CN108552325A - A kind of krill fluid composition and preparation method - Google Patents
A kind of krill fluid composition and preparation method Download PDFInfo
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- CN108552325A CN108552325A CN201810215646.XA CN201810215646A CN108552325A CN 108552325 A CN108552325 A CN 108552325A CN 201810215646 A CN201810215646 A CN 201810215646A CN 108552325 A CN108552325 A CN 108552325A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
- A23D9/04—Working-up
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- Alternative & Traditional Medicine (AREA)
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- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
- Hematology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of krill fluid composition, and the composition is made of antarctic krill oil, Purple Perilla Seed Oil, grape seed oil；The parts by weight of each component of composition are：50 ~ 500 parts of antarctic krill oil, 200 ~ 2000 parts of Purple Perilla Seed Oil, 60 ~ 600 parts of grape seed oil.A kind of preparation method of antarctic krill oil composite preparation, preparation method include the following steps：It weighs, pharmaceutically acceptable carrier or diluent is added in sieving, is uniformly mixed, is prepared into various dosage forms.The composition and its preparation of the present invention, antarctic krill oil, Purple Perilla Seed Oil, grape seed oil composition are arranged in pairs or groups by a certain percentage in component, have the effect of assisting reducing blood lipid, with synergistic function.
Description
Technical field
The present invention relates to health-care products, and in particular to a kind of krill fluid composition.
Background technology
Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil have certain lipid-lowering effect, and traditional health-care products are adopted
It is used as component for reducing blood fat with single component, lipid-lowering effect is not notable enough.Using antarctic krill oil, purple perilla seed in the present invention
Oil, grape seed oil composition are arranged in pairs or groups by a certain percentage, have the effect of assisting reducing blood lipid, have synergistic function.
Invention content
The purpose of the present invention is to overcome the defects in the prior art, designs a kind of krill fluid composition, the present invention
Composition and its preparation, antarctic krill oil, Purple Perilla Seed Oil, grape seed oil composition are arranged in pairs or groups by a certain percentage in component, are had auxiliary
The effect of reducing blood lipid is helped, there is synergistic function.
To achieve the above object, the technical solution adopted in the present invention is a kind of krill fluid composition, the combination
Object is made of antarctic krill oil, Purple Perilla Seed Oil, grape seed oil；
The parts by weight of each component of composition are：50 ~ 500 parts of antarctic krill oil, 200 ~ 2000 parts of Purple Perilla Seed Oil, grape
60 ~ 600 parts of seed oil.
Preferably, the parts by weight of each component of composition are：100 ~ 300 parts of antarctic krill oil, Purple Perilla Seed Oil 400 ~
1200 parts, 150 ~ 500 parts of grape seed oil.The parts by weight can be weight list well known to the field of medicaments such as μ g, mg, g, kg
Position.
Preferably, antarctic krill oil is extracted from krill using ultralow temperature abstraction technique；Ultralow temperature extracts
Technology is to obtain shrimp med through go out autolytic enzyme, low temperature drying of boiling using krill as raw material, and shrimp med extracts through ethyl alcohol, filtering, dense
Contracting, stand at low temperature, vacuum distillation obtain antarctic krill oil.
Preferably, Purple Perilla Seed Oil system extracts from purple perilla seed, contains 50% alpha-linolenic acid；Extracting process is to be with purple perilla seed
Raw material obtains Purple Perilla Seed Oil through screening, removal of impurities, physical squeezing, refined, filling form.
Preferably, grape seed oil extracts from grape pip；Extracting process is using grape pip as raw material, through screening, removing
Miscellaneous, physical squeezing, refined, filling form obtain grape seed oil.
A kind of preparation of krill fluid composition, the preparation is by krill fluid composition and pharmaceutically acceptable
Carrier or diluent composition.
Preferably, by the composition of 310-3100 parts by weight and the pharmaceutically acceptable load of 100-20000 parts by weight
Body or diluent composition.
Preferably, the preparation can be soft capsule.
Preferably, pharmaceutically acceptable carrier or diluent be soybean oil, corn oil, gelatin, one kind in glycerine or
Several compositions.
A kind of preparation method of antarctic krill oil composite preparation, the preparation method comprises the following steps：It weighs, mistake
Pharmaceutically acceptable carrier or diluent is added in sieve, is uniformly mixed, is prepared into various dosage forms.
The advantages of the present invention are：
Krill fluid composition, antarctic krill oil, Purple Perilla Seed Oil, grape seed oil composition are arranged in pairs or groups by a certain percentage in component, are had
There is the effect of auxiliary reducing blood lipid, there is synergistic function.
Specific implementation mode
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more
Add and clearly demonstrate technical scheme of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
Soft capsule preparation：
1, component matches：Antarctic krill oil 50g, Purple Perilla Seed Oil 2000g, grape seed oil 600g, soybean oil 350g；
2, preparation method
1）Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil are weighed according to component proportioning, soybean oil is spare；
2）Above-mentioned supplementary material is uniformly mixed, colloidal sol, pelleting, is shaped, it is dry, prepare 3000；
3, specification：Every 1.0g, 0.17g containing antarctic krill oil, Purple Perilla Seed Oil 0.67g, grape seed oil 0.2g.
