CN108635458A - A kind of composition that treating diabetes and its complication, preparation method and application - Google Patents

A kind of composition that treating diabetes and its complication, preparation method and application Download PDF

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CN108635458A
CN108635458A CN201810839648.6A CN201810839648A CN108635458A CN 108635458 A CN108635458 A CN 108635458A CN 201810839648 A CN201810839648 A CN 201810839648A CN 108635458 A CN108635458 A CN 108635458A
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parts
complication
composition
honeysuckle
radix angelicae
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齐智
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Heart & Thoracic Surgery (AREA)
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Abstract

The invention discloses a kind of composition for treating diabetes and its complication, preparation method and application.The composition of the treatment diabetes and its complication includes following raw material in parts by weight：8 20 parts of honeysuckle；3 15 parts of coptis root；4 16 parts of glutinous rehmannia；3 18 parts of pueraria lobata；5 14 parts of balsam pear；Birch is 5 18 parts fine and soft；4 16 parts of Radix Angelicae Sinensis.The composition of the present invention uses pure Chinese medicine prescription, good effect, quick, has no toxic side effect, and can preferably protect patient body healthy；The effect of with nourishing yin and promoting blood circulation, blood stasis-eliminating and stagnation-dissipating, clearing heat and detoxicating, detumescence and promoting granulation；Various complication caused by diabetes and diabetes can effectively be treated.

Description

A kind of composition that treating diabetes and its complication, preparation method and application
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically a kind for the treatment of diabetes and its composition of complication, preparation side Method and application.
Background technology
Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye, Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.According to the statistics of the World Health Organization, diabetic complication type is various, Up to more than 100 kind, such as sugared foot, neuropathy, cardio cerebrovascular affection, Eye disease etc..
At present for the treatment of diabetes and its complication, western medicine is mostly used, drug ingedient is complicated, toxic side effect By force, it is unfavorable for the health of patient.Therefore, the present invention provides a kind of Traditional-Chinese-medicine-type combination for treating diabetes and its complication Object.
Invention content
The purpose of the present invention is to provide a kind of composition for treating diabetes and its complication, preparation method and application, To solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides the following technical solutions：
A kind of composition for treating diabetes and its complication, including following raw material in parts by weight：
8-20 parts of honeysuckle；
3-15 parts of coptis root；
4-16 parts of glutinous rehmannia；
3-18 parts of pueraria lobata；
5-14 parts of balsam pear；
5-18 parts of birch young pilose antler；
4-16 parts of Radix Angelicae Sinensis.
As a further solution of the present invention：Including following raw material in parts by weight：
10-15 parts of honeysuckle；
6-12 parts of coptis root；
7-11 parts of glutinous rehmannia；
5-10 parts of pueraria lobata；
8-11 parts of balsam pear；
6-10 parts of birch young pilose antler；
8-12 parts of Radix Angelicae Sinensis.
As a further solution of the present invention：Including following raw material in parts by weight：
12 parts of honeysuckle；
9 parts of coptis root；
9 parts of glutinous rehmannia；
9 parts of pueraria lobata；
9 parts of balsam pear；
Birch is 9 parts fine and soft；
9 parts of Radix Angelicae Sinensis.
A kind of preparation method of composition that treating diabetes and its complication, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and 8-15 times of weight of mixture is added Water decocts 30-40min, filters to take filtrate；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 10-20min, supernatant is obtained by filtration；
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
As a further solution of the present invention：Step（3）In, the pressure of decompression and concentration operation is 5-8kPa, is concentrated under reduced pressure The temperature of operation is 50-60 DEG C, and the ethanol solution concentration of addition is 70-75%.
A kind of composition answering in preparing treatment diabetes and its complication medicine for treating diabetes and its complication With.
Compared with prior art, the beneficial effects of the invention are as follows：
The composition of the present invention is compounded by honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis, is produced Drug synergism, it is good effect, quick using pure Chinese medicine prescription, it has no toxic side effect, can preferably protect patient body strong Health；The composition of the present invention has the effect of nourishing yin and promoting blood circulation, blood stasis-eliminating and stagnation-dissipating, clearing heat and detoxicating, detumescence and promoting granulation；The composition of the present invention Various complication caused by diabetes and diabetes can be effectively treated, to sugared foot, neuropathy, heart and brain blood caused by diabetes The diseases such as pipe lesion, Eye disease all have preferable curative effect, can reach the effect for the treatment of both manifestation and root cause of disease.
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of composition for treating diabetes and its complication, including following raw material in parts by weight：
8 parts of honeysuckle；
3 parts of coptis root；
4 parts of glutinous rehmannia；
3 parts of pueraria lobata；
5 parts of balsam pear；
Birch is 5 parts fine and soft；
4 parts of Radix Angelicae Sinensis.
A kind of preparation method of composition that treating diabetes and its complication, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and the water of 8 times of weight of mixture is added, decocts 30min is boiled, filtrate is filtered to take；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 10min, supernatant is obtained by filtration；Wherein, the pressure of decompression and concentration operation is 5kPa, and the temperature of decompression and concentration operation is 50 DEG C, the ethanol solution concentration of addition is 70%.
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
Embodiment 2
A kind of composition for treating diabetes and its complication, including following raw material in parts by weight：
20 parts of honeysuckle；
15 parts of coptis root；
16 parts of glutinous rehmannia；
18 parts of pueraria lobata；
14 parts of balsam pear；
Birch is 18 parts fine and soft；
16 parts of Radix Angelicae Sinensis.
A kind of preparation method of composition that treating diabetes and its complication, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and the water of 15 times of weight of mixture is added, 40min is decocted, filtrate is filtered to take；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 20min, supernatant is obtained by filtration；Wherein, the pressure of decompression and concentration operation is 8kPa, and the temperature of decompression and concentration operation is 60 DEG C, the ethanol solution concentration of addition is 75%.
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
Embodiment 3
A kind of composition for treating diabetes and its complication, including following raw material in parts by weight：
12 parts of honeysuckle；
9 parts of coptis root；
9 parts of glutinous rehmannia；
9 parts of pueraria lobata；
9 parts of balsam pear；
Birch is 9 parts fine and soft；
9 parts of Radix Angelicae Sinensis.
A kind of preparation method of composition that treating diabetes and its complication, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and the water of 12 times of weight of mixture is added, 36min is decocted, filtrate is filtered to take；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 14min, supernatant is obtained by filtration；Wherein, the pressure of decompression and concentration operation is 7kPa, and the temperature of decompression and concentration operation is 55 DEG C, the ethanol solution concentration of addition is 72%.
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
Embodiment 4
A kind of composition for treating diabetes and its complication, including following raw material in parts by weight：
10 parts of honeysuckle；
6 parts of coptis root；
7 parts of glutinous rehmannia；
5 parts of pueraria lobata；
8 parts of balsam pear；
Birch is 6 parts fine and soft；
8 parts of Radix Angelicae Sinensis.
A kind of preparation method of composition that treating diabetes and its complication, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and the water of 9 times of weight of mixture is added, decocts 32min is boiled, filtrate is filtered to take；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 12min, supernatant is obtained by filtration；Wherein, the pressure of decompression and concentration operation is 6kPa, and the temperature of decompression and concentration operation is 53 DEG C, the ethanol solution concentration of addition is 72%.
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
Embodiment 5
A kind of composition for treating diabetes and its complication, including following raw material in parts by weight：
15 parts of honeysuckle；
12 parts of coptis root；
11 parts of glutinous rehmannia；
10 parts of pueraria lobata；
11 parts of balsam pear；
Birch is 10 parts fine and soft；
12 parts of Radix Angelicae Sinensis.
A kind of preparation method of composition that treating diabetes and its complication, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and the water of 14 times of weight of mixture is added, 38min is decocted, filtrate is filtered to take；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 17min, supernatant is obtained by filtration；Wherein, the pressure of decompression and concentration operation is 7kPa, and the temperature of decompression and concentration operation is 58 DEG C, the ethanol solution concentration of addition is 74%.
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party Formula, one skilled in the relevant art within the scope of knowledge, can also be under the premise of not departing from this patent objective Various changes can be made.

