CN108641913A - A kind of bio-pharmaceuticals microbial liquid culture medium stirring sterilizing cooling integrated machine - Google Patents
A kind of bio-pharmaceuticals microbial liquid culture medium stirring sterilizing cooling integrated machine Download PDFInfo
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- CN108641913A CN108641913A CN201810647602.4A CN201810647602A CN108641913A CN 108641913 A CN108641913 A CN 108641913A CN 201810647602 A CN201810647602 A CN 201810647602A CN 108641913 A CN108641913 A CN 108641913A
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- wall
- heating stirring
- bottom end
- fixedly connected
- stirring case
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
Abstract
The invention discloses a kind of bio-pharmaceuticals microbial liquid culture mediums to stir sterilizing cooling integrated machine, including heating stirring case, the side outer wall bottom end of the heating stirring case is fixedly connected with cooler bin, the internal ring wall of the heating stirring case is fixedly connected with heating net, the side top outer wall of the heating stirring case is fixedly connected with measurable type preheating apparatus for placing by preheating fixing groove, side top outer wall of the heating stirring case far from preheating fixing groove offers feeding mouth, the centre position of the bottom end outer wall of the heating stirring case is fixedly connected with rotational power case.The present invention relates to bio-pharmaceuticals relevant device technical fields.The bio-pharmaceuticals stirs sterilizing cooling integrated machine with microbial liquid culture medium, fluid nutrient medium is rapidly performed by pre- thermal agitation, heat sterilization and cooling procedure successively, reduces production equipment, improves space utilization rate, to reduce production cost, while accelerating the processing speed of culture medium.
Description
Technical field
The present invention relates to bio-pharmaceuticals relevant device technical field, specially a kind of bio-pharmaceuticals microbial liquid culture
Base stirring sterilizing cooling integrated machine.
Background technology
Bio-pharmaceuticals raw material is based on natural biomaterial, including microorganism, human body, animal, plant, marine organisms
Deng.With the development of biotechnology, purposeful artificial biological raw material obtained becomes the main source of current biological pharmaceutical raw material.
Such as the animal material made from immunization, change microorganism or other cell materials etc. made from gene structure.Bio-pharmaceutical
Feature is that pharmacological activity is high, toxic side effect is small, and nutritive value is high.Bio-pharmaceutical mainly has protein, nucleic acid, carbohydrate, lipid etc..
The component units of these substances are amino acid, nucleotide, monosaccharide, aliphatic acid etc., not only harmless to human body but also be important
Nutriment.
Vitamin, erythromycin, lincomycinum that we eat etc., penicillin, streptomysin, gentamicin of injection etc. are exactly to use
Different microorganisms fermentation biological products obtained.And such product is in batch fermentation production process, fluid nutrient medium needs to exist
Heat sterilization after stirring outside fermentation tank by a set of sterilizing installation, using being sent into sterilized fermentation tank after cooling equipment
It is interior.
Invention content
(1) the technical issues of solving
In view of the deficiencies of the prior art, it is stirred and is sterilized with microbial liquid culture medium the present invention provides a kind of bio-pharmaceuticals
Fluid nutrient medium is rapidly performed by pre- thermal agitation, heat sterilization and cooling procedure by cooling integrated machine successively, is reduced production and is set
It is standby, space utilization rate is improved, to reduce production cost, while accelerating the processing speed of culture medium.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs：A kind of bio-pharmaceuticals microorganism liquid
Body culture medium stirring sterilizing cooling integrated machine, including heating stirring case, the side outer wall bottom end of the heating stirring case are fixed
It is connected with cooler bin, the internal ring wall of the heating stirring case is fixedly connected with heating net, the side of the heating stirring case
Top outer wall is fixedly connected with measurable type preheating apparatus for placing by preheating fixing groove, and the heating stirring case is far from preheating
The side top outer wall of fixing groove offers feeding mouth, and the centre position of the bottom end outer wall of the heating stirring case is fixedly connected
There is rotational power case, and the bottom end inner wall of the rotational power case is fixedly connected with servo motor, the heating stirring case
The centre position of top inner wall be rotatably connected to linkage stirring rod, heating stirring case is run through in the bottom end of the linkage stirring rod
Bottom end inner wall and extend to the inside of rotational power case and be rotatablely connected by the output shaft of shaft coupling and servo motor, it is described
The external annulus of linkage stirring rod is fixedly connected with agitating plate, and the heating stirring case preheats apparatus for placing far from measurable type
Side bottom end is connected by discharge nozzle with cooler bin, and the discharge nozzle runs through the outer wall of cooler bin and extends to cooler bin
Inside is communicated with threaded connection outlet tube by U-shaped cooling tube, and being flowed in the cooler bin has coolant liquid.
