CN108479430A - A kind of nano-magnetic hemodialysis membrane and preparation method thereof - Google Patents
A kind of nano-magnetic hemodialysis membrane and preparation method thereof Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/38—Polyalkenylalcohols; Polyalkenylesters; Polyalkenylethers; Polyalkenylaldehydes; Polyalkenylketones; Polyalkenylacetals; Polyalkenylketals
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0006—Organic membrane manufacture by chemical reactions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/10—Analysis or design of chemical reactions, syntheses or processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/24—Mechanical properties, e.g. strength
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/36—Hydrophilic membranes
Abstract
The invention belongs to haemodialysis technical field of membrane, a kind of nano-magnetic hemodialysis membrane and preparation method thereof is disclosed, the nano-magnetic hemodialysis membrane and its preparation system include：Time control module, temperature control modules, main control module, sorting module, fused module, modification module, mixing module.The present invention has the characteristics that intensity is high, wearability is high, tear resistance is good, fatigue resistance is good；The reaction process of the present invention is simple, convenient and easy simultaneously；The nano combined hemodialysis membrane of thin layer of the present invention has the characteristics that permanent hydrophilic, low protein adsorption and excellent biocompatibility；There is the nano combined hemodialysis membrane of thin layer of the present invention high osmosis, high separability energy to have resistance tocrocking and anticoagulant property again.
Description
Technical field
The invention belongs to haemodialysis technical field of membrane more particularly to a kind of nano-magnetic hemodialysis membrane and its preparation sides
Method.
Background technology
The purpose of haemodialysis is to substitute the partial function lost in kidney failure, such as removes metabolic waste, adjust water, electricity
Solve matter and acid-base balance.Its basic principle has disperse, infiltration, convection current and ultrafiltration.The exchange of solute, moisture when dialysis, to structure
Toxin is removed when at hemodialysis, is removed moisture, is supplemented the theoretical foundation of necessary material.Small-molecule substance in uraemic patients' blood is such as
Creatinine, urea nitrogen, potassium etc. are spread into dialyzate, and the ionic sodium, chlorine plasma in dialyzate are identical with blood level, so,
It still keeps balancing inside and outside film, base, calcium ion in dialyzate etc. are then spread into blood, to reach removing toxin, correct electricity
Solve the purpose of matter disorder and acid poisoning.Haemodialysis is to utilize dialysis membrane [1] with ultra-pure water principle, it is a kind of semi-permeable membrane, is led to
Cross the relative flow of blood and dialyzate inside and outside dialysis membrane, solute is by concentration gradient difference from one side of high concentration to low dense
Spend side transport process, referred to as disperse；The result of disperse makes semi-permeable membrane both sides solute concentration reach balance.If in semi-permeable membrane side
Add negative pressure to increase transmembrane pressure, then moisture can be made to be moved from the low side of the high lateral pressure of pressure, this is known as ultrafiltration.With
This also has part solute to be moved together with water simultaneously, this is referred to as convection current.However, existing hemodialysis membrane wearability is low, anti-tear
Split difference；Poor biocompatibility simultaneously, permeability is low, and resistance tocrocking is poor.
In conclusion problem of the existing technology is：Existing hemodialysis membrane wearability is low, tear-proof is poor；It is raw simultaneously
Object poor compatibility, permeability is low, and resistance tocrocking is poor.
Invention content
In view of the problems of the existing technology, the present invention provides a kind of nano-magnetic hemodialysis membrane and its preparation sides
Method.
