CN108634931A - Eye motion analyzer suitable for Cognitive Function in Patients with Epilepsy damage test - Google Patents
Eye motion analyzer suitable for Cognitive Function in Patients with Epilepsy damage test Download PDFInfo
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- CN108634931A CN108634931A CN201810299464.5A CN201810299464A CN108634931A CN 108634931 A CN108634931 A CN 108634931A CN 201810299464 A CN201810299464 A CN 201810299464A CN 108634931 A CN108634931 A CN 108634931A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
- A61B5/163—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state by tracking eye movement, gaze, or pupil change
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4842—Monitoring progression or stage of a disease
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Abstract
The invention discloses a kind of eye motion analyzers suitable for Cognitive Function in Patients with Epilepsy damage test, system, the eye movement acquisition system being connect with test assignment generation system, the analysis system being connect with eye movement acquisition system and the display system being connect with analysis system are generated including test assignment, test assignment generates the basic data recording module and task list generation module that system includes typing patient base's data, and basic data includes epileptic's mark and divides the initial cognition grade of cognitive function of patients damage；Task list generation module generates corresponding Cognitive Function in Patients with Epilepsy according to initial cognition grade and damages test assignment list；Eye movement acquisition system carries out tracking sampling to eye movement according to test assignment list and sampled result is transmitted to eye movement analysis system；Analysis system analyzes sampled result, and analysis result is transmitted to display system；Analysis result is exported and shows and be modified according to analysis result to initially recognizing grade by display system.
Description
Technical field
The invention belongs to recognize evaluation areas, and in particular to a kind of eye suitable for Cognitive Function in Patients with Epilepsy damage test
Dynamic analyzer.
Background technology
Epilepsy is a kind of chronic disease, because of the special nature of its disease and the prolonged application of antiepileptic, patient Chang You
The cognition dysfunction of varying degree.Cognitive function is one of important prognostic indicator of epilepsy, to cognition dysfunction degree
Evaluation can be not only used for judging prognosis and rehabilitation or relevant clinical research work instructed to provide unified quantization, have preferably
The data of comparativity.The cognitive function evaluation of epileptic is increasingly caused clinical and researcher note that 2011
International anti-epileptic alliance (ILAE) has issued the treatment guidelines of epilepsy neuropsychological complication, including the relevant cognition of epilepsy
Dysfunction assess and processing specification, emphasize should to epileptic and the relevant knowledge of family members propaganda and education epilepsy Cognitive function damage,
And cognitive function evaluation should be carried out to epileptic by the clinical neuropsychology person of profession.The cognitive disorder problem of epileptic
It is caused by many factors collective effect.Cognitive function damage may be that epilepsy disease property itself determines first.Epilepsy
The paradoxical discharge of cerebral neuron can have an impact brain structure and function when breaking-out, and especially Epileptic focus is located at and cognition
Function has the frontal lobe of close association, temporal lobe etc..The long-term potential brain electrical anomaly electrical activity of certain epilepsy syndromes interictals
Cognitive function of patients can be influenced, this is particularly tight in damage of the childhood epilepsy brain in patients stage of development to child's cognitive function
Weight.Researches show that onset age smaller cognitive impairment is heavier.But there are also the discoveries of other results of study, compared to above the average age for marriage
Children, the age is smaller, and child is smaller in the damage of memory, attention and psychomotor speed etc., and analyzing this may be with
The plasticity and functional compensation of brain are related.In some secondary epilepsies patient, while brain structure is impaired to lead to epilepsy
The cognitive function of patient can be damaged.Have researches show that the seizure types of epilepsy and seizure frequency also with the close phase of Cognitive function damage
It closes.Another factor for influencing Cognitive Function in Patients with Epilepsy is the application of antiepileptic (AEDs).Although AEDs controls are insane
Epilepsy also plays the role of improving cognitive function while breaking-out, as Lamotrigine, Levetiracetam can improve cognitive function of patients.But
Topiramate is confirmed larger to Cognitive Function by multiple researchs in new A EDs, especially shows attention, memory etc., carries
Go out Topiramate and is not suitable for teenager or children.In addition the more single medicine of damage of the multiple medicine combination therapy to Cognitive Function in Patients with Epilepsy
Treatment is big, and the cognitive function of patients obstacle for the treatment of time length is also more serious.In addition, socio-psychological factor such as social environment, receiving instruction
Educate degree, Family Functions, personal mood etc. also has certain influence to Cognitive Function in Patients with Epilepsy.
