CN108577802B - Ophthalmic surgery microscope system combining OCT imaging - Google Patents
Ophthalmic surgery microscope system combining OCT imaging Download PDFInfo
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- CN108577802B CN108577802B CN201810480482.3A CN201810480482A CN108577802B CN 108577802 B CN108577802 B CN 108577802B CN 201810480482 A CN201810480482 A CN 201810480482A CN 108577802 B CN108577802 B CN 108577802B
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- 238000003384 imaging method Methods 0.000 title claims abstract description 78
- 238000001356 surgical procedure Methods 0.000 title abstract description 20
- 230000003287 optical effect Effects 0.000 claims abstract description 126
- 238000005286 illumination Methods 0.000 claims abstract description 90
- 239000000835 fiber Substances 0.000 claims description 6
- 230000010287 polarization Effects 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 5
- 238000012014 optical coherence tomography Methods 0.000 description 59
- 230000009466 transformation Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/13—Ophthalmic microscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
Abstract
The invention discloses an ophthalmic surgery microscope system combined with OCT imaging, comprising: the microscopic imaging light path module is used for carrying out amplified imaging on the detected eye; an illumination light path module for providing illumination for a light path of the microscope system; and the ophthalmic OCT imaging optical path module is used for collecting and displaying the OCT image of the eye to be detected. The ophthalmic surgery microscope system combined with OCT imaging combines the OCT imaging optical path module with the ophthalmic surgery microscope, so that a doctor can observe not only the image information of the anterior segment of the eye to be detected, but also the OCT image of the anterior segment of the eye to be detected, more image data are provided for the fundus surgery of a patient, and the application of the surgery microscope system is expanded.
Description
Technical Field
The invention relates to the field of microscope equipment, in particular to an ophthalmic surgery microscope system combined with OCT imaging.
Background
A conventional ophthalmic operating microscope 100, generally having a structure as shown in fig. 1, mainly includes a movable base 101, a column 102, a beam 103, a swing arm 104, a two-dimensional electric translation mechanism 105, a liftable connecting rod 106, and a stereoscopic operating microscope 107, and the operating microscope is mainly used for detecting an eye 2 to be inspected of an object 1 to be inspected.
As can be seen from fig. 1, the conventional operation microscope has a single function, and the reference data and images provided for the operation of the doctor are not rich and sufficient. In addition, the ophthalmic operating microscope often needs an illumination light path to perform illumination at different angles in use, while the existing operating microscope often has an unadjustable illumination angle and a single illumination angle.
The above background disclosure is only for the purpose of assisting understanding of the inventive concept and technical solutions of the present invention, and does not necessarily belong to the prior art of the present patent application, and should not be used for evaluating the novelty and inventive step of the present application in the case that there is no clear evidence that the above content is disclosed at the filing date of the present patent application.
Disclosure of Invention
The invention aims to solve the problem of single function of an ophthalmic surgery microscope in the prior art, and provides an ophthalmic surgery microscope system combined with OCT imaging.
The invention discloses an ophthalmic surgery microscope system combined with OCT imaging, comprising: the microscopic imaging light path module is used for carrying out amplified imaging on the detected eye; an illumination light path module for providing illumination for a light path of the microscope system; an ophthalmic OCT imaging optical path module; for acquiring and displaying an OCT image of the eye to be examined.
In a preferred embodiment, the illumination light path module sequentially comprises an illumination light source, a movable illumination reflector, an OCT illumination reflector and an objective lens in the emission direction of the light source, when the movable illumination reflector is moved, the main optical axis of illumination light reflected by the movable illumination reflector can be translated, and the included angle between the central axis of illumination light emitted after passing through the objective lens and the central axis of the system light path can be changed, so that adjustment of different illumination angles can be realized.
In a preferred embodiment, the ophthalmic OCT imaging optical path module comprises an OCT system light source, a fiber coupler, a reference arm assembly, a detection system, a control system and a sample arm assembly.
