CN108532298A - A kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material - Google Patents
A kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material Download PDFInfo
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- CN108532298A CN108532298A CN201810396992.2A CN201810396992A CN108532298A CN 108532298 A CN108532298 A CN 108532298A CN 201810396992 A CN201810396992 A CN 201810396992A CN 108532298 A CN108532298 A CN 108532298A
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- hyperblastosis
- overlay film
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/88—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
- D01F6/92—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of polyesters
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/19—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with synthetic macromolecular compounds
- D06M15/21—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D06M15/327—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated alcohols or esters thereof
- D06M15/333—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated alcohols or esters thereof of vinyl acetate; Polyvinylalcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/30—Synthetic polymers consisting of macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- D06M2101/32—Polyesters
Abstract
The present invention relates to a kind of preparation methods of anti-hyperblastosis fiber type three-dimensional overlay film frame material, belong to medical material tech field.Technical solution of the present invention by during electrostatic spinning by the way that nanofiber is compound, to be formed similar to natural extracellular matrix, micrometer fibers and the alternate existing fibrous web-like system of nanofiber, and realize the porosity for increasing holder while maintaining mechanical strength, effective protection regenerating tissues, it is set to be not easy to be destroyed by extraneous stress, can be again that the conveying of Nutrition and Metabolism substance and the migration of seed cell grow into and create favorable conditions by pore structure appropriate, to lay the first stone to form the regenerating tissues with normal physiological function and structure, and technical solution of the present invention is by extracting celastrus orbiculatus substance and hyperblastosis being inhibited to react, the phenomenon that reducing cell and hyperblastosis, the phenomenon that effectively reducing overlay film frame hyperblastosis in technical solution of the present invention.
Description
Technical field
The present invention relates to a kind of preparation methods of anti-hyperblastosis fiber type three-dimensional overlay film frame material, belong to medical material
Technical field.
Background technology
Up to now, there is the biliary tract prosthesis of three types in the market, be respectively traditional plastic stent, metallic support and
Biodegradable holder.Plastic stent and metallic support development are more mature, but with the accumulation of clinical practice, researcher
Find the late result existing defects after common plastics biliary tract prosthesis and metal biliary tract prosthesis implantation, and long term complication
（Such as stent stenosis, blocking, displacement）Incidence is higher.The merging operation of plastic stent is relatively simple, but because of its lumen diameter
Smaller, postoperative biliary drainage effect is extremely limited, and is susceptible to intracavitary courage mud deposition and leads to obstruction of stent, therefore needs regular
It replaces repeatedly, to increase the operational risk and economic cost for the treatment of.In addition plastic stent is as a kind of long-term existence foreign matter,
The abnormal pathologic of bile duct tissue can be caused to react.Bare metal stent has good dilating effect, but postoperative can lead to local meat
Bud hyperblastosis, long term make holder " deep embedding " enter in bile duct tissue, can not recycle and become permanent foreign matter.In view of gold
, there is metal film coated holder, the membrane structure on surface can not only effectively avoid granulation tissue in the bad feature for belonging to bare bracket
It " is grown into " from mesh, is convenient for effective recycling of holder, while also the radial tension of holder can be made " to be uniformly distributed in narrow positions
Lumen wall ", so as to improve the stress relation of holder and bile duct wall, reach good dilating effect.But this precoated metal
There are the deficiencies of following three aspect for holder：（1）In order to facilitate being taken out under scope, the lower end of holder need to be stretched out from nipple and exposure
In enteric cavity, the function of Oddi sphincters is destroyed, is easily caused " intestines-courage backflows ", is i.e. the content of enteric cavity can persistently backflow entrance
Bile duct causes the cholangitis that repeated；（2）" barrier " due to losing Oddi sphincters acts on, and surface coating reduces
Frictional resistance between tube wall makes holder be easy to be displaced to enteric cavity；（3）Holder needs to take out or adjust repeatedly under scope, increases
Add operation the risk and cost.Therefore, clinically have there is an urgent need to design a kind of Biodegradable bile duct overlay film frame
Following performance characteristic：（1）The lasting expansion that a period of time can be effectively carried out to narrow bile duct, ensures that biliary drainage is unobstructed；（2）
Surface coating structure can be relied on to maintain uniform, the good stress relation between bile duct wall, alleviate the pathology of bile duct local organization
Reaction prevents the tube chamber restenosis caused by the growing into of granulation tissue；（3）Timbering material energy after maintaining a period of time expansion support
It voluntarily degrades, without changing holder scope is underlying repeatedly；(4) it can be fully recessed into choledochus intracavitary, avoided to Oddi sphincter physiology
The destruction of structure and function effectively prevent " intestines-courage reflux " and " stent migration ".But existing degradable overlay film frame material
Lead to inflammatory reaction, smooth muscle cell proliferation after material use, to even result in restenosis, while the ratio of stent migration is suitable
Height, thus prepare it is a kind of can effectively anti-hyperblastosis three-dimensional overlay film frame it is necessary.
