CN108498217B - 3D printing degradable stent for correcting vaginal deformity and manufacturing method thereof - Google Patents
3D printing degradable stent for correcting vaginal deformity and manufacturing method thereof Download PDFInfo
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- CN108498217B CN108498217B CN201810240996.1A CN201810240996A CN108498217B CN 108498217 B CN108498217 B CN 108498217B CN 201810240996 A CN201810240996 A CN 201810240996A CN 108498217 B CN108498217 B CN 108498217B
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- 238000010146 3D printing Methods 0.000 title claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 11
- 230000000975 bioactive effect Effects 0.000 claims abstract description 9
- 238000007639 printing Methods 0.000 claims abstract description 5
- 230000006378 damage Effects 0.000 claims abstract description 3
- 208000014674 injury Diseases 0.000 claims abstract 3
- 230000008733 trauma Effects 0.000 claims abstract 2
- 210000003708 urethra Anatomy 0.000 claims description 4
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 229920001610 polycaprolactone Polymers 0.000 claims description 3
- 239000004632 polycaprolactone Substances 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 5
- 230000036262 stenosis Effects 0.000 description 5
- 208000037804 stenosis Diseases 0.000 description 5
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 206010062575 Muscle contracture Diseases 0.000 description 3
- 206010046879 Vaginal atresia Diseases 0.000 description 3
- 238000002399 angioplasty Methods 0.000 description 3
- 208000006111 contracture Diseases 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 206010058314 Dysplasia Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000001370 mediastinum Anatomy 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
A3D printing degradable stent for correcting vaginal deformity and a manufacturing method thereof are provided, the degradable stent comprises a stent main body designed according to image data of a patient, the stent main body is a hollow pipeline with openings at two ends, holes are arranged on the surface of the stent main body, and flanges are arranged at the positions of the openings at two ends of the stent main body; one side of the bracket main body is provided with a groove, and the manufacturing method is that medical image scanning is firstly carried out on the affected part of a patient; then three-dimensional reconstruction and design of the personalized porous support are carried out in a computer, and the designed support is processed by 3D printing slicing software to obtain information of each cross section layer; then guiding the information of each cross section layer after slicing into a 3D printer, and printing by using a degradable bioactive material to obtain a stent; the invention can reduce the trauma to the patient, and autologous cells can grow into the stent to form a natural cavity channel along with the lapse of time, and meanwhile, the stent is naturally degraded, thereby avoiding the risk and the injury of the secondary operation.
Description
Technical Field
The invention relates to the technical field of degradable stents, in particular to a 3D printing degradable stent for correcting vaginal deformity and a manufacturing method thereof.
Background
Vaginal deformity is a common female reproductive organ dysplasia disease, which is mostly caused by congenital developmental deformity and is commonly characterized by vaginal atresia or stenosis, vaginal diaphragm, vaginal mediastinum and the like. Once clinically diagnosed as a vaginal abnormality, particularly vaginal atresia, it is necessary to perform an immediate colpoplasty for vaginal reconstruction. The congenital vaginal-free or vaginal atresia has the incidence rate of 1: 4000-1: 5000, the incidence rate is high, the traditional operation methods comprise amniocynoplasty, peritoneovaginal angioplasty, enteron-vaginal angioplasty and the like, flap-vaginal angioplasty and the like, the operation methods all need to cut tissues from different body parts of a patient for displacement repair, the wound surface is large, in order to prevent regeneration stenosis and scar contracture after the operation, a mold needs to be placed for a long time, a lot of inconvenience is caused to the patient, and the physical and mental health is affected by different degrees.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a 3D printing degradable stent for correcting the vaginal deformity and a manufacturing method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
the utility model provides an it prints degradable support to rescue 3D for vaginal deformity, includes the support main part 1 according to patient's image data design, and support main part 1 is the open hollow pipeline 3 in both ends, and the surface of support main part 1 is equipped with hole 2.
The open positions of the two ends of the bracket main body 1 are provided with flanges 5 with different specifications according to the physical characteristics of patients and the operation requirements.
One side of the bracket main body 1 is provided with a groove 4.