In a preferred embodiment, the imaging object plane of the microscopic imaging optical path module is coplanar with the collecting object plane of the ophthalmic OCT imaging optical path module, and the imaging object plane coincides with the center of the collecting object plane.
In a preferred embodiment, the reference arm assembly includes a reference arm optical path lens and a reference arm mirror.
In a preferred embodiment, the sample arm assembly includes a polarization controller, a focusing lens, a scanning device, a field lens, an OCT illumination beamsplitter, an OCT illumination mirror, and an objective lens.
In a preferred embodiment, the microscopic imaging optical path module includes a left eye optical path and a right eye optical path which are symmetrically arranged, a left eye variable magnification optical path module and a right eye variable magnification optical path module are respectively arranged in the left eye optical path and the right eye optical path, and the left eye variable magnification optical path module and the right eye variable magnification optical path module are eccentrically and symmetrically arranged relative to a central axis of the system optical path.
In a preferred embodiment, the ophthalmic OCT imaging optical path module includes a scanning device, which is used for scanning the eye to be examined, so as to realize tomographic imaging of OCT.
In a preferred embodiment, the microscopic imaging optical path module includes a left eye optical path and a right eye optical path which are symmetrically arranged, and an operation camera module is connected to both the left eye optical path and the right eye optical path, and a virtual line is added to a preview image received and presented by the operation camera module and used for indicating a scanning position of the OCT system.
In a preferred embodiment, the microscopic imaging optical path module comprises an eyepiece optical path module for a surgeon to directly observe the eye to be inspected, and a cross reticle is arranged at the focal plane position of the eyepiece optical path module and used for indicating the scanning position of the OCT system.
Compared with the prior art, the invention has the beneficial effects that:
the ophthalmic surgery microscope system combined with OCT imaging combines the OCT imaging optical path module with the ophthalmic surgery microscope, so that a doctor can observe not only the image information of the anterior segment of the eye to be detected, but also the OCT image of the anterior segment of the eye to be detected, more image data are provided for the fundus surgery of a patient, and the application of the surgery microscope system is expanded.
Further, by arranging the movable illumination reflecting mirror in the illumination light path module, the ophthalmic surgery microscope system combined with OCT imaging can realize adjustment of different illumination angles.
Drawings
FIG. 1 is a schematic view of a prior art ophthalmic surgical microscope;
FIG. 2 is a schematic diagram of the configuration of an ophthalmic surgical microscope system incorporating OCT imaging in one embodiment of the invention;
FIG. 3 is a schematic diagram of the structure of the binocular microscopy imaging optical path in one embodiment of the present invention;
fig. 4 is a schematic diagram of the spatial arrangement of the optical paths in an embodiment of the present invention.
Reference numerals:
101. a movable base; 102. a column; 103. a cross beam; 104. swinging arms; 105. a two-dimensional motorized translation mechanism; 106. a connecting rod can be lifted; 107. a stereo surgical microscope; 1. an object to be tested; 2. the eye to be examined;
201. an objective lens; 202. a variable magnification optical path module; 203. a light splitter; 204. a binocular tube optical path module; 205. an eyepiece light path module; 206. a surgical camera module; 301. an illumination light source; 302. a condenser lens; 303. an illumination diaphragm; 304. an illumination relay lens; 305. a movable illumination mirror; an OCT illumination mirror 401; OCT illumination spectroscopy 402; an OCT system light source 501; 502. a fiber coupler; 503. a polarization controller; 504. a reference arm optical path lens; 505. a reference arm mirror; 506. a detection system; 507. a control system; 508. a focusing lens; 509. a scanning device; 10. a system optical path central axis; 111. the illumination light path enters a central shaft I; 113. the illumination light path enters a central shaft II; 12. a central axis of a microscopic imaging light path; 13. a light emitting central shaft of the illumination light path; 131. a first illumination light path transformation central shaft; 132. a second lighting light path transformation central shaft; the central shaft of the optical path of the OCT sample arm; 3. the surgeon.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like reference numerals refer to like parts unless otherwise specified. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.