Preferably, measurable type preheating apparatus for placing includes preheating containing tank, the top of the preheating containing tank
End external annulus is snapped connection by fixing chuck plate and preheating fixing groove, and the preheating containing tank passes through transparent observation slot and heating
The internal ring wall of agitator tank inlays connection.
Preferably, the bottom end outer wall of the heating stirring case and cooler bin has been fixedly connected with fixing support rack.
Preferably, the cooler bin is communicated with inlet tube, and institute close to the side top outer wall for being threadedly coupled outlet tube
The cooler bin stated is communicated with outlet tube far from the side bottom end outer wall for being threadedly coupled outlet tube.
Preferably, the bottom end inner wall that the bottom end external annulus of the linkage stirring rod passes through sealing flange and heating stirring case
Rotation connection.
Preferably, the both sides outer wall of the agitating plate offers water conservancy diversion thermal trough.
(3) advantageous effect
The present invention provides bio-pharmaceuticals microbial liquid culture mediums to stir sterilizing cooling integrated machine.Have following beneficial
Effect：
(1), the bio-pharmaceuticals stirs sterilizing cooling integrated machine with microbial liquid culture medium, passes through the one of heating stirring case
Side outer wall bottom end is fixedly connected with cooler bin, and the internal ring wall of heating stirring case is fixedly connected with heating net, and the one of heating stirring case
Side top outer wall is fixedly connected with measurable type preheating apparatus for placing by preheating fixing groove, and heating stirring case is far from pre- heat fixation
The side top outer wall of slot offers feeding mouth, and the centre position of the bottom end outer wall of heating stirring case is fixedly connected with rotational power
Case, and the bottom end inner wall of rotational power case is fixedly connected with servo motor, the centre position of the top inner wall of heating stirring case turns
Dynamic to be connected with linkage stirring rod, the bottom end for the stirring rod that links runs through the bottom end inner wall of heating stirring case and extends to rotational power case
Inside be rotatablely connected by the output shaft of shaft coupling and servo motor, the external annulus for the stirring rod that links is fixedly connected with stirring
Plate, can measure type preheating apparatus for placing includes preheating containing tank, preheat the top external annulus of containing tank by fixing chuck plate with it is pre-
Heat fixation slot snaps connection, and preheating containing tank, which is inlayed by transparent observation slot with the internal ring wall of heating stirring case, to be connect, and is reached
The measurement flask of the Semi-solid cell culture sill preheated equipped with needs is put into pre- excess heat by the purpose of heat sterilization after pre- thermal agitation
It puts in slot, heating net is begun to warm up, and is worked at the same time personnel and is passed sequentially through feeding mouth and pour into heating stirring other culture sills
In case, then the culture sill that preheating finishes is poured into heating stirring case, servo motor is started to work, and linkage stirring is driven
Bar and agitating plate rotate synchronously, and are sufficiently mixed each culture sill, and culture medium is made to be uniformly mixed, when continuing to heat one end thereafter
Between, until completing heat sterilization process, it would be desirable to which the culture sill of preheating is directly preheated in the present apparatus, it is reduced
The use of his equipment to reduce cost, and directly carries out heat sterilization process after culture medium is stirred, accelerate produce into
Journey further reduced production cost.
