CN108553361A - A kind of preparation process with pore cleanser cosmetic composition - Google Patents
A kind of preparation process with pore cleanser cosmetic composition Download PDFInfo
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- CN108553361A CN108553361A CN201810540424.5A CN201810540424A CN108553361A CN 108553361 A CN108553361 A CN 108553361A CN 201810540424 A CN201810540424 A CN 201810540424A CN 108553361 A CN108553361 A CN 108553361A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of preparation processes with pore cleanser cosmetic composition, include the following steps：Radix sophorae extracts matrine using percolation：Pulverizing medicinal materials, wetting, fitted tube, exhaust, dipping, diacolation；Golden yellow chamomile uses alcohols solvent heating extraction Flavonoid substances, citronella grass oil passes through ultrasonic assisted technique and extraction by steam distillation, by radix sophorae extracting solution 5%, golden yellow chamomile extracting solution 2%, citronella grass oil 0.5%, 50% butanediol of solvent, cosmetic base surplus, it is fitted into after mixing at normal temperatures in the bottle sterilized, complete, matrine in the percolation extraction radix sophorae of the present invention, for normal temperature and pressure Dynamic Extraction, its extraction process is equivalent to multiple counter-current extraction, higher recovery rate can be obtained with less extractant, ultrasonic assisted technique and extraction by steam distillation citronella grass oil improve the yield of citronella grass oil and citronellol relative composition in citronella grass oil is higher.
Description
Technical field
It is the present invention relates to cosmetic material extractive technique field, more particularly to a kind of with pore cleanser cosmetic composition
Preparation process.
Background technology
Kuh-seng is the plant that pulse family kuh-seng belongs to, wherein contain antioxidant matrine, and vegetable Chinese herbal medicine can balance
Pore is dredged and restrained to fat secretion, removes skin endotoxin contamination, and abundant herbal nutrition promotes damaged blood vessels nerve thin
The growth and reparation of born of the same parents restores subcutaneous capillary cell viability, and skin reproduction is compacted fine and smooth, plays the role of beauty and skin care.
Chamomile be rich in flavones active component, the ingredient have anti-oxidant, antiangiogenic, anti-inflammatory, anti-allergy and
0 antiviral effect.
Citronella oil can make blocking opening of the pores and help remove small pox and take away grease, and the work(with pore refining
Effect.
Invention content
The purpose of the present invention is to provide a kind of preparation processes with pore cleanser cosmetic composition.
The technical solution adopted by the present invention is：
A kind of preparation process with pore cleanser cosmetic composition, it is characterised in that：Include the following steps：
Step 1:Radix sophorae extracts matrine using percolation：Pulverizing medicinal materials, are packed into percolator, and medicinal powder is first before filling percolator
It is soaked with extraction solvent, avoids expanding in percolator and result in blockage, influenced the progress of diacolation operation, medicinal powder is uniformly packed into and is oozed
It filters cylinder, elastic consistent, about 9-11 centimetres of bed stuffing height after medicinal powder loads, is added solvent and excludes medicinal powder to the maximum extent
Air in gap, solvent submerge medicinal powder surface always, and dipping is placed 12~48 hours, so that solvent fully penetrated is spread, Chinese medicine
Seepage pressure effects can take diacolation at a slow speed or quick diacolation, and it is 1~3mL/min, filtrate when oozing soon to ooze the time filtrate rate of outflow slowly
The rate of outflow is 3~5mL/min, and percolate is transferred in vacuum distillation apparatus, and temperature is controlled in 60-70 DEG C, pressure-
0.08Mpa or so concentrates out ethyl alcohol, obtains the aqueous solution of matrine；
Step 2:Golden yellow chamomile uses alcohols solvent heating extraction Flavonoid substances：It leaches and extracts golden yellow chamomile, weigh 1:
50%BG, 60-70 DEG C of immersion 2h is added in 20 golden yellow chamomile powder, and 0.45 μm of filtering obtains golden yellow chamomile extracting solution；
Step 3：Citronella grass oil passes through ultrasonic assisted technique and extraction by steam distillation：A certain amount of dry nardgrass grass is weighed,
Segment is placed in flask, addition solvent and a small amount of zeolite, ultrasonic power 420W, ultrasonic time 30min, after the completion of ultrasonic disperse,
At 60-70 DEG C, distillation is completed for temperature control when distillation, stops heating, and condensed fluid stratification takes upper layer emulsion liquid to be added
Anhydrous sodium sulfate dries oil phase, obtains citronella grass oil；
Step 4：By radix sophorae extracting solution 5%, golden yellow chamomile extracting solution 2%, citronella grass oil 0.5%, 50% butanediol of solvent, change
Cosmetic matrix surplus is fitted into the bottle sterilized after mixing, that is, completes at normal temperatures.