In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In one embodiment, the ophthalmic surgical microscope system of the present invention incorporating OCT imaging comprises: the microscopic imaging light path module is used for carrying out amplified imaging on the detected eye; an illumination light path module for providing illumination for a light path of the microscope system; an ophthalmic OCT imaging optical path module; for acquiring and displaying an OCT image of the eye to be examined.
In a specific embodiment, the ophthalmic surgical microscope system combining OCT imaging according to the present invention is configured as shown in fig. 2, and includes a microscopic imaging optical path module, an illumination optical path module, and an ophthalmic OCT imaging optical path module, wherein the microscopic imaging optical path module, as shown in fig. 2, includes an objective lens 201, a variable magnification optical path module 202, a beam splitter 203, a binocular tube optical path module 204, an eyepiece optical path module 205, and a surgical camera module 206. Light emitted from a point on an imaging object plane passes through the objective lens 201, the zoom light path module 202 and the beam splitter 203, and is divided into two paths at the beam splitter: one path passes through the binocular tube optical path module 204 and the ocular lens optical path module 205 and is used for observation of the scalpel surgeon 3. The other path reaches the operation camera module 206 for operation camera shooting and picture taking. The system optical path central axis 10 is the main optical axis of the objective lens 201, which is the system optical path central axis 10. The central axis 12 of the microscopic imaging light path is the main optical axis of the microscopic imaging light path.
The microscopic imaging light path is divided into a left eye path and a right eye path, the left eye path and the right eye path are symmetrically arranged, and only one path is schematically shown in figure 2.
The illumination optical path module, as shown in fig. 2, includes an illumination light source 301, which is transmitted to an illumination diaphragm 303 through a condenser lens 302, then transmitted through an illumination relay lens 304, reflected by a movable illumination mirror 305, passes through an OCT illumination beam splitter 402, reflected by an OCT illumination mirror 401, and then transmitted through an objective lens 201, and then irradiated onto an object plane. Wherein, the main optical axis of the light emitted from the illumination light path is the light emitting central axis 13 of the illumination light path. When the movable illumination reflector 305 moves left and right, the main optical axis of the illumination light reflected by the movable illumination reflector 305 translates, and the main optical axis of the illumination light emitted after passing through the objective lens 201 also changes, that is, the angle of the illumination light incident on the eye 2 to be inspected changes, and the included angle between the central axis of the illumination light incident on the eye 2 to be inspected and the central axis 10 of the system optical path changes, so that adjustment of different illumination angles is realized. For example, referring to fig. 2, when the movable illumination mirror 305 moves to the right, the main optical axis of the illumination light reflected by the movable illumination mirror 305 translates from the first illumination optical path transformation central axis 131 to the second illumination optical path transformation central axis 132. Accordingly, the central axis of the illumination light emitted after passing through the objective lens 201 is changed from the illumination light path incident central axis one 111 to the illumination light path incident central axis two 113 (in fig. 2, the illumination light path incident central axis two 113 and the system light path central axis 10 are overlapped as an example for explanation). The angle between the central axis of the illumination light incident on the eye 2 and the central axis 10 of the optical path of the system is changed from β 1 to 0. It should be noted that fig. 2 only schematically shows one of the moving positions of the movable illumination reflecting mirror 305, and in fact, the moving position of the movable illumination reflecting mirror 305 may be continuously multiple, so that the continuous change from coaxial illumination to angular off-center illumination can be realized through the illumination light path structure.
