CN108653028B - Application of the vitexicarpin as cosmetics sun-prevention component - Google Patents

Application of the vitexicarpin as cosmetics sun-prevention component Download PDF

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Publication number
CN108653028B
CN108653028B CN201810612147.4A CN201810612147A CN108653028B CN 108653028 B CN108653028 B CN 108653028B CN 201810612147 A CN201810612147 A CN 201810612147A CN 108653028 B CN108653028 B CN 108653028B
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sun
vitexicarpin
screening agent
cosmetics
added
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CN108653028A (en
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王玲
张金龙
蒋丽刚
李欣航
毕永贤
席长洪
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Proya Cosmetics Co Ltd
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Proya Cosmetics Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

Application the present invention relates to vitexicarpin as cosmetics sun-screening agent, it is characterised in that: vitexicarpin is applied in sun-proof class cosmetics as sun-screening agent.Vitexicarpin is 1%-10% as the additive amount of sun-screening agent, and the percentage is mass percent.The advantage of the invention is that vitexicarpin is used as cosmetics sun-screening agent, and is used cooperatively with the current chemical sun of cosmetic industry, the usage amount of current chemical sun can be reduced, the beneficial effect of synergistic sun-proof result is played.

Description

Application of the vitexicarpin as cosmetics sun-prevention component
Technical field
The present invention relates to cosmetic technical field, in particular to application of the vitexicarpin as cosmetics sun-prevention component.
Background technique
Wavelength be 100-400nm ultraviolet light (UV) wavelength can be divided into UVC(100nm-280nm), UVB(280nm-320nm) And UVA(320nm-400nm) three kinds.Through being completely absorbed when ozone layer, UVB can penetrate ozone layer and enter earth surface UVC, It mainly acts on skin epidermis and causes erythema, UVA penetration power is stronger, and can penetrate to dermal layer of the skin makes skin darkening aging.
The sun-screening agent in cosmetics is broadly divided into two classes at present: 1) physical sunscreen agent: i.e. ultraviolet light screener is to pass through Reflection and scatters ultraviolet shield to skin, predominantly inorganic particulate, Typical Representative be nanoscale titanium dioxide, Zinc oxide particles.But this kind of sun-screening agent has the shortcomings that dosage is big, sun-proof result is poor, and excessive use easily blocks pore, influences skin The secretion of adipose gland and sweat gland causes the adverse consequences such as skin injury.2) chemical absorbent: this sun-screening agent itself has ultraviolet light Stronger absorbability can reduce or fully absorb ultraviolet light, human skin is made to escape injury, but this kind of sun-screening agent is thorn mostly Swash property and photosensitive material, skin allergy is easily led to when dosage is big, the absorption there are insecurity factor and to the area UVA ultraviolet light Protect the problems such as not complete enough.Currently, extracting from natural plants has the research of anti-sunlight function ingredient more and more, plant is anti- Shining ingredient consumer will be considered that is milder and has smaller stimulation when being applied to skin.Therefore, exploitation has excellent The natural sun-prevention component of sun-screening function has urgent need and vast market prospect.
Fructus viticis alias twigs of the chaste tree, calico chaste tree, capital, belong to the fruit of Verbenaceae Vitex rotundifolia.Wild pepper fruit mentions Object is taken to have effects that anti-inflammatory, anti-oxidant, antitumor and anti-aging etc..Main component in wild pepper fruit includes fructus viticis Huang Element, fructus viticis glycosides, lignanoid, flavonoids, steroid and diterpene-kind compound, wherein the content highest of vitexicarpin.
Summary of the invention
The technical problem to be solved by the present invention is to provide a kind of purposes that vitexicarpin is new.
In order to solve the above technical problems, the invention adopts the following technical scheme: sun-proof using vitexicarpin as cosmetics Ingredient is applied.Vitexicarpin is 1%-10% as the additive amount of sun-screening agent, and the percentage is mass percent.
A kind of sun-proof class cosmetics are provided, general sun-screening agent is contained, it is characterised in that: are also 1%-10% containing mass percent Vitexicarpin.