Invention content
The technical problems to be solved by the invention：For leading to inflammatory reaction, smooth after existing overlay film frame materials'use
Muscle cell multiplication provides a kind of anti-tissue to even result in restenosis, while the quite high problem of ratio of stent migration
The preparation method of Accretive Type fibre three-dimensional overlay film frame material.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
（1）It counts in parts by weight, weighs 45~50 parts of deionized waters, 10~15 parts of sodium sulfites, 3~5 parts of urea, 3~5 respectively
Part dodecyl sodium sulfate is stirred to obtain mixed liquor, in mass ratio 1:10, boiled silk is added in mixed liquor, stirring is mixed
Merging is placed in three-necked flask, is led to nitrogen and is excluded air, and heating water bath, standing are cooled to room temperature in a nitrogen atmosphere, and filtering is simultaneously
Collect filtrate；
（2）It counts in parts by weight, weighs 45~50 parts of deionized waters, 25~30 parts of isopropanols, 10~15 parts of polylactic acid, 3 respectively
~5 parts of polyvinyl alcohol and 10~15 parts of filtrates are placed in blender, are stirred and are placed in electrostatic spinning apparatus, inject spinning
And collect spinning fibre；
（3）In mass ratio 1:2, by celastrus orbiculatus vacuum freeze drying and milled 80~100 mesh sieve, abrasive flour is collected to obtain, is pressed
Mass ratio 1:5, abrasive flour is mixed with absolute ethyl alcohol and stirring, is then heated to reflux, waits after the completion of standing cooling, centrifuges
And supernatant liquor is collected, it is prepared into extracting solution；
（4）In mass ratio 1:8, polyvinyl alcohol is added in extracting solution, simultaneously ultrasonic disperse is stirred, dispersion liquid is obtained and will spin
Silk fiber is dipped in dispersion liquid, after standing, filters and collect modified spinning fibre, after dry, then by dry modification spinning
Fiber is placed in funnel-form reception device, by mutually winding and being coated to shaft reception device by fiber, you can be prepared into
The anti-hyperblastosis fiber type three-dimensional overlay film frame material.
Step（1）It is 45~50mL/min that the nitrogen, which is passed through rate,.
Step（2）It is 12kV that the electrostatic spinning, which is in electrostatic spinning voltage, under the conditions of injection rate is 1.0mL/min
Electrostatic spinning processing.
Step（4）The drying temperature is 45~50 DEG C.
Compared with other methods, advantageous effects are the present invention：
（1）Technical solution of the present invention during electrostatic spinning with being formed by, by the way that nanofiber is compound, being similar to naturally
Extracellular matrix, micrometer fibers and the alternate existing fibrous web-like system of nanofiber, and realize and maintaining mechanical strength
Increase the porosity of holder simultaneously, effective protection regenerating tissues make it be not easy to be destroyed by extraneous stress, then pass through hole appropriate
Gap structure can be that the conveying of Nutrition and Metabolism substance and the migration of seed cell grow into and create favorable conditions, to have to be formed
Normal physiological function and the regenerating tissues of structure lay the first stone；
（2）Technical solution of the present invention reduces cell and hyperblastosis by extracting celastrus orbiculatus substance and hyperblastosis being inhibited to react
The phenomenon that, meanwhile, Celastrus orbiculatus Thunb. Extract effectively adsorb and load by regarding albumen as absorption and covering material, is had
Effect reduces the phenomenon that overlay film frame hyperblastosis in technical solution of the present invention.
