CN108514569A - Oblique application of the leaf Lignum Santali Albi extract in preparing skin wound healing drug - Google Patents
Oblique application of the leaf Lignum Santali Albi extract in preparing skin wound healing drug Download PDFInfo
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The present invention provides a kind of application of oblique leaf Lignum Santali Albi extract in preparing skin wound healing drug, the extract can increase the formation of surface of a wound capillary and collagenous fibres, shorten the union of wounded skin time, and has the function of reducing inflammation and increase skin rejuvenation degree, and applied to after trauma skin, more skin smooth after, no scar, healing effect are good.
Description
Technical field
The invention belongs to pharmaceutical technology field, more particularly to a kind of oblique leaf Lignum Santali Albi extract is preparing skin wound healing medicine
Application in object.
Background technology
Skin is the maximum immune organ of human body, is played an important role in resisting extraneous pathogen stimulation.Application on human skin is normal
It can be directly exposed to there are in the environment of harmful organism, heating power, mechanicalness or chemical factor, therefore be highly prone to wound.Skin
Skin processes of wound repair can substantially be divided into three phases：The remodelling phase of inflammation phase, increment stage and tissue.In clinic often
By accelerating healing speed, prevents bacterium infection, mitigate bleeding, inflammatory reaction, wound infection and ulcer etc. and bring patient
Pain, prevent the negative effect of wound to physiological function, and the methods of wound beauty treatment skin trauma after ensureing more.
The mechanism of wound repair shows as first carrying out fibroid reparation, during being somebody's turn to do, surface of a wound substrate granulation tissue hyperplasia, and branch
Edge of wound epidermal proliferation is held, and is migrated to surface of a wound center, the Landfill covering surface of a wound completes healing.Since the repair ability of skin is limited,
Often healing time is longer, skin easily stays scar more afterwards for large skin defect；Meanwhile some underlying diseases may interfere with wound
Hinder agglutination, make wound protracted course of disease, these problems clinically still lack good countermeasure at present.
Oblique leaf santal derives from the rich resiniferous wooden rattan of the oblique leaf yellow wingceltis of pulse family Papillionoideae yellow wingceltis platymiscium and root,
Also known as leaflet drop smell good, oblique leaf wingceltis, tamarind leaf yellow wingceltis, leatherleaf wingceltis, be distributed widely in Hainan, Guangxi, Yunnan, Tibet, Burma,
The areas such as Laos, Philippine, Malaysia and Indonesia.Oblique leaf yellow wingceltis is that ethnic groups' medicinal plants such as Hainan newly provide
Source, basic research is extremely limited, focuses primarily upon the research of the related contents such as oblique leaf yellow wingceltis volatile oil, such as Zhao Weibo reports
Oblique leaf yellow wingceltis volatile oil component and oxidation resistance [Zhao Weibo, Zhang Danyan are spread the wings slowly, wait oblique leaf yellow wingceltis perfume (or spice) material volatile oil at
Point and antioxidant activity research [J] new Chinese medicines and clinical pharmacology, 2017,28 (05)：659-662.], stand in great numbers and waits quietly reporting
[Lin Lijing, Wang Suixin, Liao Liangkun wait a kind of preparations for dropping the essential oil that smells good of to the method and condition of the overcritical oil extract of oblique leaf yellow wingceltis
The Guangdong method [P]：CN107287035A, 2017-10-24.], it is anti-oxidant, antibacterial that Liao Liangkun etc. has studied oblique leaf sandalwood essential oil
And it inhibits tyrosinase activity ability [Liao Liangkun, Zhang Suhui, Zhou Wei waits oblique leaf yellow wingceltis essential oil functional activity researchs [J/OL]
Food industry science and technology：1-10].However tiltedly the extracting method and purposes of leaf santal alcohol extract there is no research to report.On above-mentioned basis
On, the present invention carries out alcohol extracting to oblique leaf santal, and it is medicinal extract that filtrate, which is concentrated and dried, and for the first time controls medicinal extract for skin wound healing
It treats.