(2), the bio-pharmaceuticals stirs sterilizing cooling integrated machine with microbial liquid culture medium, separate by heating stirring case
The side bottom end of the type of can measure preheating apparatus for placing is connected by discharge nozzle with cooler bin, and discharge nozzle runs through the outer wall of cooler bin
And the inside for extending to cooler bin is communicated with threaded connection outlet tube by U-shaped cooling tube, being flowed in cooler bin has coolant liquid, cold
But case is communicated with inlet tube close to the side top outer wall for being threadedly coupled outlet tube, and cooler bin is far from threaded connection outlet tube
Side bottom end outer wall is communicated with outlet tube, is directly quickly cooled down after having achieved the purpose that heat sterilization, will complete sterilization process
Culture medium cools down Bottomhole pressure in U-shaped successively by discharge nozzle keeps U-shaped cold under the action of cooler bin internal flow coolant liquid
But the culture medium in pipe is quickly cooled down, and in the use for reducing production equipment, improves space utilization rate, while further add
The working process rate of fast culture medium improves economic benefit to further shorten the production cycle.
Description of the drawings
Fig. 1 is schematic front view of the present invention；
Fig. 2 is appearance schematic front view of the present invention；
Fig. 3 is device for high-efficiency cleaning schematic top plan view of the present invention.
In figure：1 heating stirring case, 2 cooler bins, 3 preheating fixing grooves, 4 measurable type preheating apparatus for placing, 41 preheatings are held
Slot, 42 fixing chuck plates, 43 transparent observation slots, 5 feeding mouths, 6 linkage stirring rods, 7 rotational power casees, 8 servo motors, 9 shaft couplings,
10 agitating plates, 11 discharge nozzles, 12U shapes cooling tube, 13 are threadedly coupled outlet tube, 14 heating nets, 15 fixing support racks, 16 feed liquors
Pipe, 17 outlet tubes, 18 sealing flanges, 19 water conservancy diversion thermal troughs.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
- 3 are please referred to Fig.1, the present invention provides a kind of technical solution：A kind of bio-pharmaceuticals microbial liquid culture medium stirring
Sterilize cooling integrated machine, including heating stirring case 1, the side outer wall bottom end of heating stirring case 1 are fixedly connected with cooler bin 2, add
The internal ring wall of thermal agitation case 1 is fixedly connected with heating net 14, and the side top outer wall of heating stirring case 1 is by preheating fixing groove 3
It is fixedly connected with measurable type preheating apparatus for placing 4, side top outer wall of the heating stirring case 1 far from preheating fixing groove 3 opens up
There are feeding mouth 5, the centre position of the bottom end outer wall of heating stirring case 1 to be fixedly connected with rotational power case 7, and rotational power case 7
Bottom end inner wall be fixedly connected with servo motor 8, the centre position of the top inner wall of heating stirring case 1 is rotatably connected to linkage and stirs
Mix bar 6, the bottom end of linkage stirring rod 6 through heating stirring case 1 bottom end inner wall and extend to the inside of rotational power case 7 and pass through
Shaft coupling 9 and the output shaft of servo motor 8 are rotatablely connected, and the external annulus of linkage stirring rod 6 is fixedly connected with agitating plate 10, will fill
The measurement flask of the Semi-solid cell culture sill of preheating in need is put into preheating containing tank 41, and heating net 14 is begun to warm up, together
When staff other culture sills are passed sequentially through feeding mouth 5 and pour into heating stirring case 1, the training for then finishing preheating
Foster sill pours into heating stirring case 1, and servo motor 8 is started to work, and drives linkage stirring rod 6 and agitating plate 10 to synchronize and turns
It is dynamic, it is sufficiently mixed each culture sill, culture medium is made to be uniformly mixed, continues to heat one end time thereafter, is gone out until completing heating
Bacterium process, it would be desirable to the culture sill of preheating is directly preheated in the present apparatus, and the use of other equipment is reduced, to
Cost is reduced, and heat sterilization process is directly carried out after culture medium is stirred, production process is accelerated, further reduced life
Produce cost；Heating stirring case 1 passes through discharge nozzle 11 and 2 phase of cooler bin far from the side bottom end that measurable type preheats apparatus for placing 4
Connection, discharge nozzle 11 through cooler bin 2 outer wall and extend to the inside of cooler bin 2 screw thread be communicated with by U-shaped cooling tube 12
Connect outlet tube 13, in cooler bin 2 flowing have coolant liquid, the culture medium of sterilization process will be completed by discharge nozzle 11 successively in U
Flowing, under the action of 2 internal flow coolant liquid of cooler bin, keeps the culture medium in U-shaped cooling tube 12 quick in shape cooling tube 12
It is cooling, in the use for reducing production equipment, improve space utilization rate, while further speeded up at the processing of culture medium
Reason rate improves economic benefit to further shorten the production cycle.