Solvent in the step 1 is ethyl alcohol.
It is fine powder (100~80 mesh), middle powder (80 1 65 mesh), coarse powder (65-24 mesh), most that step 1 Chinese medicine, which crushes,
Coarse powder (24~10 mesh) 4 kinds of granularities or super coarse powder (10~5 mesh）.
Solvent in the step 3 is sodium chloride.
Advantages of the present invention：Percolation extraction radix sophorae in matrine avoid traditional extraction process yield, energy consumption,
It is not easy to the drawback produced on a large scale, and percolation is normal temperature and pressure Dynamic Extraction, extraction process is equivalent to repeatedly inverse
Stream extraction can obtain higher recovery rate with less extractant, and impurity is few, therefore the total alkali concentration of extracting solution is high, can be subsequent
Separation process lay good basis；Ultrasonic assisted technique and extraction by steam distillation citronella grass oil improve citronella grass oil
Citronellol relative composition in yield and citronella grass oil is higher.
Specific implementation mode
Embodiment 1：
A kind of preparation process with pore cleanser cosmetic composition, includes the following steps：
Step 1:Radix sophorae extracts matrine using percolation：Pulverizing medicinal materials, pulverizing medicinal materials are coarse powder (65-24 mesh), are packed into
Percolator, medicinal powder are first soaked with 60% ethanol solution before filling percolator, avoid expanding in percolator and result in blockage, influences to ooze
It filters the progress of operation, medicinal powder is uniformly packed into percolator, elastic consistent, about 10 centimetres of bed stuffing height, after medicinal powder loads,
60% ethanol solution is added and excludes air in medicinal powder gap to the maximum extent, ethanol solution submerges medicinal powder surface always, and dipping is put
It sets 30 hours, ethanol solution fully penetrated is made to spread, diacolation speed 3mL/min, percolate is transferred in vacuum distillation apparatus, temperature
Control concentrates out ethyl alcohol in 65 DEG C, pressure -0.08Mpa, obtains the aqueous solution of matrine, and liquid of filtering is 6 times with medicinal material volume ratio；
Step 2:Golden yellow chamomile uses alcohols solvent heating extraction Flavonoid substances：It leaches and extracts golden yellow chamomile, weigh 1:
50%BG, 60 DEG C of immersion 2h is added in 20 golden yellow chamomile powder, and 0.45 μm of filtering obtains golden yellow chamomile extracting solution；
Step 3：Citronella grass oil passes through ultrasonic assisted technique and extraction by steam distillation：A certain amount of dry nardgrass grass is weighed,
Segment is placed in flask, and a concentration of 10% sodium chloride and a small amount of zeolite, ultrasonic power 420W, ultrasonic time 30min, ultrasound is added
After the completion of dispersion, at 65 DEG C, distillation is completed for temperature control when distillation, stops heating, condensed fluid stratification takes upper layer emulsus
Liquid is added anhydrous sodium sulfate and dries oil phase, obtains citronella grass oil；
Step 4：By radix sophorae extracting solution 5%, golden yellow chamomile extracting solution 2%, citronella grass oil 0.5%, 50% butanediol of solvent, change
Cosmetic matrix surplus is fitted into the bottle sterilized after mixing, that is, completes at normal temperatures.
