CN108498363A - The SPF enhancer compositions and preparation method thereof that antiultraviolet effect is improved - Google Patents
The SPF enhancer compositions and preparation method thereof that antiultraviolet effect is improved Download PDFInfo
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- CN108498363A CN108498363A CN201710876198.3A CN201710876198A CN108498363A CN 108498363 A CN108498363 A CN 108498363A CN 201710876198 A CN201710876198 A CN 201710876198A CN 108498363 A CN108498363 A CN 108498363A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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Abstract
The present invention relates to a kind of SPF (Sun Protection Factor (antiultraviolet index)) enhancer compositions and preparation method thereof being improved as antiultraviolet effect of active ingredient containing afzclin (Afzelin), compared with existing ultraviolet screener, the SPF enhancer compositions together comprising inorganic and/or organic ultraviolet screener and afzclin of the invention have the advantages that show the SPF numerical value significantly improved.And, not only solve the problems, such as the gonorrhoea phenomenon that existing inorganic ultraviolet screener is brought and the skin irritatin that organic ultraviolet screener is brought, and show the enhancing effect of organic ultraviolet screener or inorganic ultraviolet screener, it thus can show the preventing ultraviolet effect significantly improved.
Description
Technical field
The present invention relates to one kind to be improved containing afzclin (Afzelin) as antiultraviolet effect of active ingredient
SPF (Sun Protection Factor (antiultraviolet index)) reinforcing agent (booster) composition and preparation method thereof,
More particularly, to a kind of following SPF increasings for containing afzclin and being improved as antiultraviolet effect of active ingredient
Strong agent composition and preparation method thereof, the composition not only solve the gonorrhoea phenomenon of existing inorganic ultraviolet screener and have
The problem of skin irritatin that machine class ultraviolet screener is brought, and compared with existing ultraviolet screener, preventing ultraviolet effect is aobvious
It writes and increases.
Background technology
In general, if the ultraviolet light excessive radiation for including in sunlight becomes to skin and forms erythema, passes through promotion
Melanin production and the reason of generate spot, not only cause the skin agings such as the increase of wrinkle, the sagging of skin and relaxation for a long time,
And the reason of can also becoming skin cancers when serious.
Ultraviolet light is the light with 400nm wavelength below sent out by the sun, is divided into long wave ultraviolet (UV-A；
320~400nm), ultraviolet B radiation (UV-B；280~320nm), short wave ultraviolet (UV-C；200~280nm), these are to skin
Skin generates optical-biological reaction, thus causes sunburn, pigmentation, light aging, cutaneum carcinoma etc., and cause a variety of skins according to wavelength
Damage.
Short wave ultraviolet (UV-C, 200~280nm) is most of smelly although causing bactericidal effect and Apoptosis
Oxygen layer absorbs and is difficult to reach skin.Ultraviolet B radiation (UV-B, 280~320nm) reaches basal layer of epidermis and upper part of dermis, makes
Skin keratinization continues, and causes sunburns and the pigmentations such as erythema, blister, and cause cell membrane damage, cutaneum carcinoma.Especially,
Long wave ultraviolet (UV-A, 320~400nm) reaches corium, thus causes instantaneity pigmentation and retardance erythema, light poison
Property, it is photo sensitive reaction, chronic photoaging because caused by generating free radical (Free radical), make corium elastomer and
Collagenous fibres are modified, and thus reduce the elasticity of skin, and cause wrinkle, atrophoderma phenomenon.Therefore in order to be protected from ultraviolet light
Sheath skin, it is necessary to use ultraviolet screener.
The type of this ultraviolet screener used to protect skin from ultraviolet light has organic ultraviolet screener
With inorganic ultraviolet screener.
Organic ultraviolet screener utilizes having such as p-aminobenzoic acid (PABA), salicylate (Salicylate) etc
Machine substance plays the role of absorption and eliminates the ultraviolet light to penetrate to the skin, skin thus protected from ultraviolet light, but also have very
The organic substance of more photoallergic reactions for being irritating to the skin and causing skin to a certain extent, therefore, although effect is good,
It is forbidden to use or prohibitive amount.
