CN108570411A - A kind of genetics assessment system before Embryonic limb bud cell - Google Patents
A kind of genetics assessment system before Embryonic limb bud cell Download PDFInfo
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- CN108570411A CN108570411A CN201810407681.1A CN201810407681A CN108570411A CN 108570411 A CN108570411 A CN 108570411A CN 201810407681 A CN201810407681 A CN 201810407681A CN 108570411 A CN108570411 A CN 108570411A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Abstract
The invention belongs to gene assessment technology fields, disclose the genetics assessment system before a kind of Embryonic limb bud cell, including user's terminal, individual database, genetic test data set, data encryption module, gene risk analysis database, gene sequencing module, data reporting device, evaluating server.The present invention effectively can accurately assess the gene of embryo before Embryonic limb bud cell, to ensure the survival rate of embryo, outstanding embryo effectively be selected to be implanted into；The present invention carries out synthesis order-checking using 3 kinds of fluorescent moleculars by gene sequencing module come labeled nucleotide simultaneously, reduce the use of your fluorescent decoration molecule and laser, cost has been saved, the molecule residual left after chemical ablation, unlikely influence DNA double helical structure stability are also reduced；The safety that gene data can be greatly improved by data encryption module prevents from being cracked, or usurps, and causes heavy losses.
Description
Technical field
The invention belongs to the genetics assessment systems before gene assessment technology field more particularly to a kind of Embryonic limb bud cell.
Background technology
Currently, embryo transfer is also known as zygote transplation, be by the body early embryo of jenny, or by vitro fertilization and
The embryo that other modes obtain, is transplanted in of the same race, other identical jenny bodies of physiological status, is allowed to continue to development and is
The technology of new individual.Embryo transfer technology both domestic and external research using modus operandi and douche extraction embryo obtain it is prodigious at
Work(, embryo transfer wine are made and obtain breeding offspring.Therefore it in order to make the success rate of embryo transfer improve, then needs to plant in embryo
To carrying out genetics assessment before entering, existing genetics assessment system accuracy is low, and database is not perfect.It cannot be guaranteed that implantation
The survival rate of embryo, the quality that cannot effectively judge embryo.
In conclusion problem of the existing technology is：Existing genetics assessment system accuracy is low, and database is endless
It is kind.It cannot be guaranteed that the survival rate of the embryo of implantation, cannot effectively judge the quality of embryo；Meanwhile existing gene sequencing is of high cost,
Speed is slow；And gene data preservation safety is not high, is easy the leakage that is cracked.
Invention content
In view of the problems of the existing technology, the present invention provides the genetics assessment systems before a kind of Embryonic limb bud cell.
The invention is realized in this way the genetics assessment system before a kind of Embryonic limb bud cell includes：
User's terminal, individual database, genetic test data set, data encryption module, gene risk analysis data
Library, gene sequencing module, data reporting device, evaluating server；
Evaluating server respectively with user's terminal, individual database, genetic test data set, data encryption module,
Gene risk analysis database, gene sequencing module, the connection of data reporting device；
Data encryption module is connect with evaluating server, for genetic test data and assessment data to be encrypted；
Gene sequencing module, connect with evaluating server, for being measured to gene global DNA sequence.
Further, the data reporting device includes：USB jack, switch, electronic display, loud speaker, shell, volume
Adjusting key.The electronic display is inlayed on the shell, is located at the centre of shell, the switch is embedded in the left side of shell, institute
It states that loud speaker is embedding on the shell, is located at the top of display screen, there are two the volume adjustment keys, is mutually close to and is all embedded in outer
The right edge of shell is connected by conducting wire with loud speaker, and the electronic display is connected by conducting wire with USB jack, switch；It is commenting
Estimate before test result is sent to data reporting device by server, opens the switch of shell left-hand end, data reporting device is used
USB data line connection evaluating server presses volume adjustment key in the data transmission, volume adjustment to size appropriate,
USB jack is come out the data received by electronic display screen displays.
