CN108652590A - A kind of compound microprobe of OCT image and preparation method thereof that integrated optical fiber sensing many reference amounts measure - Google Patents
A kind of compound microprobe of OCT image and preparation method thereof that integrated optical fiber sensing many reference amounts measure Download PDFInfo
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- CN108652590A CN108652590A CN201810479795.7A CN201810479795A CN108652590A CN 108652590 A CN108652590 A CN 108652590A CN 201810479795 A CN201810479795 A CN 201810479795A CN 108652590 A CN108652590 A CN 108652590A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
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- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/02057—Optical fibres with cladding with or without a coating comprising gratings
- G02B6/02076—Refractive index modulation gratings, e.g. Bragg gratings
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- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/255—Splicing of light guides, e.g. by fusion or bonding
- G02B6/2552—Splicing of light guides, e.g. by fusion or bonding reshaping or reforming of light guides for coupling using thermal heating, e.g. tapering, forming of a lens on light guide ends
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
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Abstract
The present invention relates to Fibre Optical Sensor medical treatment device technical fields, refer specifically to a kind of compound microprobe of OCT image that integrated optical fiber sensing many reference amounts measure, also disclose the preparation method of the compound microprobe, including multi-core optical fiber, side-hole fiber, single mode optical fiber and the multimode fibre welded successively, multi-core optical fiber includes axis fibre core and eccentric fibre core, the fibre core of axis fibre core and single mode optical fiber is respectively welded at the fibre core both ends of side-hole fiber, eccentric fibre core glazing is carved with FBG gratings, and eccentric fibre core front end and the lateral opening air cavity end on side-hole fiber and then composition F P air chambers；The front end fusion of multimode fibre has Bell's ball；Structure of the invention is reasonable, and the sensing units such as FBG gratings, F P air chambers are integrated, and is fused into Bell's ball condenser lens by multimode fibre, can effectively improve the resolution ratio of OCT image observed image；To carrying out the measurement of the parameters such as temperature, pressure while body tissue detection imaging, compact overall structure size is small, to being of great significance in body microvascular disease diagnosis etc..
Description
Technical field
The present invention relates to Fibre Optical Sensor medical treatment device technical field, refer specifically to what a kind of integrated optical fiber sensing many reference amounts measured
The compound microprobe of OCT image also discloses a kind of compound microprobe preparation of the OCT image that integrated optical fiber sensing many reference amounts measure
Method.
Background technology
OCT is a kind of lossless tomography technology, and existing its has occupied an important position in medical imaging field.With light
Deepening continuously for coherence tomography research is learned, other than the surface organs such as detection eyes, skin, tooth, also carries out interior tissue
Detection research, such as to blood vessel, stomach, liver and gall, pancreas organ detection.OCT makes to obtain the disconnected of intracorporeal organ higher resolution
Layer is possibly realized.Carry out optical fiber probe OCT technology research earliest is the Fujimoto researchs of Massachusetts Institute Technology
The probe of group, research group design uses lateral scan mode, optical fiber, GRIN Lens, speculum is encapsulated in transparent
In glass tube, and packaged glass probe is placed in rotation gear centre, is realized to quilt by motor-driven gear rotation
The scanning for surveying object side wall, has obtained peeping scanning cross-section image in rabbit esophagus inner wall using the OCT systems.Harvard of U.S. medicine
The Teamey and Bouma of institute have made great progress in the research of OCT probes, they utilize transversal scanning single mode fiber system
A standardized OCT probe is devised, which realizes the beam collimation to single mode optical fiber using gradually changed refractive index prism, uses
Microprism carries out cross-sectional scans imaging in whole search coverages.Team of domestic Zhejiang University Ding Zhi Chinese groups is using axial cone mirror and circle pair
The circular scanning imaging for claiming Amici prism probe prepared by combination to realize big depth of focus, solves dynamic in endoscopic OCT technology
The problem of focusing.
In the prior art, OCT has higher sensitivity and differentiates as a kind of strong biomedical imaging method
Rate, OCT image contribute to the various inside of human body pathology of detection and analysis.It must be to including for the imaging under internal complex environment
Other parameters including biological tissue synchronize measurement.But existing probe designs mostly use single-core fiber, lens, micro electronmechanical
Machine etc. is prepared, and structure size is big, cannot be satisfied many reference amounts while the needs measured.Therefore, the prior art needs
It improves and develops.