The invention is realized in this way a kind of nano-magnetic hemodialysis membrane preparation system includes：
Time control module, temperature control modules, main control module, sorting module, fused module, modification module, hybrid guided mode
Block；
Time control module is connect with main control module, for controlling the time for preparing reaction；
Temperature control modules are connect with main control module, are controlled for the temperature to preparation；
Main control module, with time control module, temperature control modules, sorting module, fused module, modification module, mix
Module connects, for dispatching modules normal work；
Sorting module, connect with main control module, is 100 parts for choosing polyacrylonitrile, glass fibre is 30 parts, N- ammonia second
Base piperazine is 5 parts, zinc dimethyl dithiocarbamate is 3 parts, methacryloxypropyl trimethoxy silane is 3 parts,
Acrylonitrile-butadiene-styrene copolymer is 13 parts, benzoyl peroxide is that 2 parts of mixing generate modified modified polyacrylonitrile；
Fused module, connect with main control module, PAN solution is obtained for polyacrylonitrile (PAN) to be dissolved in organic solvent, quiet
Electrospun obtains supporting layer of the nanofiber as composite membrane；Wherein the mass fraction of polyacrylonitrile (PAN) solution is 10%-
20%；
Modification module is connect with main control module, for sodium hydrogen to be added into PVAC polyvinylalcohol solution, is then added 1,3-
Propane sultone, 45-80 DEG C of reaction 10-24h, is filtered, dry, obtains the polyvinyl alcohol s-PVA of heparan modification；
Mixing module is connect with main control module, and polyvinyl alcohol and polyvinyl alcohol blending for heparan to be modified are added
Solvent is configured to the coating liquid of a concentration of 0.2-10wt%, adjusts pH to 1~2, and crosslinking agent is added, and is crosslinked 19~20min, so
It is coated on supporting layer afterwards, Room-temperature seal obtains nano combined hemodialysis membrane.
The time control module uses timing-optimal control algorithm, to nonlinear system
It finds one and allows dominant vector u (t) ∈ Rr, meet
|uj(t) |≤1, (j=1,2 ..., r) (2)
Make system from x (t0)=x0It sets out, in a certain final states moment T>t0Reach object set g (x (T), T) (g ∈ Rp), and
Make performance indicator
Ham ilton functions can be written to system (1) by maximal principle in minimum
H (x, u, λ, t)=1+ λτF (x, t)+λτB (x, t) u. (4)
Enable q (t)=Bτ(x, t) λ, i.e.,Wherein bjIt is j-th of column vector of matrix B,
λ is undetermined multiplier function, obtains optimum control uj* (t) is qj(t) lower array function：
From formula (5), if qj(t) only in [t0, T] limited a isolated point on be zero, then optimum control component u*j (t)
It is a piecewise constant function.
The temperature control modules are used based on the pid parameter Self-tuning System algorithm from optimizing, are real using increment type PID
Existing high-precision control increases following improvement：
First, to reduce the High-frequency Interference caused by sampling with differential, digital filtering is introduced in this algorithm, to make
Degree of regulation higher, digital filtering have different methods, and what this algorithm was taken is first order filtering；
First order filtering method is exactly a kind of dynamic filter method for realizing RC low-pass filters in digital form, to one
RC low-pass filters, transmission function are：L (s)=1/ (τ s+1) wherein τ=RC is filter time constant, and the formula is discrete
Change can obtain：
e′k=α e 'k|-1+(1-α)ek (1)
In formula：α=τ/(τ+T)；T is the sampling period；ekThe input of filter when being sampled for kth time；e′kFor kth time sampling
When filter output；e′K-1For the sampling of kth -1 time when filter output；Using equation (1) to deviation signal ekIt is repaiied
Just, then by revised deviation e 'kAs the deviation signal of kth time sampling instant, substitutes into PID formulas and calculated, just
Reduce influence of the High-frequency Interference to digital IIR filters formula；
Secondly, to reduce the overshoot caused by integral action, stable state accuracy is improved, this algorithm uses integral separation
Pid algorithm；For reduce because be manually entered and foreign impacts interference caused by vibrate, this algorithm adds amplitude limiting processing, that is, works as | e |
>ε, then Δ U=λ, the maximum fluctuation value that λ allows for you；
The threshold value △ e of one position of set-up of control system control, computer to the error e that is obtained after data processing into
Row judges, specific as follows：
If ε >=| e |>△ e carry out PD control, improve the dynamic characteristic of control,
When | e |<When △ e, PID control is carried out, ensures control accuracy, when | e |>When ε, Δ U=λ (constant).