Inorganic ultraviolet screener uses the more inorganic matter such as titanium dioxide and zinc oxide etc using representative
Matter makes ultraviolet reflection and scattering, prevents ultraviolet light from penetrating to the skin to protect skin, therefore, with organic ultraviolet screener
It compares, although not stimulating skin, presence the shortcomings that gonorrhoea phenomenon occurs when being coated on skin.
In order to solve these problems, the research for following material is being carried out：Skin can be can be safely used for by developing
The ultraviolet screener in natural materials (plant or marine microorganism etc.) source increases existing organic and inorganic UV resistance with this
Thus antiultraviolet effect of line agent can reduce the material of these substances used.For example, in Korean granted patent 10-
It discloses in No. 1326556 and is used containing the antiultraviolet of garden burnet and Veronica linariifolia (V.linariaefolia) mixed extract
Cosmetic composition discloses the antiultraviolet containing river hedge extract in Korean granted patent the 10-11148978th and uses
Cosmetic composition.It is public in Korean granted patent the 10-1638950th also, as the product for preventing gonorrhoea phenomenon
The water in oil antiultraviolet cosmetic composition for the solid-like that inorganic ultraviolet screener is not used is opened.
But up to the present, developed natural origin ultraviolet materials is only limitted to by eliminating induced by ultraviolet irradiation
Inflammatory cytokine or active oxygen etc. play the role of protecting skin from ultraviolet light, and there is presently no about by these materials
When being directly used in dosage form, actually show that high spf value or SPF enhance the report of effect.
On the other hand, it is known that afzclin (Afzelin；Kaempferol3-O- α-L-rhamnopyranoside (kaempferia galamgas
Phenol 3-O- α-L- rhamnopyranosyloxyhies glucosides)) it is flavonoids series, have for Pseudomonas aeruginosa (Pseudomonas
Aeruginosa the anti-inflammatory efficacy of antibacterial effect and anticancer function and inhibition COX-1/COX-2), was recently proposed and passes through increasing
Blacken the possibility that pigment synthesis can be used as hickie Remedies.
About this afzclin, the present inventor have been reported that afzclin about preventing hypopigmentation of skin disease, pre-
Anti- inflammation related skin complaints and effect (the Korean granted patent 10-1223684 that skin is protected by antiultraviolet
Number), wherein having found out through antiultraviolet to protect the effect of skin be to make to have the effect of to protect skin from ultraviolet light
The effect of melanocyte activity and inhibit UV-induced keratinocyte and fibroblastic cytotoxicity
Effect.Afzclin is directly used in ultraviolet screener dosage form however, having not been reported so far, thus obtains afzclin
Antiultraviolet index (SPF, Sun Protection Factor) rising effect and enhancing effect.
Accordingly, the present inventor, as object, is directly used in dosage form using from the substance of nature, and filter out with
It is that existing ultraviolet screener compares the substance that can show that higher antiultraviolet effect as a result, it has been found that following fact, will
When afzclin makes an addition to existing inorganic and/or organic ultraviolet screener, the spf value significantly increased is shown, to not only
Show enhancing effect, and can solve gonorrhoea phenomenon that inorganic ultraviolet screener and organic ultraviolet screener are brought and
The problem of skin irritatin, has thus completed the present invention.
Invention content
Technical problems to be solved
Therefore, technical problem to be solved by the present invention lies in provide the SPF comprising natural materials as active ingredient and increase
Strong agent (booster) composition not only solves the problems, such as organic and the ultraviolet screener of inorganic, but also antiultraviolet is imitated
Fruit is increased.
Also, another technical problem to be solved by this invention is, provides the increased SPF of the preventing ultraviolet effect and increases
The preparation method of strong agent composition.