Invention content
Based on this, the purpose of the present invention is to provide a kind of oblique leaf Lignum Santali Albi extracts in preparing skin wound healing drug
Application.
To achieve the above object, the present invention provides following technical solutions：
A kind of application of oblique leaf Lignum Santali Albi extract in preparing skin wound healing drug.
Another object of the present invention, which also resides in, provides a kind of drug for skin wound healing, and concrete scheme is as follows：
The active component of a kind of drug for skin wound healing, the drug includes oblique leaf Lignum Santali Albi extract.
In wherein some embodiments, the oblique leaf Lignum Santali Albi extract is the alcohol extract of oblique leaf santal.
In wherein some embodiments, in the alcohol extract, general flavone mass percent is not less than 10%.
In wherein some embodiments, the preparation process of the oblique leaf Lignum Santali Albi extract includes：Take oblique leaf santal medicinal material, powder
Ethyl alcohol extraction is added to get oblique leaf Lignum Santali Albi extract in broken, sieving.
In wherein some embodiments, the oblique leaf santal medicinal material is the wooden rattan and/or root of oblique leaf santal.
In wherein some embodiments, the oblique leaf santal medicinal material is that oblique leaf santal is that pulse family Papillionoideae Dalbergia is planted
The oblique leaf yellow wingceltis Dalbergia pinnata of object.
In wherein some embodiments, the mass volume ratio (g/ml) of the oblique leaf santal medicinal material and the ethyl alcohol is 1：(4
~6).
In wherein some embodiments, the addition ethyl alcohol is extracted as：Addition ethanol solution, ultrasonic extraction 2~3 times, often
2~3 hours secondary extraction times；Ethyl alcohol is recovered under reduced pressure at -0.06~-0.08MPa, 48~52 DEG C, is concentrated into medicinal extract, then 58
At~62 DEG C be dried in vacuo to get.
In wherein some embodiments, which is prepared by the oblique leaf Lignum Santali Albi extract and pharmaceutically acceptable auxiliary material
It forms.
In wherein some embodiments, the drug is exterior-applied formulation, including paste, cataplasm, film, tincture, gel
Agent and spray.
Based on the above-mentioned technical proposal, the present invention has the following effects that：
The present invention has found that the extract prepared as raw material using oblique leaf santal can increase by a large amount of creative works of inventor
Add the formation of surface of a wound capillary and collagenous fibres, shorten the union of wounded skin time, and with reduction inflammation and increases skin
The effect of recovery degree, and applied to after trauma skin, skin smooth, no scar, healing effect are good more afterwards.Above-mentioned oblique leaf santal carries
It is natural origin to take object, non-stimulated, promotes wound healing effect good, can be answered in preparing the drug for promoting wound healing
With, with alleviate it is clinical in patient wound heal the time required to difficult, healing long, and more after the problem of easily staying spot.
A kind of drug including oblique leaf Lignum Santali Albi extract provided by the invention, when preparing the drug, it is suitable on the one hand to select
Raw material, by being extracted to the rich resiniferous wooden rattan of oblique leaf santal and/or root, another aspect Optimized Extraction Process side
Method controls the zone of reasonableness of general flavone content, and the Herbal medicines for external use being prepared is in wound affected part so that wound healing time shortens
Obviously, healing rate is dramatically speeded up.Meanwhile as ointment, having and being close to wound, the effect of surface of a wound physiological moistening is kept,
It has antibacterial, anti-inflammatory, detumescence concurrently simultaneously, promotes vascular endothelial cell proliferation, the effect of accelerating wound healing, and healing skin is smooth
Softness, no protrusion and scar so that it prepares novel wound healing drug and has more market potential, has a extensive future.
Description of the drawings
Fig. 1 is each group wound healing in rabbits situation map；
Fig. 2 is the rear skin biopsy HE coloration results of a group rabbit.
