CN108553381A - A kind of desalination chloasma essence microcapsules and preparation method thereof - Google Patents
A kind of desalination chloasma essence microcapsules and preparation method thereof Download PDFInfo
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a kind of desalination chloasma essence microcapsules and preparation method thereof, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, and capsule-core is to desalinate chloasma essence, and the mass ratio of cyst wall and capsule-core is 1~3:1, a diameter of 2~6mm of microcapsules；By weight, the desalination chloasma essence includes：7~19 parts of saualane, 3~9 parts of vitamin E, 2~8 parts of vitamin C, 1~3 part of human lysozyme, 2~8 parts of aloe extract, 8~16 parts of Megranate Seed P.E, 2~8 parts of grape seed extract, 3~11 parts of tea polyphenols, 2~11 parts of allantoin, 3~9 parts of hyaluronic acid.(1) desalination chloasma essence microcapsules of the present invention can effectively desalinate chloasma, prevent pigmentation, and to skin without pessimal stimulation；(2) desalination chloasma essence microcapsules of the present invention can repair damaged skin cuticula, maintain skin stabilization.
Description
Technical field
The invention belongs to cosmetic technical fields, are related to a kind of basic skin-protection product, specially a kind of desalination chloasma essence
Magnificent element microcapsules and preparation method thereof.
Background technology
Chloasma faciei is that a kind of color and luster coffee color betiding face or hazel metabolism of pigment are abnormal and pigmented
Skin disease, how long at eye socket, cheek, nose both sides etc., the clear border of spot, present situation is not of uniform size, start for it is dotted,
Strip, after be expanded into patch, shape claims " butterfly macules " as butterfly.Its cause of disease is not yet got clear, but sick with part internal medicine,
Such as chronic liver disease, dysmenorrhoea, irregular menstruation, chronic metritis adnexitis, fibroid, tuberculosis, chronic alcoholism is related.Medicine
Object, if oral contraceptive and solarization have outside the Pass, (rear) endocrine disturbance relationship is more close between forepart pregnant women, so middle aged woman
Female's incidence is high.
The method for the treatment of chloasma includes that recessiveness removes seed-skin method, tyrosinase inhibitor, inhibits melanin life in the prior art
At preparation, selective melanin cellulotoxic preparation, destruction melanin granule method etc..But the above method is easy to cause keratoderma
Destruction, to cutaneous health.
Invention content
Present invention solves the technical problem that：In order to overcome the deficiencies of existing technologies, acquisition is a kind of can to desalinate chloasma
Essence, and on the basis of preventing pigmentation to skin without pessimal stimulation, maintain keratoderma to stablize, the present invention provides
A kind of desalination chloasma essence microcapsules and preparation method thereof.
Technical solution：A kind of desalination chloasma essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid,
Wherein, cyst wall is sericin shell membrane, and capsule-core is to desalinate chloasma essence, and the mass ratio of cyst wall and capsule-core is 1~3:1, it is micro-
A diameter of 2~6mm of capsule；By weight, the desalination chloasma essence includes：7~19 parts of saualane, vitamin E
3~9 parts, 2~8 parts of vitamin C, 1~3 part of human lysozyme, 2~8 parts of aloe extract, 8~16 parts of Megranate Seed P.E, Portugal
2~8 parts of grape seed extract, 3~11 parts of tea polyphenols, 2~11 parts of allantoin, 3~9 parts of hyaluronic acid.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core
For desalination chloasma essence, the mass ratio of cyst wall and capsule-core is 1:1, a diameter of 2mm of microcapsules；By weight, described
Desalinating chloasma essence includes：7 parts of saualane, 3 parts of vitamin E, 2 parts of vitamin C, 1 part of human lysozyme, aloe extract
2 parts, 8 parts of Megranate Seed P.E, 2 parts of grape seed extract, 3 parts of tea polyphenols, 2 parts of allantoin, 3 parts of hyaluronic acid.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core
For desalination chloasma essence, the mass ratio of cyst wall and capsule-core is 2:1, a diameter of 3mm of microcapsules；By weight, described
Desalinating chloasma essence includes：11 parts of saualane, 6 parts of vitamin E, 5 parts of vitamin C, 2 parts of human lysozyme, aloe extraction
6 parts of object, 11 parts of Megranate Seed P.E, 5 parts of grape seed extract, 7 parts of tea polyphenols, 8 parts of allantoin, 7 parts of hyaluronic acid.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core
For desalination chloasma essence, the mass ratio of cyst wall and capsule-core is 3:1, a diameter of 6mm of microcapsules；By weight, described
Desalinating chloasma essence includes：19 parts of saualane, 9 parts of vitamin E, 8 parts of vitamin C, 3 parts of human lysozyme, aloe extraction
8 parts of object, 16 parts of Megranate Seed P.E, 8 parts of grape seed extract, 11 parts of tea polyphenols, 11 parts of allantoin, 9 parts of hyaluronic acid.