Also, another technical problem to be solved by this invention is, provides increased using the preventing ultraviolet effect
SPF enhancer compositions increase the method for antiultraviolet effect of skin.
Technical solution
In order to solve the above technical problem, the present invention provides a kind of SPF reinforcing agent groups that antiultraviolet effect is improved
Close object, which is characterized in that include inorganic ultraviolet screener, organic ultraviolet screener or inorganic and organic mixing antiultraviolet together
Agent and afzclin.
Also, in order to solve above-mentioned another technical problem, the present invention provides what a kind of antiultraviolet effect was improved
The preparation method of SPF enhancer compositions, which is characterized in that inorganic ultraviolet screener, organic ultraviolet screener or it is inorganic and
Afzclin is further added in organic mixing ultraviolet screener.
Also, in order to solve above-mentioned another technical problem, the present invention provides a kind of antiultraviolet effect increasing skin
Method, be coated on skin by the SPF enhancer compositions for being improved described antiultraviolet effect.
Preferably, it is a feature of the present invention that on the basis of composition total weight, the composition includes 0.01~5.0
The afzclin of weight %.
Preferably, it is a feature of the present invention that the SPF enhancer compositions have 20~60 spf value.
Hereinafter, in this specification, the increased enhancer compositions of spf value are referred to as " SPF enhancer compositions ".
The term " enhancing effect (Boosting Effect) " used in the present invention can indicate through additional specific factor,
The effect held relative to existing element shows increase effect or even synergy, in more detail, can indicate that specific factor is aobvious
The effect shown is appended to the effect that existing element is held to show in series, or shows the expectation of increase effect or more not
The effect arrived.
Also, the term " increase " used in the present invention can indicate that the effect held relative to existing element shows rising
Effect can indicate that effect that specific factor is shown is appended to the effect that existing element is held and shows in series in more detail
Show, or shows the unexpected effect for increasing effect or more.
The SPF enhancer compositions of the present invention are characterized in that, include inorganic and/or organic ultraviolet screener and Ah together
Good fortune beans glycosides, afzclin and chemical ultraviolet screener and physics ultraviolet screener as active ingredient are used in mixed way, thus may be used
Enhancing (boosting) effect for improving preventing ultraviolet effect is remarkable.
A specific embodiment according to the present invention, in the SPF enhancer compositions, with SPF enhancer compositions
Total weight on the basis of, may include the active ingredient afzclin of 0.01~5.0 weight %.At this point, when the content of afzclin
When less than 0.01 weight %, SPF enhancings (boosting) have little effect, and when the content of afzclin is more than 5.0 weight %, have
The problem of there may be the stability that cannot ensure dosage form.
A specific embodiment according to the present invention, the SPF enhancer compositions include inorganic ultraviolet screener
And the ultraviolet screener of one or more of organic ultraviolet screener, of the invention includes afzclin as active ingredient
SPF enhancer compositions not only solve the gonorrhoea phenomenon that inorganic ultraviolet screener is brought and the skin that organic ultraviolet screener is brought
The problem of stimulation, and there is higher SPF numerical value compared with existing ultraviolet screener, thus enhancing effect is very excellent.
According to a preferred embodiment of the invention, that of the invention includes inorganic and/or organic ultraviolet screener and A Fu together
The SPF enhancer compositions of beans glycosides show 20~60 spf value, this be be used alone existing inorganic ultraviolet screener or
Organic ultraviolet screener, or the SPF numerical value that the ultraviolet screener comprising inorganic and organic ultraviolet screener has are compared, with
1.2 times or more, preferably with 1.4 times or more, the numerical value that is more preferably significantly risen with 2~3 times or more.
Specific embodiment according to the present invention, it is of the invention include inorganic and/or organic ultraviolet screener together with
The SPF enhancer compositions of afzclin have and can solve gonorrhoea phenomenon that existing inorganic ultraviolet screener is brought and organic
The advantages of skin irritatin problem that ultraviolet screener is brought.
