CN108478940A - The system for carrying out tumour radiotherapy based on heavy ion cyclotron - Google Patents
The system for carrying out tumour radiotherapy based on heavy ion cyclotron Download PDFInfo
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- CN108478940A CN108478940A CN201810404568.8A CN201810404568A CN108478940A CN 108478940 A CN108478940 A CN 108478940A CN 201810404568 A CN201810404568 A CN 201810404568A CN 108478940 A CN108478940 A CN 108478940A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
- A61N5/1065—Beam adjustment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Radiation-Therapy Devices (AREA)
Abstract
The present invention discloses a kind of system carrying out tumour radiotherapy based on heavy ion cyclotron, including heavy ion avcceleration system, energy selection system, beam guide, fixation for treatment chamber system;The heavy ion beam that the heavy ion avcceleration system generates, its beam energy is adjusted according to treatment energy demand by energy selection system, and expands to the size for the treatment of in-vivo tumour, then is transferred to arbitrary subsystem under fixation for treatment chamber system through beam guide.The present invention operates its heavy ion avcceleration system, energy selection system, beam guide and the completion of fixation for treatment chamber system to the conformal therapy of tumour by heavy particle therapy planning system, keeps treatment more effective and reduces side effect.It is an advantage of the invention that beam intensity is big, and it is compact-sized, while effectively treatment tumour, system manufacturing cost and installation space are reduced to the greatest extent, to reduce treatment cost.
Description
Technical field
The invention belongs to medical domain, be related to a kind of be based on what heavy ion cyclotron carried out tumour radiotherapy
System.
Background technology
Malignant tumour is always one of the threat of human life and health most serious, X-ray used in traditional radiation therapy
Equal photon beams will inevitably be damaged to the normal structure of tumor vicinity in irradiation, not only since its physical dosage is distributed
Side effect is caused, also usually radiological dose is limited and reduces cure rate.And the heavy ion suitable for tumour radiotherapy has
Bragg peak physical characteristic identical with proton while killing cancer cell, is effectively protected the normal structure of patient's body.
In bragg peak end, relative biological effectiveness (RBE) reaches peak, and with bragg peak dramatic decrease.In addition heavy ion has
There are double-strand DSB functions, biological effect ratio X-ray and proton to be higher by 2-3 times, in addition proton and X camera shootings are to weary oxygen cancer cell
Therapeutic effect is poor, and heavy ion has smaller oxygen enhancement ratio (OER), can kill weary oxygen cancer cell, therapeutic effect is more excellent.
Although the superiority of heavy particle therapy has obtained the approval in the world, the heavy particle therapy system in current China is main
From foreign countries' introduction, core technology relies on foreign countries, and buying and maintenance cost are very high, and builds great difficulty there are three therapeutic communities
Point:Cost is extremely expensive, and floor space is wide, and building time is long.These difficult points cause final medical expense high, and Most patients are all
It can not undertake, thus heavy ion is difficult to universal for the cause of oncotherapy and is promoted.
Under existing situation, the core technology of heavy particle therapy is grasped, it is to promote heavy particle therapy system to reduce treatment cost
The most important thing.
Application number CN201710948544.4 discloses a kind of Proton therapy system based on compact superconducting cyclotron,
It is controlled including superconducting cyclotron system, energy selection system, beam guide, fixation for treatment room subsystem and rotary frame
Treat subsystem;The Proton therapy system system is treated using proton, has 2 therapeutic rooms:Rotation+fixed, it controls
The energy intensity maximum 200Mev for the treatment of.
Invention content
The purpose of the present invention is to provide a kind of systems carrying out tumour radiotherapy based on heavy ion cyclotron, can
To realize that the core technology country researches and develops, it is 80MeV to 400MeV to be continuously adjusted proton beam energy range, have it is compact-sized,
The advantages such as floor space is small, side effect is low.
The purpose of the present invention can be achieved through the following technical solutions:
Based on the system that heavy ion cyclotron carries out tumour radiotherapy, including heavy ion avcceleration system, energy
Selection system, beam guide, fixation for treatment chamber system;The heavy ion beam that the heavy ion avcceleration system generates, according to
Treatment energy demand adjusts its beam energy by energy selection system, and expands to the size for the treatment of in-vivo tumour, then through line
Transport system is transferred to arbitrary subsystem under fixation for treatment chamber system.
The heavy ion avcceleration system, which generates, is treating the line that internal range depth is 3.5cm-30cm.
The beam intensity range that the energy selection system is adjusted is 80MeV to 400MeV.
Fixing bundle stream is carried out three angular deflections transmission by the beam guide, respectively 90 ° fixed lines, 45 °
Fixed line and horizontal fixed line.
The fixation for treatment chamber system includes 90 ° of fixation for treatment rooms, 45 ° of fixation for treatment rooms, horizontal fixation for treatment room, is realized
90 °, 45 ° and the horizontal treatment for fixing line;The fixation for treatment chamber system is treated for single chamber, using fixation for treatment room.
