CN108618750A - Differentiate the method for obstructive sleep apnea and centric sleep apnea - Google Patents
Differentiate the method for obstructive sleep apnea and centric sleep apnea Download PDFInfo
- Publication number
- CN108618750A CN108618750A CN201710168866.7A CN201710168866A CN108618750A CN 108618750 A CN108618750 A CN 108618750A CN 201710168866 A CN201710168866 A CN 201710168866A CN 108618750 A CN108618750 A CN 108618750A
- Authority
- CN
- China
- Prior art keywords
- sleep apnea
- centric
- trapezoidal wave
- obstructive sleep
- air flue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4818—Sleep apnoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
Abstract
The present invention relates to a kind of methods differentiating obstructive sleep apnea and centric sleep apnea, including：One trapezoidal wave is exported by lung ventilator；The air flue flow in patient airway is acquired, the air flue changes in flow rate situation in a period of time after trapezoidal wave exports is obtained；The air flue changes in flow rate situation includes gas flow rate；Amplitude, gas flow rate based on trapezoidal wave calculate airway resistance；Judge that patient is to differentiate obstructive sleep apnea or centric sleep apnea according to airway resistance.The method of the present invention has the advantages that identification is accurate, it is simple to realize.
Description
Technical field
The present invention relates to lung ventilator field, more particularly to a kind of differentiation obstructive sleep apnea is exhaled with central sleep
Inhale the method for pause.
Background technology
Sleep apnea low-ventilatory syndrome refers to apnea recurrent exerbation 30 times in 7 hours sleep procedures every night
Above or apnea hypopnea indexes (Apnea/Hypopnea Index, often referred to simply as AHI) >=5 time/hour simultaneously
With a kind of sleep breathing disorders of the clinical symptoms such as drowsiness.
Sleep apnea is generally divided into obstructive sleep apnea (Obstructive Sleep Apnea, usually letter
Referred to as OSA), centric sleep apnea (Central Sleep Apnea, often referred to simply as CSA) and Combination sleep exhale
Inhale pause (Mixed Sleep Apnea, often referred to simply as MSA) three types.Wherein, OSA refers to the pine of the soft tissue near throat
It relaxes and causes upper respiratory tract obstruction, respiratory tract narrows and is led to sleep apnea.CSA refers to respiratory center nerve once in
Wind and wound etc. are damaged by obstacle, cannot normally convey the instruction of breathing to be led to sleep-respiratory dysfunction.MSA refers to above-mentioned
The two and the symptom deposited.
Either obstructive sleep apnea or centric sleep apnea, performance clinically all include
Flow amplitude whithin a period of time is 0 or close to 0.This of obstructive sleep apnea and centric sleep apnea
One similar clinical manifestation, the automatic discrimination for central apnea and obstructive apnea cause difficulty.
Invention content
It is an object of the invention to overcome the prior art to sentence central apnea and the automatic of obstructive apnea
The defect not having difficulties a kind of can do automatic discrimination to provide to central apnea and obstructive apnea
Method.
To achieve the goals above, the present invention provides a kind of differentiation obstructive sleep apneas to be exhaled with central sleep
The method of pause is inhaled, including：
Step 1) exports a trapezoidal wave by lung ventilator；
Air flue flow in step 2), acquisition patient airway obtains the air flue flow in a period of time after trapezoidal wave exports
Situation of change；The air flue changes in flow rate situation includes gas flow rate；
The gas flow rate that step 3), the amplitude based on the exported trapezoidal wave of lung ventilator, step 2) obtain calculates airway resistance；
Step 4) judges that patient is to differentiate obstructive sleep apnea according to the airway resistance that step 3) is calculated,
Or centric sleep apnea.
In above-mentioned technical proposal, the duration of the trapezoidal wave is between -5 seconds 0.5 second.
In above-mentioned technical proposal, the duration of the trapezoidal wave is 2 seconds.
In above-mentioned technical proposal, in the step 3), the calculation formula of the airway resistance is as follows：
Wherein, R (t) indicates the airway resistance of t moment；Δ Um (t) indicates the amplitude of the trapezoidal wave of t moment；Q (t) indicates t
The flow velocity at moment；C is lung compliance, and C uses a fixed value.