In order to intuitively represent the optical path structure of microscopic imaging, the two eyepieces are turned into the opposite directions as shown in fig. 3, namely, the two optical paths of the binocular tube are turned into 180 degrees, and the two optical paths of the binocular tube can adjust the relative positions of the binocular tube according to the binocular pupil distance of an operator 3 during actual use. In the optical path structure of the binocular tube shown in fig. 3, the rear part of the serial number is added with "01" to indicate the device number corresponding to the left optical path, and "02" to indicate the device number corresponding to the right optical path, that is, 20201 and 20202 are the zoom optical path modules 202 corresponding to the left and right eyes respectively; 20301. 20302 is the spectroscope 203 corresponding to the left and right eyes respectively; 20601. 20602 are the operation camera modules 206 corresponding to the left and right eyes respectively; 20401. 20402 are the binocular tube optical path modules 204 corresponding to the left and right eyes respectively; 20501. 20502 are the eyepiece light path modules 205 corresponding to the left and right eyes, respectively.
Ophthalmic OCT imaging Optical path module, wherein "OCT" is "Optical Coherence Tomography, short for Optical Coherence Tomography". The detailed optical path structure of the ophthalmic OCT imaging optical path module is shown in FIG. 2, and comprises an OCT system light source 501, a fiber coupler 502, a reference arm assembly, a detection system 506, a control system 507 and a sample arm assembly. Wherein the reference arm assembly comprises a reference arm optical path lens 504 and a reference arm reflector 505; the sample arm assembly includes a polarization controller 503, a focusing lens 508, a scanning device 509, an OCT illumination beam splitter 402, an OCT illumination mirror 401, and an objective lens 201.
The specific working principle of the ophthalmic OCT imaging optical path is as follows: light output by the OCT system light source 501 provides light to the sample arm assembly and the reference arm assembly via the fiber coupler 502. The reference arm assembly has a known length and reflects the light back into the fiber coupler 502 through the reference arm mirror 505. The sample arm assembly provides light for the eye 2 to be detected, the light scattered from the sample interferes in the optical fiber coupler 502 through the light reflected by the sample arm and the reference arm, the interference light is detected by the detection system 506, and the OCT image of the sample to be detected is displayed through the processing of the control system 507. The sample is scanned by the scanning device 509, and tomographic imaging of OCT is achieved.
The OCT system light entering the sample arm assembly is first modulated in polarization by the polarization controller 503. The OCT system light exits through an optical fiber end face (not shown), and becomes collimated light after passing through a sample arm optical path focusing lens 508, and after the collimated light beam is reflected by a scanning device 509, the light beam is reflected by an OCT illumination beam splitter 402 and an OCT illumination mirror 401. The light beam then passes through the objective lens 201 and enters the eye 2 of the object 1. At this time, the imaging object plane of the microscopic imaging optical path module is coplanar with the collection object plane of the ophthalmic OCT imaging optical path module, and the imaging object plane coincides with the center of the collection object plane. In a preferred embodiment, the OCT system light source 501 outputs light having a wavelength of about near infrared light.
In the above embodiment, the ophthalmic surgical microscope system of the present invention incorporating OCT imaging has a spatial arrangement of the optical path as shown in fig. 4, and fig. 4 is a top view of the objective lens 201, wherein most components in the optical path are omitted, and only the relative positions of several key components are symbolically illustrated. 20201 and 20202 are the zoom light path modules 202 corresponding to the left and right eyes, respectively; 1201. 1202 are the main optical axes of the left-eye variable magnification light path module 20201 and the right-eye variable magnification light path module 20202, respectively. The spatial distribution of the variable magnification optical path module 202 and the OCT illumination mirror 401 with respect to the objective lens 201 is shown in fig. 4. The left-eye variable-magnification light path module 20201 and the right-eye variable-magnification light path module 20202 are eccentrically and symmetrically arranged relative to the system light path central axis 10.