Heavy ion avcceleration system includes ion source unit, center, the first magnet unit, radio frequency unit, line extraction
Unit, the first beam survey unit and vacuum unit;Wherein, ion source unit uses ecr ion source, and ion source head is along iron yoke and lid
Center is pierced at plate center;The heavy ion that ion source generates is drawn and accelerates the preferable heavy ion beam of quality in center;First
Magnet unit attach most importance to ion acceleration process provide magnetic field environment;Radio frequency unit includes radio frequency cavity and radio frequency source, is provided continuous steady
Fixed high frequency accelerating potential provides current field condition for the accelerator of heavy ion;Line draws the electrostatic deflection plates of unit by line
Deviate out of accelerator running track and draws;First beam surveys unit and uses matter bar probe and bend probe, to the quality of line
And intensity measures;Vacuum unit includes vacuum pump, Roots's dry pump, and the operation for entire accelerator provides high vacuum environment.
Energy selection system includes degrader system, the second beam survey unit and line expanding element, limits slit unit, will
The heavy ion that accelerator is drawn is adjusted to the required energy in each therapeutic room's treatment head inlet, and is adjusted according to Treatment need
The dispersion parameters of beam center, beam cross section, analyzer, line energy spread and Annual distribution and line.
Beam guide includes that the second magnet unit, line blocking unit and third beam survey unit, is responsible for have accorded with
The treatment port of the beam steering fixed angle of conjunction demand, and line is started or stoped according to the signal of control system at any time.
Beneficial effects of the present invention:
1. the treatment system of the present invention for carrying out oncotherapy based on heavy ion is compact-sized, floor space is small, subtracts
Lack volume and expense, reduces cost, and improve efficiency of service;
2. the treatment system of the present invention for carrying out oncotherapy based on heavy ion has energy selection system, beam is adjusted
Stream energy intensity realizes precisely treatment, improves the effect for the treatment of;
3. present invention employs advanced Cryogenics, high energy consumption and high the problem of radiating are reduced, beam is improved
Flow the efficiency accelerated in accelerator;Fixation for treatment chamber system of the present invention point three different orientation treatment (90 degree, 45 degree and water
It is flat);
The terminal that the present invention is drawn in line uses beam loading, for absorbing and stopping line, reduces to surrounding people
With the radiation injury of environment.
Description of the drawings
In order to facilitate the understanding of those skilled in the art, the present invention will be further described below with reference to the drawings.
Fig. 1 is that the present invention is based on the layouts of the system of heavy ion cyclotron progress tumour radiotherapy;
Wherein:1, heavy ion avcceleration system;2, energy selection system;3, beam guide;4,90 ° of fixation for treatment
Room;5,45 ° of fixation for treatment rooms;6, horizontal fixation for treatment room.
Specific implementation mode
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Based on the system that heavy ion cyclotron carries out tumour radiotherapy, as shown in Figure 1, including heavy ion avcceleration
System 1, energy selection system 2, beam guide 3, fixation for treatment chamber system.The heavy ion beam of heavy ion avcceleration system,
Powerful beam energy is drawn according to treatment energy demand, energy selection system adjusts energy range in 80MeV to 400MeV's
Heavy ion beam energy, and the size for the treatment of in-vivo tumour is expanded to, then it is transferred to lower of fixation for treatment room through beam guide
Subsystem of anticipating is used for the conformal therapy to tumour.
During actual implementation, heavy ion avcceleration system 1 can occur in the internal range depth for the treatment of and be
The heavy ion beam of 3.5cm-30cm comprising ion source unit, center, the first magnet unit, radio frequency unit, line draw list
Member, the first beam survey unit and vacuum unit;
Wherein, ion source unit uses ecr ion source, ion source head to pierce into center along iron yoke and cover plate central, props up
Support system auxiliary adjustment ion source position and depth;Center can by ion source generate heavy ion draw and accelerate quality compared with
Good heavy ion beam;First magnet unit includes superconducting magnet, magnetic pole, iron yoke and iron yoke cover board, and ion acceleration of attaching most importance to process carries
For magnetic field environment;Radio frequency unit includes radio frequency cavity and radio frequency source, can provide the high frequency accelerating potential of continuous-stable, attach most importance to from
The accelerator of son provides current field condition;The electrostatic deflection plates that line draws unit can be inclined out of accelerator running track by line
From extraction;First beam surveys unit and uses matter bar probe and bend probe, is measured to the quality and intensity of line;Vacuum unit
Including vacuum pump, Roots's dry pump etc., the operation for entire accelerator provides high vacuum environment, to reduce energy loss, improves
Operational efficiency.
During actual implementation, energy selection system 2 includes degrader system, the second beam surveys unit and line extends
Unit, limitation slit unit, the required energy in each therapeutic room's treatment head inlet is adjusted to by the heavy ion that accelerator is drawn
Amount, and beam center, beam cross section, analyzer, line energy spread and Annual distribution and line are adjusted according to Treatment need
The parameters such as dispersion.