Invention content
In view of the defects and deficiencies of the prior art, the present invention intends to provide it is a kind of it is reasonable for structure, can accurately at
Realize as institutional framework and simultaneously many reference amounts measure integrated optical fiber sensing many reference amounts measure the compound microprobe of OCT image and its
Preparation method.
To achieve the goals above, the present invention uses following technical scheme：
The compound microprobe of OCT image that a kind of integrated optical fiber sensing many reference amounts of the present invention measure, including weld successively
Multi-core optical fiber, side-hole fiber, single mode optical fiber and the multimode fibre connect, multi-core optical fiber include axis fibre core and eccentric fibre core, axis
The fibre core of fibre core and single mode optical fiber is respectively welded at the fibre core both ends of side-hole fiber, and the bias fibre core glazing is carved with FBG gratings,
And eccentric fibre core front end constitutes F-P air chambers in turn with the lateral opening air cavity end on side-hole fiber；The multimode fibre
Front end is fused into Bell's ball.
A kind of compound microprobe preparation method of OCT image that integrated optical fiber sensing many reference amounts measure, its step are as follows：
S1, the specification setting multi-core optical fiber that the compound microprobe of OCT image that many reference amounts measure is sensed according to integrated optical fiber, side
The size of hole optical fiber, single mode optical fiber, multimode fibre, Bell's ball；
S2, a length is inscribed less than 6mm on the eccentric fibre core for carrying hydrogen multi-core optical fiber by extraordinary infrared femtosecond laser
Ultrashort FBG gratings, make laser vernier focusing in eccentric fibre core and generate local indexes of refraction modulation, close to the position of FBG gratings
Set and cut flat with multi-core optical fiber front end, make its with side-hole fiber by fibre core to welding in a manner of fibre core, while ensureing the inclined of multi-core optical fiber
Heart fibre core is aligned with the lateral opening air cavity of side-hole fiber, side-hole fiber and single mode optical fiber by fibre core to welding in a manner of fibre core, Jin Er
F-P air chambers are formed on side-hole fiber, single mode optical fiber is welded with multimode fibre with covering alignment thereof again；
S3, it is made to be melt into Bell's ball, adjustment arc welding machine ginseng the front end electric discharge of multimode fibre using arc welding machine
Then number is processed by shot blasting Bell's ball with obtaining the lens closest to spherical shape to obtain one with fiber end face in 47 °
The polishing section at inclination angle, the silver coating that coating a layer thickness is 100nm on polishing section, then plate one on silver coating surface
The silicon dioxide layer of protection of layer 150nm, makes polishing section reach 87% or more reflectivity；
S4, the specification that the compound microprobe of OCT image that many reference amounts measure is sensed according to above-mentioned integrated optical fiber determine flexible skin
Internal diameter, outer diameter and the length value of lower test tube, using with material preparation of the human organ with compatibility with transparent exit window
Flexible subcutaneous test tube；
S5, the compound microprobe of OCT image that above-mentioned integrated optical fiber sensing many reference amounts measure is encapsulated in flexible subcutaneous test tube
Inside make the polishing section on Bell's ball corresponding with transparent exit window, injection uv-curable glue is to fill in flexible subcutaneous test tube
Gap between Bell's ball and flexible subcutaneous test tube.
The present invention has the beneficial effect that：Structure of the invention is reasonable, using multi-core optical fiber by sensitivities such as FBG gratings, F-P air chambers
Unit is integrated in an optical fiber, is fused into Bell's ball condenser lens by multimode fibre, can be effectively improved OCT image observation chart
The resolution ratio of picture；To the measurement into parameters such as trip temperature, pressure while body tissue detection imaging, compact overall structure, ruler
It is very little small, to being of great significance in body microvascular disease diagnosis etc..
Description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is the preparation process schematic diagram of the present invention.
In figure：
1, multi-core optical fiber；2, side-hole fiber；3, single mode optical fiber；4, multimode fibre；11, axis fibre core；12, eccentric fibre core；
13, FBG gratings；21, F-P air chambers；41, Bei Erqiu；42, section is polished.
Specific implementation mode
Technical scheme of the present invention is illustrated with embodiment below in conjunction with the accompanying drawings.