Further, the genetic test data set includes：Object lens, adjusting rod, eyepiece, micro slide, shading box, flexible bullet
Spring, pedestal；The object lens are fixedly connected on by nut on eyepiece, the perpendicular placement of the two, and the middle section of the eyepiece is embedding
Enter on adjusting rod, and front end is used to observe, and adjusting rod vertical connection eyepiece, the adjusting rod are connected by screw shading box,
The shading box inner wall side bonds have pedestal, and adjustable spring is embedded on the pedestal, and the end of the adjustable spring is inserted into
In on micro slide, the micro slide is located at the underface of object lens, and the shading box between the object lens and micro slide has a hole；
When carrying out genetic test, distilled water first is added in examined solution so that blood cell breakage, add later detergent and
Alcohol so that DNA assembles, and is heated with boiling water, and glass bar gentle agitation is used in combination, and after detergent is added, action wants light and slow, soft,
Otherwise a large amount of foam is easy tod produce, is operated with being unfavorable for subsequent step.
Further, the data encryption module encryption method is as follows：
1st step acquires source data；
2nd step, is ranked up source data, so as to the data set after being sorted；
3rd step is fitted the data set with multivalue power function, digital simulation parameter alpha2、β2；
4th step is fitted, digital simulation parameter alpha with diadic power function enemy data and mantissa's evidence1、β1, wherein described
Head data are first data in the data set after sequence, and the mantissa is according to last number in the data set after being sequence
According to；
5th step, according to calculated parameter value α2、β2And β1, correct α1To make revised parameter alpha1' range exist
α1And α2Between；
6th step, according to the four of gained parameter alphas2、β2、α1' and β1, operator transformation is carried out to source data, obtains encrypting defeated
Go out data.
Further, the acquired source data be journal file, data on data warehouse and/or line.
Further, the sequence includes being ranked up according to sequence from big to small.
Further, the method further includes：If discovery mantissa evidence is right less than 1 after being ranked up to source data
Data set after sequence is pre-processed, in order to avoid numerical value is too small, the pretreatment includes：
Wherein yiIt is source data, yNIt is mantissa's evidence in the data set after sorting.
, according to before being fitted, head data are being increased a times, wherein the increasing with diadic power function enemy data and mantissa
Big multiple a is to be formulated by the business side of offer data, or formulated according to user's needs.
Further, the amendment α1The step of include：
Wherein y1It is the head data in the data set after sorting, α1' it is revised parameter.
Further, described the step of carrying out operator transformation to source data, includes：
Wherein Yi is encryption output data, and yi is source data, and yN is mantissa's evidence in the data set after sequence.
Further, the gene sequencing module sequencing approach is as follows：
One, single stranded DNA to be measured is connected on general DNA sequence dna, is then attached to glass basic surface；
Two, by the catalysis of archaeal dna polymerase, the fluorescent decoration nucleic acid molecules with DNA chain base complementrity to be sequenced are added
Enter onto primer strand, wherein three kinds of nucleic acid molecules have fluorescence, a kind of not have fluorescence；
Three, by imaging system, the different fluorescence signals carried on per segment DNA are read, use the laser point of three kinds of wavelength
Other priority irradiating sample, each laser can excite corresponding fluorophor, and generate corresponding fluorescence, by can after filter plate
To be collected into the fluorescence signal, the signal that the every bit of glass surface generates can be all recorded；
Four, the connection molecule between chemical ablation blocking group and fluorescent molecular and base；
Five, the sequencing of next round is carried out.
Further, a nucleic acid molecules can only be added in the step 2 in every DNA chain every time.
Further, in the step 2, dNTP, the archaeal dna polymerase of four kinds of fluorescent markers are added in the slide of sequencing, delays
Solution is rushed, Mn2+ is expanded at primer, buffer solution 100mmol/LTris-HClpH=7.8,20mmol/LMnCl2,
The dNTP of tetra- kinds of fluorescent markers of 2mmol/L, the archaeal dna polymerase Thermosequenase of 1 unit are protected from light condition in 60 DEG C of constant temperature
Lower reaction 30min.