Measurable type preheating apparatus for placing 4 includes preheating containing tank 41, and the top external annulus for preheating containing tank 41 passes through admittedly
Determine snap-gauge 42 to snap connection with preheating fixing groove 3, the inner ring that preheating containing tank 41 passes through transparent observation slot 43 and heating stirring case 1
Wall inlays connection.
Heating stirring case 1 and the bottom end outer wall of cooler bin 2 have been fixedly connected with fixing support rack 15.
Cooler bin 2 is communicated with inlet tube 16 close to the side top outer wall for being threadedly coupled outlet tube 13, and cooler bin 2 is separate
The side bottom end outer wall for being threadedly coupled outlet tube 13 is communicated with outlet tube 17.
The bottom end inner wall rotation connection that the bottom end external annulus of stirring rod 6 that links passes through sealing flange 18 and heating stirring case 1.
The both sides outer wall of agitating plate 10 offers water conservancy diversion thermal trough 19.
In use, the measurement flask of the Semi-solid cell culture sill preheated equipped with needs is put into preheating containing tank 41,
Heating net 14 is begun to warm up, and is worked at the same time personnel and is passed sequentially through feeding mouth 5 and pour into heating stirring case 1 other culture sills
In, then the culture sill that preheating finishes is poured into heating stirring case 1, servo motor 8 is started to work, and linkage stirring is driven
Bar 6 and agitating plate 10 rotate synchronously, and are sufficiently mixed each culture sill, and culture medium is made to be uniformly mixed, and continue to heat one end thereafter
Time, until completing heat sterilization process, it would be desirable to which the culture sill of preheating is directly preheated in the present apparatus, is reduced
The use of other equipment to reduce cost, and directly carries out heat sterilization process after culture medium is stirred, accelerates production
Process further reduced production cost；The culture medium of sterilization process will be completed by discharge nozzle 11 successively in U-shaped cooling tube 12
Interior flowing makes the culture medium in U-shaped cooling tube 12 be quickly cooled down, is reducing under the action of 2 internal flow coolant liquid of cooler bin
The use of production equipment, improves space utilization rate, while further speeded up the working process rate of culture medium, to
The production cycle is further shortened, economic benefit is improved.
It should be noted that herein, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also include other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions.By sentence " including one ... the element limited, it is not excluded that
There is also other identical elements in the process, method, article or apparatus that includes the element ".