Embodiment 2：
A kind of preparation process with pore cleanser cosmetic composition, includes the following steps：
Step 1:Radix sophorae extracts matrine using percolation：Pulverizing medicinal materials, pulverizing medicinal materials are middle powder (80 1 65 mesh), are packed into
Percolator, medicinal powder are first soaked with 60% ethanol solution before filling percolator, avoid expanding in percolator and result in blockage, influences to ooze
It filters the progress of operation, medicinal powder is uniformly packed into percolator, elastic consistent, about 9 centimetres of bed stuffing height, after medicinal powder loads,
60% ethanol solution is added and excludes air in medicinal powder gap to the maximum extent, ethanol solution submerges medicinal powder surface always, and dipping is put
It sets 12 hours, ethanol solution fully penetrated is made to spread, diacolation speed is 2mL/min, and percolate is transferred in vacuum distillation apparatus,
Temperature control concentrates out ethyl alcohol in 60 DEG C, pressure -0.08Mpa, obtains the aqueous solution of matrine, and liquid of filtering is 4 with medicinal material volume ratio
Times；
Step 2:Golden yellow chamomile uses alcohols solvent heating extraction Flavonoid substances：It leaches and extracts golden yellow chamomile, weigh 1:
50%BG, 60 DEG C of immersion 2h is added in 20 golden yellow chamomile powder, and 0.45 μm of filtering obtains golden yellow chamomile extracting solution；
Step 3：Citronella grass oil passes through ultrasonic assisted technique and extraction by steam distillation：A certain amount of dry nardgrass grass is weighed,
Segment is placed in flask, and 6% sodium chloride and a small amount of zeolite, ultrasonic power 420W, ultrasonic time 30min is added, and ultrasonic disperse is completed
Afterwards, at 60 DEG C, distillation is completed for temperature control when distillation, stops heating, and condensed fluid stratification takes upper layer emulsion liquid to be added
Anhydrous sodium sulfate dries oil phase, obtains citronella grass oil, solvent is sodium chloride；
Step 4：By radix sophorae extracting solution 5%, golden yellow chamomile extracting solution 2%, citronella grass oil 0.5%, 50% butanediol of solvent, change
Cosmetic matrix surplus is fitted into the bottle sterilized after mixing, that is, completes at normal temperatures.
Embodiment 3：
A kind of preparation process with pore cleanser cosmetic composition, includes the following steps：
Step 1:Radix sophorae extracts matrine using percolation：Pulverizing medicinal materials, pulverizing medicinal materials are that (24~10 mesh are packed into most coarse powder
Percolator, medicinal powder are first soaked with 60% ethanol solution before filling percolator, avoid expanding in percolator and result in blockage, influences to ooze
It filters the progress of operation, medicinal powder is uniformly packed into percolator, elastic consistent, about 11 centimetres of bed stuffing height, after medicinal powder loads,
60% ethanol solution is added and excludes air in medicinal powder gap to the maximum extent, ethanol solution submerges medicinal powder surface always, and dipping is put
It sets 48 hours, ethanol solution fully penetrated is made to spread, diacolation speed is 5mL/min, and percolate is transferred in vacuum distillation apparatus,
Temperature control concentrates out ethyl alcohol in 70 DEG C, pressure -0.08Mpa, obtains the aqueous solution of matrine, and liquid of filtering is 8 with medicinal material volume ratio
Times；
Step 2:Golden yellow chamomile uses alcohols solvent heating extraction Flavonoid substances：It leaches and extracts golden yellow chamomile, weigh 1:
50%BG, 70 DEG C of immersion 2h is added in 20 golden yellow chamomile powder, and 0.45 μm of filtering obtains golden yellow chamomile extracting solution；
Step 3：Citronella grass oil passes through ultrasonic assisted technique and extraction by steam distillation：A certain amount of dry nardgrass grass is weighed,
Segment is placed in flask, and 12% sodium chloride is added and a small amount of zeolite, ultrasonic power 420W, ultrasonic time 30min, ultrasonic disperse are complete
Cheng Hou, at 70 DEG C, distillation is completed for temperature control when distillation, stops heating, condensed fluid stratification takes upper layer emulsion liquid to add
Enter anhydrous sodium sulfate drying oil phase, obtains citronella grass oil；
Step 4：By radix sophorae extracting solution 5%, golden yellow chamomile extracting solution 2%, citronella grass oil 0.5%, 50% butanediol of solvent, change
Cosmetic matrix surplus is fitted into the bottle sterilized after mixing, that is, completes at normal temperatures.