The side surface of the bracket main body 1 is locally or integrally provided with holes 2, the holes 2 are regular round holes, rectangular holes or irregular mesh structures, the diameter range of the round holes is 0.3-3 mm, the side length size range of the rectangular holes is 0.3-3 mm, and the porosity is 30-85%.
The manufacturing method of the 3D printing degradable stent for correcting the vaginal deformity comprises the following steps:
firstly, medical image scanning is carried out on a patient part;
secondly, three-dimensional reconstruction and design of a personalized porous stent are carried out on the vaginal structure of a patient in a computer, the outer diameter size of the stent is set according to the size of the correction preforming, and the size of the groove 4 on one side of the stent is designed according to the position relation and the size of the urethra;
thirdly, processing the designed bracket by using 3D printing slicing software to obtain the information of each cross section layer; then leading the information of each cross section layer after slicing into a 3D printer, and printing by using a degradable bioactive material to obtain the 3D printing degradable stent for correcting the vaginal deformity.
The degradable bioactive material comprises polylactic acid and polycaprolactone.
The invention has the beneficial effects that:
through the mode of 3D printing, print into with patient assorted individualized support with degradable bioactive material, it not only can reduce the wound to the patient, can also replace the mould that the postoperative was placed to autologous cell can grow into the support along with the time, forms natural chamber way, and the risk and the damage of secondary operation have been avoided to the support natural degradation simultaneously.
The invention solves the problems of regeneration stenosis and contracture in the traditional operation mode, does not need to place a mould, reduces the operation difficulty and the later nursing difficulty, saves the operation time and lightens the physical and mental burden of a patient.
Drawings
Fig. 1 is a front view of a degradable stent according to an embodiment of the invention.
Fig. 2 is a top view of a degradable stent according to an embodiment of the invention.
FIG. 3 is a diagram of a degradable stent in an embodiment of the invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and examples, but the specific structures and materials of the present invention are not limited to the examples described below.
Referring to fig. 1, 2 and 3, a 3D prints degradable support for correcting vaginal deformity includes support main body 1 designed according to patient's image data, support main body 1 is the open hollow pipeline 3 in both ends, the open position in support main body 1 both ends sets up the flange 5 of different specifications according to patient's physical characteristics and operation demand, one side of support main body 1 is provided with recess 4, full hole 2 is established on support main body 1's surface, the diameter of hole 2 is 2 mm.
The manufacturing method of the 3D printing degradable stent for correcting the vaginal deformity comprises the following steps:
firstly, medical image scanning is carried out on a patient part;
secondly, three-dimensional reconstruction and design of a personalized porous stent are carried out on the vaginal structure of a patient in a computer, the outer diameter size of the stent is set according to the size of the correction preforming, and the size of the groove 4 on one side of the stent is designed according to the position relation and the size of the urethra;
thirdly, processing the designed bracket by using 3D printing slicing software to obtain the information of each cross section layer; then guiding the information of each cross section layer after slicing into a 3D printer, and printing by using a degradable bioactive material to obtain a 3D printing degradable stent for correcting the vaginal deformity; the degradable bioactive material comprises polylactic acid and polycaprolactone.
During operation, the stent is placed in the preforming position for suturing without placing a supporting mold, so that the problems of mold falling, displacement and urethra compression caused by excretion in the physiological period are solved; the 3D printing customized integral forming technology is adopted, so that the support is perfectly matched with a human body physiological structure, secondary repairing of the support is not needed in the operation, the support made of degradable materials can promote cell regeneration and repair in vivo, the support plays a role in supporting left and right in vivo in the earlier stage, postoperative regeneration stenosis and contracture can be prevented, after autologous tissue repair is completed, the support is naturally degraded in vivo, no residue is left, the necessity of secondary operation is avoided, and a new thought and an effective treatment means are provided for vaginal reconstruction operations such as vaginal occlusion, vaginal stenosis and the like caused by various reasons.