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of bio-pharmaceuticals stirs sterilizing cooling integrated machine, including heating stirring case (1) with microbial liquid culture medium, special
Sign is：The side outer wall bottom end of the heating stirring case (1) is fixedly connected with cooler bin (2), the heating stirring case
(1) internal ring wall is fixedly connected with heating net (14), and the side top outer wall of the heating stirring case (1) passes through pre- heat fixation
Slot (3) is fixedly connected with measurable type preheating apparatus for placing (4), and the heating stirring case (1) is far from preheating fixing groove (3)
Side top outer wall offers feeding mouth (5), and the centre position of the bottom end outer wall of the heating stirring case (1) is fixedly connected with
Rotational power case (7), and the bottom end inner wall of the rotational power case (7) is fixedly connected with servo motor (8), the heating
The centre position of the top inner wall of agitator tank (1) is rotatably connected to linkage stirring rod (6), the bottom of the linkage stirring rod (6)
End through heating stirring case (1) bottom end inner wall and extend to the inside of rotational power case (7) and pass through shaft coupling (9) and servo electricity
The output shaft of machine (8) is rotatablely connected, and the external annulus of the linkage stirring rod (6) is fixedly connected with agitating plate (10), described
Heating stirring case (1) passes through discharge nozzle (11) and cooler bin (2) phase far from the side bottom end that measurable type preheats apparatus for placing (4)
Connection, the discharge nozzle (11) through cooler bin (2) outer wall and extend to the inside of cooler bin (2) and pass through U-shaped cooling tube
(12) it is communicated with and is threadedly coupled outlet tube (13), being flowed in the cooler bin (2) has coolant liquid.
2. a kind of bio-pharmaceuticals according to claim 1 stirs sterilizing cooling integrated machine with microbial liquid culture medium,
It is characterized in that：The measurable type preheating apparatus for placing (4) includes preheating containing tank (41), the preheating containing tank (41)
Top external annulus by fixing chuck plate (42) and preheating fixing groove (3) snap connection, the preheating containing tank (41) passes through
Transparent observation slot (43) is inlayed with the internal ring wall of heating stirring case (1) to be connect.
3. a kind of bio-pharmaceuticals according to claim 1 stirs sterilizing cooling integrated machine with microbial liquid culture medium,
It is characterized in that：The bottom end outer wall of the heating stirring case (1) and cooler bin (2) has been fixedly connected with fixing support rack (15).
4. a kind of bio-pharmaceuticals according to claim 1 stirs sterilizing cooling integrated machine with microbial liquid culture medium,
It is characterized in that：The cooler bin (2) is communicated with inlet tube (16) close to the side top outer wall for being threadedly coupled outlet tube (13),
And the cooler bin (2) is communicated with outlet tube (17) far from the side bottom end outer wall for being threadedly coupled outlet tube (13).
5. a kind of bio-pharmaceuticals according to claim 1 stirs sterilizing cooling integrated machine with microbial liquid culture medium,
It is characterized in that：The bottom end that the bottom end external annulus of the linkage stirring rod (6) passes through sealing flange (18) and heating stirring case (1)
Inner wall is rotatablely connected.
6. a kind of bio-pharmaceuticals according to claim 1 stirs sterilizing cooling integrated machine with microbial liquid culture medium,
It is characterized in that：The both sides outer wall of the agitating plate (10) offers water conservancy diversion thermal trough (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810647602.4A CN108641913A (en) | 2018-06-22 | 2018-06-22 | A kind of bio-pharmaceuticals microbial liquid culture medium stirring sterilizing cooling integrated machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810647602.4A CN108641913A (en) | 2018-06-22 | 2018-06-22 | A kind of bio-pharmaceuticals microbial liquid culture medium stirring sterilizing cooling integrated machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108641913A true CN108641913A (en) | 2018-10-12 |
Family
ID=63753114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810647602.4A Withdrawn CN108641913A (en) | 2018-06-22 | 2018-06-22 | A kind of bio-pharmaceuticals microbial liquid culture medium stirring sterilizing cooling integrated machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108641913A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112755230A (en) * | 2021-01-21 | 2021-05-07 | 张文 | Culture medium that makes things convenient for business turn over is disinfected and is used frame device |
-
2018
- 2018-06-22 CN CN201810647602.4A patent/CN108641913A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112755230A (en) * | 2021-01-21 | 2021-05-07 | 张文 | Culture medium that makes things convenient for business turn over is disinfected and is used frame device |
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Application publication date: 20181012 |