CN108619425A - Treat the righting removing summer-heat Chinese medicine and preparation method thereof of tumor in digestive tract - Google Patents
Treat the righting removing summer-heat Chinese medicine and preparation method thereof of tumor in digestive tract Download PDFInfo
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Abstract
The invention discloses the righting removing summer-heat Chinese medicines and preparation method thereof for the treatment of tumor in digestive tract.Chinese medicine is made of following a few taste bulk pharmaceutical chemicals:Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard.Preparation method is：First, bulk pharmaceutical chemicals are weighed according to required；Then, dried pinellia and honey mixing, decoct, stirring, ultrasonic mixing obtains mixed liquor；Finally, Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard are added water to cook, takes out body, filtrate is mixed with the mixed liquor in second step, the righting removing summer-heat traditional Chinese medicine liquid for the tumor in digestive tract that obtains medical treatment.Compared with prior art, the benefits of advantageous effect of the application is with clearing heat, releasing toxin, removing swelling analgesic, invigorating qi for strengthening superficies, dissipate stasis of blood hemostasis, detumescence ding-tong；There is treating both manifestation and root cause of disease, the small feature of toxic side effect can improve the immunity of patient, improve the quality of life of patient malignant tumor of digestive tract；And preparation method, easy to operate, raw material sources are wide.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of righting removing summer-heat Chinese medicine for treating tumor in digestive tract and its system
Preparation Method.
Background technology
Malignant tumor of digestive tract occupies forefront in the morbidity and death of all malignant tumours, greatly endangers the mankind's
Health, according to the literature, number of the infected is 96.43~267.03 to 32, China counties and cities' malignant tumour annual every 100,000 for each person,
Wherein malignant tumor of digestive tract accounts for 60%, includes mainly gastric cancer, colorectal cancer, liver cancer, cancer of pancreas, gallbladder cancer and the cancer of the esophagus.By
In early stage tumor in digestive tract non-evident sympton, with the development of the state of an illness, can gradually appear it is nonspecific, be analogous to gastritis or stomach
The symptom of ulcer, including upper abdomen glutted uncomfortable or secret anguish, pantothenic acid, belch, nausea, occasionally have vomiting, anorexia, digestion not
Good, fecal occult blood is positive or melena, unknown cause it is weak, become thin or progressive anaemia etc..When clinical symptoms are apparent, lesion
Belong to late period, has been middle and advanced stage when most Patients with Gastrointestinal Cancer obtain clarifying a diagnosis therefore, it can not row radical-ability
Operation.Current operation excision is still unique scheme of current radical cure early stage malignant tumor of digestive tract, and the main means treated,
But operative treatment is suitable for early metaphase tumour, late period uses the less effective of operative treatment.Chinese medicine is being disappeared with integral treatment instrument
Change road advanced tumor, fit applications reduce pain, extend life to controlling progression of the disease after especially performing the operation and during chemicotherapy
Life has certain clinical meaning.
This disease belongs to the scopes such as Chinese medicine " gastric disorder causing nausea ", " dysphagic ", " epigastric pain " " mass located in the upper or lower abdomen " " accumulation ".Its clinical manifestation is because of the state of an illness
The above-mentioned different disease of progress period different manifestations.From the point of view of the generation, development of the disease, this disease basic pathogenesis has with body ressitance weakened while pathogenic factors prevailing
It closes, such as《Doctor must always read accumulations》：Product at, positive unsaturated vapor, then heresy occupies it.The positive unsaturated vapor of body, the poly- stomach of perverse trend do not dissipate,
Hair Weishang skin can be accumulated, canceration occurs, and it is weakened body resistance based on taste virtual loss.The domination of pathogen is gone out with pathological forms such as phlegm-blood stasis, tumor poison internal resistances
It is existing.Work oesophagus, stomach are stayed as someone is considered as this cause of disease cancer poison, the operation of channels and collaterals mechanism of qi is hindered, causes body fluid cannot normal defeated cloth
Then stay and become phlegm, it is the stasis of blood that vim and vigour, which are not normally functioning and then stop, and cancer poison and phlegm-blood stasis are fought knot, then formed lump it is soft or it is hard such as
Rock, what is pushed away does not move.Cancerous swelling not only consumes human righteousness, damages viscera function, and is easy to flee that it is dirty, forms primary tumor and turns
Move stove.