A kind of nano-magnetic haemodialysis membrane preparation method includes the following steps：
Step 1 controls the time for preparing reaction by time control module；It is prepared by temperature control modules
Temperature controlled；
Step 2, main control module scheduling sorting module selection polyacrylonitrile is 100 parts, glass fibre is 30 parts, N- ammonia second
Base piperazine is 5 parts, zinc dimethyl dithiocarbamate is 3 parts, methacryloxypropyl trimethoxy silane is 3 parts,
Acrylonitrile-butadiene-styrene copolymer is 13 parts, benzoyl peroxide is that 2 parts of mixing generate modified modified polyacrylonitrile；
Polyacrylonitrile (PAN) is dissolved in organic solvent by fused module and obtains PAN solution by step 3, and electrostatic spinning obtains
Supporting layer to nanofiber as composite membrane；Wherein the mass fraction of polyacrylonitrile (PAN) solution is 10%-20%；
Sodium hydrogen is added into PVAC polyvinylalcohol solution by modification module for step 4, is then added 1, in 3-N-morpholinopropanesulfonic acid
Ester, 45-80 DEG C of reaction 10-24h, is filtered, dry, obtains the polyvinyl alcohol s-PVA of heparan modification；
Solvent is added in step 5, the polyvinyl alcohol and polyvinyl alcohol blending for being modified heparan by mixing module, prepares
At the coating liquid of a concentration of 0.2-10wt%, pH to 1~2 is adjusted, crosslinking agent is added, 19~20min is crosslinked, is then coated with and is propping up
It supports on layer, Room-temperature seal obtains nano combined hemodialysis membrane.
Further, the molar ratio of the sodium hydrogen and polyvinyl alcohol is 1：5~1:1；1,3- propane sultones and polyvinyl alcohol
Molar ratio be 1：5~1:1.
Further, the mass ratio for the polyvinyl alcohol and polyvinyl alcohol that the heparan is modified is 1：1~1：4.
Further, solvent is n,N-Dimethylformamide DMF in the step 3.
Further, the technological parameter of electrostatic spinning is in the step 3：Voltage is 18~24kV, and solution propulsion rate is
17~20 μ L/min, it is 16~30cm to receive distance.
Advantages of the present invention and good effect are：The present invention has high intensity, wearability height, tear resistance good, antifatigue
The good feature of property；The reaction process of the present invention is simple, convenient and easy simultaneously；Time control module is calculated using timing-optimal control
Method, can realize the time control optimized to reaction process, and temperature control modules are used based on the pid parameter from optimizing from whole
High accuracy temperature control can be realized by determining algorithm.The nano combined hemodialysis membrane of thin layer of the present invention has permanent hydrophilic, low
The characteristics of protein adsorption and excellent biocompatibility；The nano combined hemodialysis membrane of thin layer of the present invention has Thief zone
Property, high separability energy have resistance tocrocking and anticoagulant property again.
Description of the drawings
Fig. 1 is that the present invention implements the nano-magnetic hemodialysis membrane provided and preparation method thereof flow chart.
Fig. 2 is that the present invention implements the nano-magnetic hemodialysis membrane provided and its preparation system structure diagram.
In Fig. 2：1, time control module；2, temperature control modules；3, main control module；4, sorting module；5, module is fused；
6, modification module；7, mixing module.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Below in conjunction with the accompanying drawings and specific embodiment is further described the application principle of the present invention.
As shown in Figure 1, a kind of nano-magnetic hemodialysis membrane provided by the invention and preparation method thereof includes the following steps：
Step S101 controls the time for preparing reaction by time control module；By temperature control modules system
Standby temperature is controlled；
Step S102, main control module scheduling sorting module selection polyacrylonitrile is 100 parts, glass fibre is 30 parts, N- ammonia
Ethyl piperazidine is 5 parts, zinc dimethyl dithiocarbamate is 3 parts, methacryloxypropyl trimethoxy silane 3
Part, acrylonitrile-butadiene-styrene copolymer are 13 parts, benzoyl peroxide is that 2 parts of mixing generate modified modified polypropenes
Nitrile；
Polyacrylonitrile (PAN) is dissolved in organic solvent by fused module and obtains PAN solution by step S103, electrostatic spinning,
Obtain supporting layer of the nanofiber as composite membrane；Wherein the mass fraction of polyacrylonitrile (PAN) solution is 10%-20%；
Sodium hydrogen is added into PVAC polyvinylalcohol solution by modification module by step S104, is then added 1, in 3-N-morpholinopropanesulfonic acid
Ester, 45-80 DEG C of reaction 10-24h, is filtered, dry, obtains the polyvinyl alcohol s-PVA of heparan modification；
Step S105, the polyvinyl alcohol and polyvinyl alcohol blending for being modified heparan by mixing module are added solvent, match
The coating liquid of a concentration of 0.2-10wt% is made, adjusts pH to 1~2, crosslinking agent is added, is crosslinked 19~20min, is then coated with
On supporting layer, Room-temperature seal obtains nano combined hemodialysis membrane.