The vitexicarpin, Chinese nickname " 5- hydroxyl -2- (3- hydroxyl -4- methoxyphenyl) -3,6,7- trimethoxies Benzopyran-4-one ", molecular formula: C19H18O8, molecular weight: 374.35, No. CAS: 479-91-4.
There are the product of Chengdu Rui Fensi Biotechnology Co., Ltd, quotient in vitexicarpin purity >=98%, commercial product The name of an article is Vitexicarpin.
The present invention is directly made an addition to using vitexicarpin as sun-prevention component in sun-proof class cosmetics, and " is changed with 2015 editions Cosmetic technical specification of security " in be related to UVA and UVB sun-screening agent and be used in compounding, there is good synergistic function.
The test experiments of vitexicarpin sun-proof result are as follows.
Experiment one: the sun-proof result measurement experiment of vitexicarpin
In order to preferably prove the sun-proof result of vitexicarpin, the present invention is below without adding any other sun-screening agent Formula in add respectively 3%, 5%, 10% vitexicarpin formula A, B and C, be specifically shown in Table 1.
The W/O ultra light sun block lotion formula of the addition dosage difference vitexicarpin of table 1
It is separate Material name A(% (w/w)) B(% (w/w)) C(% (w/w))
A1 Cyclomethicone 24.00% 24.00% 24.00%
A2 Permethyl 99A 10.00% 10.00% 10.00%
A3 Dimethyl siloxane/vinyldimethylsiloxane cross-linked polymer 4.00% 4.00% 4.00%
B1 PEG-10 dimethyl silicone polymer 1.00% 1.00% 1.00%
B2 PEG/PPG-19/19 dimethyl siloxane/cyclomethicone mixture 0.25% 0.25% 0.25%
B3 Tocopherol acetate 0.10% 0.10% 0.10%
B4 Diisopropyl sebacate 6.00% 6.00% 6.00%
B5 Pentaerythrite tetraethyl capronate 4.00% 4.00% 4.00%
C1 Water 31.6% 29.6% 24.6%
C2 Ethyl alcohol 12.00% 12.00% 12.00%
C3 Phenoxyethanol 0.20% 0.20% 0.20%
C4 Glycerol 3.00% 3.00% 3.00%
C5 Sodium citrate 0.85% 0.85% 0.85%
D Vitexicarpin 3.00% 5.00% 10.00%
Preparation process:
(1) emulsion pot: part A is added in emulsion pot, stirs evenly, after then part B is added, stirs evenly and heat To 78-82 DEG C, 50 DEG C are cooled to after being completely dissolved.
(2) kettle: kettle is added in C1, sequentially adds other raw materials of C portion, stirs evenly, until whole dissolutions, and be heated to 50℃。
(3) emulsion pot: emulsion pot, control plus water speed is added by online mixer in raw material in kettle, discharge port is not Must there are water, bottom homogeneous 2500rpm, until water phase adds.
(4) 40 DEG C are cooled to, D part material is added, to uniform, stop online mixer, passes through 50 within stirring 15 minutes The discharging of mesh filter.
To the ultra light sun block lotion of above-mentioned addition different amounts vitexicarpin formula A, formula B and formula C carry out spf value and The measurement of PFA value, concrete outcome are as shown in table 2.
2 different amounts vitexicarpin ultra light sun block lotion of table is formulated A, formula B and the spf value and PFA value that are formulated C
Formula Vitexicarpin dosage % Spf value PFA value
It is formulated A 3.00% 5.00±0.13 2.98
It is formulated B 5.00% 9.56±0.16 5.16
It is formulated C 10.00% 20.00±0.18 9.73
As shown in Table 2, with the increase of vitexicarpin dosage, the spf value and PFA value of ultra light sun block lotion show aobvious Increased trend is write, in being formulated C when the dosage of vitexicarpin is 10%, spf value rises to 20 or so, PFA value and then increases To 10 or so.Thus illustrate that vitexicarpin has effects that good uv blocking A and UVB, can be used as sun-screening agent be added to it is sun-proof In cosmetics, increase the sun-proof ability of cosmetics.