It tests being often used neuropsychological test in the research of Cognitive Function in Patients with Epilepsy.There is research trend in selection
Comprehensive scale, the common Wechsler adults in the country and children's intelligence test, foreign literature report often selection Halstead
The complete psychological tests of Reitan, Stanford-Binet intelligence tests, Loewenstein Cognitive Assessment batteries of tests etc..Test
Project contains the various aspects of cognitive function.But the test method has the following defects：Tester need to have the neural heart
Specialty background of science, or pass through relevant speciality training, with the objectivity of stringent control test, reduce measurement error；Subjectivity
It is relatively strong；Ununified standard.At present for the research of neuropsychological test, there are problems that lacking evidence-based medical；Greatly
There are serious methodology defects in terms of research and design and test selection for most Neuropsychology researchs；Certain diseases are due to suffering from
Person has the sense of hearing or mobility impairment, cannot complete neuropsychological measurement or unsuitable repeat assessment；Neuropsychological test is commented
Estimate its limited sensitivity（Such as Wechsler remembers scale）；Longitudinal research is designed without（Enough）Control condition, and
And its analysis group data is without considering single result.
Invention content
The object of the invention is being provided in a kind of eye motion analyzer suitable for Cognitive Function in Patients with Epilepsy damage test, with solution
Technological deficiency certainly existing in the prior art.
To achieve the above object, the present invention provides a kind of eye movements point suitable for Cognitive Function in Patients with Epilepsy damage test
Analyzer, including test assignment generate system, generate eye movement acquisition system and eye movement acquisition system that system is connect with test assignment
The analysis system of connection and the display system being connect with analysis system, it includes basic data typing mould that test assignment, which generates system,
Block and task list generation module,
Basic data recording module be used for typing patient basic data, basic data include epilepsy change the outfit identification and divide patient
The initial cognition grade of Cognitive function damage；
Task list generation module generates corresponding Cognitive Function in Patients with Epilepsy according to initial cognition grade and damages test assignment list；
Eye movement acquisition system carries out tracking sampling to eye movement according to test assignment list and sampled result is transmitted to eye movement
Analysis system；
Analysis system analyzes sampled result, and analysis result is transmitted to display system；
Analysis result is exported and shows and be modified according to analysis result to initially recognizing grade by display system.
Preferably, eye motion analyzer further includes generating the task that system and analysis system are connect with test assignment respectively to track
System, task tracking system are used to judge whether test assignment is fully completed according to sampled result：Continue to call if not completing
Eye movement acquisition system acquires eye movement sample, otherwise sampled result is allowed to be transmitted to eye movement analysis system.
Preferably, eye motion analyzer further includes the physiological characteristic acquisition system being connect with analysis system, physiological characteristic acquisition
The physiological characteristic of acquisition is transmitted to analysis system so that analysis system integrates eye movement and physiological characteristic integrates by system
Analysis.
Preferably, test assignment includes twitching of the eyelid amplitude, twitching of the eyelid number, in twitching of the eyelid incubation period, returns regarding property twitching of the eyelid or change direction
Any one in type twitching of the eyelid or multinomial combination.
Preferably, physiological characteristic includes heartbeat, brain electricity or any one in skin resistance or multinomial combination.
Preferably, analysis result includes scan path and gaze duration.
The invention has the advantages that：
1, the present invention carries out carrying out objective analysis to the Cognitive function damage situation of epileptic by eye motion status data,
Reduce influence of evaluator's subjective consciousness for result.
2, capable of being damaged to Cognitive Function in Patients with Epilepsy in conjunction with other physiological characteristics for the present invention carries out integration test.
3, test content selection of the invention combination is more flexible, with strong points, can be from each of cognitive impairment
Aspect selects multinomial Neuropsychology to be tested.
4, present invention test susceptibility is high, using quantitative analysis, convenient for comparing and follow-up.
Below with reference to accompanying drawings, the present invention is described in further detail.
Description of the drawings
The attached drawing constituted part of this application is used to provide further understanding of the present invention, schematic reality of the invention
Example and its explanation are applied for explaining the present invention, is not constituted improper limitations of the present invention.In the accompanying drawings：
Fig. 1 is the system knot of the eye motion analyzer for being suitable for Cognitive Function in Patients with Epilepsy damage test of the preferred embodiment of the present invention
Composition；
Fig. 2 is the detection side of the eye motion analyzer for being suitable for Cognitive Function in Patients with Epilepsy damage test of the preferred embodiment of the present invention
Method flow chart.