Claims (2)
1. The utility model provides a correct vaginal deformity and print degradable support with 3D which characterized in that: the medical support comprises a support main body (1) designed according to image data of a patient, wherein the support main body (1) is a hollow pipeline (3) with two open ends, and a hole (2) is formed in the surface of the support main body (1);
flanges (5) with different specifications are arranged at the open positions at the two ends of the bracket main body (1) according to the physical characteristics of a patient and the surgical requirements;
one side of the bracket main body (1) is provided with a groove (4);
holes (2) are locally or integrally arranged on the side surface of the bracket main body (1), the holes (2) are regular round holes, rectangular holes or irregular mesh structures, the diameter range of the round holes is 0.3-3 mm, the side length size range of the rectangular holes is 0.3-3 mm, and the porosity is 30-85%;
the degradable bioactive material is printed into the personalized support matched with the patient in a 3D printing mode, so that the trauma to the patient is reduced, a mold placed after the operation can be replaced, autologous cells grow into the support along with the lapse of time to form a natural cavity, and meanwhile, the support is naturally degraded, so that the risk and damage of a secondary operation are avoided;
the degradable bioactive material comprises polylactic acid and polycaprolactone.
2. The manufacturing method of the 3D printing degradable stent for correcting the vaginal deformity, which is characterized by comprising the following steps:
firstly, medical image scanning is carried out on a patient part;
secondly, three-dimensional reconstruction and design of a personalized porous stent are carried out on the vaginal structure of a patient in a computer, the outer diameter size of the stent is set according to the size of the correction preforming, and the size of a groove (4) on one side of the stent is designed according to the position relation and the size of the urethra;
thirdly, processing the designed bracket by using 3D printing slicing software to obtain the information of each cross section layer; then leading the information of each cross section layer after slicing into a 3D printer, and printing by using a degradable bioactive material to obtain the 3D printing degradable stent for correcting the vaginal deformity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810240996.1A CN108498217B (en) | 2018-03-22 | 2018-03-22 | 3D printing degradable stent for correcting vaginal deformity and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810240996.1A CN108498217B (en) | 2018-03-22 | 2018-03-22 | 3D printing degradable stent for correcting vaginal deformity and manufacturing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108498217A CN108498217A (en) | 2018-09-07 |
| CN108498217B true CN108498217B (en) | 2021-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810240996.1A Active CN108498217B (en) | 2018-03-22 | 2018-03-22 | 3D printing degradable stent for correcting vaginal deformity and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117507367B (en) * | 2024-01-08 | 2024-04-05 | 北京阿迈特医疗器械有限公司 | Support printing method and device with mark points |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427612A (en) * | 2014-10-07 | 2017-12-01 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | Degradable medical treatment device on demand |
| CN107614050A (en) * | 2015-04-14 | 2018-01-19 | 贝勒医学院 | Vagina support, vaginal dilator and its manufacture method |
| CN207118927U (en) * | 2017-01-11 | 2018-03-20 | 东莞市正生瑞生物医学科技有限公司 | A kind of Medical vagina support |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4982369B2 (en) * | 2004-08-13 | 2012-07-25 | ラトガース，ザ ステート ユニバーシティ | Radiopaque polymeric stent |
| ES2578080T3 (en) * | 2009-09-30 | 2016-07-20 | Coloplast A/S | Implantable fabric in the body to repair the pelvic floor |
| CN105013072B (en) * | 2015-07-24 | 2018-08-31 | 严聪颖 | Band medicine delayed release device for uterus |
| US20170087344A1 (en) * | 2015-09-25 | 2017-03-30 | Therapeutic Solutions International, Inc. | Devices and methods for reducing the risk of preterm labor and preterm birth |
| CN105536060B (en) * | 2016-03-01 | 2018-12-11 | 湘潭大学 | For the composition of 3D printing cartilage frame and microballoon and preparation method thereof |
| CN105641753B (en) * | 2016-03-08 | 2019-07-05 | 吴志宏 | A kind of 3D printing biodegradable stent of the achievable blood vessel transfer of compound rhBMP-2 |
| CN106344231B (en) * | 2016-10-27 | 2018-05-08 | 中国人民解放军第四军医大学 | Treat the degradable tracheae support arm of 3D printing and its manufacture method of tracheostenosis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427612A (en) * | 2014-10-07 | 2017-12-01 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | Degradable medical treatment device on demand |
| CN107614050A (en) * | 2015-04-14 | 2018-01-19 | 贝勒医学院 | Vagina support, vaginal dilator and its manufacture method |
| CN207118927U (en) * | 2017-01-11 | 2018-03-20 | 东莞市正生瑞生物医学科技有限公司 | A kind of Medical vagina support |
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