Invention content
The object of the present invention is to provide a kind of righting removing summer-heat Chinese medicines and preparation method thereof for treating tumor in digestive tract.
To achieve the goals above, the technical solution that the application uses for：
The righting removing summer-heat Chinese medicine for treating tumor in digestive tract, is made of following a few taste bulk pharmaceutical chemicals by following weight proportions:
15 parts~45 parts of Radix Astragali, 15 parts~45 parts of coix seed, 5 parts~15 parts of indigo naturalis, 5 parts~20 parts of spina gleditsiae, 5 parts of Radix Notoginseng
5 parts~15 parts of~10 parts, 5 parts~10 parts of dried pinellia, 15 parts~45 parts of honey and the membrane of a chicken's gizzard.
Further, it is made by following weight proportions of following a few taste bulk pharmaceutical chemicals:
30 parts of Radix Astragali, 30 parts of coix seed, 10 parts of indigo naturalis, 12 parts of spina gleditsiae, 8 parts of Radix Notoginseng, 8 parts of dried pinellia, 30 parts of honey and
10 parts of the membrane of a chicken's gizzard.
The preparation method for treating the righting removing summer-heat Chinese medicine of tumor in digestive tract, includes the following steps：
S1, the bulk pharmaceutical chemicals for weighing required parts by weight：15 parts~45 parts of Radix Astragali, 15 parts~45 parts of coix seed, indigo naturalis 5 parts~15
5 parts of part, 5 parts~20 parts of spina gleditsiae, 5 parts~10 parts of Radix Notoginseng, 5 parts~10 parts of dried pinellia, 15 parts~45 parts of honey and the membrane of a chicken's gizzard~
15 parts；
S2, after mixing dried pinellia with honey, the distilled water of 2 times of amounts is added, boils 40min~60min, does not stop after boiling
Stirring, and raise repetition at least 200 times, place into container, be put into togerther in ultrasonic machine together with container, ultrasound is mixed
20min~30min is closed, mixed liquor is obtained；
S3, Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard are added water to submerge, is boiled
40min~60min takes out body 2~3 times, each 1h~2h with water, and temperature controls at 80 DEG C~85 DEG C, filtrate is obtained with S2
Mixed liquor mixing, the righting removing summer-heat traditional Chinese medicine liquid for the tumor in digestive tract that obtains medical treatment.
Radix Astragali, sweet, tepor, return lung, spleen, liver and kidney channel.There is enhancing body's immunity, liver protection, diuresis, anti-aging, resist and answer
Sharp, decompression and wide antibacterial action.Radix Astragali invigorating qi for strengthening superficies, diuresis myogenic, antitoxin apocenosis.
Coix seed is cool in nature, sweet in flavor, light, enters spleen, lung, kidney channel, has effects that Li Shui, invigorating the spleen, eliminating impediment, clearing away heat and eliminating pus.
Indigo naturalis nature and flavor are salty-cold, clearing heat and detoxicating, blood cooling and ecchymoses removing, clearing liver-fire, arresting convulsion.
Spina gleditsiae acrid flavour, it is warm-natured；Return liver, stomach, eliminating toxic of subsiding a swelling, apocenosis, desinsection.
Radix Notoginseng is sweet in flavor, slight bitter, Return liver, stomach；Dissipate stasis of blood hemostasis, detumescence ding-tong.
Dried pinellia is acrid in flavour and warm in nature.It is toxic.Returns spleen, stomach, lung channel；It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；Externally used detumescence stops
Bitterly.