Experiment two, vitexicarpin and the experiment of UVB and UVA sun-screening agent synergy are tested
(1) the effect of ultra light sun block lotion of addition UVB sun-screening agent and vitexicarpin, compares
By the D phase in ultra light sun block lotion basic components (see Table 1) successively with 3% existing UVB sun-screening agent: such as the diethyl in table 3 Base hexyl amide-based small triazinone, ethylhexyl methoxy cinnamate, ethylhexyl salicylate, Uvinul T 150, Hu Mo Willow ester, Octocrilene, Phenylbenzimidazolesulfonic acid, Dimethicodiethylbenzalmalonate replace forming the ultra light sun block lotion for adding different sun-screening agents, so Afterwards by the dosage of the above sun-screening agent be reduced to 1.5% and be separately added into 1.5% vitexicarpin formed addition 1.5%UVB prevent Shine multiple ultra light sun block lotion formulas of agent and 1.5% vitexicarpin.
Using SPF tester (producer: Optometrics company, the U.S., model: Optometrics LLC SPF290S) corresponding SPF (spf value) is measured, specific test result is as shown in table 3.
Table 3 adds the spf value of the ultra light sun block lotion of different UVB sun-screening agents and vitexicarpin
Serial number Sun-screening agent Spf value
1 3% Diethylhexyl Butamido Triazon 7.95±0.35
2 + 1.5% vitexicarpin of 1.5% Diethylhexyl Butamido Triazon 11.95±0.56
3 3% ethylhexyl methoxy cinnamate 6.30±0.43
4 + 1.5% vitexicarpin of 1.5% ethylhexyl methoxy cinnamate 10.05±0.61
5 3% ethylhexyl salicylate 3.15±0.12
6 + 1.5% vitexicarpin of 1.5% ethylhexyl salicylate 7.92±0.68
7 3% Uvinul T 150 7.80±0.32
8 + 1.5% vitexicarpin of 1.5% Uvinul T 150 11.83±0.65
9 3% Homosalate 3.00±0.15
10 + 1.5% vitexicarpin of 1.5% Homosalate 7.75±0.18
11 3% Octocrilene 4.50±0.11
12 + 1.5% vitexicarpin of 1.5% Octocrilene 8.30±0.23
13 3% Phenylbenzimidazolesulfonic acid potassium 6.30±0.10
14 + 1.5% vitexicarpin of 1.5% Phenylbenzimidazolesulfonic acid potassium 10.03±0.33
15 3% Dimethicodiethylbenzalmalonate 3.15±0.18
16 + 1.5% vitexicarpin of 1.5% Dimethicodiethylbenzalmalonate 7.95±0.45
As shown in Table 3, in existing UVB sun-screening agent Diethylhexyl Butamido Triazon, methoxy cinnamic acid ethyl hexyl The spf value that the ultra light sun block lotion of 1.5% vitexicarpin is added in ester etc. is apparently higher than individually addition 3%UVB sun-screening agent and 3% wild pepper The spf value of the ultra light sun block lotion of sub- flavine (being shown in Table 2, spf value is 5.00 ± 0.13), thus illustrates that vitexicarpin is sun-proof to UVB Agent has good sun-proof building capability.
(2) the effect of ultra light sun block lotion of addition UVA sun-screening agent and vitexicarpin, compares
By D in ultra light sun block lotion basic components (see Table 1) successively in table 4 3% existing UVA sun-screening agent and be added to The UVA sun-screening agent of 1.5% vitexicarpin is replaced, and obtains the ultra light sun block lotion of the identical different sun-screening agents of addition dosage, according to The measuring method of " 2015 cosmetics safety technical specification " middle-ultraviolet lamp protection index (PFA value) measures corresponding ultra light sun block lotion PFA value, by taking measurement PFA value when volunteer smears 40min as an example, concrete outcome is as shown in table 4.
