CN108514624A - 一种用于口腔护理的中药饮片及其制备方法 - Google Patents
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Abstract
本发明公开了一种用于口腔护理的中药饮片及其制备方法,属于中药饮片技术领域,由以下重量份数的原料制成:甘草12‑20份、薄荷23‑30份、厚朴12‑18份、黄柏5‑12份、透骨草6‑13份、佩兰5‑10份、当归10‑20份、神曲3‑9份、山楂10‑18份、大黄8‑15份、连翘5‑10份、地龙1‑5份、香附2‑8份、黄芪2‑8份、郁金1‑5份。本发明制备的中药饮片对口腔溃疡治疗效果显著,并护理口腔,预防口腔疾病,便于保存和携带,服用方便。
Description
技术领域
本发明属于中药饮片技术领域,具体涉及一种用于口腔护理的中药饮片及其制备方法。
背景技术
口腔是消化管的起始部分,前借口裂与外界相通,后经咽峡与咽相续。人的口腔不仅有适宜于各种微生物生长的温度、湿度和营养源,加之口腔解剖结构的复杂、理化性质的差异,给口腔内各种微生物的生长、繁殖和定居提供了非常适宜的环境和条件。口腔护理是基础护理技术操作中的一项重要内容,是保持口腔清洁预防疾病的手段之一,它能提高人工气道病人咳嗽反射的敏感性。口腔护理的一般方法包括口腔护理溶液护理法和接触式摩擦法;溶液护理法包含有含漱法和冲洗法,接触式摩擦法有刷牙法、擦洗法和咀嚼法。临床上有很多疾病因口腔卫生不良引起,做好患者口腔护理,有益疾病恢复、预防相关并发症,促进患者身心健康。
口腔溃疡是发病率和复发率均较高的口腔黏膜疾病,多发生于唇、舌缘、口腔黏膜处。近年研究表明,口腔溃疡发生与人体免疫功能降低有密切关系,故免疫功能低下、老年人等人群为口腔溃疡的高发性人群。目前临床上治疗复发性口腔溃疡的常用药物有局部使用糖皮质激素或促进溃疡伤口愈合的生长因子药物、免疫抑制剂或免疫调节剂等,但由于疾病存在一定的发病周期,需长期使用,故药物的成本高、副作用较大,临床使用上有一定的局限性。引起口腔溃疡可并发口臭、慢性咽炎、便秘、头痛、头晕、恶心、乏力、烦躁、发热、淋巴结肿大等全身症状。引起口腔溃疡的原因有:1、缺乏微量元素如锌、铁、叶酸、维生素B12等,可降低免疫功能,增加复发性口腔溃疡发病的可能性。2、消化系统疾病及功能紊乱如胃溃疡,十二指肠溃疡,慢性或迁延性肝炎,结肠炎、腹胀、消化不良、腹泻或便秘等情况都可能引起口腔溃疡并可能伴随着口臭的发生。3、免疫反映复发性口腔溃疡首先与免疫有着很密切的关系。有的患者表现为免疫缺陷,有的患者则表现为自身免疫反应,也就是由于各种因素,使人体正常的免疫系统,对自身组织抗原,产生免疫反映,而引起组织的破坏而发生疾病。4、精神因素当今的社会,来自各方的压力太大了,有的患者在生活、工作的重压下,容易出现精神紧张、情绪波动、睡眠状况不佳的情况,而这些情况也是引起经常口腔溃疡的原因之一。因此,研制一种治疗口腔溃疡并护理口腔的中药饮片至关重要。
公开号为CN105288130A的专利文献公开了一种治疗口腔溃疡的中药组合物及其草药汤剂的制备方法。该中药组合物由以下质量份组分组成:生地20-30份、黄芩10-15份、麦冬10-20份、磁石12-24份、沙参10-24份、玄参12-24份、茵陈15-30份和升麻6-12份。该治疗口腔溃疡的中药组合物完全使用天然纯中药,副作用小。治疗口腔溃疡的草药汤剂对口腔溃疡的痊愈比率高达74.0%,显效(包括痊愈和有效)比率高达87.8%。但是,该方法制备的中药组合物对治疗口腔溃疡的有效率低,不能对口腔进行有效护理,而且该中药组合物为汤剂,不利于保存和携带,服用不方便。