In above-mentioned technical proposal, in the step 4), airway resistance is less than 20cmH2O/L/S is determined as central sleep
Otherwise apnea is determined as obstructive sleep apnea.
The advantage of the invention is that：
The present invention exports a trapezoidal wave by lung ventilator, air flue flow in a period of time after then investigation trapezoidal wave exports
Situation of change, and then airway pressure is calculated, to doing automatic discrimination to the type of apnea.The method of the present invention, which has, to be known
Advantage inaccurate, realization is simple.
Description of the drawings
Fig. 1 is the air flue air-flow variation feelings of the patient with obstructive sleep apnea after lung ventilator output trapezoidal wave
Condition schematic diagram；
Fig. 2 is the air flue air-flow variation feelings of the patient with centric sleep apnea after lung ventilator output trapezoidal wave
Condition schematic diagram；
Fig. 3 is the stream of a kind of differentiation obstructive sleep apnea of the present invention and the method for centric sleep apnea
Cheng Tu.
Specific implementation mode
In conjunction with attached drawing, the invention will be further described.
The differentiation obstructive sleep apnea of the present invention and the method combination lung ventilator of centric sleep apnea are real
It is existing.The lung ventilator at least should include：Flow-generator is used to provide gas-pressurized；Mask, for close with the face of patient
Sealing-in merges transmits gas-pressurized to the air flue of patient when in use；Air delivery pipe, be used to connect the flow-generator with
Mask；Sensor, for measuring respiratory flow and pressure signal near the flow-generator；Controller is surveyed for receiving
The respiratory flow and pressure signal of amount, and control the operation of the flow-generator and control the transmission of gas.Currently on the market
Common lung ventilator majority can meet above-mentioned hardware requirement.
The applicant in view of obstructive sleep apnea and difference of the centric sleep apnea on pathology,
I.e.：Patient airway resistance with obstructive sleep apnea is big, and the patient airway with centric sleep apnea
Resistance is small, and a trapezoidal wave is exported to patient by lung ventilator.Due to the difference of airway resistance size, in the effect of the trapezoidal wave
Under, as depicted in figs. 1 and 2, the air flue of the patient with obstructive sleep apnea not will produce airflow fluctuation or can only produce
The airflow fluctuation of raw amplitude very little, and the air flue of the patient with centric sleep apnea can then generate gas by a relatively large margin
Stream fluctuation.The airflow fluctuation situation of air flue is acquired, and then calculates airway resistance, so that it may to realize to obstructive sleep apnea
With the differentiation of centric sleep apnea.
With reference to figure 3, the method for a kind of differentiation obstructive sleep apnea and centric sleep apnea of the invention
Include the following steps：
Step 1) exports a trapezoidal wave by lung ventilator；
In this step, the duration of exported trapezoidal wave between -5 seconds 0.5 second, as a kind of preferred implementation,
In one embodiment, the duration of the trapezoidal wave is 2 seconds.
In the prior art, generally use Sasser does breathing detection, concussion breathing detection wind turbine required it is relatively high,
And unsuitable pressure oscillations can cause discomfort or the awakening of patient, therefore compared with Sasser, the ladder employed in the present invention
Shape wave energy reduces the requirement to wind turbine, advantageously reduces cost, and will not cause discomfort to patient.
Air flue flow in step 2), acquisition patient airway obtains the air flue flow in a period of time after trapezoidal wave exports
Situation of change；
In this step, the air flue flow in air flue can be acquired by the gas flow sensor of lung ventilator, it is especially terraced
Shape wave sends out the air flue flow in rear a period of time, and then obtains the air flue changes in flow rate situation in the period.
Step 3) calculates airway resistance.
Airway resistance is calculated by the gas flow rate that the amplitude of trapezoidal wave, step 2) obtain, the calculation formula of airway resistance is such as
Under：
Wherein, R (t) indicates the airway resistance of t moment；Δ Um (t) indicates the amplitude of the trapezoidal wave of t moment；Q (t) indicates t
The flow velocity at moment, size can be obtained by step 2)；C is lung compliance, C may be used a fixed value (such as：80ml/
cmH2O)。
Step 4) judges that patient is to differentiate obstructive sleep apnea according to the airway resistance that step 3) is calculated,
Or centric sleep apnea.
In one embodiment, airway resistance is less than 20cmH2O/L/S can be determined as centric sleep apnea, no
Then it is determined as obstructive sleep apnea.