As shown in fig. 4, "eccentric arrangement" herein means that the left-eye variable magnification optical path module 20201 and the right-eye variable magnification optical path module 20202 are both located on one side (left side as shown in fig. 4) of a vertical plane passing through the system optical path central axis 10, that is, the left-eye variable magnification optical path module 20201 and the right-eye variable magnification optical path module 20202 are eccentrically arranged with respect to the system optical path central axis 10, and the advantage of eccentric arrangement of the microscopic imaging optical path is that the system OCT optical path can be incident on the eye 2 to be inspected of the object 1 to be inspected along the system main optical axis 10; the term "symmetrically disposed" as used herein means that, as shown in fig. 4, the left-eye variable magnification optical path module 20201 and the right-eye variable magnification optical path module 20202 are vertically symmetrical with respect to a horizontal plane passing through the system optical path central axis 10, that is, the left-eye variable magnification optical path module 20201 and the right-eye variable magnification optical path module 20202 are symmetrically disposed with respect to the system optical path central axis 10.
Because the OCT light path of the eye 2 to be detected of the incident object 1 to be measured is along the central axis 10 of the optical path of the system, and when the object plane of the microscope imaging is clearest, the center of the visual field is positioned on the central axis 10 of the optical path of the system, so a cross reticle can be arranged at the focal plane position (not shown) of the eyepiece light path module 205, and the doctor can be guided to operate the scanning of the OCT light path; or a virtual line is added to the preview image received and presented by the surgical camera module 206 to indicate the scanning position. Since the surgical camera module 206 can realize the same imaging visual field as that of the main surgeon when the optical eyepiece light path module 205 is used for observation, the two schemes can indicate the scanning position of the OCT system.
According to the ophthalmic surgery microscope system combined with OCT imaging, the OCT imaging optical path module is combined with the ophthalmic surgery microscope, so that a doctor can observe not only an image of an anterior segment of an eye to be detected, but also an OCT image of the anterior segment of the eye to be detected, more image data are provided for fundus surgery of a patient, and application of the surgery microscope system is expanded.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
It should be noted that, according to the implementation requirement, each module/component described in the present application can be divided into more modules/components, and two or more modules/components or parts of modules/components can be combined into a new module/component to achieve the purpose of the present invention.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several equivalent substitutions or obvious modifications can be made without departing from the spirit of the invention, and all the properties or uses are considered to be within the scope of the invention.
Claims (8)
1. An ophthalmic surgical microscope system incorporating OCT imaging, comprising:
the microscopic imaging light path module is used for carrying out amplified imaging on the detected eye;
an illumination light path module, configured to provide illumination for the light path of the microscope system, where the illumination light path module sequentially includes an illumination light source, a movable illumination mirror, an OCT illumination mirror, and an objective lens in an emission direction of the light source, and when the movable illumination mirror moves along an axial direction of a main optical axis of illumination light reflected by the movable illumination mirror, the main optical axis of the illumination light reflected by the movable illumination mirror translates, and the main optical axis of the illumination light emitted from the objective lens after being reflected by the OCT illumination mirror also changes while a main optical axis of the objective lens, i.e., a system light path central axis, is unchanged, so that an included angle between a central axis of the illumination light emitted from the objective lens and the system light path central axis changes, i.e., an angle at which the illumination light enters the eye to be inspected changes, and an included angle between a central axis of the illumination light entering the eye to be inspected, thereby realizing the adjustment of different illumination angles;
and the ophthalmic OCT imaging optical path module is used for collecting and displaying the OCT image of the eye to be detected.
2. The ophthalmic surgical microscope system in combination with OCT imaging of claim 1, wherein the ophthalmic OCT imaging optical path module comprises an OCT system light source, a fiber optic coupler, a reference arm assembly, a detection system, a control system, and a sample arm assembly.
3. The ophthalmic surgical microscope system in combination with OCT imaging of claim 2, wherein the imaging object plane of the microscopic imaging optical path module is coplanar with the collection object plane of the ophthalmic OCT imaging optical path module and the imaging object plane coincides with the center of the collection object plane.
4. The ophthalmic surgical microscope system in combination with OCT imaging of claim 2, wherein the sample arm assembly comprises a polarization controller, a focusing lens, a scanning device, an OCT illumination beamsplitter, an OCT illumination mirror, and an objective lens.