As shown in Figure 1, the compound microprobe of OCT image that a kind of integrated optical fiber sensing many reference amounts of the present invention measure,
Include multi-core optical fiber 1, side-hole fiber 2, single mode optical fiber 3 and the multimode fibre 4 welded successively with covering alignment thereof, multi-core optical fiber
1 includes axis fibre core 11 and eccentric fibre core 12, and the fibre core of axis fibre core 11 and single mode optical fiber 3 is respectively welded at side-hole fiber 2
Fibre core both ends, bias 12 glazing of fibre core are carved with FBG gratings 13, and eccentric 12 front end of fibre core with it is lateral opening on side-hole fiber 2
Air cavity end on and then composition F-P air chambers 21；The front end of the multimode fibre 4 is fused into Bell's ball 41.
A kind of compound microprobe preparation method of OCT image that integrated optical fiber sensing many reference amounts measure, its step are as follows：
S1, according to integrated optical fiber sense many reference amounts measure the compound microprobe of OCT image specification setting multi-core optical fiber 1,
The size of side-hole fiber 2, single mode optical fiber 3, multimode fibre 4, Bell's ball 41；
S2, by extraordinary infrared femtosecond laser, one length of inscription is less than on the eccentric fibre core 12 for carrying hydrogen multi-core optical fiber 1
The ultrashort FBG gratings 13 of 6mm make laser vernier focusing in eccentric fibre core 12 and generate local indexes of refraction modulation, close to FBG light
The position of grid 13 cuts flat with 1 front end of multi-core optical fiber, make its with side-hole fiber 2 by fibre core to welding in a manner of fibre core, while ensureing more
The eccentric fibre core 12 of core fibre 1 is aligned with the lateral opening air cavity of side-hole fiber 2, and side-hole fiber 2 is with single mode optical fiber 3 with fibre core to fibre core
Mode is welded, and then F-P air chambers 21 are formed on side-hole fiber 2, and single mode optical fiber 3 is again with multimode fibre 4 with the covering side of alignment
Formula is welded；
For the FBG gratings 13 on eccentric fibre core 12, center reflection wavelength is：
λB=2neffΛ
In formula, Λ is fiber grating period, neffFor the effective refractive index of grating region；Λ and neffIt can be by external environment shadow
Ring (temperature, stress etc.) and change, so as to cause the drift of 13 center reflection wavelength of FBG gratings, when probe go deep into it is internal
When, neffCentainly, it and is not affected by force.
Because air low coefficient of thermal expansion and thermo-optical coeffecient, F-P air chambers 21 can ignore the response of temperature, F
21 wavelength of F-P air chambers and the variation relation that chamber is grown are as follows：
Cause the long L variations of chamber when pressure acts on F-P air chambers 21, can find out corresponding cavity length according to wave length shift becomes
Change, further finds out pressure；
S3, so that it is melt into Bell's ball 41 the front end electric discharge of multimode fibre 4 using arc welding machine, adjust arc welding machine
Then parameter is processed by shot blasting that one is in fiber end face with acquisition to obtain the lens closest to spherical shape to Bell's ball 41
The polishing section 42 at 47 ° of inclination angle, the silver coating that coating a layer thickness is 100nm on polishing section 42, then in silver coating
The silicon dioxide layer of protection of last layer 150nm is plated on surface, and polishing section 42 is made to reach 87% or more reflectivity；
S4, the specification that the compound microprobe of OCT image that many reference amounts measure is sensed according to above-mentioned integrated optical fiber determine flexible skin
Internal diameter, outer diameter and the length value of lower test tube, using with material preparation of the human organ with compatibility with transparent exit window
Flexible subcutaneous test tube；
S5, the compound microprobe of OCT image that above-mentioned integrated optical fiber sensing many reference amounts measure is encapsulated in flexible subcutaneous test tube
Inside make the polishing section 42 on Bell's ball 41 corresponding with transparent exit window, in flexible subcutaneous test tube injection uv-curable glue with
Fill the gap between Bell's ball 41 and flexible subcutaneous test tube.
The above is only the better embodiment of the present invention, therefore all constructions according to described in present patent application range,
The equivalent change or modification that feature and principle are done, is included within the scope of present patent application.