Specific implementation mode
To facilitate the understanding of the present invention, it below with reference to embodiment to invention is more fully described, is given below
Presently preferred embodiments of the present invention.But the present invention can realize in many different forms, however it is not limited to described herein
Embodiment.Purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to the technical field of the present invention
The normally understood meaning of technical staff is identical.Used term is intended merely to describe specific reality in the description of the invention
Apply the purpose of example, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more relevant institutes
Any and all combinations of list of items.
Embodiment 1
The present embodiment provides the preparation methods of oblique leaf Lignum Santali Albi extract, and steps are as follows：
It by the wooden rattan 1kg of oblique leaf santal, crushes, crosses 20 mesh sieve, it is molten that the ethyl alcohol that 5000mL mass concentrations are 95% is added
Liquid ultrasonic extraction 2 times, each extraction time are 2 hours, filtering, merging filtrate, and in -0.07MPa, temperature is to be depressurized back at 50 DEG C
Ethyl alcohol is received, is concentrated into medicinal extract, then be dried in vacuo to get the oblique leaf Lignum Santali Albi extract of the present invention at 60 DEG C.
According to Determination Method of Flavone Content specified in 2015 editions Chinese Pharmacopoeias, to total Huang in oblique leaf Lignum Santali Albi extract
Ketone content is measured, and it is 20.8% to obtain general flavone content in the oblique leaf Lignum Santali Albi extract of gained under the extracting method.
It is prepared by 2 oblique leaf Lignum Santali Albi extract cataplasm of embodiment
CMC-Na 0.8g are weighed, appropriate purified water is added, heating water bath dissolving makes into 20% solution, then adds appropriate sweet
Oil stirs evenly, and is A phases；10%PVA aqueous solutions and 10% aqueous gelatin solution, respectively B phases and C phases are obtained with legal system；First by B phases and C
Phase mixing is then added to A phases, and the oblique leaf Lignum Santali Albi extract of finely ground superfine silica gel powder and preheating is added after stirring evenly, is coated with while hot
It on non-woven fabrics, is placed in Constant Temp. Oven, 70 DEG C of dry 2h obtain oblique leaf Lignum Santali Albi extract cataplasm.
It is prepared by 3 oblique leaf Lignum Santali Albi extract gelling agent of embodiment
2.5g Carbomer-940s are weighed, it is spare with the wetting of 11mL glycerine plus distilled water 60mL swellings, left at room temperature over night
(Ⅰ)；Oblique leaf Lignum Santali Albi extract 5g is weighed, absolute ethyl alcohol is added, is made it dissolve completely, it is spare (II)；Urea 20g is weighed, is added
Distilled water 20mL dissolvings, it is spare (III)；By I, II, III mixing, it is slowly added to Tween-80 1.0g, triethanolamine is added and adjusts in right amount
Save pH value to 7.0, be eventually adding distilled water to 200g, stir evenly, deaerate, sterilize, embedding to get.
It is prepared by 4 oblique leaf Lignum Santali Albi extract spray of embodiment
Oblique leaf Lignum Santali Albi extract 50g is weighed, polysorbate -80 25g, sodium benzoate 5g, glycerine 30mL, 100mL is anhydrous
Ethyl alcohol, by several times be added distilled water 500mL, stirring and dissolving, be sterile filtered, add distilled water to 1000mL dispense to get.
It is prepared by 5 oblique leaf Lignum Santali Albi extract tincture of embodiment
Oblique leaf Lignum Santali Albi extract 50g is weighed, the ethyl alcohol 500mL that mass concentration is 70%, stirring and dissolving is added, and be added
2.5g Laurocapram mixings.It is another that glycerine and distillation appropriate amount of water, mixing is taken to be added in above-mentioned alcoholic solution, distilled water is added by several times
500mL, stirring and dissolving, be sterile filtered, add distilled water to 1000mL dispense to get.