Evaluating server is used is handled and is obtained assessment result, formula using weighted arithmetical average to verifying result
For
Wherein:xiFor each verification result score；wiFor the corresponding flexible strategy of each verification object, i.e. importance；Y is to be tied to verifying
Fruit seeks the assessment result of weighted arithmetic average；
The flexible strategy in weighted arithmetical average are solved using arithmetic of linearity regression, multiple linear regression model
General type be
As Y and X1, X2..., XmWhen meeting above-mentioned relation formula, then claim Y and X1, X2..., XmBetween linear correlation, claim
Formula (2) is m member normal linear regression models, and abbreviation m members linear regression model (LRM) or m member linear models have this model：
EY=α0+α1X1+α2X2+…+αmXm (3)
This formula is known as Y to X1, X2..., XmRegression function or theory return equation, controlled variable X1, X2..., XmReferred to as
Regression variable or regression vectors, α0Referred to as regression constant, αm(m ＞ 1) is known as regression coefficient, is unknown parameter；
When applying mechanically Multiple Linear Regression Function computational security assessment result, it is assessment result to enable the Y in formula (3), is enabled
X1, X2..., XmIt is each verification item as a result, enabling α0=0, enable αm(m ＞ 1) is each weights for verifying item, by that will verify result
(X1, X2..., Xm) substitute into above formula can obtain assessment result (Y)；And network information security valuation functions, it is exactly the polynary line
Property regression function.
Advantages of the present invention and good effect are：Reasonable design of the present invention, can be effectively before Embryonic limb bud cell to embryo's
Gene is accurately assessed, and to ensure the survival rate of embryo, outstanding embryo is effectively selected to be implanted into；Meanwhile the present invention
Synthesis order-checking is carried out using a kind of new nucleotide decorating molecule by gene sequencing module, uses K2CO3Aqueous solution carries out chemistry and cuts
It removes, to cut off fluorescent molecular and 3 '-OH protecting groups, the method being sequenced in synthesis is allowed smoothly to be realized；It is glimmering using 3 kinds
Optical molecule carrys out labeled nucleotide and carries out synthesis order-checking, reduces the use of your fluorescent decoration molecule and laser, has saved cost,
Also reduce the molecule residual left after chemical ablation, unlikely influence DNA double helical structure stability；Pass through data encryption module
The safety that gene data can be greatly improved prevents from being cracked, or usurps, and causes heavy losses.
Description of the drawings
Fig. 1 is the structural schematic diagram of the genetics assessment system before Embryonic limb bud cell provided in an embodiment of the present invention；
Fig. 2 is data reporting apparatus structure block diagram provided in an embodiment of the present invention；
Fig. 3 is genetic test data set structure diagram provided in an embodiment of the present invention；
In figure：1, USB jack；2, it switchs；3, loud speaker；4, electronic display；5, shell；6, volume adjustment key, 7, object
Mirror；8, adjusting rod；9, eyepiece；10, micro slide；11, shading box；12, adjustable spring；13, pedestal；14, user's terminal；15、
Individual database；16, genetic test data set；17, data encryption module；18, gene risk analysis database；19, gene
Sequencer module；20, data reporting device；21, evaluating server.
Specific implementation mode
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and coordinate attached drawing
Detailed description are as follows.
The structure of the present invention is explained in detail below in conjunction with the accompanying drawings.
As shown in Figure 1, Figure 2 and Figure 3, the present invention includes user's terminal 14, individual database 15, genetic test data dress
Set 16, data encryption module 17, gene risk analysis database 18, gene sequencing module 19, data reporting device 20, assessment clothes
Business device 21.
Evaluating server 21 adds with user's terminal 14, individual database 15, genetic test data set 16, data respectively
Close module 17, gene risk analysis database 18, gene sequencing module 19, data reporting device 20 connect；
The data reporting device 20 includes：USB jack 1, switch 2, electronic display 4, loud speaker 3, shell 5, volume
Adjusting key 6.The electronic display 4 is embedded on shell 5, is located at the centre of shell 5, and the switch 2 is embedded in the left side of shell 5
Side, the loud speaker 3 are located at the top of display screen 4 on the shell 5, and there are two the volume adjustment keys 6, be mutually close to and
It is all embedded in the right edge of shell 5, is connected with loud speaker 6 by conducting wire, the electronic display 4 passes through conducting wire and USB jack
1, switch 2 is connected；
The genetic test data set 16 includes：Object lens 7, eyepiece 9, micro slide 10, shading box 11, stretch adjusting rod 8
Spring 12, pedestal 13；The object lens 7 are fixedly connected on by nut on eyepiece 9, the perpendicular placement of the two, in the eyepiece 9
Between be partially submerged on adjusting rod 8, and front end is for observing, and 8 vertical connection eyepiece 9 of adjusting rod, the adjusting rod 8 pass through screw
Shading box 11 is connected, 11 inner wall side bonds of the shading box have pedestal 13, adjustable spring 12, institute are embedded on the pedestal 13
The end for stating adjustable spring 12 is inserted in 10 on micro slide, and the micro slide 10 is located at the underface of object lens 7, the object lens 7 with
Shading box 11 between micro slide 10 has a hole；
Data encryption module 17 is connect with evaluating server 21, for adding to genetic test data and assessment data
It is close；
Gene sequencing module 19 is connect with evaluating server 21, for being measured to gene global DNA sequence.