The PFA value of table 4 addition vitexicarpin and the ultra light sun block lotion of different UVA sun-screening agents
Serial number Sun-screening agent PFA value
1 3% fourth methoxy dibenzoylmethane 4.20(PA++)
2 + 1.5% vitexicarpin of 1.5% fourth methoxy dibenzoylmethane 6.32(PA++)
3 3% dioxy ammonia formyl hydroxy yl benzoic acid ethyl ester 3.75(PA+)
4 + 1.5% vitexicarpin of 1.5% dioxy ammonia formyl hydroxy yl benzoic acid ethyl ester 6.03(PA++)
5 3% phenyl dibenzimidazole tetrasulfonic acid ester disodium 4.50(PA++)
6 + 1.5% vitexicarpin of 1.5% phenyl dibenzimidazole tetrasulfonic acid ester disodium 7.15(PA++)
As shown in Table 4,3% fourth methoxy dibenzoylmethane, dioxy ammonia formyl hydroxy yl benzoic acid ethyl ester, benzene are added The PFA value of the ultra light sun block lotion of base bisbenzimidazole tetrasulfonic acid ester disodium within the scope of 3-5 there is the UVA down to middle rank to protect energy Power, and the PFA value for adding above three 1.5%UVA sun-screening agent and 1.5% vitexicarpin ultra light sun block lotion be 6 or more, Within the scope of PFA value 4-8, there is the UVA protective capacities of middle rank, PFA value is apparently higher than individually addition 3%UVA sun-screening agent and 3% climing Jing Zi flavine (is shown in Table the PFA value that 2, PFA value is ultra light sun block lotion 2.98).Thus illustrate that fructus viticis has very UVA sun-screening agent Good sun-proof building capability.
(3) the effect of ultra light sun block lotion of addition UVA/UVB sun-screening agent and vitexicarpin, compares
Ultra light sun block lotion is formulated D in (see Table 1) and successively uses 3% existing UVA/UVB sun-screening agent oxygen phenyl triazine, Asia in table 5 Methyl pair-benzotriazole base tetramethyl butyl phenol is replaced, and is obtained different ultra light sun block lotion formulas, is then prevented the above The dosage for shining agent is reduced to 1.5% and is separately added into 1.5% vitexicarpin formation addition 1.5%UVA/UVB sun-screening agent and 1.5% Multiple ultra light sun block lotion formulas of vitexicarpin.
In conjunction with above-mentioned to the PFA value of ultra light sun block lotion and the measuring method of spf value, to being added to UVA/UVB sun-screening agent The sun-proof function of ultra light sun block lotion is evaluated, and concrete outcome is as shown in table 5.
The spf value of table 5 addition vitexicarpin and the ultra light sun block lotion of different UVA/UVB sun-screening agents
Serial number Sun-screening agent PFA value
1 3% oxygen phenyl triazine 7.20(PA++)
2 + 1.5% vitexicarpin of 1.5% oxygen phenyl triazine 9.89(PA+++)
3 3% methylene bis-benzotriazolyl tetramethyl butyl phenol 5.85(PA++)
4 + 1.5% vitexicarpin of 1.5% methylene bis-benzotriazolyl tetramethyl butyl phenol 8.87(PA+++)
As shown in Table 5, the ultra light sun block lotion for adding above-mentioned sun-screening agent all has the ability of uv blocking A/UVB, and is added to wild pepper The PFA and spf value of sub- flavine ultra light sun block lotion are apparently higher than the oxygen phenyl triazine and di-2-ethylhexylphosphine oxide-benzo for being not added with vitexicarpin The PFA and spf value of triazolyl tetramethyl butyl phenol, and simultaneously above PFA and the spf value of the only vitexicarpin of addition 3% (see Table 2, PFA value and spf value are respectively 2.98 and 5.00 ± 0.13), illustrate that vitexicarpin has synergy UVA/UVB sun-proof The effect of agent.