6 oblique leaf santal of embodiment promotes wound healing pharmacodynamic experiment：
Following pharmacodynamic experiment is carried out with oblique leaf Lignum Santali Albi extract prepared by embodiment 1.
Experiment one：Oblique leaf Lignum Santali Albi extract influences rabbit union of wounded skin
Experimental animal：Rabbit 24,2.5~3.0Kg of weight, half male and half female, by Traditional Chinese Medicine University Of Guangzhou experimental animal
The heart provides (quality certification number：SCXF (Guangdong) 2013-0020).It raises in Traditional Chinese Medicine University Of Guangzhou's cleaning grade animal house, single cage is fed
It supports, adaptable fed one week before testing is fed with standard rabbit material, ad lib and drinking-water, day and night lighting.
Experimental method：Rabbit 24, is randomly divided into 4 groups, sets up model group (physiological saline), positive controls (furans west
Woods), oblique leaf Lignum Santali Albi extract group and Normal group.All equal auricular veins of rabbit inject the anesthesia of 1% yellow Jackets, anesthesia
After be in rabbit back hair 7cm × 9cm, then hair is purified with 8% sodium sulfide solution.In addition to Normal group, every rabbit quilt
The symmetrical circular wound for respectively cutting 1 a diameter of 2cm, deep about 2mm, does not damage deep fascia layer at hair.It is given daily after modeling
Medicine is primary, and 100 μ L of administration, oblique leaf Lignum Santali Albi extract group are applied with administration 2g, continuously give every time every time for model group and positive controls
Medicine heals completely to wound.
The measurement of surface of a wound normal observation and healing rate：Visually observe surface of a wound color after rabbit modeling, if swelling, sepage,
Granulation tissue is grown and wound healing situation, and photographs to record.It is recorded with thin transparent membrane respectively at modeling the 1st, 3,7,13 days
Surface of a wound area, then real area size, Wound healing rate computational methods are measured with standard grid paper：Wound healing rate=(the surface of a wound
Initial area-does not heal surface of a wound area)/surface of a wound initial area × 100%
Skin slice HE dyeing observations：4 groups of rabbit the 16th day auricular vein after modeling injects 10%KCL solution
2.5mL/Kg is put to death, and every back of Normal group both sides cut one piece of normal skin, other 3 groups cut back both sides wound
Skin after healing, every piece of skin area cut is about 1cm2, it is deep to deep fascia layer.The skin histology cut is immediately placed in
4% paraformaldehyde is fixed, and fixed be put into automatic tissue dehydration apparatus for 24 hours is dehydrated, then paraffin embedding, and the stone that thickness is 5 μm is made
Wax is sliced, and is carried out haematoxylin-Yihong (HE) respectively and is dyed, tissues observed inflammatory reaction, capillary, glue under light microscope
The proliferative conditions such as fibrinogen and epithelial cell, and photograph to record.
Experimental result is as shown in table 1-3.
The observation comparison of 1 wound healing in rabbits situation of table
Each group wound healing in rabbits situation is shown in Fig. 1.
The 2 wound healing in rabbits time of table
| Group | Surface of a wound number (a) | Healing time (day) |
| Physiological saline group | 12 | 15.57±0.79 |
| Nitrofurazone group | 12 | 13.89±1.45 |
| Oblique leaf Lignum Santali Albi extract group | 12 | 12.25±0.45 |
Wound healing rate：3 groups of rabbit surface of a wound areas are gradually reduced at any time after modeling, the 3rd, 7,13 day Wound healing rate
It see the table below.As seen from table, the 3rd day after modeling, oblique leaf Lignum Santali Albi extract group Wound healing rate is significantly higher than physiological saline group (P ＜
0.05), slightly below nitrofurazone group (P ＜ 0.01)；The 7th day after modeling, oblique leaf santal group is close with nitrofurazone group healing rate,
There was no significant difference (P ＞ 0.05), is above physiological saline group (P ＜ 0.05)；The 13rd day after modeling, oblique leaf santal group healing rate
Higher than nitrofurazone and physiological saline group (P ＜ 0.05), healing effect is good.