The molar ratio of sodium hydrogen and polyvinyl alcohol provided by the invention is 1：5~1:1；1,3- propane sultones and polyvinyl alcohol
Molar ratio be 1：5~1:1.
The mass ratio of polyvinyl alcohol and polyvinyl alcohol that heparan provided by the invention is modified is 1：1~1：4.
Solvent is N,N-dimethylformamide DMF in step S103 provided by the invention.
The technological parameter of electrostatic spinning is in step S103 provided by the invention：Voltage is 18~24kV, and solution promotes speed
Rate is 17~20 μ L/min, and it is 16~30cm to receive distance.
As shown in Fig. 2, nano-magnetic hemodialysis membrane provided by the invention and its preparation system include：Time control module
1, temperature control modules 2, main control module 3, sorting module 4, fused module 5, modification module 6, mixing module 7.
Time control module 1 is connect with main control module 3, for controlling the time for preparing reaction；
Temperature control modules 2 are connect with main control module 3, are controlled for the temperature to preparation；
Main control module 3, with time control module 1, temperature control modules 2, sorting module 4, fused module 5, modification module
6, mixing module 7 connects, for dispatching modules normal work；
Sorting module 4 is connect with main control module 3, is 100 parts for choosing polyacrylonitrile, glass fibre is 30 parts, N- ammonia
Ethyl piperazidine is 5 parts, zinc dimethyl dithiocarbamate is 3 parts, methacryloxypropyl trimethoxy silane 3
Part, acrylonitrile-butadiene-styrene copolymer are 13 parts, benzoyl peroxide is that 2 parts of mixing generate modified modified polypropenes
Nitrile；
Fused module 5, connect with main control module 3, PAN solution is obtained for polyacrylonitrile (PAN) to be dissolved in organic solvent,
Electrostatic spinning obtains supporting layer of the nanofiber as composite membrane；Wherein the mass fraction of polyacrylonitrile (PAN) solution is 10%-
20%；
Modification module 6 is connect with main control module 3, for the addition sodium hydrogen into PVAC polyvinylalcohol solution, is then added 1,
3-N-morpholinopropanesulfonic acid lactone, 45-80 DEG C of reaction 10-24h, is filtered, dry, obtains the polyvinyl alcohol s-PVA of heparan modification；
Mixing module 7 is connect with main control module 3, and polyvinyl alcohol and polyvinyl alcohol blending for heparan to be modified add
Enter solvent, be configured to the coating liquid of a concentration of 0.2-10wt%, adjust pH to 1~2, crosslinking agent is added, is crosslinked 19~20min,
It is then coated on supporting layer, Room-temperature seal, obtains nano combined hemodialysis membrane.
The time control module uses timing-optimal control algorithm, to nonlinear system
It finds one and allows dominant vector u (t) ∈ Rr, meet
|uj(t) |≤1, (j=1,2 ..., r) (2)
Make system from x (t0)=x0It sets out, in a certain final states moment T>t0Reach object set g (x (T), T) (g ∈ Rp), and
Make performance indicator
Ham ilton functions can be written to system (1) by maximal principle in minimum
H (x, u, λ, t)=1+ λ τ f (x, t)+λ τ B (x, t) u. (4)
Enable q (t)=Bτ(x, t) λ, i.e.,Wherein bjBe matrix B arrange for j-th to
Amount, λ is undetermined multiplier function, obtains optimum control uj* (t) is qj(t) lower array function：
From formula (5), if qj(t) only in [t0, T] limited a isolated point on be zero, then optimum control component u*j (t)
It is a piecewise constant function.