Specific implementation mode
Count in parts by weight, respectively weigh 45~50 parts of deionized waters, 10~15 parts of sodium sulfites, 3~5 parts of urea, 3~
5 parts of dodecyl sodium sulfates are placed in beaker, are stirred to obtain mixed liquor and in mass ratio 1:10, boiled silk is added to mixed
It closes in liquid, is stirred and is placed in three-necked flask, lead to nitrogen and exclude air, it is 45~50mL/ that control nitrogen, which is passed through rate,
Min is placed in 3~5h of heating water bath, standing at 74~80 DEG C and is cooled to room temperature, filters and collect filtrate in a nitrogen atmosphere, then
Count in parts by weight, weigh respectively 45~50 parts of deionized waters, 25~30 parts of isopropanols, 10~15 parts of polylactic acid, 3~5 parts it is poly-
Vinyl alcohol and 10~15 parts of filtrates are placed in blender, are stirred and are placed in electrostatic spinning apparatus, setting electrostatic spinning electricity
Pressure is 12kV, injection rate 1.0mL/min, injects spinning and collects spinning fibre, in mass ratio 1:2, by celastrus orbiculatus vacuum
It is freeze-dried and milled 80~100 mesh sieves, collect to obtain abrasive flour, in mass ratio 1:5, abrasive flour and absolute ethyl alcohol are stirred
Mixing is mixed, 3~5h is then heated to reflux, is waited after the completion of standing cooling, is centrifuged and collect supernatant liquor, be prepared into extraction
Liquid, in mass ratio 1:8, polyvinyl alcohol is added in extracting solution, be stirred be placed in ultrasonic disperse 10 under 200~300W~
15min obtains dispersion liquid and spinning fibre is dipped in dispersion liquid, stand 20~for 24 hours after, filter and to collect modified spinning fine
Dimension at 45~50 DEG C after dry 3~5h, then dry modification spinning fibre is placed in funnel-form reception device, pass through by
Fiber mutually winds and coats to shaft reception device, you can is prepared into the anti-hyperblastosis fiber type three-dimensional overlay film branch
Frame material.
It counts in parts by weight, weighs 45 parts of deionized waters, 10 parts of sodium sulfites, 3 parts of urea, 3 parts of dodecyl sulphurs respectively
Sour sodium is placed in beaker, is stirred to obtain mixed liquor and in mass ratio 1:10, boiled silk is added in mixed liquor, stirring is mixed
Merging is placed in three-necked flask, is led to nitrogen and is excluded air, it is 45mL/min that control nitrogen, which is passed through rate, is placed in a nitrogen atmosphere
Heating water bath 3h, standing are cooled to room temperature at 74 DEG C, filter and collect filtrate, then count in parts by weight, and weighing 45 parts respectively goes
Ionized water, 25 parts of isopropanols, 10 parts of polylactic acid, 3 parts of polyvinyl alcohol and 10 parts of filtrates are placed in blender, are stirred and are placed in
In electrostatic spinning apparatus, setting electrostatic spinning voltage is 12kV, injection rate 1.0mL/min, injects spinning and collects spinning
Fiber, in mass ratio 1:2, by celastrus orbiculatus vacuum freeze drying and milled 80 mesh sieve, collect to obtain abrasive flour, in mass ratio 1:
5, abrasive flour is mixed with absolute ethyl alcohol and stirring, is then heated to reflux 3h, is waited after the completion of standing cooling, is centrifuged and collect
Supernatant liquor is prepared into extracting solution, in mass ratio 1:8, polyvinyl alcohol is added in extracting solution, is stirred and is placed in 200W
Lower ultrasonic disperse 10min obtains dispersion liquid and spinning fibre is dipped in dispersion liquid, after standing 20h, filters and collects modified spinning
Silk fiber at 45 DEG C after dry 3h, then dry modification spinning fibre is placed in funnel-form reception device, by by fiber
It mutually winds and coats to shaft reception device, you can be prepared into the anti-hyperblastosis fiber type three-dimensional overlay film frame material
Material.