3 wound healing in rabbits rate of table
| Group | 3rd day | 7th day | 13rd day |
| Physiological saline group | 24.62±2.47 | 53.66±3.45 | 95.13±2.03 |
| Nitrofurazone group | 38.83±6.17 | 56.26±3.76 | 98.21±1.12 |
| Oblique leaf Lignum Santali Albi extract group | 29.17±4.19 | 56.02±2.85 | 100 |
More skin biopsy HE coloration results after：Visible angle in oblique leaf Lignum Santali Albi extract group and nitrofurazone group skin epidermis
Change layer, stratum granulosum and stratum spinosum epidermidis, epidermis stratum spinosum epidermidis and skin corium collagenous fibres and slightly has hyperplasia, unobvious.Physiological saline group
Parts of skin region epidermis is invisible, and Collagen Proliferation is apparent in skin corium, it is seen that capillary and most explicitly cells lose
Hair follicle and sebaceous glands.The oblique visible apparent new capillary vessel of leaf Lignum Santali Albi extract group and a small number of inflammatory cells, and nitrofurazone group
It is more then to show as inflammatory cell, prompts the rear inflammation of oblique leaf santal group less, repairing effect is good.Refer to attached drawing 2.
The experimental results showed that oblique leaf Lignum Santali Albi extract has the formation for increasing surface of a wound capillary and collagenous fibres, hence it is evident that
Shortening wound healing time, improve wound healing rate and reduce inflammation effect.Neoplastic skin surface is smooth, protrusion without exception
And scar, healing effect are good.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above real
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of application of oblique leaf Lignum Santali Albi extract in preparing skin wound healing drug.
2. a kind of drug for skin wound healing, which is characterized in that its active component includes oblique leaf Lignum Santali Albi extract.
3. drug according to claim 2, which is characterized in that the oblique leaf Lignum Santali Albi extract is：The alcohol extracting of oblique leaf santal
Object；And/or
In the extract of the oblique leaf santal, general flavone mass percent is not less than 10%.
4. drug according to claim 2, which is characterized in that the preparation process of the oblique leaf Lignum Santali Albi extract includes：It takes
Oblique leaf santal medicinal material crushes, sieving, and ethyl alcohol extraction is added to get oblique leaf Lignum Santali Albi extract.
5. drug according to claim 4, which is characterized in that the oblique leaf santal medicinal material is the wooden rattan of oblique leaf santal
And/or root.
6. drug according to claim 5, which is characterized in that it is pulse family butterfly that the oblique leaf santal medicinal material, which is oblique leaf santal,
The oblique leaf yellow wingceltis of flower subfamily yellow wingceltis platymiscium.
7. drug according to claim 5, which is characterized in that the quality volume of the oblique leaf santal medicinal material and the ethyl alcohol
It is 1 than (g/ml)：(4~6).
8. drug according to claim 5, which is characterized in that the addition ethyl alcohol is extracted as：Ethanol solution, ultrasound is added
Extraction 2~3 times, 2~3 hours each extraction times；Ethyl alcohol is recovered under reduced pressure at -0.06~-0.08MPa, 48~52 DEG C, concentrates
To medicinal extract, then at 58~62 DEG C be dried in vacuo to get.
9. according to claim 2~8 any one of them drug, which is characterized in that the drug is extracted by the oblique leaf santal
Object is prepared with pharmaceutically acceptable auxiliary material.
10. drug according to claim 9, which is characterized in that the drug be exterior-applied formulation, including paste, cataplasm,
Film, tincture, gelling agent and spray.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113244285A (en) * | 2021-06-08 | 2021-08-13 | 广东安道医疗器械有限公司 | Preparation method and application of lignum Dalbergiae Odoriferae extract |
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Application publication date: 20180911 |