Embodiment 2
Soft capsule preparation：
1, component matches：Antarctic krill oil 500g, Purple Perilla Seed Oil 200g, grape seed oil 60g, soybean oil 240g
2, preparation method
1）Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil are weighed according to component proportioning, soybean oil is spare；
2）Above-mentioned supplementary material is uniformly mixed, colloidal sol, pelleting, is shaped, it is dry, prepare 1000；
3, specification：Every 1.0g, 0.5g containing antarctic krill oil, Purple Perilla Seed Oil 0.2g, grape seed oil 0.06g.
Embodiment 3
Soft capsule preparation：
1, component matches：Antarctic krill oil 100g, Purple Perilla Seed Oil 1200g, grape seed oil 500g, soybean oil 200g
2, preparation method
1）Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil are weighed according to prescription, soybean oil is spare；
2）Above-mentioned supplementary material is uniformly mixed, colloidal sol, pelleting, is shaped, it is dry, prepare 2000；
3, specification：Every 1.0g, 0.05g containing antarctic krill oil, Purple Perilla Seed Oil 0.6g, grape seed oil 0.25g.
Embodiment 4
Soft capsule preparation：
1, component matches：Antarctic krill oil 300g, Purple Perilla Seed Oil 400g, grape seed oil 150g, soybean oil 150g
2, preparation method
1）Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil are weighed according to component proportioning, soybean oil is spare；
2）Above-mentioned supplementary material is uniformly mixed, colloidal sol, pelleting, is shaped, it is dry, prepare 1000；
3, specification：Every 1.0g, 0.3g containing antarctic krill oil, Purple Perilla Seed Oil 0.4g, grape seed oil 0.15g.
Embodiment 5
Soft capsule preparation：
1, component matches：Antarctic krill oil 200g, Purple Perilla Seed Oil 500g, grape seed oil 200g, soybean oil 100g；
2, preparation method
1）Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil are weighed according to component proportioning, soybean oil is spare；
2）Above-mentioned supplementary material is uniformly mixed, colloidal sol, pelleting, is shaped, it is dry, prepare 1000；
3, specification：Every 1.0g, 0.2g containing antarctic krill oil, Purple Perilla Seed Oil 0.5g, grape seed oil 0.2g.
Implement the effect of human experimentation verification antarctic krill oil composite preparation
1, experimental subjects and method
1.1 experimental subjects
This experiment whole subjects are simple dyslipidemia crowd, man 20, female 16 in 36 subjects；Age is in 35-60
Between year, average age（51.7±7.4）Year.
1.2 experimental method
Grouping：36 subjects are randomly divided into 3 groups, positive controls（N=12）, experiment one group（N=12）With test two groups（N=
12）.Positive controls take krill fat capsule, 4/day（Every 0.3g containing krill oil）；It tests one group and takes the present invention's
Composition group, 4/day（It is prepared with reference to the method for embodiment 4, every 0.3g containing antarctic krill oil, Purple Perilla Seed Oil 0.4g, grape
Seed oil 0.15g）；Test two groups of compositions for taking the present invention, 4/day（It is prepared with reference to the method for embodiment 5, every contains the South Pole
Krill oil 0.2g, Purple Perilla Seed Oil 0.5g, grape seed oil 0.2g））；It continuously takes according to the method described above 6 weeks.During entire experiment,
Usually life and eating habit are kept, takes hematometry indices on an empty stomach.
1.3 test index
1.3.1 body composition test：The serum total cholesterol of subject is tested before experiment and after experiment with automatic clinical chemistry analyzer
（TC）, triglycerides（TG）, low-density lipoprotein（LDL-C）, high-density lipoprotein（HDL-C）.
1.4 data statistics
The data obtained Excel processing is examined using t and carries out statistical analysis to test data, indicated with mean ± SD.
, experimental result and analysis
2.1 body composition analysis results
2.1.1 front and back subject's TC testing results are tested
Table 1：The front and back subject's TC situations of change of experiment
Compared with before take, * P<0.05；Compared with positive controls,#P<0.05；
As can be seen from Table 1, compared with before experiment, two groups of positive controls, one group of experiment and experiment TC are remarkably decreased（P<
0.05）;Compared with positive controls, one group and two groups of TC of experiment is remarkably decreased（P<0.05）；
2.1.2 front and back TG testing results are tested
Table 2：Subject's TG testing results
Compared with before take, * P<0.05；Compared with positive controls,#P<0.05；
As can be seen from Table 2, compared with before experiment, two groups of positive controls, one group of experiment and experiment TG are remarkably decreased（P<
0.05）;Compared with positive controls, one group and two groups of TG of experiment is remarkably decreased（P<0.05）；
2.1.3 front and back LDL-C testing results are tested
Table 3：Subject's LDL-C testing results
Compared with before take, * P<0.05；Compared with positive controls,#P<0.05；
As can be seen from Table 3, compared with before experiment, two groups of positive controls, one group of experiment and experiment LDL-C are remarkably decreased（P
<0.05）;Compared with positive controls, one group and two groups of LDL-C of experiment is remarkably decreased（P<0.05）；
2.1.4 front and back HDL-C testing results are tested
Table 4：Subject's HDL-C testing results
Compared with before take, * P<0.05；Compared with positive controls,#P<0.05；
As can be seen from Table 4, compared with before experiment, positive controls HDL-C is slightly increased, two groups of HDL- of one group of experiment and experiment
C is significantly increased（P<0.05）;Compared with positive controls, one group and two groups of HDL-C of experiment significantly increases（P<0.05）；
3, conclusion
Antarctic krill oil, Purple Perilla Seed Oil, grape seed oil are compounded in specific proportions in the composition of the present invention, are had centainly
Effect for reducing blood fat.