According to a preferred embodiment of the invention, organic ultraviolet screener may include being selected from Dioxybenzone
(dioxybenzone), dihydroxyacetone (DHA) (dihydroxyacetone), menthyl anthranilate (menthyl
Anthranilate), UVINUL MS 40 (benzophenone-4), octyl salicylate (octylsalicylate), triethanolamine
Salicylate (triethanolamine salicylate), Cinoxate (cinoxate), oxybenzone (oxybenzone), cyanogen
Double cinnamic acid monooctyl esters (octocrylene), digalloyl trioleate (digalloyl trioleate), to dimethyl
Amyl benzoate (p-dimethylbenzoic acidamyl), p-methoxycinnamic acid diethanolamine salt
(diethanolamine p-methoxycinnamate), octyl methoxycinnamate (octylmethoxycinnamate),
P-aminobenzoic acid (p-aminobenzoic acid), glyceryl PABA (glyceryl PABA), ethyldihydroxypropyl
PABA (ethyldihydroxypropyl PABA), octyldimethyl PABA (octyldimetyl PABA), 2- phenyl benzos
Imidazoles -5- sulfonic acid (2-phenylbenzimidazole-5-sulphonic acid), Homosalate (homosalate), cresols
It is bent azoles (drometrizole), butylmethoxydibenzoylmethane (butylmethoxydibenzoylmethane), pungent
Base triazinone (octyltriazone), 3- (4- methyl benzylidenes)-camphor (3- (4-methylbenzylidene)-
Camphor), PARSOL 500 (4-methylbenzylidene camphor), 3- Benzylidene camphors (3-
Benzylidenecamphor), camphor benzene pricks ammonium (camphorbenzalkonium), sulfo group Benzylidene camphor
(sulphobenzylidene camphor) and sulfomethvl Benzylidene camphor (sulphomethylbenzylidene
One or more of) camphor ingredient.
According to a preferred embodiment of the invention, the inorganic ultraviolet screener may include selected from titanium dioxide, oxidation
The ingredient of one or more of zinc and iron oxide.
In the SPF enhancer compositions of the present invention, other than described inorganic and/or organic ultraviolet screener, as benefit
Helping property adding ingredient further include selected from glycerine, butanediol, Crodaret, tocopherol acetate, citric acid,
At least one of panthenol, saualane, sodium citrate and allantoin ingredient, it is preferable that further include glycerine, polyoxyethylene hydrogen
Change castor oil, tocopherol acetate, saualane and sodium citrate, including in butanediol, citric acid, panthenol and allantoin
At least one ingredient, it is highly preferred that can further include glycerine, butanediol, Crodaret, tocopheryl acetate
Ester, citric acid, panthenol, saualane, sodium citrate or allantoin.
Also, the present invention SPF enhancer compositions in, as other additives can contain selected from surfactant,
Emulsifier, soap acid, solvent, adhesive, diluent, lubricant, stabilizer, fragrance, water, lower alcohol, tackifier, chelating agent, color
Element, preservative, colorant, preservative agent, antibiotic, antioxidant, antifoaming agent, antiseptic, anti redeposition agent, enzyme, vegetable oil or
Mineral oil, fat, fluorescent material, fungicide, hydrotaxis evocating substance, moisturizer, aromatic, carrier, protein, silicone,
One kind or two or more cosmeceutical or pharmacology in solubilizer, sugar derivatives, opacifier, vitamin, plant extracts and wax
Acceptable excipient on.
The SPF enhancer compositions of the present invention can be with aqueous, aqueous-alcoholic or oiliness dispersion, point of emulsion types
The emulsion of the milk type of scattered object, aqueous, anhydrous or lipophilic gel, liquid or semiliquid concentration, disperses in aqueous shape
Fatty shape and obtain (O/W) or opposite to that (W/O), or the creams of soft, cream or solid concentration, gel, creams-are solidifying
Suspension, solution or the emulsion or microemulsion of glue, foam or ointment type, microcapsules, particle or ion and/or it is non-from
The form of the defoaming dispersion of subtype, the forms such as powder, spray discharge pattern or the patch other than it carry out dosage form.