It counts in parts by weight, weighs 47 deionized waters, 12 parts of sodium sulfites, 4 parts of urea, 4 parts of dodecyl sodium sulfonates respectively
Sodium is placed in beaker, is stirred to obtain mixed liquor and in mass ratio 1:10, boiled silk is added in mixed liquor, is stirred
It is placed in three-necked flask, leads to nitrogen and exclude air, it is 47mL/min that control nitrogen, which is passed through rate, is placed in 77 in a nitrogen atmosphere
Heating water bath 4h at DEG C, standing are cooled to room temperature, and filter and collect filtrate, then count in parts by weight, respectively weigh 47 parts go from
Sub- water, 27 parts of isopropanols, 12 parts of polylactic acid, 4 parts of polyvinyl alcohol and 12 parts of filtrates are placed in blender, be stirred be placed in it is quiet
In electric spinning device, setting electrostatic spinning voltage is 12kV, injection rate 1.0mL/min, injects spinning and collects spinning fibre
Dimension, in mass ratio 1:2, by celastrus orbiculatus vacuum freeze drying and milled 90 mesh sieve, collect to obtain abrasive flour, in mass ratio 1:5,
Abrasive flour is mixed with absolute ethyl alcohol and stirring, is then heated to reflux 4h, is waited after the completion of standing cooling, is centrifuged and collect
Layer clear liquid, is prepared into extracting solution, in mass ratio 1:8, polyvinyl alcohol is added in extracting solution, is stirred and is placed under 250W
Ultrasonic disperse 125min obtains dispersion liquid and spinning fibre is dipped in dispersion liquid, after standing 22h, filters and collects modified spinning
Silk fiber at 47 DEG C after dry 4h, then dry modification spinning fibre is placed in funnel-form reception device, by by fiber
It mutually winds and coats to shaft reception device, you can be prepared into the anti-hyperblastosis fiber type three-dimensional overlay film frame material
Material.
It counts in parts by weight, weighs 50 parts of deionized waters, 15 parts of sodium sulfites, 5 parts of urea, 5 parts of dodecyl sulphurs respectively
Sour sodium is placed in beaker, is stirred to obtain mixed liquor and in mass ratio 1:10, boiled silk is added in mixed liquor, stirring is mixed
Merging is placed in three-necked flask, is led to nitrogen and is excluded air, it is 50mL/min that control nitrogen, which is passed through rate, is placed in a nitrogen atmosphere
Heating water bath 5h, standing are cooled to room temperature at 80 DEG C, filter and collect filtrate, then count in parts by weight, and weighing 50 parts respectively goes
Ionized water, 30 parts of isopropanols, 15 parts of polylactic acid, 5 parts of polyvinyl alcohol and 15 parts of filtrates are placed in blender, are stirred and are placed in
In electrostatic spinning apparatus, setting electrostatic spinning voltage is 12kV, injection rate 1.0mL/min, injects spinning and collects spinning
Fiber, in mass ratio 1:2, celastrus orbiculatus vacuum freeze drying and milling is sieved with 100 mesh sieve, collects to obtain abrasive flour, in mass ratio
1:5, abrasive flour is mixed with absolute ethyl alcohol and stirring, is then heated to reflux 5h, is waited after the completion of standing cooling, is centrifuged and receive
Collect supernatant liquor, is prepared into extracting solution, in mass ratio 1:8, polyvinyl alcohol is added in extracting solution, is stirred and is placed in
Ultrasonic disperse 15min under 300W obtains dispersion liquid and spinning fibre is dipped in dispersion liquid, after standing for 24 hours, filters and collects and change
Property spinning fibre, at 50 DEG C after dry 5h, then dry modification spinning fibre is placed in funnel-form reception device, pass through by
Fiber mutually winds and coats to shaft reception device, you can is prepared into the anti-hyperblastosis fiber type three-dimensional overlay film branch
Frame material.
Example 1,2,3 prepared by the present invention is tested for the property, specific test result is as follows shown in table table 1：
1 performance test table of table
As seen from the above table, the overlay film frame material that prepared by the present invention has excellent mechanical property and bio-compatible performance.