In figure, 1, test assignment generate system；11, basic data recording module；12, task list generation module；2, eye
Dynamic acquisition system；3, analysis system；4, display system；5, physiological characteristic acquisition system；6, task tracking system.
Specific implementation mode
The embodiment of the present invention is described in detail below in conjunction with attached drawing, but the present invention can be defined by the claims
Implement with the multitude of different ways of covering.
The present invention provides a kind of eye motion analyzers suitable for Cognitive Function in Patients with Epilepsy damage test, referring to Fig. 1, packet
Test assignment is included to generate system 1, generate eye movement acquisition system 2 and the company of eye movement acquisition system 2 that system 1 is connect with test assignment
The analysis system 3 connect and the display system 4 being connect with analysis system 3, it includes basic data typing that test assignment, which generates system 1,
Module 11 and task list generation module 12,
Basic data recording module 11 is used for the basic data of typing patient, and basic data includes that epileptic's mark and division are suffered from
The initial cognition grade of person's Cognitive function damage；
Task list generation module 12 generates corresponding Cognitive Function in Patients with Epilepsy damage test assignment row according to initial cognition grade
Table；
Eye movement acquisition system 2 carries out tracking sampling to eye movement according to test assignment list and sampled result is transmitted to eye movement
Analysis system 3；
Analysis system 3 analyzes sampled result, and analysis result is transmitted to display system 4；
Analysis result is exported and shows and be modified according to analysis result to initially recognizing grade by display system 4.
Basic data includes epileptic's mark and divides the initial cognition grade of cognitive function of patients damage.Epileptic
It is identified as a kind of mark for distinguishing different epileptics comprising patients' basic status such as patient age, gender and illness duration
Attribute.The initial cognition grade for dividing cognitive function of patients damage is professional institution, such as epilepsy center, the epileptic provided
The grade classification of cognitive ability.The grade is to identify the foundation of epileptic's cognitive ability size.Task list generation module 12
Corresponding Cognitive Function in Patients with Epilepsy, which is generated, according to initial cognition grade damages test assignment list.It is not according to initial cognition grade
Epilepsy sufferer with the extent of damage provides different test contents, and the effect of test is enable to be optimal.If for recognizing work(
Can weaker epileptic give extremely strong stimulation test assignment, the weaker epileptic of recognizing ability can also show higher
Cognitive ability, vice versa.Referring to Fig. 2, after test assignment list generates, eye movement acquisition system 2 starts, and acquires the fortune of eyeball
It is dynamic.Goal stimulus can be given in external world's setting stimulus at this time, improve oculomotor accuracy or frequency etc..Analysis system
All test contents in 3 pairs of test assignment lists of system record, and the data of record are carried out inter-process, and to having handled
Data analyzed.The real-time analysis that carries out when analysis can be data sampling, or all after sampling again into
Row analysis.The data that analysis system 3 has been handled are shown by display system 4.Related personnel can be according to analysis result pair
Initial cognition grade is modified.To more accurately be divided to cognitive function of patients damage.
Preferably, eye motion analyzer further include generated respectively with test assignment task that system 1 and analysis system 3 are connect with
Track system 6, task tracking system 6 are used to judge whether test assignment is fully completed according to sampled result：Continue if not completing
It calls eye movement acquisition system 2 to acquire eye movement sample, otherwise sampled result is allowed to be transmitted to eye movement analysis system 3.
Task tracking system 6 analyzes sampled result after the completion of eye movement sampling system samples, if test assignment arranges
There is no all tests to complete for test content in table, then continues to call eye movement acquisition system 2 to not collected eye motion
Data are acquired after content all in test assignment list is fully completed acquisition, by collected data export to point
Analysis system 3 is analyzed.Task tracking system 6 may be set to be in eye movement sampling system sampling process carry out real-time tracking with
Acquired eye movement data when feedback, the i.e. not collected eye movement data of constant feedback are to ensure that eye movement sampling system completes acquisition
Integrality.