When the dosage form is cream, creams or when gel, as carrier components can utilize animal oil, vegetable oil, wax, paraffin,
Starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talcum or zinc oxide etc..
When the dosage form is powder or spraying, lactose, talcum, silica, hydroxide can be utilized as carrier components
Aluminium, calcium silicates or polyamide powder especially when the dosage form is spraying, can further include such as chlorofluorocarbon
(chlorofluorohydrocarbon), the propellant of propane/butane or dimethyl ether etc.
When the dosage form is solution or emulsion, solvent, solubilizer or opacifiers are utilized as carrier components, such as have
Water, ethyl alcohol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, Ergol, propylene glycol, 1,3 butylene glycol, aliphatic are sweet
Grease, polyethylene glycol (polyethylene glycol) or sorbitan fatty ester.
It is dilute using the liquid such as water, ethyl alcohol or propylene glycol etc as carrier components when the dosage form is suspension
Release the suspending agent, micro- of agent, such as ethoxylated isostearyl alcohols, polyoxyethylene sorbitol ester and polyoxyethylene sorbitol acid anhydride ester etc
Crystalline cellulose, inclined aluminium hydroxide, bentonite, agar or tragacanth etc..
According to one embodiment of present invention, a kind of SPF enhancer compositions that antiultraviolet effect is improved are provided
Preparation method, which is characterized in that further add afzclin in described inorganic and/or organic ultraviolet screener.
Specific embodiment according to the present invention, which is characterized in that using the total weight of SPF enhancer compositions as base
Standard adds the afzclin with the amount of 0.01~5.0 weight %.At this point, the additive amount when afzclin is less than 0.01 weight
When measuring %, SPF enhancings (boosting) have little effect, when the additive amount of afzclin is more than 5.0 weight %, it is possible to exist
The problem of cannot ensure the stability of dosage form.
According to the present invention, afzclin is added in existing inorganic and/or organic ultraviolet screener, thus, it is possible to prepare
Compared with the SPF numerical value of existing ultraviolet screener, has and risen with 1.2 times or more, preferably risen with 1.4 times or more, it is more excellent
The SPF enhancer compositions for selecting antiultraviolet effect of 20~60 spf value risen with 2~3 times or more to be improved.
According to one embodiment of present invention, provide it is a kind of increase skin antiultraviolet effect method, pass through by
The SPF enhancer compositions that described antiultraviolet effect is improved are coated on the skin of individual.
The term " individual " used in the present invention refers to all animals including the mammals such as mouse, domestic animal, people,
Indicate that it is necessary to the animal of body is protected from ultraviolet light.
The term " coating " used in the present invention indicates to utilize any suitable method, such as is smeared with hand or tool, or
The methods of person is contacted using gauze or patch, spray, spray, make the skin contact of individual to the SPF reinforcing agent groups of the present invention
Object is closed, it is intended that thus the SPF enhancer compositions of the present invention are absorbed into inside skin.
The frequency that the SPF enhancer compositions of the present invention are coated on to the skin of individual can be different with each individual,
It is recommended that being coated within one day 1 time, it is coated within preferably one day 2 times, is coated with 3 times within more preferably one day, being possible to as needed can be different.
Specific embodiment according to the present invention, compared with the SPF numerical value that existing ultraviolet screener is held, the present invention
SPF enhancer compositions have risen with 1.2 times or more, preferably risen with 1.4 times or more, more preferably on 2~3 times or more
20~60 spf value risen can increase antiultraviolet effect when by the SPF enhancer compositions for individual skin
It is 1.2 times or more, preferably 1.4 times or more, more preferably 2~3 times or more.
Specific embodiment according to the present invention, SPF enhancer compositions of the invention and existing ultraviolet screener
It compares, not only enhancing effect is excellent, but also can solve gonorrhoea phenomenon and organic anti-purple that existing inorganic ultraviolet screener is brought
The problem of skin irritatin that outside line agent is brought.