17 encryption method of data encryption module provided by the invention is as follows：
1st step acquires source data；
2nd step, is ranked up source data, so as to the data set after being sorted；
3rd step is fitted the data set with multivalue power function, digital simulation parameter alpha2、β2；
4th step is fitted, digital simulation parameter alpha with diadic power function enemy data and mantissa's evidence1、β1, wherein described
Head data are first data in the data set after sequence, and the mantissa is according to last number in the data set after being sequence
According to；
5th step, according to calculated parameter value α2、β2And β1, correct α1To make revised parameter alpha1' range exist
α1And α2Between；And
6th step, according to the four of gained parameter alphas2、β2、α1' and β1, operator transformation is carried out to source data, obtains encrypting defeated
Go out data.
Acquired source data provided by the invention is journal file, data on data warehouse and/or line.
Sequence provided by the invention includes being ranked up according to sequence from big to small.
Method provided by the invention further includes：If discovery mantissa evidence is right less than 1 after being ranked up to source data
Data set after sequence is pre-processed, in order to avoid numerical value is too small, the pretreatment includes：
Wherein yiIt is source data, yNIt is mantissa's evidence in the data set after sorting.
, according to before being fitted, head data are being increased a times, wherein the increasing with diadic power function enemy data and mantissa
Big multiple a is to be formulated by the business side of offer data, or formulated according to user's needs.
The step of 1 α of amendment provided by the invention includes：
Wherein y1It is the head data in the data set after sorting, α1' it is revised parameter.
It is provided by the invention to source data carry out operator transformation the step of include：
Wherein Yi is encryption output data, and yi is source data, and yN is mantissa's evidence in the data set after sequence.
19 sequencing approach of gene sequencing module provided by the invention is as follows：
One, single stranded DNA to be measured is connected on general DNA sequence dna, is then attached to glass basic surface；
Two, complementary DNA primer and general DNA sequence dna are matched, and primer is equipped with 3-OH functional groups and carries out DNA
Extended chemical reaction；
Three, by the catalysis of archaeal dna polymerase, the fluorescent decoration nucleic acid molecules with DNA chain base complementrity to be sequenced are added
Enter onto primer strand, wherein three kinds of nucleic acid molecules have fluorescence, a kind of not have fluorescence；
Four, by imaging system, the different fluorescence signals carried on per segment DNA are read, use the laser point of three kinds of wavelength
Other priority irradiating sample, each laser can excite corresponding fluorophor, and generate corresponding fluorescence, by can after filter plate
To be collected into the fluorescence signal, the signal that the every bit of glass surface generates can be all recorded；
Five, chemical ablation blocking group, the connection point between termination group and fluorescent molecular and base on 3 '-OH
Son；
Six, the sequencing of next round is carried out.
A nucleic acid molecules can only be added in step 2 provided by the invention in every DNA chain every time.
In step 2 provided by the invention, dNTP, the archaeal dna polymerase of four kinds of fluorescent markers are added in the slide of sequencing,
Buffer solution, Mn2+ are expanded at primer, buffer solution 100mmol/LTris-HClpH=7.8,20mmol/LMnCl2,
The dNTP of tetra- kinds of fluorescent markers of 2mmol/L, the archaeal dna polymerase Thermosequenase of 1 unit are protected from light condition in 60 DEG C of constant temperature
Lower reaction 30min.