It is the step to the method for the differentiation obstructive sleep apnea and centric sleep apnea of the present invention above
Rapid description.In order to verify the validity of the method for the present invention, the applicant simulates OSA and CSA by active simulated lung, is simulating
Airway resistance can be set in the process.
In first simulated experiment, a kind of typical CSA of simulation breathes form, and the setup parameter of active lung is：Air flue
Resistance R=3.5cmH2O/L/S, lung acting Pmuscle=0cmH2O.The method institute using the present invention in first simulated experiment
Obtained testing result is as shown in table 1.
Table 1
In second simulated experiment, a kind of typical OSA of simulation breathes form, and the setup parameter of active lung is：Air flue
Resistance R=80cmH2O/L/S, lung acting Pmuscle=5cmH2O.The method institute using the present invention in second simulated experiment
Obtained testing result is as shown in table 2.
Table 2
Above-mentioned two simulated experiment proves：Although calculated airway resistance has error, sentencing for CSA and OSA is not influenced
Determine result.
It should be noted last that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting.Although ginseng
It is described the invention in detail according to embodiment, it will be understood by those of ordinary skill in the art that, to the technical side of the present invention
Case is modified or replaced equivalently, and without departure from the spirit and scope of technical solution of the present invention, should all be covered in the present invention
Right in.
Claims (5)
1. a kind of method differentiating obstructive sleep apnea and centric sleep apnea, including：
Step 1) exports a trapezoidal wave by lung ventilator；
Air flue flow in step 2), acquisition patient airway obtains the air flue changes in flow rate in a period of time after trapezoidal wave exports
Situation；The air flue changes in flow rate situation includes gas flow rate；
The gas flow rate that step 3), the amplitude based on the exported trapezoidal wave of lung ventilator, step 2) obtain calculates airway resistance；
Step 4) judges that patient is to differentiate obstructive sleep apnea according to the airway resistance that step 3) is calculated, still
Centric sleep apnea.
2. the method according to claim 1 for differentiating obstructive sleep apnea and centric sleep apnea,
It is characterized in that, the duration of the trapezoidal wave is between -5 seconds 0.5 second.
3. the method according to claim 2 for differentiating obstructive sleep apnea and centric sleep apnea,
It is characterized in that, the duration of the trapezoidal wave is 2 seconds.
4. the method according to claim 1 for differentiating obstructive sleep apnea and centric sleep apnea,
It is characterized in that, in the step 3), the calculation formula of the airway resistance is as follows：
Wherein, R (t) indicates the airway resistance of t moment；Δ Um (t) indicates the amplitude of the trapezoidal wave of t moment；Q (t) indicates t moment
Flow velocity；C is lung compliance, and C uses a fixed value.
5. the method according to claim 1 for differentiating obstructive sleep apnea and centric sleep apnea,
It is characterized in that, in the step 4), airway resistance is less than 20cmH2O/L/S is determined as centric sleep apnea, otherwise
It is determined as obstructive sleep apnea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710168866.7A CN108618750A (en) | 2017-03-21 | 2017-03-21 | Differentiate the method for obstructive sleep apnea and centric sleep apnea |
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|---|---|---|---|
| CN201710168866.7A CN108618750A (en) | 2017-03-21 | 2017-03-21 | Differentiate the method for obstructive sleep apnea and centric sleep apnea |
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| CN108618750A true CN108618750A (en) | 2018-10-09 |
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| CN201710168866.7A Pending CN108618750A (en) | 2017-03-21 | 2017-03-21 | Differentiate the method for obstructive sleep apnea and centric sleep apnea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497949A (en) * | 2018-12-12 | 2019-03-22 | 深圳融昕医疗科技有限公司 | Detection method, device, ventilator and the storage medium of apnea type |
-
2017
- 2017-03-21 CN CN201710168866.7A patent/CN108618750A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497949A (en) * | 2018-12-12 | 2019-03-22 | 深圳融昕医疗科技有限公司 | Detection method, device, ventilator and the storage medium of apnea type |
| CN109497949B (en) * | 2018-12-12 | 2022-04-22 | 深圳融昕医疗科技有限公司 | Method and device for detecting apnea type, breathing machine and storage medium |
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Application publication date: 20181009 |