Invention effect
As described above, compared with existing ultraviolet screener, of the invention includes inorganic and/or organic antiultraviolet together
The SPF enhancer compositions of agent and afzclin have the advantages that show the SPF numerical value significantly improved.Also, it not only solves
The problem of skin irritatin that the gonorrhoea phenomenon and organic ultraviolet screener that existing inorganic ultraviolet screener is brought are brought, Er Qieke
The enhancing effect (Boosting Effect) for showing organic ultraviolet screener or inorganic ultraviolet screener, thus can show
The preventing ultraviolet effect significantly improved is shown.
Specific implementation mode
Hereinafter, in order to contribute to the understanding of the present invention, embodiment etc. is enumerated to be described in detail.But reality of the invention
Following embodiment can be should not be construed as being limited to a variety of different model deformations, the scope of the present invention by applying example.The present invention
Embodiment be in order to general technical staff of the technical field of the invention be described more fully the present invention and provide.
<Embodiment 1>The preparation of antiultraviolet containing afzclin organic sunscreen frost
In order to know the SPF enhancing effects of afzclin, in known antiultraviolet organic sunscreen frost COLIPA dosage forms
Middle addition afzclin prepares organic SPF reinforcing agents containing afzclin with composition ratio shown in following table 1.
It is not added with afzclin in the control group for comparing.
Table 1
<Experimental example 1>The SPF of antiultraviolet containing afzclin organic sunscreen frost is measured
Spf value is measured according to following scheme.Specifically, the anti-purple containing afzclin that will be prepared in above-described embodiment 1
Outside line organic sunscreen frost and the not antiultraviolet of the control group containing afzclin organic sunscreen frost, by the same method
It is spread evenly across coarse polymethyl methacrylate plate (polymethylmethacrylate PMMA in the same amount
Plate) (Sa=2 μm, 50x50mm).After 10 minutes dry, sensing equipment (ultraviolet transmittance analyzer (UV is utilized
Transmittance Analyzer) UV-2000S, Labsphere), in multiple position finding UV absorbances of PMMA plates.Its
As a result it is shown in following table 2.
Table 2
| Reference examples | Embodiment 1 | |
| SPF is average (Mean) | 10.33 | 27.54 |
| SPF standard deviations (Standrad deviation) | 0.39 | 2.90 |
As recorded in above-mentioned table 2, the antiultraviolet organic sunscreen frost of the embodiment 1 of the invention containing afzclin with
Control group COLIPA dosage forms not containing afzclin are compared, and show significantly high SPF.
<Embodiment 2>The preparation of antiultraviolet containing afzclin inorganic sunscreens frost
In order to know the SPF enhancing effects of afzclin, in antiultraviolet addition A Fu beans in inorganic sunscreens creme type
Glycosides prepares the inorganic SPF reinforcing agents containing afzclin with composition ratio shown in following Table 3.
It is not added with afzclin in the control group for comparing.
Table 3
<Experimental example 2>The SPF of antiultraviolet containing afzclin inorganic sunscreens frost is measured
According to scheme identical with the experimental example 1, the anti-purple containing afzclin prepared in the embodiment 2 is measured
Outside line inorganic sunscreens frost and the not spf value of the antiultraviolet of the control group containing afzclin inorganic sunscreens frost.
Table 4
| Reference examples | Embodiment 2 | |
| SPF is average (Mean) | 37.14 | 51.64 |
| SPF standard deviations (Standrad deviation) | 4.30 | 6.89 |
As recorded in above-mentioned table 4, the dosage form (embodiment 2) and reference examples comprising afzclin (Afzelin) of the invention
It compares, antiultraviolet index is improved.
<Experimental example 3>Normal individual trial experiment for the SPF for evaluating afzclin
Using the dosage form prepared in embodiment 1, normal individual trial experiment is carried out.