The membrane of a chicken's gizzard is sweet, flat, returns spleen, stomach, small intestine, bladder warp.For diseases such as indigestion, seminal emission night sweat.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) dried pinellia can promote the normal differentiation of tumour cell in side, be converted into and reached maturity just by heterocyst
Normal cell；Because dried pinellia is toxic, it is aided with honey, mitigates the irritation toxicity of dried pinellia, while retains its antitumor work
With for monarch drug in a prescription；Coix seed invigorating spleen to remove dampness is with righting gas；Anticancer, while the heart of a lotus seed are focused on resolving sputum removing toxic substances using indigo naturalis, spina gleditsiae simultaneously
Seed of jog's tears dampness removing is leaked with toxin expelling, is altogether this with strengthening vital QI to eliminate pathogenic factors for monarch drug in a prescription；Radix Astragali invigorating qi for strengthening superficies, diuresis myogenic, antitoxin apocenosis；Radix Notoginseng
Dissipate stasis of blood hemostasis, detumescence ding-tong；Simultaneously in entire therapeutic process, pays attention to caring for shield stomach Qi, make with the membrane of a chicken's gizzard with the fortune spleen that helps digestion.So all
Medicine compatibility plays the benefits of with clearing heat, releasing toxin, removing swelling analgesic, invigorating qi for strengthening superficies, dissipate stasis of blood hemostasis, detumescence ding-tong altogether；And it is pernicious to alimentary canal
Tumour has treating both manifestation and root cause of disease, significant in efficacy, and the small feature of toxic side effect can improve the quality of life of patient.
(2) preparation method provided by the invention, easy to operate, raw material sources are wide.
Specific implementation mode
In order to make the present invention technological means, creation characteristic, achieving the goal is easy to understand with effect, below in conjunction with
Technical scheme of the present invention is clearly and completely described in specific embodiments of the present invention.
Embodiment 1
The righting removing summer-heat Chinese medicine for treating tumor in digestive tract, is made of following a few taste bulk pharmaceutical chemicals by following weight proportions:
15 parts of Radix Astragali, 15 parts of coix seed, 5 parts of indigo naturalis, 5 parts of spina gleditsiae, 5 parts of Radix Notoginseng, 5 parts of dried pinellia, 15 parts of honey and chicken
Interior golden 5 parts.
The preparation method of the righting removing summer-heat Chinese medicine of this treatment tumor in digestive tract, includes the following steps：
S1, the bulk pharmaceutical chemicals for weighing required parts by weight：15 parts of Radix Astragali, 15 parts of coix seed, 5 parts of indigo naturalis, 5 parts of spina gleditsiae, Radix Notoginseng 5
Part, 5 parts of dried pinellia, 15 parts of honey and 5 parts of the membrane of a chicken's gizzard；
S2, after mixing dried pinellia with honey, the distilled water of 2 times of amounts is added, boils 40min, is ceaselessly stirred after boiling,
And it raises repetition at least 200 times, places into container, be put into togerther in ultrasonic machine together with container, ultrasonic mixing
20min obtains mixed liquor；
S3, Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard are added water to submerge, is boiled
40min takes out body 2, each 1h with water, and temperature controls at 80 DEG C, filtrate is mixed with the mixed liquor obtained in S2, obtains medical treatment and disappears
Change the righting removing summer-heat traditional Chinese medicine liquid of road tumour.
Embodiment 2
The righting removing summer-heat Chinese medicine for treating tumor in digestive tract, is made of following a few taste bulk pharmaceutical chemicals by following weight proportions:
45 parts of Radix Astragali, 45 parts of coix seed, 15 parts of indigo naturalis, 20 parts of spina gleditsiae, 10 parts of Radix Notoginseng, 10 parts of dried pinellia, 45 parts of honey
With 15 parts of the membrane of a chicken's gizzard.
The preparation method of the righting removing summer-heat Chinese medicine of this treatment tumor in digestive tract, includes the following steps：
S1, the bulk pharmaceutical chemicals for weighing required parts by weight：45 parts of Radix Astragali, 45 parts of coix seed, 15 parts of indigo naturalis, 20 parts of spina gleditsiae, three
15 parts of 7 10 parts, 10 parts of dried pinellia, 45 parts of honey and the membrane of a chicken's gizzard；
S2, after mixing dried pinellia with honey, the distilled water of 2 times of amounts is added, boils 60min, is ceaselessly stirred after boiling,
And it raises repetition at least 200 times, places into container, be put into togerther in ultrasonic machine together with container, ultrasonic mixing
30min obtains mixed liquor；
S3, Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard are added water to submerge, is boiled
60min takes out body 3 times, each 2h with water, and temperature controls at 85 DEG C, filtrate is mixed with the mixed liquor obtained in S2, is obtained medical treatment
The righting removing summer-heat traditional Chinese medicine liquid of tumor in digestive tract.