The temperature control modules are used based on the pid parameter Self-tuning System algorithm from optimizing, are real using increment type PID
Existing high-precision control increases following improvement：
First, to reduce the High-frequency Interference caused by sampling with differential, digital filtering is introduced in this algorithm, to make
Degree of regulation higher, digital filtering have different methods, and what this algorithm was taken is first order filtering；
First order filtering method is exactly a kind of dynamic filter method for realizing RC low-pass filters in digital form, to one
RC low-pass filters, transmission function are：L (s)=1/ (τ s+1) wherein τ=RC is filter time constant, and the formula is discrete
Change can obtain：
e′k=α e ' k | -1+ (1- α) ek (1)
In formula：α=τ/(τ+T)；T is the sampling period；ekThe input of filter when being sampled for kth time；e′kFor kth time sampling
When filter output；e′K-1For the sampling of kth -1 time when filter output；Using equation (1) to deviation signal ekIt is repaiied
Just, then by revised deviation e 'kAs the deviation signal of kth time sampling instant, substitutes into PID formulas and calculated, just
Reduce influence of the High-frequency Interference to digital IIR filters formula；
Secondly, to reduce the overshoot caused by integral action, stable state accuracy is improved, this algorithm uses integral separation
Pid algorithm；For reduce because be manually entered and foreign impacts interference caused by vibrate, this algorithm adds amplitude limiting processing, that is, works as | e |
>ε, then Δ U=λ, the maximum fluctuation value that λ allows for you；
The threshold value △ e of one position of set-up of control system control, computer to the error e that is obtained after data processing into
Row judges, specific as follows：
If ε >=| e |>△ e carry out PD control, improve the dynamic characteristic of control,
When | e |<When △ e, PID control is carried out, ensures control accuracy, when | e |>When ε, Δ U=λ (constant).
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (8)
1. a kind of nano-magnetic hemodialysis membrane preparation system, which is characterized in that the nano-magnetic haemodialysis film preparation system
System includes：
Time control module, temperature control modules, main control module, sorting module, fused module, modification module, mixing module；
Time control module is connect with main control module, for controlling the time for preparing reaction；
Temperature control modules are connect with main control module, are controlled for the temperature to preparation；
Main control module is connect with time control module, temperature control modules, for dispatching modules normal work；
Sorting module, for choosing polyacrylonitrile be 100 parts, glass fibre is 30 parts, N- aminoethyl piperazines are 5 parts, dimethyl
Zinc dithiocarbamate is 3 parts, methacryloxypropyl trimethoxy silane is 3 parts, acrylonitrile-butadiene-benzene second
Alkene copolymer is 13 parts, benzoyl peroxide is that 2 parts of mixing generate modified modified polyacrylonitrile；
Fused module, obtains PAN solution, electrostatic spinning obtains nanofiber for polyacrylonitrile (PAN) to be dissolved in organic solvent
Supporting layer as composite membrane；Wherein the mass fraction of polyacrylonitrile (PAN) solution is 10%-20%；
Then for sodium hydrogen to be added into PVAC polyvinylalcohol solution 1,3-propane sultone is added, 45-80 DEG C anti-in modification module
10-24h is answered, is filtered, it is dry, obtain the polyvinyl alcohol s-PVA of heparan modification；
Mixing module, polyvinyl alcohol and polyvinyl alcohol blending for heparan to be modified are added solvent, are configured to a concentration of
The coating liquid of 0.2-10wt% adjusts pH to 1~2, and crosslinking agent is added, and is crosslinked 19~20min, is then coated on supporting layer,
Room-temperature seal obtains nano combined hemodialysis membrane.
2. nano-magnetic hemodialysis membrane preparation system as described in claim 1, which is characterized in that the time control module
Using timing-optimal control algorithm, to nonlinear system
It finds one and allows dominant vector u (t) ∈ Rr, meet
|uj(t) |≤1, (j=1,2 ..., r) (2)
Make system from x (t0)=x0It sets out, in a certain final states moment T>t0Reach object set g (x (T), T) (g ∈ Rp), and make performance
Index
Ham ilton functions can be written to system (1) by maximal principle in minimum
H (x, u, λ, t)=1+ λτF (x, t)+λτB (x, t) u (4)
Enable q (t)=Bτ(x, t) λ, i.e.,Wherein bjIt is j-th of column vector of matrix B, λ is undetermined
Multiplier function obtains optimum control uj* (t) is qj(t) lower array function：
From formula (5), if qj(t) only in [t0, T] limited a isolated point on be zero, then optimum control component u*j (t) is one
Piecewise constant function.