After selected testee, by between the shoulder and waist of testee, in back it is clean other than vertebra
And flat position is chosen to be experiment position.
It, will totally 13 testees' conducts pair according to No. 2014-75 test method of food pharmaceuticals state security department's bulletin
As come carry out this experiment.After the forward index for 3 being determined as object sample, this examination is carried out as object by 10
It tests, the SPF of sample is determined with 10 this test result.
Specifically, by sample with 2mg/cm2Amount be coated on 40cm2The area of (8x5cm).The sample of 80 ± 2mg is uniform
Ground titration twist is smeared so that sample is equably up and down at coating position with the finger for taking surgical glove
It is coated on whole coating position.For sample is coated with the ultraviolet irradiation amount at position, bright increasing degree is set as 15%.It comments
The minimum erythema dose (ED) (MEDp) at valence sample coating position is irradiated after ultraviolet light after 16~24 hours, by several practicians
Judge according to determinating reference.Antiultraviolet index (SPF) calculates as follows.
[mathematical expression 1]
According to above-mentioned mathematical expression 1, the antiultraviolet index (SPFi) of each testee is calculated separately, by 10 be averaged
Value determines SPF.
[mathematical expression 2]
Result by the dosage form prepared in embodiment 1 for normal individual trial experiment is shown in following table 5 and table 6.
Table 5
Table 6
| Sample ID | SPF numerical value | Standard deviation | 20% average section | 95% confidence interval |
| High standard sample | 14.8 | ±1.9 | ±3.0 | ±1.4 |
| Embodiment 1 | 20.1 | ±1.9 | ±4.0 | ±1.4 |
As shown in Table 6 above, the SPF of the ultraviolet screener containing afzclin (Afzelin) prepared in embodiment 1 is true
It is set to 20.The antiultraviolet index of test result, standard sample is standard sample and evaluation sample within the limits prescribed
95% confidence interval is within average value ± 20% of the antiultraviolet index measured, thus it is confirmed that experiment is accurate
Property.In this experiment, harmful example is not observed in the overall process of coated sample, irradiation ultraviolet light and the minimum erythema dose (ED) of judgement.
Industrial applicibility
As described above, compared with existing ultraviolet screener, of the invention includes inorganic and/or organic antiultraviolet together
The SPF enhancer compositions of agent and afzclin have the advantages that show the SPF numerical value significantly improved.Also, it not only solves
The skin irritatin problem that the gonorrhoea phenomenon and organic ultraviolet screener that existing inorganic ultraviolet screener is brought are brought, and show
The enhancing effect (Boosting Effect) for going out organic ultraviolet screener or inorganic ultraviolet screener, thus can show
The preventing ultraviolet effect significantly improved.
Claims (10)
1. a kind of SPF enhancer compositions that antiultraviolet effect is improved, which is characterized in that include inorganic UV resistance together
Line agent, organic ultraviolet screener or inorganic and organic mixing ultraviolet screener and afzclin.
2. the SPF enhancer compositions that antiultraviolet effect according to claim 1 is improved, which is characterized in that with
On the basis of composition total weight, include the afzclin of 0.01~5.0 weight %.
3. the SPF enhancer compositions that antiultraviolet effect according to claim 1 is improved, which is characterized in that institute
Stating SPF enhancer compositions has 20~60 spf value.
4. the SPF enhancer compositions that antiultraviolet effect according to claim 1 is improved, which is characterized in that institute
It includes selected from Dioxybenzone, dihydroxyacetone (DHA), menthyl anthranilate, UVINUL MS 40, water to state organic ultraviolet screener
Poplar acid monooctyl ester, trolamine salicylate, Cinoxate, oxybenzone, octocrylene, two nutgall acyls, three oleic acid
Ester, to mesitylenic acid pentyl ester, p-methoxycinnamic acid diethanolamine salt, octyl methoxycinnamate, p-aminobenzoic acid,
Glyceryl PABA, ethyldihydroxypropyl PABA, octyldimethyl PABA, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, Homosalate,
Drometrizole, butylmethoxydibenzoylmethane, octyl triazone, 3- (4- methyl benzylidenes)-camphor, 4- methylbenzenes
Methylidenecamphor, 3- Benzylidene camphors, camphor benzene are pricked in ammonium, sulfo group Benzylidene camphor and sulfomethvl Benzylidene camphor
More than one ingredient.