The present invention carries out ultraviolet detection, test result such as Fig. 1 institute to the vitexicarpin by ultraviolet specrophotometer Show, vitexicarpin is in 280 ~ 320nm(UVB), 320 ~ 400nm(UVA) there is apparent absorption peak in range of wavelengths, show wild pepper Sub- flavine has good absorption effect to UVA and UVB, can be used as sun-prevention component use, and finds to be added to sun-proof class There can be good synergistic function with UVA and UVB sun-screening agent in cosmetics.
In conclusion vitexicarpin have the function of absorb in, long wave ultraviolet, can be used as sun-screening agent be added to it is anti- It shines in class cosmetics, plays and resist the sun-proof effect of ultraviolet light.Vitexicarpin is as cosmetics sun-screening agent and cosmetic industry Current chemical sun is used cooperatively, and can reduce the usage amount of current chemical sun, plays synergistic sun-proof result Beneficial effect.
Detailed description of the invention
Fig. 1 is that the ultraviolet detection of Fructus Viticis extract vitexicarpin composes schematic diagram.
Specific embodiment
The present invention will be further described combined with specific embodiments below, but the invention is not limited to following embodiments.
Embodiment 1:
Sun-proof class cosmetics of a kind of addition vitexicarpin as sun-screening agent.
A kind of table 6 Water-In-Oil (W/O) sunscreen
It is separate Material name %(w/w)
A1 Cyclomethicone 24.00%
A2 Permethyl 99A 10.00%
A3 Dimethyl siloxane/vinyldimethylsiloxane cross-linked polymer 4.00%
B1 PEG-10 dimethyl silicone polymer 1.00%
B2 PEG/PPG-19/19 dimethyl siloxane/cyclomethicone mixture 0.25%
B3 Tocopherol acetate 0.10%
B4 Diisopropyl sebacate 6.00%
B5 Pentaerythrite tetraethyl capronate 4.00%
C1 Water Surplus
C2 Ethyl alcohol 12.00%
C3 Phenoxyethanol 0.20%
C4 Glycerol 3.00%
C5 Sodium citrate 0.85%
D1 Vitexicarpin 8.00%
D2 Essence 0.20%
Preparation process:
(1) emulsion pot: part A is added in emulsion pot, stirs evenly, after then part B is added, stirs evenly and heat To 78-82 DEG C, 50 DEG C are cooled to after being completely dissolved.
(2) kettle: kettle is added in C1, sequentially adds other raw materials of C portion, stirs evenly, until whole dissolutions, and be heated to 50℃。
(3) emulsion pot: emulsion pot, control plus water speed is added by online mixer in raw material in kettle, discharge port is not Must there are water, bottom homogeneous 2500rpm, until water phase adds.
(4) 40 DEG C are cooled to, D part material is added, to uniform, stop online mixer, passes through 50 within stirring 15 minutes The discharging of mesh filter.
What above-mentioned 8% vitexicarpin of addition was prepared as the ultra light sun block lotion formula of sun-screening agent according to preparation process The PFA and spf value of ultra light sun block lotion are respectively 8.18,14.37 ± 0.15.
Embodiment 2:
A kind of cosmetics being added to UVA, UVB, UVA/UVB and vitexicarpin sun-screening agent.
A kind of table 7 oil-in-water (O/W) sunscreen
Preparation process:
(1) kettle: being first added A1, is uniformly dispersed after component A2, A3 are pre-mixed addition, and component A4-A8 is then added Stirring is to being completely dissolved, and heat is to 80-85 DEG C.
(2) part B raw material is added in kettle, is stirred evenly.Then C1 is added, stirs evenly, avoids a large amount of foams. It is maintained at 80-83 DEG C.
(3) it oil cauldron: accurately weighs component D constituent part and is added in oily phase pot, be heated with stirring to 80-83 DEG C.
Addition component E1 in (4) 75 DEG C of emulsion pots, 2800rpm high speed homogenization 8 minutes.Stop cooling.
(5) water phase pot is added in the water of the part F1, then F2 is added, after mixing evenly, by 100 mesh filters by water Pot is pumped into emulsion pot with the material in oil cauldron, 2800rpm high speed homogenization 10 minutes, then cools down.