Evaluating server is used is handled and is obtained assessment result, formula using weighted arithmetical average to verifying result
For
Wherein:xiFor each verification result score；wiFor the corresponding flexible strategy of each verification object, i.e. importance；Y is to be tied to verifying
Fruit seeks the assessment result of weighted arithmetic average；
The flexible strategy in weighted arithmetical average are solved using arithmetic of linearity regression, multiple linear regression model
General type be
As Y and X1, X2..., XmWhen meeting above-mentioned relation formula, then claim Y and X1, X2..., XmBetween linear correlation, claim
Formula (2) is m member normal linear regression models, and abbreviation m members linear regression model (LRM) or m member linear models have this model：
EY=α0+α1X1+α2X2+…+αmXm (3)
This formula is known as Y to X1, X2..., XmRegression function or theory return equation, controlled variable X1, X2..., XmReferred to as
Regression variable or regression vectors, α0Referred to as regression constant, αm(m ＞ 1) is known as regression coefficient, is unknown parameter；
When applying mechanically Multiple Linear Regression Function computational security assessment result, it is assessment result to enable the Y in formula (3), is enabled
X1, X2..., XmIt is each verification item as a result, enabling α0=0, enable αm(m ＞ 1) is each weights for verifying item, by that will verify result
(X1, X2..., Xm) substitute into above formula can obtain assessment result (Y)；And network information security valuation functions, it is exactly the polynary line
Property regression function.
The present invention operation principle be：
User's terminal 14 sends a signal to evaluating server 21, and the evaluating server 21 is according to individual database
15, genetic test data set 16, gene risk analysis database 18, gene sequencing module 19 carry out the gene order measured
Analysis feedback；Assessment result is finally transmitted to data reporting device 20 by evaluating server 21, is obtained by data reporting device 20
To test result, finally, genetic test data and assessment data are encrypted by data encryption module 17.
Before test result is sent to data reporting device 20 by evaluating server 21, the switch of 5 left-hand end of shell is opened
2, data reporting device USB data line is connected evaluating server 21 and volume adjustment key 5 is pressed, sound in the data transmission
Amount, which is adjusted, arrives size appropriate, and 1 data received of USB jack are shown by electronic display 4.
When carrying out genetic test, distilled water first is added in examined solution so that blood cell breakage adds again later
Enter detergent and alcohol so that DNA assembles, and is heated with boiling water, and glass bar gentle agitation is used in combination, and after detergent is added, action is wanted
It is light and slow, soft, a large amount of foam is otherwise easy tod produce, is operated with being unfavorable for subsequent step.Alcohol is added and is stirred with glass bar
When, action wants light and slow, in order to avoid the fracture of DNA molecular, causes DNA molecular that cannot form flocculent deposit, the floccule is put later
Enter on the micro slide 10 in shading box 11, be powered to the device, reduce the diffraction of light, transfers adjusting rod 8 in suitable position, see
Observation of eyes mirror 9, and observed data are recorded, and write the data to evaluating server 21.
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form,
Every any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to
In the range of technical solution of the present invention.
Claims (8)
1. the genetics assessment system before a kind of Embryonic limb bud cell, which is characterized in that the genetics assessment system before the Embryonic limb bud cell
System includes：
User's terminal, individual database, genetic test data set, data encryption module, gene risk analysis database, base
Because of sequencer module, data reporting device, evaluating server；
Evaluating server respectively with user's terminal, individual database, genetic test data set, data encryption module, gene
Risk analysis database, gene sequencing module, the connection of data reporting device；
Data encryption module is connect with evaluating server, for genetic test data and assessment data to be encrypted；
Gene sequencing module, connect with evaluating server, for being measured to gene global DNA sequence.
2. the genetics assessment system before Embryonic limb bud cell as described in claim 1, which is characterized in that the data reporting device
Including：USB jack, switch, electronic display, loud speaker, shell, volume adjustment key；The electronic display is embedded in shell
On, it is located at the centre of shell, for the switch embedded in the left side of shell, the loud speaker is embedding on the shell, is located at display screen
Top, there are two the volume adjustment keys, is mutually close to and is all embedded in the right edge of shell, passes through conducting wire and loud speaker phase
Even, the electronic display is connected by conducting wire with USB jack, switch；Test result is sent to report in evaluating server
Before data set, the switch of shell left-hand end is opened, data reporting device USB data line is connected evaluating server, in number
According in transmission, volume adjustment key is pressed, volume adjustment to size appropriate, the data received are passed through electronic display by USB jack
Display screen is shown.