公告号为CN107126392A的专利文献公开了一种护理口腔的漱口溶液及其制备方法,属于口腔护理用品领域。该口腔护理的漱口溶液包括以下重量份的原料:冰片1-2份、鲜薄荷20-30份、艾叶20-30份、夏枯草20-30份、鱼腥草20-30份、甘草20-30份、白芍20-30份、乙醇3-5份、竹醋液25-35份、椰油酰胺丙基甜菜碱0.1-0.3份、硼酸0.1-0.5份、氯化钠1-2份、双蒸水90-95份。该申请制备的护理口腔的漱口溶液口感接受度好,具有良好的杀菌、除口臭及止痛止血功效,保护口腔的健康。但是,该漱口液仅仅对口腔进行基础的护理,不能对口腔疾病进行治疗,漱口液在口中作用时间短,效果差,经验证该漱口液对治疗口腔溃疡等疾病效果差。
发明内容
有鉴于此,本发明提供一种用于口腔护理的中药饮片及其制备方法,对口腔溃疡治疗效果显著,并护理口腔,预防口腔疾病,服用方便。
为解决上述技术问题,本发明采用的技术方案为:
一种用于口腔护理的中药饮片,由以下重量份数的原料制成:
甘草12-20份、薄荷23-30份、厚朴12-18份、黄柏5-12份、透骨草6-13份、佩兰5-10份、当归10-20份、神曲3-9份、山楂10-18份、大黄8-15份、连翘5-10份、地龙1-5份、香附2-8份、黄芪2-8份、郁金1-5份。
优选的,一种用于口腔护理的中药饮片,由以下重量份数的原料组成:甘草13-18份、薄荷25-29份、厚朴13-16份、黄柏6-10份、透骨草7-12份、佩兰6-9份、当归12-18份、神曲4-8份、山楂11-17份、大黄9-13份、连翘6-9份、地龙2-4.5份、香附3-7份、黄芪3-7份、郁金2-4.5份。
优选的,一种用于口腔护理的中药饮片,由以下重量份数的原料组成:甘草15份、薄荷28份、厚朴14份、黄柏8份、透骨草10份、佩兰8份、当归16份、神曲7份、山楂15份、大黄12份、连翘7份、地龙3份、香附5份、黄芪5份、郁金3份。
优选的,所述一种用于口腔护理的中药饮片的制备方法,包含以下步骤:
S1:称取黄柏,切片后加入浓度为40-50%的乙醇溶液拌匀,浸泡6-8h后取出,置锅内用文火炒至微干,取出晒干,制得黄柏片;
S2:称取透骨草、佩兰、地龙和步骤S1得到的黄柏片捡净,加水煎煮4-5h后,超声处理2-3h,取液体,过滤后减压浓缩成浸膏;
S3:称取甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金捡净,干燥,灭菌、粉碎,得到粉料一;
S4:将步骤S2得到的浸膏和步骤S3得到的粉料一进行搅拌混合,干燥,粉碎,得到粉料二;
S5:将步骤S4得到的粉料二放入汽爆机中汽爆,得到汽爆破壁粉;
S6:将步骤S5得到的汽爆破壁粉压制成片剂,即可。
优选的,所述步骤S1中,乙醇溶液的重量为黄柏的2-3倍。
优选的,所述步骤S2中,水的重量为透骨草、佩兰、地龙和黄柏片总重的10-12倍。
优选的,所述步骤S2中,超声处理,功率为250W,频率为50kHz。
优选的,所述步骤S3中,粉料一的粒度为80-100目。
优选的,所述步骤S4中,粉料二的粒度为150-200目。
优选的,所述步骤S5中,汽爆压力为1-1.5MPa,温度为120-135℃,时间为10-12min。
本发明的有益效果是:
引起口腔溃疡的原因有:微量元素的缺乏,消化系统疾病及功能紊乱,免疫功能降低,精神压力大等。引起口腔溃疡可并发口臭、慢性咽炎、便秘、头痛、头晕、恶心、乏力、烦躁、发热、淋巴结肿大等全身症状。慢性浅表性胃炎和口臭中医认为主要是脾胃之热导致的清气不能上升、浊气不能下降引起的。本发明以利脾健脾消食,理气化湿为主要功效,从根本上预防口腔溃疡,并兼具提高免疫力,缓解精神压力,补充微量元素的功效,有效预防口腔溃疡的发生。本发明中含有多种抑制口腔细菌的药物,起到有效的杀菌抗菌效果,有利于保持口气清新,对口腔的护理起到重要的作用。
甘草,为豆科植物甘草的干燥根,性味甘,平;归心、肺、脾、胃经;具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药的功效。与连翘同用,共奏清热解毒之功,同时缓和大黄泻下作用及其对胃肠道的刺激。
薄荷含有薄荷醇,该物质可清新口气并具有多种药性,还具有防腐杀菌、利尿、化痰、健胃和助消化等功效。
厚朴味辛、性温,具有行气化湿、温中止痛、降逆平喘的功效。厚朴煎剂对葡萄球菌、链球菌、具核梭杆菌等有较强的抗菌作用。
黄柏清热,燥湿,泻火,解毒,治热痢,泄泻,消渴,黄疸,痔疮,目赤肿痛,口舌生疮,疮疡肿毒,对变异链球菌、白色念珠菌等具有较好的抑制作用。
透骨草祛风除湿,该品辛温,辛能行散,温胜寒湿。入肝经,故能祛风除湿,抗炎、杀菌。
佩兰用于湿阻脾胃、脘腹胀满、湿温初起,以及口中甜腻等症。佩兰气味芳香,善于化湿醒脾,治疗湿阻脾胃症候,气味清香,性平不温,故又为治疗湿温病症要。此外,又适用于湿热内阻、口中甜腻多涎、口气腐臭之症。
当归及其萃取物阿魏酸钠和当归多醣对单核-巨噬细胞系统有明显的刺激作用,对免疫功能低下的机体也有免疫调解和恢复作用。当归对健康人的淋巴细胞转化也有促进作用,可润肠通便,与大黄合用治疗血虚便秘;与大黄、薄荷等组成防风通圣散,可泻热通便。
神曲入脾、胃、大肠经,健脾消食,理气化湿,解表,治脾胃俱虚,含多量酵母菌和B族维生素,干酵母菌中也含多种B族维生素,增进食欲,维持正常消化机能等。
山楂入脾、胃、肝经,消食积,散瘀血,驱绦虫,治肉积,症瘕,痰饮,消食健胃,行气散瘀。
大黄具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒等功效,用于胃肠实热积滞,大便秘结,腹胀腹痛等,能导湿热从大便而出。主治:实热便秘;热结胸痞;湿热泻痢;小便不利;目赤;咽喉肿痛;口舌生疮;胃热呕吐。
连翘清热解毒,有抗菌作用,可抑制伤寒杆菌、大肠杆菌、葡萄球菌、链球菌、抗结核杆菌。
地龙含有丰富的铁、锌等微量元素,提高免疫力,性寒味咸,清热、镇痉、止喘、利尿。
香附理气解郁,调经止痛,用于肝郁气滞,胸、胁、脘腹胀痛,消化不良,月经不调,经闭痛经,寒疝腹痛,乳房胀痛。
黄芪具有补气固表,利尿托毒,排脓,敛疮生肌的功效,能显著增加血液中的白细胞总数,促进中性粒细胞及巨噬细胞的吞噬功能和杀菌能力,明显增强细胞免疫,对变异链球菌和乳杆菌的生长及产酸均有抑制作用。
郁金能行气破瘀,通经络,抗菌,与香附协同作用,缓解精神抑郁。
本发明的制备方法,将黄柏用乙醇浸泡后炒制,解毒抑菌效果更好,将透骨草、佩兰、地龙和黄柏片制成浸膏后与其他原料制成的粉末混合后干燥,继续粉碎,然后进行汽爆破壁,药材细胞经破壁后,提高有效成份的释放速度,有利于各组分之间协同作用。本发明制备的中药饮片对口腔溃疡治疗效果显著,并护理口腔,预防口腔疾病,便于保存和携带,服用方便。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面对本发明实施例的技术方案进行清楚、完整地描述。显然,所描述的实施例是本发明的一部分实施例,而不是全部的实施例。基于所描述的本发明的实施例,本领域普通技术人员所获得的所有其他实施例,都属于本发明保护的范围。