Embodiment 3
The righting removing summer-heat Chinese medicine for treating tumor in digestive tract, is made of following a few taste bulk pharmaceutical chemicals by following weight proportions:
30 parts of Radix Astragali, 30 parts of coix seed, 10 parts of indigo naturalis, 12 parts of spina gleditsiae, 8 parts of Radix Notoginseng, 8 parts of dried pinellia, 30 parts of honey and
10 parts of the membrane of a chicken's gizzard.
The preparation method of the righting removing summer-heat Chinese medicine of this treatment tumor in digestive tract, includes the following steps：
S1, the bulk pharmaceutical chemicals for weighing required parts by weight：30 parts of Radix Astragali, 30 parts of coix seed, 10 parts of indigo naturalis, 12 parts of spina gleditsiae, three
10 parts of 78 parts, 8 parts of dried pinellia, 30 parts of honey and the membrane of a chicken's gizzard；
S2, after mixing dried pinellia with honey, the distilled water of 2 times of amounts is added, boils 60min, is ceaselessly stirred after boiling,
And it raises repetition at least 200 times, places into container, be put into togerther in ultrasonic machine together with container, ultrasonic mixing
30min obtains mixed liquor；
S3, Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard are added water to submerge, is boiled
50min takes out body 3 times, each 2h with water, and temperature controls at 85 DEG C, filtrate is mixed with the mixed liquor obtained in S2, is obtained medical treatment
The righting removing summer-heat traditional Chinese medicine liquid of tumor in digestive tract.
Clinical observation and curative effect
1.1, general information：Infusion in Patients with Digestive 60 is chosen, is divided into two groups, one group is control group, and one group is
Treatment group, every group 30.The state of an illness between control group and the patient for the treatment of group is not significantly different.The trouble of control group and treatment group
The concrete condition of person such as table 1.
The concrete condition of the patient of 1 control group of table and treatment group summarizes
1.3, clinical stages：TNM standards according to International Union Against Cancer (UICC) 1987 about malignant tumour are faced
Bed is by stages.In 60 malignant tumor patients, majority is mid-term (accounting for 86%), and has the transfer of different situations, such as stomach, brain, abdominal cavity
Transfer, ascites and fever, bleeding, pain etc..
1.4, clinical criteria：
(1) clinical efficacy：Clinical efficacy is divided into complete incidence graph (CR), part alleviates (PR), stablizes (SD), progress (PD) 4
A grade, wherein lesion completely disappear and the time be more than 4 weeks be CR；After lesion maximum major diameter and maximum perpendicular diameter are multiplied after treatment
And reduction degree preceding significantly lower than treatment is more than 50%, other lesions are unchanged, and it is PR that no new lesion time of occurrence, which is more than 4 weeks,；
Lesion maximum major diameter and maximum perpendicular diameter reduce degree less than 50% after being multiplied, increase degree less than 25%, no new lesion occurs
It is SD that time, which is more than 4 weeks,；Lesion maximum major diameter and maximum perpendicular diameter exist after being multiplied with the preceding obvious increase for the treatment of and degree
25% or more or to have new lesion to occur be PD.Total effective=CR+PR.(1) clinical efficacy：Clinical efficacy is divided into complete incidence graph
(CR), part alleviates (PR), stablizes (SD), progress (PD) 4 grades, and wherein lesion completely disappears and the time is more than 4 weeks for CR；
And reduction degree preceding significantly lower than treatment is more than 50% after lesion maximum major diameter and maximum perpendicular diameter are multiplied after treatment, other lesions
Unchanged, it is PR that no new lesion time of occurrence, which is more than 4 weeks,；It is insufficient that lesion maximum major diameter and maximum perpendicular diameter reduce degree after being multiplied
50%, increase degree less than 25%, it is SD that no new lesion time of occurrence, which is more than 4 weeks,；Lesion maximum major diameter and maximum perpendicular diameter phase
With obvious increase before treatment and degree 25% or more or to have new lesion to occur be PD after multiplying.Total effective=CR+PR.