Any description above desalinates the preparation method of chloasma essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion Han 230~260mmol/L adjusts pH to 6~8, after lasting stirring
It is placed in 30~37 DEG C of insulating box and reacts；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 30~37 DEG C of insulating box, reacts 6~12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
Preferably, the mass percent concentration of sericin solution is 3~7%.
Preferably, the metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
Preferably, the molecular weight of the sericin is 10000~80000Da.
Advantageous effect：(1) desalination chloasma essence microcapsules of the present invention can effectively desalinate chloasma, prevent color
It is plain calm, and to skin without pessimal stimulation；(2) desalination chloasma essence microcapsules of the present invention can repair damaged skin
Cuticula maintains skin stabilization.
Specific implementation mode
Embodiment 1
A kind of desalination chloasma essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall
For sericin shell membrane, capsule-core is to desalinate chloasma essence, and the mass ratio of cyst wall and capsule-core is 1:1, microcapsules it is a diameter of
2mm；By weight, the desalination chloasma essence includes：7 parts of saualane, 3 parts of vitamin E, 2 parts of vitamin C, people
1 part of lysozyme, 2 parts of aloe extract, 8 parts of Megranate Seed P.E, 2 parts of grape seed extract, 3 parts of tea polyphenols, 2 parts of allantoin,
3 parts of hyaluronic acid.
The preparation method of the desalination chloasma essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 230mmol/L, adjusts pH to 6, and lasting stirring is placed on 30 DEG C
Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 30 DEG C of insulating box, reacts 6 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 3%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Embodiment 2
A kind of desalination chloasma essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall
For sericin shell membrane, capsule-core is to desalinate chloasma essence, and the mass ratio of cyst wall and capsule-core is 2:1, microcapsules it is a diameter of
3mm；By weight, the desalination chloasma essence includes：11 parts of saualane, 6 parts of vitamin E, 5 parts of vitamin C, people
2 parts of lysozyme, 6 parts of aloe extract, 11 parts of Megranate Seed P.E, 5 parts of grape seed extract, 7 parts of tea polyphenols, 8 parts of allantoin,
7 parts of hyaluronic acid.
The preparation method of the desalination chloasma essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 250mmol/L, adjusts pH to 7, and lasting stirring is placed on 34 DEG C
Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 35 DEG C of insulating box, reacts 9 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 5%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Embodiment 3
A kind of desalination chloasma essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall
For sericin shell membrane, capsule-core is to desalinate chloasma essence, and the mass ratio of cyst wall and capsule-core is 3:1, microcapsules it is a diameter of
6mm；By weight, the desalination chloasma essence includes：19 parts of saualane, 9 parts of vitamin E, 8 parts of vitamin C, people
3 parts of lysozyme, 8 parts of aloe extract, 16 parts of Megranate Seed P.E, 8 parts of grape seed extract, 11 parts of tea polyphenols, allantoin 11
Part, 9 parts of hyaluronic acid.
The preparation method of the desalination chloasma essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 260mmol/L, adjusts pH to 8, and lasting stirring is placed on 37 DEG C
Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from
Then each component of capsule-core is added in son, lasting stirring, which is placed in 37 DEG C of insulating box, reacts 12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 7%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
The desalination chloasma essence microcapsules that Examples 1 to 3 prepares are detected, the results are shown in table below.
Wherein, the data statistics source of total cure rate is as follows：200 chloasma faciei patients between summarizing 2014 to 2018 are
Women, 30~55 years old age, the course of disease 3~8 years.
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Embedding rate/% | 96 | 99 | 98 |
| Total cure rate/% | 92.3 | 98.5 | 97.3 |
Claims (8)
1. a kind of desalination chloasma essence microcapsules, which is characterized in that microcapsules are the transparent sphere soft capsule of nucleocapsid,
Wherein, cyst wall is sericin shell membrane, and capsule-core is to desalinate chloasma essence, and the mass ratio of cyst wall and capsule-core is 1~3:1, it is micro-
A diameter of 2~6mm of capsule；By weight, the desalination chloasma essence includes：7~19 parts of saualane, vitamin E
3~9 parts, 2~8 parts of vitamin C, 1~3 part of human lysozyme, 2~8 parts of aloe extract, 8~16 parts of Megranate Seed P.E, Portugal
2~8 parts of grape seed extract, 3~11 parts of tea polyphenols, 2~11 parts of allantoin, 3~9 parts of hyaluronic acid.