Claims (2)
1. a kind of compound microprobe of OCT image that integrated optical fiber sensing many reference amounts measure, it is characterised in that：Including to weld successively
Multi-core optical fiber (1), side-hole fiber (2), single mode optical fiber (3) and multimode fibre (4), multi-core optical fiber (1) includes axis fibre core
(11) and eccentric fibre core (12), the fibre core of axis fibre core (11) and single mode optical fiber (3) is respectively welded at the fibre core of side-hole fiber (2)
Both ends, described bias fibre core (12) glazing are carved with FBG gratings (13), and on eccentric fibre core (12) front end and side-hole fiber (2)
Lateral opening air cavity end on and then composition F-P air chambers (21)；The front end of the multimode fibre (4) is fused into Bell's ball (41).
2. the compound microprobe preparation side of OCT image that a kind of integrated optical fiber sensing many reference amounts according to claim 1 measure
Method, its step are as follows：
S1, specification setting multi-core optical fiber (1), the side that the compound microprobe of OCT image that many reference amounts measure is sensed according to integrated optical fiber
The size of hole optical fiber (2), single mode optical fiber (3), multimode fibre (4), Bell's ball (41)；
S2, by extraordinary infrared femtosecond laser, one length of inscription is less than on the eccentric fibre core (12) for carrying hydrogen multi-core optical fiber (1)
The ultrashort FBG gratings (13) of 6mm make laser vernier focusing in eccentric fibre core (12) and generate local indexes of refraction modulation, close
The position of FBG gratings (13) cuts flat with multi-core optical fiber (1) front end, make its with side-hole fiber (2) by fibre core to welding in a manner of fibre core,
Ensure that the eccentric fibre core (12) of multi-core optical fiber (1) is aligned with the lateral opening air cavity of side-hole fiber (2) simultaneously, side-hole fiber (2) and list
Mode fiber (3), to welding in a manner of fibre core, and then forms F-P air chambers (21), single mode optical fiber by fibre core on side-hole fiber (2)
(3) it is welded again with covering alignment thereof with multimode fibre (4)；
S3, so that it is melt into Bell's ball (41) the front end electric discharge of multimode fibre (4) using arc welding machine, adjust arc welding machine
Then parameter is processed by shot blasting that one is in fiber end face with acquisition to obtain the lens closest to spherical shape to Bell's ball (41)
The polishing section (42) at 47 ° of inclination angle, the silver coating that coating a layer thickness is 100nm in polishing section (42), then in silver
Coating surface plates the silicon dioxide layer of protection of last layer 150nm, and polishing section (42) is made to reach 87% or more reflectivity；
S4, the specification that the compound microprobe of OCT image that many reference amounts measure is sensed according to above-mentioned integrated optical fiber determine flexible subcutaneous examination
Internal diameter, outer diameter and the length value of pipe, using with flexibility of material preparation of the human organ with compatibility with transparent exit window
Subcutaneous test tube；
S5, the compound microprobe of OCT image that above-mentioned integrated optical fiber is sensed to many reference amounts measurement, which are encapsulated in flexible subcutaneous test tube, to be made
Polishing section (42) on Bell's ball (41) is corresponding with transparent exit window, in flexible subcutaneous test tube injection uv-curable glue with
Fill the gap between Bell's ball (41) and flexible subcutaneous test tube.