表1 实施例1至6中各重量份数的原料组成
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 | |
甘草 | 12 | 13 | 14 | 15 | 18 | 20 |
薄荷 | 23 | 25 | 26 | 28 | 29 | 30 |
厚朴 | 12 | 12.5 | 13 | 14 | 16 | 18 |
黄柏 | 5 | 6 | 7 | 8 | 10 | 12 |
透骨草 | 6 | 8 | 9 | 10 | 12 | 13 |
佩兰 | 5 | 6 | 7 | 8 | 9 | 10 |
当归 | 10 | 12 | 14 | 16 | 18 | 20 |
神曲 | 3 | 5 | 6 | 7 | 8 | 9 |
山楂 | 10 | 12 | 14 | 15 | 17 | 18 |
大黄 | 8 | 10 | 11 | 12 | 13 | 15 |
连翘 | 5 | 6 | 7 | 7 | 8 | 10 |
地龙 | 1 | 2 | 2.5 | 3 | 4 | 5 |
香附 | 2 | 3 | 4 | 5 | 6 | 8 |
黄芪 | 2 | 3 | 4 | 5 | 7 | 8 |
郁金 | 1 | 1.5 | 2 | 3 | 4 | 5 |
实施例1
一种用于口腔护理的中药饮片的原料组成见表1。
所述一种用于口腔护理的中药饮片的制备方法,包含以下步骤:
S1:称取黄柏,切片后加入浓度为40%的乙醇溶液拌匀,乙醇溶液的重量为黄柏的2倍,浸泡6h后取出,置锅内用文火炒至微干,取出晒干,制得黄柏片;
S2:称取透骨草、佩兰、地龙和步骤S1得到的黄柏片捡净,加水煎煮4h后,水的重量为透骨草、佩兰、地龙和黄柏片总重的10倍,超声处理2h,功率为250W,频率为50kHz,取液体,过滤后减压浓缩成浸膏;
S3:称取甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金捡净,干燥,灭菌、粉碎,得到粉料一,粒度为80目;
S4:将步骤S2得到的浸膏和步骤S3得到的粉料一进行搅拌混合,干燥,粉碎,得到粉料二,粒度为150目;
S5:将步骤S4得到的粉料二放入汽爆机中汽爆,汽爆压力为1MPa,温度为120℃,时间为12min,得到汽爆破壁粉;
S6:将步骤S5得到的汽爆破壁粉压制成片剂,即可。
实施例2
一种用于口腔护理的中药饮片的原料组成见表1。
所述一种用于口腔护理的中药饮片的制备方法,同实施例1。
实施例3
一种用于口腔护理的中药饮片的原料组成见表1。
所述一种用于口腔护理的中药饮片的制备方法,包含以下步骤:
S1:称取黄柏,切片后加入浓度为45%的乙醇溶液拌匀,乙醇溶液的重量为黄柏的3倍,浸泡8h后取出,置锅内用文火炒至微干,取出晒干,制得黄柏片;
S2:称取透骨草、佩兰、地龙和步骤S1得到的黄柏片捡净,加水煎煮5h后,水的重量为透骨草、佩兰、地龙和黄柏片总重的12倍,超声处理3h,功率为250W,频率为50kHz,取液体,过滤后减压浓缩成浸膏;
S3:称取甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金捡净,干燥,灭菌、粉碎,得到粉料一,粒度为90目;