5. The ophthalmic surgical microscope system combining OCT imaging of claim 1, wherein the microscopic imaging optical path module comprises a left eye optical path and a right eye optical path that are symmetrically disposed, and a left eye variable magnification optical path module and a right eye variable magnification optical path module are disposed in the left eye optical path and the right eye optical path, respectively, and the left eye variable magnification optical path module and the right eye variable magnification optical path module are eccentrically and symmetrically disposed with respect to the system optical path central axis, and the eccentric disposition means that the left eye variable magnification optical path module and the right eye variable magnification optical path module are both located on one side of a vertical plane passing through the system optical path central axis, and the symmetrical disposition means that the left eye variable magnification optical path module and the right eye variable magnification optical path module are vertically symmetrical with respect to a horizontal plane passing through the system optical path central axis.
6. The ophthalmic surgical microscope system combining OCT imaging of claim 1, wherein the ophthalmic OCT imaging optical path module comprises a scanning device for scanning the eye to be examined to achieve tomographic imaging of OCT.
7. The ophthalmic surgical microscope system combining OCT imaging of claim 6, wherein a surgical camera module is connected to the microscopic imaging optical path module, and a virtual line is added to the preview image received and presented by the surgical camera module to indicate a scanning position of the OCT system.
8. The ophthalmic surgical microscope system with OCT imaging of claim 6, wherein the microscopic imaging optical path module comprises an eyepiece optical path module for direct observation of the eye to be examined by the surgeon, the focal plane position of the eyepiece optical path module being provided with a cross reticle for indicating the scanning position of the OCT system.
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| CN110638527B (en) * | 2019-07-01 | 2021-06-01 | 中国科学院苏州生物医学工程技术研究所 | Operation microscopic imaging system based on optical coherence tomography augmented reality |
| CN111887992A (en) * | 2020-07-15 | 2020-11-06 | 中国科学院苏州生物医学工程技术研究所 | Intelligent surgical robot system based on optical coherence tomography |
| CN113589514A (en) * | 2021-08-10 | 2021-11-02 | 浙江未来技术研究院(嘉兴) | Micro external view mirror system |
| CN115554020B (en) * | 2022-09-02 | 2023-05-16 | 重庆贝奥新视野医疗设备有限公司 | Three-dimensional navigation system for ophthalmic surgery and implementation method |
| CN115634098B (en) * | 2022-10-25 | 2023-08-01 | 重庆贝奥新视野医疗设备有限公司 | High-speed ophthalmic surgery navigation OCT system and implementation method |
| CN116699819B (en) * | 2023-08-04 | 2023-11-17 | 杭州安劼医学科技有限公司 | 3D surgical microscope optical system and 3D image presentation method |
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| DE102007019680A1 (en) * | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Ophthalmic surgical microscope with OCT system |
| JP5754976B2 (en) * | 2010-03-31 | 2015-07-29 | キヤノン株式会社 | Image processing apparatus and control method |
| DE102011088039B4 (en) * | 2011-12-08 | 2020-01-16 | Leica Microsystems (Schweiz) Ag | Surgical microscope system for ophthalmology and associated detection unit |
| US9724239B2 (en) * | 2014-07-14 | 2017-08-08 | Novartis Ag | Movable wide-angle ophthalmic surgical system |
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Address after: Room L302, Building 2, Skyworth Innovation Valley, No. 8 Tangtou 1st Road, Tangtou Community, Shiyan Street, Bao'an District, Shenzhen City, Guangdong Province, 518108 Patentee after: Shenzhen Moting Medical Technology Co.,Ltd. Address before: 518000 803, block B, Jingang center, Jingang building, houye community, Xixiang street, Bao'an District, Shenzhen, Guangdong Patentee before: Shenzhen moting Medical Technology Co.,Ltd. |
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| CP03 | Change of name, title or address |