3. nano-magnetic hemodialysis membrane preparation system as described in claim 1, which is characterized in that the temperature control modules
Using based on the pid parameter Self-tuning System algorithm from optimizing, using increment type PID, following change is increased for realization high-precision control
Into：
First, to reduce the High-frequency Interference caused by sampling with differential, digital filtering is introduced in this algorithm, to make adjusting
Precision higher, digital filtering have different methods, and what this algorithm was taken is first order filtering；
First order filtering method is exactly a kind of dynamic filter method for realizing RC low-pass filters in digital form, low to a RC
Bandpass filter, transmission function are：L (s)=1/ (τ s+1) wherein τ=RC is filter time constant, can by the formula discretization
：
e′k=α e ' k | -1+ (1- α) ek (1)
In formula：α=τ/(τ+T)；T is the sampling period；ekThe input of filter when being sampled for kth time；e′kTo be filtered when kth time sampling
The output of wave device；e′K-1For the sampling of kth -1 time when filter output；Using equation (1) to deviation signal ekIt is modified,
Then by revised deviation e 'kAs the deviation signal of kth time sampling instant, substitutes into PID formulas and calculated, just reduced
Influence of the High-frequency Interference to digital IIR filters formula；
Secondly, to reduce the overshoot caused by integral action, stable state accuracy is improved, this algorithm uses integral separating PID calculation
Method；For reduce because be manually entered and foreign impacts interference caused by vibrate, this algorithm adds amplitude limiting processing, that is, works as | e |>ε, then
The maximum fluctuation value that Δ U=λ, λ allow for you；
The threshold value △ e of one position of set-up of control system control, computer sentence the error e obtained after data processing
It is disconnected, it is specific as follows：
If ε >=| e |>△ e carry out PD control, improve the dynamic characteristic of control,
When | e |<When △ e, PID control is carried out, ensures control accuracy, when | e |>When ε, Δ U=λ (constant).
4. a kind of nano-magnetic haemodialysis membrane preparation method includes the following steps：
Step 1 controls the time for preparing reaction by time control module；The temperature prepared by temperature control modules
Degree is controlled；
Step 2, main control module scheduling sorting module selection polyacrylonitrile is 100 parts, glass fibre is 30 parts, N- aminoethyl piperazines
Piperazine is 5 parts, zinc dimethyl dithiocarbamate is 3 parts, methacryloxypropyl trimethoxy silane is 3 parts, propylene
Nitrile-butadiene-styrene copolymer is 13 parts, benzoyl peroxide is that 2 parts of mixing generate modified modified polyacrylonitrile；
Polyacrylonitrile (PAN) is dissolved in organic solvent and obtains PAN solution by step 3, electrostatic spinning, obtains nanofiber as multiple
Close the supporting layer of film；Wherein the mass fraction of polyacrylonitrile (PAN) solution is 10%-20%；
Sodium hydrogen is added into PVAC polyvinylalcohol solution for step 4, and 1,3-propane sultone, 45-80 DEG C of reaction 10- is then added
For 24 hours, it filters, it is dry, obtain the polyvinyl alcohol s-PVA of heparan modification；
Step 5, the polyvinyl alcohol and polyvinyl alcohol blending that heparan is modified are added solvent, are configured to a concentration of 0.2-
The coating liquid of 10wt% adjusts pH to 1~2, and crosslinking agent is added, and is crosslinked 19~20min, is then coated on supporting layer, room temperature
Sealing, obtains nano combined hemodialysis membrane.
5. nano-magnetic hemodialysis membrane as claimed in claim 2 and preparation method thereof, which is characterized in that the sodium hydrogen with it is poly-
The molar ratio of vinyl alcohol is 1：5~1:1；The molar ratio of 1,3- propane sultones and polyvinyl alcohol is 1：5~1：1.
6. nano-magnetic haemodialysis membrane preparation method as claimed in claim 2, which is characterized in that the heparan was modified
The mass ratio of polyvinyl alcohol and polyvinyl alcohol is 1：1~1：4.
7. nano-magnetic haemodialysis membrane preparation method as claimed in claim 2, which is characterized in that organic in the step 3
Solvent is N,N-dimethylformamide DMF.
8. nano-magnetic haemodialysis membrane preparation method as claimed in claim 2, which is characterized in that electrostatic in the step 3
The technological parameter of spinning is：Voltage is 18~24kV, and it is 17~20 μ L/min that solution, which promotes rate, receive distance for 16~
30cm。
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