5. the SPF enhancer compositions that antiultraviolet effect according to claim 1 is improved, which is characterized in that institute
It includes the ingredient selected from one or more of titanium dioxide, zinc oxide and iron oxide to state inorganic ultraviolet screener.
6. a kind of preparation method for the SPF enhancer compositions that antiultraviolet effect is improved, which is characterized in that inorganic anti-
Afzclin is further added in ultraviolet light agent, organic ultraviolet screener or inorganic and organic mixing ultraviolet screener.
7. the preparation method for the SPF enhancer compositions that antiultraviolet effect according to claim 6 is improved, special
Sign is, on the basis of composition total weight, the afzclin is added with the amount of 0.01~5.0 weight %.
8. the preparation method for the SPF enhancer compositions that antiultraviolet effect according to claim 6 is improved, special
Sign is that organic ultraviolet screener includes selected from Dioxybenzone, dihydroxyacetone (DHA), menthyl anthranilate, hexichol
Ketone -4, octyl salicylate, trolamine salicylate, Cinoxate, oxybenzone, octocrylene, two nutgalls
Acyl trioleate, to mesitylenic acid pentyl ester, p-methoxycinnamic acid diethanolamine salt, octyl methoxycinnamate, to ammonia
Yl benzoic acid, glyceryl PABA, ethyldihydroxypropyl PABA, octyldimethyl PABA, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID,
Homosalate, drometrizole, butylmethoxydibenzoylmethane, octyl triazone, 3- (4- methyl benzylidenes)-camphor tree
Brain, PARSOL 500,3- Benzylidene camphors, camphor benzene prick ammonium, sulfo group Benzylidene camphor and sulfomethvl benzene
The ingredient of one or more of methylidenecamphor.
9. the preparation method for the SPF enhancer compositions that antiultraviolet effect according to claim 6 is improved, special
Sign is that the inorganic ultraviolet screener includes the ingredient selected from one or more of titanium dioxide, zinc oxide and iron oxide.
10. a kind of method of the antiultraviolet effect for increasing skin, by according to any one of claims 1 to 5 will prevent
The SPF enhancer compositions that ultraviolet light effect is improved are coated on the skin of individual.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170026375A KR101995997B1 (en) | 2017-02-28 | 2017-02-28 | A SPF booster composition having an improved ultraviolet blocking effect comprising afzelin and a process for the preparation thereof |
| KR10-2017-0026375 | 2017-02-28 |
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| Publication Number | Publication Date |
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| CN108498363A true CN108498363A (en) | 2018-09-07 |
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| CN201710876198.3A Pending CN108498363A (en) | 2017-02-28 | 2017-09-25 | The SPF enhancer compositions and preparation method thereof that antiultraviolet effect is improved |
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| Country | Link |
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| KR (1) | KR101995997B1 (en) |
| CN (1) | CN108498363A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112294726A (en) * | 2020-11-24 | 2021-02-02 | 东莞波顿香料有限公司 | Herba Veronicae Didyma extract and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000030185A1 (en) | 2020-12-09 | 2022-06-09 | Prod Gianni S R L | ALKYL ESTERS OF LIPOAMINO ACIDS AS SPF BOOSTERS |
| EP4431081A1 (en) | 2023-03-13 | 2024-09-18 | Prodotti Gianni S.r.l. | Cosmetic compositions with enhanced sun protection factor and preparation thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20180099232A (en) | 2018-09-05 |
| KR101995997B1 (en) | 2019-07-04 |
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