(2) changes in immune function：Respectively at taking patient empty stomach peripheric venous blood 3mL before and after treatment, t lymphocyte subset is detected
Variation (including the CD of group4+、CD8+、CD4+/CD8+)。
(3) quality of life：According to pretherapy and post-treatment Cattell score (KPS) situation of change by quality of life be divided into raising, decline,
Stablize 3 ranks, wherein score increase degree compared with before treatment is improved not less than 10 points after treatment；After treatment score with control
Relatively reduction degree is not less than 10 points to decline before treating, and score between raising and reduction is steady compared with before treatment after treatment
It is fixed.
1.5, therapy：
The righting removing summer-heat traditional Chinese medicine liquid of the treatment tumor in digestive tract of the embodiment of the present application 3 is taken by treatment group, twice a day, often
Secondary 200mL, 20 days as one therapeutic course, totally 3 courses for the treatment of；
Control group does not take the traditional Chinese medicine liquid of the application, using traditional therapy.
Two groups are carried out at the same time auxiliary treatment, such as hydrothorax of dispelling, ascites, analgesic, stop blooding, improve a poor appetite and defaecation.
1.6, clinical observation result
(1) patient clinical curative effect is shown in Table 2
2 clinical efficacy statistical result of table
By table 2 it is found that the total effective rate for the treatment of group is substantially better than control group.
(2) comparison of the pretherapy and post-treatment t lymphocyte subset group of patient：
The case where patient pretherapy and post-treatment t lymphocyte subset group, is shown in Table 3, by table 3 it is found that CD after treatment group's treatment4+、CD4 +/CD8+Significantly raised compared with before treatment, difference is statistically significant.CD after treatment group's treatment8+It is reduced compared with before treatment,
But no significant difference.Illustrate that the drug of the application can improve the immunity of patient.
The comparison of the pretherapy and post-treatment t lymphocyte subset group of 3 treatment group patient of table
(3) patients ' life quality improves the comparison of degree:
After treatment group and control group treatment patients, quality of life improves situation, such as table 4.By table 4 it is found that treatment
Quality of life is improved after group patient generally believes treatment compared to control group patient, also illustrates, the drug energy of the application
It is enough effectively improved the quality of life of patient, conditions of patients recurrence rate significantly reduces.
4 treatment group of table and control group patients ' life quality improve degree statistical result
In conclusion the advantageous effect of the application is with clearing heat, releasing toxin, removing swelling analgesic, invigorating qi for strengthening superficies, dissipate stasis of blood hemostasis, disappears
The benefits of swollen analgesic therapy；There is treating both manifestation and root cause of disease, significant in efficacy to malignant tumor of digestive tract, the small feature of toxic side effect can improve trouble
The immunity of person improves the quality of life of patient；And preparation method, easy to operate, raw material sources are wide.
Disclosed above is only presently preferred embodiments of the present invention, and still, the embodiment of the present invention is not limited to this, Ren Heben
What the technical staff in field can think variation should all fall into protection scope of the present invention.
Claims (3)
1. treating the righting removing summer-heat Chinese medicine of tumor in digestive tract, which is characterized in that press following weight proportions by following a few taste bulk pharmaceutical chemicals
It is made:
15 parts~45 parts of Radix Astragali, 15 parts~45 parts of coix seed, 5 parts~15 parts of indigo naturalis, 5 parts~20 parts of spina gleditsiae, Radix Notoginseng 5 parts~10
Part, 5 parts~10 parts of dried pinellia, 15 parts~45 parts of honey and 5 parts~15 parts of the membrane of a chicken's gizzard.
