CN108578786A - A kind of preparation method of selfreparing medical catheter coating - Google Patents
A kind of preparation method of selfreparing medical catheter coating Download PDFInfo
- Publication number
- CN108578786A CN108578786A CN201810233085.6A CN201810233085A CN108578786A CN 108578786 A CN108578786 A CN 108578786A CN 201810233085 A CN201810233085 A CN 201810233085A CN 108578786 A CN108578786 A CN 108578786A
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- China
- Prior art keywords
- medical catheter
- selfreparing
- coating
- chitosan
- solution
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Abstract
The invention discloses a kind of preparation methods of selfreparing medical catheter coating, first by positively charged chitosan (CS) solution drop coating on medical catheter material, be dipped in again in negatively charged dialdehyde starch (DS) solution it is multiple with distilled water flushing after taking out medical catheter for a period of time, it is repeated multiple times in medical catheter over-assemble chitosan and dialdehyde starch.Since the connection of invertibity schiff bases can be formed between the amino of chitosan and the aldehyde radical of dialdehyde starch, and the Schiff alkaloid substance formed has good biology performance, therefore has self-healing properties and antibacterial action by this medical catheter coating prepared by LBL self-assembly method.The method of the present invention is simple and effective, easy to operate, and required time is shorter.
Description
Technical field
The present invention relates to a kind of technologies of preparing of selfreparing medical catheter coating, belong to medical catheter technical field.
Background technology
Medical catheter belongs to basic medical device product, is the tube chamber product general name being connected to inside and outside human body.Have poly- to benzene
Naphthalate, fluororesin, stainless steel, superelastic alloy, polyvinyl chloride, the different materials product such as polyurethane are diagnosing,
Drain is treated, and is offerd medicine, monitoring, and gas conveying is transmitted and is widely used in blood and rehabilitation.Health Care in China system at this stage
System relative maturity, aging situation become clear day by day, and medical catheter demand grows steadily.
Medical catheter service life is to differ for 24 hours to 90 days.It in use can be by a degree of extraneous ring
The influence in border, such as mechanical wear, body fluid impact, strong acid and strong base corrosion etc., these influences can limit the use scope of medical catheter,
It reduces the service life of medical catheter and influences its using effect.
Self-repair material be it is a kind of when by environmental damage can self-regeneration damage location under certain condition material
Material.Self-repair material can be divided into external source type self-repair material and Intrinsical self-repair material according to its Principles.Intrinsical
Self-repair material realizes the self-healing properties of material using the fracture and recombination of the invertibity valence link of constituent material itself.The present invention
Coatings are built using reversible schiff bases, and it is combined with medical catheter, extend the service life of medical catheter.
Invention content
Technical problem：The invention discloses a kind of preparation methods of selfreparing medical catheter coating, due to the ammonia of chitosan
The connection of invertibity schiff bases can be formed between base and the aldehyde radical of dialdehyde starch, and the Schiff alkaloid substance formed has good life
Object performance, therefore there is self-healing properties and antibacterial action by this medical catheter coating prepared by LBL self-assembly method.
Technical solution：First by positively charged chitosan (CS) solution drop coating on medical catheter material, then soaked
Enter into negatively charged dialdehyde starch (DS) solution to take out for a period of time it is multiple with distilled water flushing after medical catheter, it is repeatedly more
It is secondary in medical catheter over-assemble chitosan and dialdehyde starch.
The preparation method of the selfreparing medical catheter coating is using LBL self-assembly method successively by chitosan solution and double
Starch aldehyde liquid deposition obtains the selfreparing medical catheter coating, specifically comprises the following steps to medical catheter surface：
Step 1: using medical catheter, medical catheter is cleaned into drying,
Step 2: by positively charged chitosan CS solution drop coating on above-mentioned medical catheter material；
Step 3: the medical catheter for being coated with chitosan CS solution is immersed in negatively charged dialdehyde starch again after dry
It is impregnated in DS solution；
Step 4: multiple with distilled water flushing after taking out medical catheter after being soaked for a period of time；
Step 5: repeat the above steps two to step 4 process it is multiple, to obtain selfreparing medical catheter coating.
Wherein, the medical catheter uses silastic material.
A concentration of 10-30mg/mL of the chitosan CS solution.
A concentration of 1-3mg/mL of the dialdehyde starch DS solution.
The soaking time is 2~10min.
Advantageous effect：The present invention is reviewed one's lessons by oneself using chitosan (CS) and dialdehyde starch (DS) by prepared by LBL self-assembly method
Multiple medical catheter coating, has the following advantages：
1. method is simple and effective, easy to operate, and required time is shorter, and required equipment is simple.
2. the material selected all is the preferable material of biocompatibility, the medical catheter coating prepared has preferable anti-
Bacterium performance.
3. selfreparing may be implemented in the medical catheter coating prepared, the service life of medical catheter is extended.
Specific implementation mode
The present invention is done below and is further explained.The following example is merely to illustrate the present invention, but is not used to limit
The practical range of the fixed present invention.
The medical catheter uses silastic material.
A concentration of 10-30mg/mL of the chitosan CS solution.
A concentration of 1-3mg/mL of the dialdehyde starch DS solution.
The soaking time is 2~10min.
The preparation of selfreparing medical catheter coating, includes the following steps：
Step 1: by positively charged chitosan (CS) solution drop coating on medical catheter material；Then it is dipped in again
It is multiple with distilled water flushing after taking-up medical catheter after to a period of time in negatively charged dialdehyde starch (DS) solution；In repetition
Process is stated repeatedly to obtain selfreparing medical catheter coating, wherein soaking time is 2~10min.