S4:将步骤S2得到的浸膏和步骤S3得到的粉料一进行搅拌混合,干燥,粉碎,得到粉料二,粒度为180目;
S5:将步骤S4得到的粉料二放入汽爆机中汽爆,汽爆压力为1.5MPa,温度为135℃,时间为10min,得到汽爆破壁粉;
S6:将步骤S5得到的汽爆破壁粉压制成片剂,即可。
实施例4
一种用于口腔护理的中药饮片的原料组成见表1。
所述一种用于口腔护理的中药饮片的制备方法,同实施例3。
实施例5
一种用于口腔护理的中药饮片的原料组成见表1。
所述一种用于口腔护理的中药饮片的制备方法,包含以下步骤:
S1:称取黄柏,切片后加入浓度为50%的乙醇溶液拌匀,乙醇溶液的重量为黄柏的2.5倍,浸泡7h后取出,置锅内用文火炒至微干,取出晒干,制得黄柏片;
S2:称取透骨草、佩兰、地龙和步骤S1得到的黄柏片捡净,加水煎煮4.5h后,水的重量为透骨草、佩兰、地龙和黄柏片总重的11倍,超声处理3h,功率为250W,频率为50kHz,取液体,过滤后减压浓缩成浸膏;
S3:称取甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金捡净,干燥,灭菌、粉碎,得到粉料一,粒度为100目;
S4:将步骤S2得到的浸膏和步骤S3得到的粉料一进行搅拌混合,干燥,粉碎,得到粉料二,粒度为200目;
S5:将步骤S4得到的粉料二放入汽爆机中汽爆,汽爆压力为1.2MPa,温度为130℃,时间为11min,得到汽爆破壁粉;
S6:将步骤S5得到的汽爆破壁粉压制成片剂,即可。
实施例6
一种用于口腔护理的中药饮片的原料组成见表1。
所述一种用于口腔护理的中药饮片的制备方法,同实施例5。
实施例7
一种用于口腔护理的中药饮片的原料组成,同实施例4,但与实施例4不同的是,本实施例中添加6重量份的吴茱萸。所述一种用于口腔护理的中药饮片的制备方法,同实施例4,其中,6重量份的吴茱萸加入到步骤S3中,与甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金一起捡净,干燥,灭菌、粉碎。
实施例8
一种用于口腔护理的中药饮片的原料组成,同实施例4,但与实施例4不同的是,本实施例中添加7重量份的吴茱萸。所述一种用于口腔护理的中药饮片的制备方法,同实施例4,其中,7重量份的吴茱萸加入到步骤S3中,与甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金一起捡净,干燥,灭菌、粉碎。
对比例1
一种用于口腔护理的中药饮片的原料组成及制备方法,同实施例1,但与实施例1不同的是,本对比例中缺少透骨草、佩兰和神曲。
对比例2
一种用于口腔护理的中药饮片的原料组成及制备方法,同实施例1,但与实施例1不同的是,本对比例中缺少厚朴、地龙和郁金。
对比例3
一种用于口腔护理的中药饮片的原料组成及制备方法,同实施例4,但与实施例4不同的是,缺少步骤S1,即将没有将黄柏浸泡和炒制。
对比例4
一种用于口腔护理的中药饮片的原料组成及制备方法,同实施例4,但与实施例4不同的是,缺少步骤S5,即将没有将粉料二汽爆。
中药饮片性能检测