3. the genetics assessment system before Embryonic limb bud cell as described in claim 1, which is characterized in that the genetic test data
Device includes：Object lens, adjusting rod, eyepiece, micro slide, shading box, adjustable spring, pedestal；The object lens are fixed by nut to be connected
It is connected on eyepiece, the perpendicular placement of the two, on the middle section insertion adjusting rod of the eyepiece, and front end is used to observe, and adjusts
Pole vertical connection eyepiece, the adjusting rod are connected by screw shading box, and the shading box inner wall side bonds have pedestal, institute
It states and is embedded with adjustable spring on pedestal, the end of the adjustable spring is inserted on micro slide, and the micro slide is located at object lens
Underface, the shading box between the object lens and micro slide have a hole；When carrying out genetic test, first in examined solution
Middle addition distilled water so that blood cell breakage adds detergent and alcohol later so that DNA assembles, and is heated with boiling water, and
With glass bar gentle agitation, after detergent is added, action wants light and slow, soft, a large amount of foam is otherwise easy tod produce, after being unfavorable for
Operate to continuous step.
4. the genetics assessment system before Embryonic limb bud cell as described in claim 1, which is characterized in that the data encryption module
Encryption method is as follows：
1st step, acquires source data, and source data is journal file, data on data warehouse and/or line；
2nd step is ranked up source data according to sequence from big to small；
3rd step is fitted the data set with multivalue power function, digital simulation parameter alpha2、β2；
4th step is fitted, digital simulation parameter alpha with diadic power function enemy data and mantissa's evidence1、β1, wherein the head number
According to being first data in data set after sequence, the mantissa is according to the last one data in the data set after being sequence；
5th step, according to calculated parameter value α2、β2And β1, correct α1To make revised parameter alpha1' range in α1And α2
Between；
6th step, according to the four of gained parameter alphas2、β2、α1' and β1, operator transformation is carried out to source data, obtains encryption output number
According to.
5. the genetics assessment system before Embryonic limb bud cell as claimed in claim 4, which is characterized in that the method further includes：
If finding that mantissa according to being less than 1, pre-processes the data set after sequence after being ranked up to source data, in order to avoid number
It is worth too small, the pretreatment includes：
Wherein yiIt is source data, yNIt is mantissa's evidence in the data set after sorting；
, according to before being fitted, head data are being increased a times, wherein described increase again with diadic power function enemy data and mantissa
Number a is formulated by the business side of offer data.
6. the genetics assessment system before Embryonic limb bud cell as claimed in claim 4, which is characterized in that the step of 1 α of amendment
Including：
Wherein y1It is the head data in the data set after sorting, α1' it is revised parameter.
7. the genetics assessment system before Embryonic limb bud cell as claimed in claim 4, which is characterized in that described to be carried out to source data
The step of operator transformation includes：
Wherein Yi is encryption output data, and yi is source data, and yN is mantissa's evidence in the data set after sequence.
8. the genetics assessment system before Embryonic limb bud cell as described in claim 1, which is characterized in that evaluating server is adopted
Handled and obtained that assessment result, formula are to verifying result with weighted arithmetical average
Wherein:xiFor each verification result score；wiFor the corresponding flexible strategy of each verification object, i.e. importance；Y is to ask verifying result
The assessment result of weighted arithmetic average；
The flexible strategy in weighted arithmetical average are solved using arithmetic of linearity regression, the one of multiple linear regression model
As form be
As Y and X1, X2..., XmWhen meeting above-mentioned relation formula, then claim Y and X1, X2..., XmBetween linear correlation, claim formula (2)
For m member normal linear regression models, abbreviation m members linear regression model (LRM) or m member linear models have this model：
EY=α0+α1X1+α2X2+…+αmXm (3)
This formula is known as Y to X1, X2..., XmRegression function or theory return equation, controlled variable X1, X2..., XmReferred to as return
Variable or regression vectors, α0Referred to as regression constant, αm(m ＞ 1) is known as regression coefficient, is unknown parameter；
When applying mechanically Multiple Linear Regression Function computational security assessment result, it is assessment result to enable the Y in formula (3), enables X1,
X2..., XmIt is each verification item as a result, enabling α0=0, enable αm(m ＞ 1) is each weights for verifying item, by that will verify result (X1,
X2..., Xm) substitute into above formula can obtain assessment result (Y)；And network information security valuation functions, it is exactly that the multiple linear returns
Return function.
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