Preferably, eye motion analyzer further includes the physiological characteristic acquisition system 5 being connect with analysis system 3, and physiological characteristic is adopted
The physiological characteristic of acquisition is transmitted to analysis system 3 so that analysis system 3 integrates eye movement and physiological characteristic carries out by collecting system 5
Comprehensive analysis.Physiological characteristic includes heartbeat, brain electricity or any one in skin resistance or multinomial combination.Epileptic couple
It is not necessarily limited to the movement of eyeball in the feedback of stimulation, heartbeat, brain wave and skin resistance can also change.By physiology
Feature is combined with eye movement, can more comprehensively be evaluated the cognitive function damaged condition of epileptic.
Preferably, test assignment include but not limited to twitching of the eyelid amplitude, twitching of the eyelid number, twitching of the eyelid incubation period, return regard property twitching of the eyelid and
Change direction type twitching of the eyelid.
Twitching of the eyelid number is more, shows that the search process of target is longer.Twitching of the eyelid incubation period is to be presented to target first by stimulation
The time that a twitching of the eyelid starts, incubation period is longer, shows that the cognition of target is more difficult.Twitching of the eyelid amplitude is bigger, show new region or
The stimulus of new position is bigger to the stimulation of target.Regarding property twitching of the eyelid is returned, shows the avoidance to stimulus to target.Direction change type
Twitching of the eyelid shows that target loses interest to stimulus.
Preferably, analysis result data includes scan path and gaze duration.
The conclusions such as scan path and gaze duration can be built according to the data that test assignment obtains to analyze cognition energy
Power.There are many analysis result datas, can be used for comprehensive analysis cognitive ability.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (6)
1. the eye motion analyzer suitable for Cognitive Function in Patients with Epilepsy damage test, which is characterized in that generated including test assignment
System（1）And the test assignment generates system（1）The eye movement acquisition system of connection（2）And the eye movement acquisition system（2）
The analysis system of connection（3）And with the analysis system（3）The display system of connection（4）, the test assignment generation system
（1）Including basic data recording module（11）With task list generation module（12）,
The basic data recording module（11）For the basic data of typing patient, the basic data includes that epileptic knows
The initial cognition grade that do not damaged with division cognitive function of patients；
The task list generation module（12）Corresponding Cognitive Function in Patients with Epilepsy damage is generated according to the initial cognition grade
Test assignment list；
The eye movement acquisition system（2）Tracking sampling is carried out to eye movement according to test assignment list and transmits sampled result
To eye movement analysis system（3）；
The analysis system（3）Sampled result is analyzed, and analysis result is transmitted to display system（4）；
The display system（4）Analysis result is exported and shows and the initial cognition grade is repaiied according to analysis result
Just.
2. the eye motion analyzer according to claim 1 suitable for Cognitive Function in Patients with Epilepsy damage test, feature exists
In the eye motion analyzer further includes generating system with test assignment respectively（1）With the analysis system（3）The task of connection with
Track system（6）, the task tracking system（6）For judging whether test assignment is fully completed according to sampled result：If not complete
At then continuing to call the eye movement acquisition system（2）Eye movement sample is acquired, sampled result is otherwise allowed to be transmitted to analysis system
System（3）.
3. the eye motion analyzer according to claim 1 suitable for Cognitive Function in Patients with Epilepsy damage test, feature exists
In the eye motion analyzer further includes and the analysis system（3）The physiological characteristic acquisition system of connection（5）, the physiology spy
Levy acquisition system（5）The physiological characteristic of acquisition is transmitted to analysis system（3）For analysis system（3）Comprehensive eye movement and life
It manages feature and carries out comprehensive analysis.
4. the eye motion analyzer according to claim 1 suitable for Cognitive Function in Patients with Epilepsy damage test, feature exists
In the test assignment includes twitching of the eyelid amplitude, twitching of the eyelid number, in twitching of the eyelid incubation period, returns regarding property twitching of the eyelid or change in the type twitching of the eyelid of direction
Any one or multinomial combination.
5. the eye motion analyzer according to claim 1 suitable for Cognitive Function in Patients with Epilepsy damage test, feature exists
In the physiological characteristic includes heartbeat, brain electricity or any one in skin resistance or multinomial combination.
6. the eye motion analyzer according to claim 1 suitable for Cognitive Function in Patients with Epilepsy damage test, feature exists
In the analysis result includes scan path and gaze duration.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109875500A (en) * | 2019-01-30 | 2019-06-14 | 北京津发科技股份有限公司 | Data acquisition device and method |
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