抑菌实验:取本发明实施例1~8、对比例1~4所得中药饮片,分别干燥、粉碎后,均称取30克,用浓度75 %乙醇溶液600 mL浸泡10h,81℃水浴回流提取10h,保留提取液,重复提取三次,提取液合并,减压过滤,滤液分别减压蒸馏至无乙醇味,浓缩物用蒸馏水定容为2 g/m L生药。然后低温离心,取上清液,用0.22μm孔径的滤菌器滤除提取物中细菌后置于棕色瓶中,精确称重后置于无菌锥形瓶中作为样品组,并按上述方法制备不加中药饮片的对照样品组,将十三组分别加入70毫升的磷酸盐缓冲液(0.03moL/L)和5mL变异链球菌、白色念珠菌、具核梭杆菌的菌液,在25℃、200rpm/min条件下,振荡培养,分别于1小时取样,计算细菌数量变化。抑菌率的计算:依据公式X=(A-B)/A×100%,X为抑菌率;A为试验样品振荡前平均菌落数;B为试验样品振荡后平均菌落数。判断标准:不加样品组振荡前后的菌落数差值要在10以内,试验样品抑菌率与对照组样品抑菌率之差>26%,可判定该产品有抗菌作用。
本发明实施例1~8、对比例1~4的实验结果如表2所示。
表2 抑菌测试结果
由表2可以看出,本发明制备的中药饮片对口腔常见的细菌具有显著的抑制作用,其中实施例7和8添加了吴茱萸,抗菌消炎,温中,止痛,理气,治疗脚气,疝气,口疮溃疡等,抑菌效果最优。而对比例1未添加透骨草、佩兰和神曲,对比例2未添加厚朴、地龙和郁金,中药饮片抑菌效果均明显下降;对比例3未将黄柏浸泡炒制,对比例4未进行汽爆,抑菌效果均较差,说明对黄柏进行浸泡炒制和对粉料进行汽爆,有利于杀菌成分的释放,提高杀菌效果。
中药饮片疗效观察与评价
资料:选取2017年1月至2018年5月收治的伴随口臭的口腔溃疡的患者240例,随机分成12组,每组20例,每组患者在年龄、病程等一般资料无统计学差异。
治疗方法:给予上述12组患者分别使用实施例1~8及对比例1~4所制备的中药饮片,每片重1g±0.05g,每日口含3片,坚持食用3天。
疗效标准:痊愈:伤口愈合,无瘢痕,无疼痛,无口臭;显效:伤口愈合,有轻微红肿或瘢痕,无口臭,轻微疼痛;有效:伤口基本愈合,有红肿或瘢痕,有疼痛感,口臭减轻;无效:伤口不愈合,有口臭。
表3 疗效评价结果
组别/指标 | 总数/人 | 痊愈/人 | 显效/人 | 有效/人 | 无效 | 总有效率/% |
实施例1 | 20 | 16 | 3 | 1 | 0 | 100 |
实施例2 | 20 | 16 | 4 | 0 | 0 | 100 |
实施例3 | 20 | 17 | 3 | 0 | 0 | 100 |
实施例4 | 20 | 18 | 2 | 0 | 0 | 100 |
实施例5 | 20 | 17 | 3 | 0 | 0 | 100 |
实施例6 | 20 | 17 | 3 | 0 | 0 | 100 |
实施例7 | 20 | 19 | 1 | 0 | 0 | 100 |
实施例8 | 20 | 19 | 1 | 0 | 0 | 100 |
对比例1 | 20 | 12 | 3 | 3 | 2 | 90 |
对比例2 | 20 | 12 | 2 | 3 | 3 | 85 |
对比例3 | 20 | 11 | 1 | 3 | 5 | 75 |
对比例4 | 20 | 12 | 2 | 2 | 4 | 80 |
表3结果显示,对于口腔溃疡患者,本发明的痊愈率达到80%以上,有效率达到100%,效果显著。对比例1未添加透骨草、佩兰和神曲,对比例2未添加厚朴、地龙和郁金,工艺均未改变,但中药饮片药效明显下降,说明本发明各成分之间协同作用,从而使药效发挥显著;对比例3未将黄柏浸泡炒制,中药饮片的有效率仅为75%,说明将黄柏进行加工,显著提高中药饮片的有效成分含量,对比例4未进行汽爆,中药饮片的有效率仅为80%,说明粉料进行汽爆,有利于提高中药饮片的药用价值。
临床长期观察结果
张某,女,32岁,职员,河南南阳人,因工作压力大,脾胃不和,口臭,口腔溃疡发生多次,口腔溃疡发生后,服用实施例8的中药饮片每日口含3片,3天后痊愈,之后每日口含1片,1个月后每隔一日口含1片,3个月均未出现口腔溃疡,无口臭,精神状态好。