In experimentation：Investigate the influence factor of the matrine in percolation extraction radix sophorae：
1, influence experiment of the powder size to recovery rate
Granularity should be according to version in 2000《Chinese Pharmacopoeia》Defined fine powder (100~80 mesh), middle powder (80 1 65 mesh), coarse powder
(65-24 mesh), most coarse powder (24~10 mesh) 4 kinds of granularities and super coarse powder (10~5 mesh）The kuh-seng powder of totally 5 kinds of granularities is done pair
Than experiment.
Each granularity kuh-seng powder respectively takes 300 g, 3 deciles to be sub-packed in 3 500 mL beakers, adds people's distilled water each 500
ML leaches 12 h with condition at room temperature, and each bottle takes 1 mL of leachate to detect total alkaloid concentration, is counted after organizing interior calculating mean concentration
Recovery rate is calculated, the alkaloid seepage pressure effects rate under different grain size that obtains enters following table：
2, influence of the diacolation solvent strength to yield
The characteristic of ethanol solution is dissolved in using matrine, we extract kuh-seng using this common free of contamination reagent of ethyl alcohol
Matrine in root determines best process by testing.
Each concentration measures three shares, and the kuh-seng powder for dispensing addition 100g in beaker is put into percolating device after impregnating 12h
In, it takes percolate to survey total alkali, calculates every group of average value, obtain under diacolation solvent strength difference alkaloid seepage pressure effects rate enters
Table：
3, influence experiment of the diacolation speed to seepage pressure effects rate
Chinese medicine seepage pressure effects are divided into diacolation at a slow speed and quick diacolation, and it is 1~3mL/min to ooze the time filtrate rate of outflow slowly, is oozed soon
When the filtrate rate of outflow be 3~5mL/min choose 1,2,3,4,5mL.min-1Carry out five horizontal experiment tests.Take 15 parts of 100g's
60% ethyl alcohol of radix sophorae coarse powder impregnates 12h, and each group is respectively with 1,2,3,4,5mL.min-1Diacolation speed extract, solid-liquid ratio
It is 4, takes percolate to carry out average value in content analysis calculating group, obtain diacolation speed difference alkaloid seepage pressure effects rate and enter following table：
4, influence experiment of the solid-liquid ratio to extraction rate
In general, post processing extraction solvent consumption more at most alkaloid extraction is more complete, medicine material utilization rate is higher.But extraction time gets over
Length, the alkaloid concentrations of extracting solution are lower, and subsequent processing amount is bigger.Otherwise it is opposite.The extraction of general 6 times of solid-liquid ratio alkaloids is
Relatively completely.In order to more fully measure the analysis of ratio again to Extraction solvent amount and medicinal material, 2,3,4,5,6 times of solid-liquid ratios are chosen in this experiment
Five levels are tested.
Each 100 g of 15 parts of coarse powder is taken to be sub-packed in 500 mL beakers, 60% solution impregnation, 12 h, 3 parts are 1 group, each group difference
The percolate of 2,3,4,5,6 times of column volumes is collected, separately sampled carry out thin-layer chromatographic analysis calculates after organizing interior calculating mean concentration
Recovery rate, obtain different feed liquid than alkaloid recovery rate such as following table：
。
Conclusion：Principal element for influencing kuh-seng alkaloid recovery rate obtains the optimal of each factor through experiment of single factor
Parameter is：Coarse powder, 60% ethanol solution diacolation, diacolation speed take 3 mL.min-1, percolate is 6 times with medicinal material volume ratio.
Matrine in the percolation extraction radix sophorae of the present invention avoids traditional extraction process in yield, energy consumption, inconvenience
Drawback in large-scale production, and percolation is normal temperature and pressure Dynamic Extraction, extraction process is equivalent to repeatedly adverse current and extracts
It takes, higher recovery rate can be obtained with less extractant, and impurity is few, therefore the total alkali concentration of extracting solution is high, can be subsequent divide
Good basis is laid from process；Ultrasonic assisted technique and extraction by steam distillation citronella grass oil improve the yield of citronella grass oil
And the citronellol relative composition in citronella grass oil is higher.