2. the righting removing summer-heat Chinese medicine for the treatment of tumor in digestive tract as described in claim 1, which is characterized in that by following a few taste raw materials
Medicine is made by following weight proportions:
In 30 parts of Radix Astragali, 30 parts of coix seed, 10 parts of indigo naturalis, 12 parts of spina gleditsiae, 8 parts of Radix Notoginseng, 8 parts of dried pinellia, 30 parts of honey and chicken
10 parts of gold.
3. the preparation method of the righting removing summer-heat Chinese medicine for the treatment of tumor in digestive tract as claimed in claim 1 or 2, which is characterized in that
Include the following steps：
S1, the bulk pharmaceutical chemicals for weighing required parts by weight：15 parts~45 parts of Radix Astragali, 15 parts~45 parts of coix seed, 5 parts~15 parts of indigo naturalis,
5 parts~20 parts of spina gleditsiae, 5 parts~10 parts of Radix Notoginseng, 5 parts~10 parts of dried pinellia, 15 parts~45 parts of honey and the membrane of a chicken's gizzard 5 parts~15
Part；
S2, after mixing dried pinellia with honey, the distilled water of 2 times of amounts is added, boils 40min~60min, is ceaselessly stirred after boiling
It mixes, and raises repetition at least 200 times, place into container, be put into togerther in ultrasonic machine together with container, ultrasonic mixing
20min~30min obtains mixed liquor；
S3, Radix Astragali, coix seed, indigo naturalis, spina gleditsiae, Radix Notoginseng, dried pinellia, honey and the membrane of a chicken's gizzard are added water to submerge, boil 40min~
60min takes out body 2~3 times, each 1h~2h with water, and temperature controls the mixed liquor that at 80 DEG C~85 DEG C, will be obtained in filtrate and S2
Mixing, the righting removing summer-heat traditional Chinese medicine liquid for the tumor in digestive tract that obtains medical treatment.
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Citations (5)
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| CN101791343A (en) * | 2010-03-23 | 2010-08-04 | 杜建 | Traditional Chinese medicine for treating tumor of digestive tract, strengthening body resistance and removing summer-heat |
| CN104147127A (en) * | 2014-07-25 | 2014-11-19 | 黑龙江中医药大学 | Traditional Chinese medicinal composition for treating malignant tumors, as well as preparation method and application thereof |
| CN105535437A (en) * | 2016-01-07 | 2016-05-04 | 淮安市第一人民医院 | Traditional Chinese medicine composition for treating malignant tumors of upper gastrointestinal tract and preparing method |
| CN105920534A (en) * | 2016-06-16 | 2016-09-07 | 陕西中医药大学附属医院 | Traditional Chinese medicine composition for treating digestive tract malignant tumors and preparation of composition |
| CN106727965A (en) * | 2016-12-30 | 2017-05-31 | 黑龙江中医药大学 | A kind of Chinese medicine composition for preventing and treating malignant tumor of digestive tract and its application |
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2018
- 2018-07-20 CN CN201810805978.3A patent/CN108619425A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791343A (en) * | 2010-03-23 | 2010-08-04 | 杜建 | Traditional Chinese medicine for treating tumor of digestive tract, strengthening body resistance and removing summer-heat |
| CN104147127A (en) * | 2014-07-25 | 2014-11-19 | 黑龙江中医药大学 | Traditional Chinese medicinal composition for treating malignant tumors, as well as preparation method and application thereof |
| CN105535437A (en) * | 2016-01-07 | 2016-05-04 | 淮安市第一人民医院 | Traditional Chinese medicine composition for treating malignant tumors of upper gastrointestinal tract and preparing method |
| CN105920534A (en) * | 2016-06-16 | 2016-09-07 | 陕西中医药大学附属医院 | Traditional Chinese medicine composition for treating digestive tract malignant tumors and preparation of composition |
| CN106727965A (en) * | 2016-12-30 | 2017-05-31 | 黑龙江中医药大学 | A kind of Chinese medicine composition for preventing and treating malignant tumor of digestive tract and its application |
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Application publication date: 20181009 |