李某,男,50岁,农民,河南南阳人,因脾虚火旺,口臭,口腔溃疡发生多次,口腔溃疡发生后,服用实施例8的中药饮片每日口含3片,3天后痊愈,之后每隔一日口含1片,2个月均未出现口腔溃疡,无口臭。
最后说明的是,以上实施例仅用以说明本发明的技术方案而非限制,本领域普通技术人员对本发明的技术方案所做的其他修改或者等同替换,只要不脱离本发明技术方案的精神和范围,均应涵盖在本发明的权利要求范围当中。
Claims (10)
1.一种用于口腔护理的中药饮片,其特征在于:由以下重量份数的原料制成:
甘草12-20份、薄荷23-30份、厚朴12-18份、黄柏5-12份、透骨草6-13份、佩兰5-10份、当归10-20份、神曲3-9份、山楂10-18份、大黄8-15份、连翘5-10份、地龙1-5份、香附2-8份、黄芪2-8份、郁金1-5份。
2.如权利要求1所述的一种用于口腔护理的中药饮片,其特征在于:由以下重量份数的原料组成:甘草13-18份、薄荷25-29份、厚朴13-16份、黄柏6-10份、透骨草7-12份、佩兰6-9份、当归12-18份、神曲4-8份、山楂11-17份、大黄9-13份、连翘6-9份、地龙2-4.5份、香附3-7份、黄芪3-7份、郁金2-4.5份。
3.如权利要求1所述一种用于口腔护理的中药饮片,其特征在于:由以下重量份数的原料组成:甘草15份、薄荷28份、厚朴14份、黄柏8份、透骨草10份、佩兰8份、当归16份、神曲7份、山楂15份、大黄12份、连翘7份、地龙3份、香附5份、黄芪5份、郁金3份。
4.如权利要求1至3任意一项所述一种用于口腔护理的中药饮片的制备方法,其特征在于:包含以下步骤:
S1:称取黄柏,切片后加入浓度为40-50%的乙醇溶液拌匀,浸泡6-8h后取出,置锅内用文火炒至微干,取出晒干,制得黄柏片;
S2:称取透骨草、佩兰、地龙和步骤S1得到的黄柏片捡净,加水煎煮4-5h后,超声处理2-3h,取液体,过滤后减压浓缩成浸膏;
S3:称取甘草、薄荷、厚朴、当归、神曲、山楂、大黄、连翘、香附、黄芪、郁金捡净,干燥,灭菌、粉碎,得到粉料一;
S4:将步骤S2得到的浸膏和步骤S3得到的粉料一进行搅拌混合,干燥,粉碎,得到粉料二;
S5:将步骤S4得到的粉料二放入汽爆机中汽爆,得到汽爆破壁粉;
S6:将步骤S5得到的汽爆破壁粉压制成片剂,即可。
5.如权利要求4所述一种用于口腔护理的中药饮片的制备方法,其特征在于:所述步骤S1中,乙醇溶液的重量为黄柏的2-3倍。
6.如权利要求4所述一种用于口腔护理的中药饮片的制备方法,其特征在于:所述步骤S2中,水的重量为透骨草、佩兰、地龙和黄柏片总重的10-12倍。
7.如权利要求4所述一种用于口腔护理的中药饮片的制备方法,其特征在于:所述步骤S2中,超声处理,功率为250W,频率为50kHz。
8.如权利要求4所述一种用于口腔护理的中药饮片的制备方法,其特征在于:所述步骤S3中,粉料一的粒度为80-100目。
9.如权利要求4所述一种用于口腔护理的中药饮片的制备方法,其特征在于:所述步骤S4中,粉料二的粒度为150-200目。
10.如权利要求4所述一种用于口腔护理的中药饮片的制备方法,其特征在于:所述步骤S5中,汽爆压力为1-1.5MPa,温度为120-135℃,时间为10-12min。
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