Claims (4)
1. a kind of preparation process with pore cleanser cosmetic composition, it is characterised in that：Include the following steps：
Step 1:Radix sophorae extracts matrine using percolation：Pulverizing medicinal materials, are packed into percolator, and medicinal powder is first before filling percolator
It is soaked with extraction solvent, avoids expanding in percolator and result in blockage, influenced the progress of diacolation operation, medicinal powder is uniformly packed into and is oozed
It filters cylinder, elastic consistent, about 9-11 centimetres of bed stuffing height after medicinal powder loads, is added solvent and excludes medicinal powder to the maximum extent
Air in gap, solvent submerge medicinal powder surface always, and dipping is placed 12~48 hours, so that solvent fully penetrated is spread, Chinese medicine
Seepage pressure effects can take diacolation at a slow speed or quick diacolation, and it is 1~3mL/min, filtrate when oozing soon to ooze the time filtrate rate of outflow slowly
The rate of outflow is 3~5mL/min, and percolate is transferred in vacuum distillation apparatus, and temperature is controlled in 60-70 DEG C, pressure-
0.08Mpa or so concentrates out ethyl alcohol, obtains the aqueous solution of matrine；
Step 2:Golden yellow chamomile uses alcohols solvent heating extraction Flavonoid substances：It leaches and extracts golden yellow chamomile, weigh 1:
50%BG, 60-70 DEG C of immersion 2h is added in 20 golden yellow chamomile powder, and 0.45 μm of filtering obtains golden yellow chamomile extracting solution；
Step 3：Citronella grass oil passes through ultrasonic assisted technique and extraction by steam distillation：A certain amount of dry nardgrass grass is weighed,
Segment is placed in flask, addition solvent and a small amount of zeolite, ultrasonic power 420W, ultrasonic time 30min, after the completion of ultrasonic disperse,
At 60-70 DEG C, distillation is completed for temperature control when distillation, stops heating, and condensed fluid stratification takes upper layer emulsion liquid to be added
Anhydrous sodium sulfate dries oil phase, obtains citronella grass oil；
Step 4：By radix sophorae extracting solution 5%, golden yellow chamomile extracting solution 2%, citronella grass oil 0.5%, 50% butanediol of solvent, change
Cosmetic matrix surplus is fitted into the bottle sterilized after mixing, that is, completes at normal temperatures.
2. a kind of preparation process with pore cleanser cosmetic composition according to claim 1, it is characterised in that：It is described
Solvent in step 1 is ethyl alcohol.
3. a kind of preparation process with pore cleanser cosmetic composition according to claim 1, it is characterised in that：It is described
It is fine powder (100~80 mesh), middle powder (80 1 65 mesh), coarse powder (65-24 mesh), most coarse powder (24~10 that step 1 Chinese medicine, which crushes,
Mesh) 4 kinds of granularity or super coarse powder (10~5 mesh）.
4. a kind of preparation process with pore cleanser cosmetic composition according to claim 1, it is characterised in that：It is described
Solvent in step 3 is sodium chloride.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948817A (en) * | 2014-01-15 | 2014-07-30 | 北京工商大学 | External application traditional Chinese medicine composition with effects of acne and comedo removing and telangiectasis relieving, and skin care preparation and preparation method thereof |
| CN104784252A (en) * | 2015-05-07 | 2015-07-22 | 黑龙江省兽医科学研究所 | Preparation method and application of sophora flavescens total alkaloid extractive |
| CN106420483A (en) * | 2016-11-07 | 2017-02-22 | 北京痘博士痤疮医学研究院 | Skin-clearing blackhead dissolving solution |
-
2018
- 2018-05-30 CN CN201810540424.5A patent/CN108553361A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948817A (en) * | 2014-01-15 | 2014-07-30 | 北京工商大学 | External application traditional Chinese medicine composition with effects of acne and comedo removing and telangiectasis relieving, and skin care preparation and preparation method thereof |
| CN104784252A (en) * | 2015-05-07 | 2015-07-22 | 黑龙江省兽医科学研究所 | Preparation method and application of sophora flavescens total alkaloid extractive |
| CN106420483A (en) * | 2016-11-07 | 2017-02-22 | 北京痘博士痤疮医学研究院 | Skin-clearing blackhead dissolving solution |
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