2. a kind of desalination chloasma essence microcapsules according to claim 1, which is characterized in that microcapsules are nucleocapsid knot
The transparent sphere soft capsule of structure, wherein cyst wall is sericin shell membrane, and capsule-core is desalination chloasma essence, cyst wall and capsule-core
Mass ratio be 1:1, a diameter of 2mm of microcapsules；By weight, the desalination chloasma essence includes：Saualane 7
Part, 3 parts of vitamin E, 2 parts of vitamin C, 1 part of human lysozyme, 2 parts of aloe extract, 8 parts of Megranate Seed P.E, grape pip carry
Take 2 parts of object, 3 parts of tea polyphenols, 2 parts of allantoin, 3 parts of hyaluronic acid.
3. a kind of desalination chloasma essence microcapsules according to claim 1, which is characterized in that microcapsules are nucleocapsid knot
The transparent sphere soft capsule of structure, wherein cyst wall is sericin shell membrane, and capsule-core is desalination chloasma essence, cyst wall and capsule-core
Mass ratio be 2:1, a diameter of 3mm of microcapsules；By weight, the desalination chloasma essence includes：Saualane 11
Part, 6 parts of vitamin E, 5 parts of vitamin C, 2 parts of human lysozyme, 6 parts of aloe extract, 11 parts of Megranate Seed P.E, grape pip
5 parts of extract, 7 parts of tea polyphenols, 8 parts of allantoin, 7 parts of hyaluronic acid.
4. a kind of desalination chloasma essence microcapsules according to claim 1, which is characterized in that microcapsules are nucleocapsid knot
The transparent sphere soft capsule of structure, wherein cyst wall is sericin shell membrane, and capsule-core is desalination chloasma essence, cyst wall and capsule-core
Mass ratio be 3:1, a diameter of 6mm of microcapsules；By weight, the desalination chloasma essence includes：Saualane 19
Part, 9 parts of vitamin E, 8 parts of vitamin C, 3 parts of human lysozyme, 8 parts of aloe extract, 16 parts of Megranate Seed P.E, grape pip
8 parts of extract, 11 parts of tea polyphenols, 11 parts of allantoin, 9 parts of hyaluronic acid.
5. the preparation method of any desalination chloasma essence microcapsules of Claims 1 to 4, which is characterized in that the side
Method includes the following steps：
(1) the sericin solution for preparing the metal ion Han 230~260mmol/L, adjusts pH to 6~8, and lasting stirring is placed on
It is reacted in 30~37 DEG C of insulating box；
(2) solution after reacting step (1) centrifuges precipitation, is washed with deionized and removes extra metal ion, so
The each component of capsule-core is added afterwards, lasting stirring, which is placed in 30~37 DEG C of insulating box, reacts 6~12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
6. the preparation method of desalination chloasma essence microcapsules according to claim 5, which is characterized in that sericin
The mass percent concentration of solution is 3~7%.
7. the preparation method of desalination chloasma essence microcapsules according to claim 5, which is characterized in that the metal
Ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
8. the preparation method of desalination chloasma essence microcapsules according to claim 5, which is characterized in that the silk gum
The molecular weight of albumen is 10000~80000Da.
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| CN201810530517.XA CN108553381A (en) | 2018-05-29 | 2018-05-29 | A kind of desalination chloasma essence microcapsules and preparation method thereof |
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| CN201810530517.XA CN108553381A (en) | 2018-05-29 | 2018-05-29 | A kind of desalination chloasma essence microcapsules and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464359A (en) * | 2018-11-21 | 2019-03-15 | 佛山科学技术学院 | Skin care item and preparation method thereof containing bird's nest peptide |
| IT202100016454A1 (en) * | 2021-06-23 | 2022-12-23 | Nanomnia Srl | METHOD FOR THE CREATION OF MICRO/NANO CAPSULES CONTAINING EXTRACTS OF MICROALGAE AND/OR CYANOBACTERIA FOR COSMETIC USE |
-
2018
- 2018-05-29 CN CN201810530517.XA patent/CN108553381A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464359A (en) * | 2018-11-21 | 2019-03-15 | 佛山科学技术学院 | Skin care item and preparation method thereof containing bird's nest peptide |
| IT202100016454A1 (en) * | 2021-06-23 | 2022-12-23 | Nanomnia Srl | METHOD FOR THE CREATION OF MICRO/NANO CAPSULES CONTAINING EXTRACTS OF MICROALGAE AND/OR CYANOBACTERIA FOR COSMETIC USE |
| EP4108225A1 (en) * | 2021-06-23 | 2022-12-28 | Nanomnia Srl | Method for producing micro/nano capsules containing extracts of microalgae and/or cyanobacteria for cosmetic use |
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Application publication date: 20180921 |