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| CN201810479795.7A CN108652590B (en) | 2018-05-18 | 2018-05-18 | OCT imaging composite microprobe integrating fiber sensing multi-parameter measurement and preparation method thereof |
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| CN201810479795.7A CN108652590B (en) | 2018-05-18 | 2018-05-18 | OCT imaging composite microprobe integrating fiber sensing multi-parameter measurement and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108873171A (en) * | 2018-07-16 | 2018-11-23 | 哈尔滨工程大学 | A kind of multi-core optical fiber class bessel beam Optical Tweezers Array |
| CN109709499A (en) * | 2019-01-23 | 2019-05-03 | 西北大学 | A kind of probe-type magnetic field vector sensor and preparation method thereof based on fiber grating |
| CN110118539A (en) * | 2019-05-24 | 2019-08-13 | 西南交通大学 | A kind of optical fiber obliquity sensor overcoming temperature interference and method |
| CN112859237A (en) * | 2021-01-05 | 2021-05-28 | 武汉华之洋科技有限公司 | Composite detection device based on multi-core optical fiber sensor |
| CN113143231A (en) * | 2021-04-19 | 2021-07-23 | 武汉理工大学 | Human body invasive pressure and temperature multi-parameter real-time optical fiber detection method and system |
| CN113340561A (en) * | 2021-08-02 | 2021-09-03 | 中国空气动力研究与发展中心空天技术研究所 | Eccentric cylindrical single-hole pneumatic probe for measuring precision in high altitude |
| CN113440105A (en) * | 2021-06-10 | 2021-09-28 | 广州永士达医疗科技有限责任公司 | OCT probe applied to lumen pressure and temperature detection |
| CN113975908A (en) * | 2020-03-23 | 2022-01-28 | 艾感科技(广东)有限公司 | Air filtering system and method based on nanofiber membrane |
| CN114098837A (en) * | 2021-11-11 | 2022-03-01 | 武汉理工大学 | Force-shape self-sensing puncture needle based on light interference and long grating chirp effect |
| WO2024060314A1 (en) * | 2022-09-21 | 2024-03-28 | 上海超光微医疗科技有限公司 | Medical treatment device and treatment probe |
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2018
- 2018-05-18 CN CN201810479795.7A patent/CN108652590B/en active Active
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108873171A (en) * | 2018-07-16 | 2018-11-23 | 哈尔滨工程大学 | A kind of multi-core optical fiber class bessel beam Optical Tweezers Array |
| CN109709499A (en) * | 2019-01-23 | 2019-05-03 | 西北大学 | A kind of probe-type magnetic field vector sensor and preparation method thereof based on fiber grating |
| CN109709499B (en) * | 2019-01-23 | 2021-04-27 | 西北大学 | Probe type vector magnetic field sensor based on fiber bragg grating and manufacturing method thereof |
| CN110118539A (en) * | 2019-05-24 | 2019-08-13 | 西南交通大学 | A kind of optical fiber obliquity sensor overcoming temperature interference and method |
| CN113975908A (en) * | 2020-03-23 | 2022-01-28 | 艾感科技(广东)有限公司 | Air filtering system and method based on nanofiber membrane |
| CN112859237A (en) * | 2021-01-05 | 2021-05-28 | 武汉华之洋科技有限公司 | Composite detection device based on multi-core optical fiber sensor |
| CN112859237B (en) * | 2021-01-05 | 2022-06-24 | 武汉华之洋科技有限公司 | Composite detection device based on multi-core optical fiber sensor |
| CN113143231B (en) * | 2021-04-19 | 2023-08-22 | 武汉理工大学 | Human body invasive pressure temperature multi-parameter real-time optical fiber detection method and system |
| CN113143231A (en) * | 2021-04-19 | 2021-07-23 | 武汉理工大学 | Human body invasive pressure and temperature multi-parameter real-time optical fiber detection method and system |
| CN113440105A (en) * | 2021-06-10 | 2021-09-28 | 广州永士达医疗科技有限责任公司 | OCT probe applied to lumen pressure and temperature detection |
| CN113440105B (en) * | 2021-06-10 | 2024-01-26 | 广州永士达医疗科技有限责任公司 | OCT probe applied to lumen pressure and temperature detection |
| CN113340561B (en) * | 2021-08-02 | 2021-10-29 | 中国空气动力研究与发展中心空天技术研究所 | Eccentric cylindrical single-hole pneumatic probe for measuring precision in high altitude |
| CN113340561A (en) * | 2021-08-02 | 2021-09-03 | 中国空气动力研究与发展中心空天技术研究所 | Eccentric cylindrical single-hole pneumatic probe for measuring precision in high altitude |
| CN114098837A (en) * | 2021-11-11 | 2022-03-01 | 武汉理工大学 | Force-shape self-sensing puncture needle based on light interference and long grating chirp effect |
| CN114098837B (en) * | 2021-11-11 | 2023-12-26 | 武汉理工大学 | Force-shape self-sensing puncture needle based on optical interference and long grating chirp effect |
| WO2024060314A1 (en) * | 2022-09-21 | 2024-03-28 | 上海超光微医疗科技有限公司 | Medical treatment device and treatment probe |
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