Claims (4)
1. a kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material, it is characterised in that specific preparation process
For：
（1）It counts in parts by weight, weighs 45~50 parts of deionized waters, 10~15 parts of sodium sulfites, 3~5 parts of urea, 3~5 respectively
Part dodecyl sodium sulfate is stirred to obtain mixed liquor, in mass ratio 1:10, boiled silk is added in mixed liquor, stirring is mixed
Merging is placed in three-necked flask, is led to nitrogen and is excluded air, and heating water bath, standing are cooled to room temperature in a nitrogen atmosphere, and filtering is simultaneously
Collect filtrate；
（2）It counts in parts by weight, weighs 45~50 parts of deionized waters, 25~30 parts of isopropanols, 10~15 parts of polylactic acid, 3 respectively
~5 parts of polyvinyl alcohol and 10~15 parts of filtrates are placed in blender, are stirred and are placed in electrostatic spinning apparatus, inject spinning
And collect spinning fibre；
（3）In mass ratio 1:2, by celastrus orbiculatus vacuum freeze drying and milled 80~100 mesh sieve, abrasive flour is collected to obtain, is pressed
Mass ratio 1:5, abrasive flour is mixed with absolute ethyl alcohol and stirring, is then heated to reflux, waits after the completion of standing cooling, centrifuges
And supernatant liquor is collected, it is prepared into extracting solution；
（4）In mass ratio 1:8, polyvinyl alcohol is added in extracting solution, simultaneously ultrasonic disperse is stirred, dispersion liquid is obtained and will spin
Silk fiber is dipped in dispersion liquid, after standing, filters and collect modified spinning fibre, after dry, then by dry modification spinning
Fiber is placed in funnel-form reception device, by mutually winding and being coated to shaft reception device by fiber, you can be prepared into
The anti-hyperblastosis fiber type three-dimensional overlay film frame material.
2. a kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material according to claim 1, special
Sign is：Step（1）It is 45~50mL/min that the nitrogen, which is passed through rate,.
3. a kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material according to claim 1, special
Sign is：Step（2）It is 12kV that the electrostatic spinning, which is in electrostatic spinning voltage, under the conditions of injection rate is 1.0mL/min
Electrostatic spinning processing.
4. a kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material according to claim 1, special
Sign is：Step（4）The drying temperature is 45~50 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810396992.2A CN108532298A (en) | 2018-04-28 | 2018-04-28 | A kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material |
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| CN201810396992.2A CN108532298A (en) | 2018-04-28 | 2018-04-28 | A kind of preparation method of anti-hyperblastosis fiber type three-dimensional overlay film frame material |
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|---|---|---|---|---|
| CN101036802A (en) * | 2006-12-30 | 2007-09-19 | 苏州大学 | Antheraea pernyi silk fibrion biology medicine material and the preparation method |
| CN102526423A (en) * | 2012-01-06 | 2012-07-04 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Medicine composition for treating ischemic heart disease |
| CN103588678A (en) * | 2008-04-18 | 2014-02-19 | 里亚塔医药公司 | Compound including an anti-inflammatory pharmacore and method of use |
| CN104027525A (en) * | 2013-03-06 | 2014-09-10 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Drug for treatment of ischemic heart disease, preparation method and application thereof |
| CN105582246A (en) * | 2016-02-23 | 2016-05-18 | 刘元梅 | Traditional Chinese medicine composition for preventing restenosis after percutaneous coronary intervention |
| CN107029290A (en) * | 2017-03-31 | 2017-08-11 | 芜湖扬展新材料科技服务有限公司 | A kind of fibroin tissue renovation material containing microcapsules |
| CN107929817A (en) * | 2017-12-01 | 2018-04-20 | 蒋文明 | A kind of preparation method of degradable blood vessel bracket material |
-
2018
- 2018-04-28 CN CN201810396992.2A patent/CN108532298A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036802A (en) * | 2006-12-30 | 2007-09-19 | 苏州大学 | Antheraea pernyi silk fibrion biology medicine material and the preparation method |
| CN103588678A (en) * | 2008-04-18 | 2014-02-19 | 里亚塔医药公司 | Compound including an anti-inflammatory pharmacore and method of use |
| CN102526423A (en) * | 2012-01-06 | 2012-07-04 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Medicine composition for treating ischemic heart disease |
| CN104027525A (en) * | 2013-03-06 | 2014-09-10 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Drug for treatment of ischemic heart disease, preparation method and application thereof |
| CN105582246A (en) * | 2016-02-23 | 2016-05-18 | 刘元梅 | Traditional Chinese medicine composition for preventing restenosis after percutaneous coronary intervention |
| CN107029290A (en) * | 2017-03-31 | 2017-08-11 | 芜湖扬展新材料科技服务有限公司 | A kind of fibroin tissue renovation material containing microcapsules |
| CN107929817A (en) * | 2017-12-01 | 2018-04-20 | 蒋文明 | A kind of preparation method of degradable blood vessel bracket material |
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