In this experiment, compare with before experiment, the amplitude that experimental group TC, TG, LDL-C decline is greater than positive controls, real
It tests the amplitude that group HDL-C rises and is greater than positive controls, illustrate that subject takes the composition of the present invention in auxiliary reducing blood lipid
Aspect advantageously compared to folk prescription has certain synergistic function.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of krill fluid composition, which is characterized in that the composition is by antarctic krill oil, Purple Perilla Seed Oil, grape pip
Oil composition；
The parts by weight of each component of composition are：50 ~ 500 parts of antarctic krill oil, 200 ~ 2000 parts of Purple Perilla Seed Oil, grape
60 ~ 600 parts of seed oil.
2. krill fluid composition as described in claim 1, which is characterized in that the parts by weight of each component of composition
For：100 ~ 300 parts of antarctic krill oil, 400 ~ 1200 parts of Purple Perilla Seed Oil, 150 ~ 500 parts of grape seed oil.
3. krill fluid composition as described in claim 1, which is characterized in that antarctic krill oil is extracted using ultralow temperature
Technology is extracted from krill；Ultralow temperature abstraction technique is gone out autolytic enzyme, low temperature through boiling using krill as raw material
It is dried to obtain shrimp med, shrimp med obtains antarctic krill oil through ethyl alcohol extraction, filtering, concentration, stand at low temperature, vacuum distillation.
4. krill fluid composition as described in claim 1, which is characterized in that Purple Perilla Seed Oil system extracts from purple perilla seed,
Containing 50% alpha-linolenic acid；Extracting process be using purple perilla seed as raw material, through screening, removal of impurities, physical squeezing, it is refined, filling into
To Purple Perilla Seed Oil.
5. krill fluid composition as described in claim 1, which is characterized in that grape seed oil extracted from grape pip and
At；Extracting process is to obtain grape seed oil through screening, removal of impurities, physical squeezing, refined, filling form using grape pip as raw material.
6. a kind of preparation of krill fluid composition according to any one of claims 1 to 5, which is characterized in that the preparation by
Krill fluid composition and pharmaceutically acceptable carrier or diluent composition.
7. the preparation of krill fluid composition as claimed in claim 6, which is characterized in that by 310-3100 parts by weight
Composition and 100-20000 parts by weight pharmaceutically acceptable carrier or diluent composition.
8. the preparation of krill fluid composition as claimed in claim 6, which is characterized in that the preparation can be flexible glue
Capsule.
9. the preparation of krill fluid composition as claimed in claim 6, which is characterized in that pharmaceutically acceptable carrier or
Diluent is the composition of one or more of soybean oil, corn oil, gelatin, glycerine.
10. a kind of preparation method of antarctic krill oil composite preparation, which is characterized in that the preparation method includes following step
Suddenly：It weighs, pharmaceutically acceptable carrier or diluent is added in sieving, is uniformly mixed, is prepared into various dosage forms.
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| CN201810215646.XA CN108552325A (en) | 2018-03-15 | 2018-03-15 | A kind of krill fluid composition and preparation method |
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| CN201810215646.XA CN108552325A (en) | 2018-03-15 | 2018-03-15 | A kind of krill fluid composition and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269883A (en) * | 2018-11-05 | 2019-09-24 | 中冠生物科技(珲春)有限公司 | A kind of composition and its application in the product for preparing blood pressure lowering |
| CN114711321A (en) * | 2022-03-19 | 2022-07-08 | 浙江新研坤科技有限公司 | Euphausia superba oil gel candy added with plant omega 3 and preparation method thereof |
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| CN102492537A (en) * | 2011-11-14 | 2012-06-13 | 辽宁省大连海洋渔业集团公司 | Method for extracting krill oil from antarctic krill |
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2018
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269883A (en) * | 2018-11-05 | 2019-09-24 | 中冠生物科技(珲春)有限公司 | A kind of composition and its application in the product for preparing blood pressure lowering |
| CN114711321A (en) * | 2022-03-19 | 2022-07-08 | 浙江新研坤科技有限公司 | Euphausia superba oil gel candy added with plant omega 3 and preparation method thereof |
| CN114711321B (en) * | 2022-03-19 | 2024-03-15 | 浙江新研坤科技有限公司 | Euphausia superba oil gel candy added with plant omega 3 and preparation method thereof |
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