(6) 37 DEG C of addition G constituent parts, 2800rpm homogeneous 2 minutes, stir evenly, and 35 DEG C of inspections are qualified to pass through 100 mesh Filter discharging.
Oil-in-water (O/W) the ultra light sun block lotion formula A and B of above-mentioned 1% and 10% vitexicarpin of addition is according to preparation process The PFA/SPF value for the ultra light sun block lotion being prepared is respectively 11.8/35.28 ± 0.16,16.32/51.88 ± 0.12.
Embodiment 3:
A kind of cosmetics being added to UVA, UVB, UVA/UVB and vitexicarpin sun-screening agent.
8 Water-In-Oil of table (W/O) sunscreen
It is separate Material name A(% (w/w)) B(% (w/w))
A1 Cyclomethicone 24.00% 24.00%
A2 Permethyl 99A 10.00% 10.00%
A3 Zinc oxide (surface treatment: aqueous silica/hydrogenation dimethyl silicone polymer) 8.00% 8.00%
A4 Dimethyl siloxane/vinyldimethylsiloxane cross-linked polymer 4.00% 4.00%
B1 The own ester of diethylamino oxybenzene formylbenzoate 4.00% 4.00%
B2 Ethylhexyl methoxy cinnamate 9.50% 9.50%
B3 Octocrilene 3.50% 3.50%
B4 PEG-10 dimethyl silicone polymer 1.00% 1.00%
B5 Methylene bis-benzotriazolyl tetramethyl butyl phenol 2.00% 2.00%
B6 PEG/PPG-19/19 dimethyl siloxane/cyclomethicone mixture 0.25% 0.25%
B7 Tocopherol acetate 0.10% 0.10%
B8 Diisopropyl sebacate 6.00% 6.00%
B9 Pentaerythrite tetraethyl capronate 4.00% 4.00%
C1 Water Surplus Surplus
C2 Ethyl alcohol 12.00% 12.00%
C3 Phenoxyethanol 0.20% 0.20%
C4 Glycerol 3.00% 3.00%
C5 Sodium citrate 0.85% 0.85%
D1 (daily) essence 0.20% 0.20%
D2 Vitexicarpin 1.00% 10.00%
Preparation process:
(1) emulsion pot: the independent homogenous disperse 15min of A phase raw material, until substantially uniformity；
(2) B phase raw material is heated with stirring to 80-85 DEG C to being completely dissolved, and is added in emulsion pot, is dispersed with stirring uniformly；
(3) kettle: the uniform mixed dissolution of C phase raw material；
(4) emulsion pot being added by online mixer in raw material in kettle, control plus water speed, discharge port must not have water, Bottom homogeneous 2500rpm, until water phase adds.
(5) lotion is cooled to 35 DEG C, and D part material is added, and stirring 15 minutes logical to uniform, stopping online mixer Cross the discharging of 50 mesh filters.
Water-In-Oil (W/O) the ultra light sun block lotion formula A and B of above-mentioned 1% and 10% vitexicarpin of addition is according to preparation process The PFA/SPF value for the ultra light sun block lotion being prepared is respectively 12.35/34.55 ± 0.11,15.43/50.12 ± 0.18.

Claims (2)

1. application of the vitexicarpin as cosmetics sun-screening agent, it is characterised in that: the wild pepper that addition mass percent is 1-10% Sub- flavine is applied in sun-proof class cosmetics as sun-screening agent.
2. a kind of sun-proof class cosmetics include conventional sunscreen agent, it is characterised in that: be also the climing of 1%-10% containing mass percent Jing Zi flavine.
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CN105055207A (en) * 2015-07-29 2015-11-18 江苏奇力康皮肤药业有限公司 Traditional Chinese medicine moistening shampoo and preparation method thereof
CN106420513A (en) * 2016-12-28 2017-02-22 广州环亚化妆品科技有限公司 Traditional Chinese medicine extraction composition with effects of whitening skin and dispelling speckle and preparation method and application of traditional Chinese medicine extraction composition

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