Claims (6)

1. a kind of composition for treating diabetes and its complication, which is characterized in that including following raw material in parts by weight：
8-20 parts of honeysuckle；
3-15 parts of coptis root；
4-16 parts of glutinous rehmannia；
3-18 parts of pueraria lobata；
5-14 parts of balsam pear；
5-18 parts of birch young pilose antler；
4-16 parts of Radix Angelicae Sinensis.
2. it is according to claim 1 treatment diabetes and its complication composition, which is characterized in that including below according to The raw material of parts by weight meter：
10-15 parts of honeysuckle；
6-12 parts of coptis root；
7-11 parts of glutinous rehmannia；
5-10 parts of pueraria lobata；
8-11 parts of balsam pear；
6-10 parts of birch young pilose antler；
8-12 parts of Radix Angelicae Sinensis.
3. it is according to claim 1 treatment diabetes and its complication composition, which is characterized in that including below according to The raw material of parts by weight meter：
12 parts of honeysuckle；
9 parts of coptis root；
9 parts of glutinous rehmannia；
9 parts of pueraria lobata；
9 parts of balsam pear；
Birch is 9 parts fine and soft；
9 parts of Radix Angelicae Sinensis.
4. a kind of preparation method of composition according to any treatment diabetes and its complication of claim 1-3, It is characterized in that, includes the following steps：
（1）Honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch young pilose antler and Radix Angelicae Sinensis are weighed by above-mentioned formula, it is spare；
（2）By honeysuckle, coptis root, glutinous rehmannia, pueraria lobata, balsam pear, birch is fine and soft and Radix Angelicae Sinensis mixes, and 8-15 times of weight of mixture is added Water decocts 30-40min, filters to take filtrate；
（3）By step（2）Obtained filtrate is concentrated under reduced pressure, and concentrate is obtained；Then ethanol solution is added in concentrate, stirs After mixing 10-20min, supernatant is obtained by filtration；
（4）Repeat step（3）Four times, medicinal extract is obtained to get finished product.
5. the preparation method of the composition of the treatment diabetes and its complication stated according to claim 4, which is characterized in that step （3）In, the pressure of decompression and concentration operation is 5-8kPa, and the temperature of decompression and concentration operation is 50-60 DEG C, and the ethanol solution of addition is dense Degree is 70-75%.
6. a kind of composition according to any treatment diabetes and its complication of claim 1-3 is preparing treatment glycosuria Application in disease and its complication medicine.
CN201810839648.6A 2018-07-27 2018-07-27 A kind of composition that treating diabetes and its complication, preparation method and application Pending CN108635458A (en)

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Application Number Priority Date Filing Date Title
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101675970A (en) * 2008-09-16 2010-03-24 倪海军 Pure traditional Chinese medicine preparation for treating diabetes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101675970A (en) * 2008-09-16 2010-03-24 倪海军 Pure traditional Chinese medicine preparation for treating diabetes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
草央等: "《中国铁路旅客服务手册 武汉分册》", 30 April 2005, 中国铁道出版社 *

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