN201810744895.8A CN108653246A (en) | 2018-07-09 | 2018-07-09 | A kind of preparation method of gram vertical boron sieve release membranes of good water-proof effect |
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| CN108653246A true CN108653246A (en) | 2018-10-16 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105623461A (en) * | 2014-11-04 | 2016-06-01 | 江苏冠军涂料科技集团有限公司 | Waterborne epoxy decorative finish board waterproof coating |
| CN106221389A (en) * | 2016-08-16 | 2016-12-14 | 李长虹 | A kind of water-repellent paint |
| US20170152273A1 (en) * | 2015-11-30 | 2017-06-01 | Anacor Pharmaceuticals Inc. | Topical Pharmaceutical Formulations For Treating Inflammatory-Related Conditions |
| CN107236448A (en) * | 2017-07-25 | 2017-10-10 | 合肥嘉仕诚能源科技有限公司 | A kind of organic nano water-repellent paint |
-
2018
- 2018-07-09 CN CN201810744895.8A patent/CN108653246A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105623461A (en) * | 2014-11-04 | 2016-06-01 | 江苏冠军涂料科技集团有限公司 | Waterborne epoxy decorative finish board waterproof coating |
| US20170152273A1 (en) * | 2015-11-30 | 2017-06-01 | Anacor Pharmaceuticals Inc. | Topical Pharmaceutical Formulations For Treating Inflammatory-Related Conditions |
| CN106221389A (en) * | 2016-08-16 | 2016-12-14 | 李长虹 | A kind of water-repellent paint |
| CN107236448A (en) * | 2017-07-25 | 2017-10-10 | 合肥嘉仕诚能源科技有限公司 | A kind of organic nano water-repellent paint |
Non-Patent Citations (2)
| Title |
|---|
| 周祥兴: "《包装用塑料制品的生产配方和生产工艺》", 31 December 2010 * |
| 高涛 等: "《药剂学》", 30 May 2017 * |
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