Embodiment 1：
By chitosan (CS) the solution drop coating of 10mg/mL on medical catheter material；Then medical catheter is immersed in again
Distilled water flushing is used after taking out medical catheter after 5min in dialdehyde starch (DS) solution with 1mg/mL 5 times；It repeats the above process
10 times to obtain selfreparing medical catheter coating,
Embodiment 2：
By chitosan (CS) the solution drop coating of 20mg/mL on medical catheter material；Then medical catheter is immersed in again
Distilled water flushing is used after taking out medical catheter after 5min in dialdehyde starch (DS) solution with 2mg/mL 5 times；Repeat the above process 5
It is secondary to obtain selfreparing medical catheter coating.
Embodiment 3：
By chitosan (CS) the solution drop coating of 30mg/mL on medical catheter material；Then medical catheter is immersed in again
Distilled water flushing is used after taking out medical catheter after 10min in dialdehyde starch (DS) solution with 3mg/mL 5 times；It repeats the above process
7 times so that obtain selfreparing medical catheter coating.
Claims (5)
1. a kind of preparation method of selfreparing medical catheter coating, which is characterized in that the preparation of the selfreparing medical catheter coating
Method is obtained successively by chitosan solution and dialdehyde starch liquid deposition to medical catheter surface using LBL self-assembly method
The selfreparing medical catheter coating, specifically comprises the following steps：
Step 1: using medical catheter, medical catheter is cleaned into drying,
Step 2: by positively charged chitosan CS solution drop coating on above-mentioned medical catheter material；
Step 3: it is molten that the medical catheter for being coated with chitosan CS solution is immersed in negatively charged dialdehyde starch DS again after dry
It is impregnated in liquid；
Step 4: multiple with distilled water flushing after taking out medical catheter after being soaked for a period of time；
Step 5: repeat the above steps two to step 4 process it is multiple, to obtain selfreparing medical catheter coating.
2. the preparation method of selfreparing medical catheter coating according to claim 1, which is characterized in that described medical to lead
Pipe uses silastic material.
3. the preparation method of selfreparing medical catheter coating according to claim 1, which is characterized in that the chitosan
A concentration of 10-30mg/mL of CS solution.
4. the preparation method of selfreparing medical catheter coating according to claim 1, which is characterized in that the dialdehyde forms sediment
A concentration of 1-3mg/mL of powder DS solution.
5. the preparation method of selfreparing medical catheter coating according to claim 1, which is characterized in that when the described immersion
Between be 2~10min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810233085.6A CN108578786A (en) | 2018-03-21 | 2018-03-21 | A kind of preparation method of selfreparing medical catheter coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810233085.6A CN108578786A (en) | 2018-03-21 | 2018-03-21 | A kind of preparation method of selfreparing medical catheter coating |
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| Publication Number | Publication Date |
|---|---|
| CN108578786A true CN108578786A (en) | 2018-09-28 |
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| CN201810233085.6A Withdrawn CN108578786A (en) | 2018-03-21 | 2018-03-21 | A kind of preparation method of selfreparing medical catheter coating |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109369973A (en) * | 2018-10-19 | 2019-02-22 | 东南大学 | A kind of preparation method for the selfreparing film promoting coral cell adherence |
| CN109965828A (en) * | 2019-03-01 | 2019-07-05 | 浙江大学 | A kind of compound selfreparing silicone tube of binary applied to medical endoscope |
| CN110170429A (en) * | 2019-05-20 | 2019-08-27 | 东南大学 | A kind of preparation method of iron-based bottom adherency enhancing coatings |
| CN113117154A (en) * | 2019-12-31 | 2021-07-16 | 东莞市先健医疗有限公司 | Hydrophilic coating solution, method for preparing the same, and medical device coated with the same |
| CN113802364A (en) * | 2021-09-01 | 2021-12-17 | 昆明理工大学 | Preparation method of self-repairing, acid-base-resistant and antibacterial multilayer film coating |
| CN115505335A (en) * | 2022-09-22 | 2022-12-23 | 南京林业大学 | Self-repairing fire early warning coating, preparation method and application |
-
2018
- 2018-03-21 CN CN201810233085.6A patent/CN108578786A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109369973A (en) * | 2018-10-19 | 2019-02-22 | 东南大学 | A kind of preparation method for the selfreparing film promoting coral cell adherence |
| CN109965828A (en) * | 2019-03-01 | 2019-07-05 | 浙江大学 | A kind of compound selfreparing silicone tube of binary applied to medical endoscope |
| CN110170429A (en) * | 2019-05-20 | 2019-08-27 | 东南大学 | A kind of preparation method of iron-based bottom adherency enhancing coatings |
| CN113117154A (en) * | 2019-12-31 | 2021-07-16 | 东莞市先健医疗有限公司 | Hydrophilic coating solution, method for preparing the same, and medical device coated with the same |
| CN113802364A (en) * | 2021-09-01 | 2021-12-17 | 昆明理工大学 | Preparation method of self-repairing, acid-base-resistant and antibacterial multilayer film coating |
| CN113802364B (en) * | 2021-09-01 | 2023-03-10 | 昆明理工大学 | Preparation method of self-repairing, acid-base-resistant and antibacterial multilayer film coating |
| CN115505335A (en) * | 2022-09-22 | 2022-12-23 | 南京林业大学 | Self-repairing fire early warning coating, preparation method and application |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180928 |
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| WW01 | Invention patent application withdrawn after publication |