During actual implementation, beam guide 3 includes the second magnet unit, line blocking unit and third
Beam surveys unit, is responsible for the treatment port for the beam steering fixed angle for having met demand, and can be according to control system
Signal start or stop line at any time.Fixing bundle stream can be carried out three angular deflection transmission by beam guide, respectively
For 90 ° of fixed lines, 45 ° of fixed lines and horizontal fixed line.
During actual implementation, fixation for treatment chamber system includes 90 ° of 4,45 ° of fixation for treatment rooms fixation for treatment room 5, water
The treatment of 90 °, 45 ° and horizontal fixed line may be implemented in flat fixation for treatment room 6.It treats chamber system to treat for single chamber, using solid
Determine therapeutic room.
Each system cooperates, and is controlled by heavy particle therapy planning system, to meet all kinds of oncotherapy need
It asks.
It is embodied in:Ecr ion source in heavy ion avcceleration system 1 makes neutral atom or molecular ionization generate thin
The electrostatic deflection plates of pencil-shaped heavy ion beam, center draw line from ion source, and make line from low-energy state transition
To the conventional acceleration mode with MeV magnitude energy.Then the line with conventional speeds enters magnet unit, in magnet list
It is moved according to the beam path of physical Design in the magnetic field of member.Under the electric field action of high frequency unit, line starts to do convolution fortune
Dynamic, often moving a circle will be accelerated several times, and energy is continuously increased and moving radius constantly increases.Energy reaches peak
Line can move to outmost turns, be drawn out to outside accelerator by the electrostatic deflection plates of line extraction system.Beam in accelerator
The relative positional accuracy of flow center is less than 1mm, and the dosage control accuracy each put is better than the 1% of mean dose.
The line drawn from superconducting cyclotron, into energy selection system.Intensity is obtained after degrader to exist
Line between 80MeV to 400MeV is then adjusted control to the energy spread of line by limiting slit, finally meets and control
The line for the treatment of demand enters Beam Transport Systems.It is mounted with several blocks of focus magnets in Beam Transport Systems, keeps line
Focus on transmission in pipeline.According to the signal of control system, fixing bundle flow through overshoot magnet to 90 ° of directions or 45 ° of directions or
Horizontal direction into horizontal deflection with transport, line is transported to final fixation for treatment port by guidance magnets again.
In order to ensure that when causing danger, can rapidly switch off line, system is set altogether there are five line block device, first
At the stream outlet of superconducting cyclotron, it can be ensured that block the line of accelerator generation immediately when causing danger
Transmission.Other 3 line block devices are located on the beam transport line in three directions in fixation for treatment room, are provided a system to multiple
Line tripping protection, it is ensured that patient and staff escape injury.
The present invention operates its heavy ion avcceleration system, energy selection system, line by heavy particle therapy planning system
Transport system and fixation for treatment chamber system complete the conformal therapy to tumour, keep treatment more effective and reduce side effect.The present invention
The advantages of be that beam intensity is big, it is compact-sized, effectively treatment tumour while, to the greatest extent reduce system manufacturing cost
And installation space, to reduce treatment cost.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to preferably explain the present invention
Principle and practical application, to enable skilled artisan to be best understood by and utilize the present invention.The present invention is only
It is limited by claims and its full scope and equivalent.
Claims (8)
1. the system for carrying out tumour radiotherapy based on heavy ion cyclotron, which is characterized in that including heavy ion avcceleration
System, energy selection system, beam guide, fixation for treatment chamber system;The weight that the heavy ion avcceleration system generates from
Beamlet adjusts its beam energy according to treatment energy demand by energy selection system, and expands to the size for the treatment of in-vivo tumour,
Again arbitrary subsystem under fixation for treatment chamber system is transferred to through beam guide.
2. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, feature exist
In the heavy ion avcceleration system, which generates, is treating the line that internal range depth is 3.5cm-30cm.
3. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, feature exist
In the beam intensity range that the energy selection system is adjusted is 80MeV to 400MeV.
4. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, feature exist
In fixing bundle stream is carried out three angular deflections and transmitted by the beam guide, respectively 90 ° fixed lines, 45 ° of fixing bundles
Stream and horizontal fixed line.
5. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, feature exist
Include 90 ° of fixation for treatment rooms, 45 ° of fixation for treatment rooms, horizontal fixation for treatment room in, the fixation for treatment chamber system, realize 90 °,
45 ° and the horizontal treatment for fixing line;The fixation for treatment chamber system is treated for single chamber, using fixation for treatment room.
6. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, heavy ion add
Fast device system includes ion source unit, center, the first magnet unit, radio frequency unit, line draws unit, the first beam surveys unit
And vacuum unit;
Wherein, ion source unit uses ecr ion source, and center is pierced into ion source head along iron yoke and cover plate central;Center
The heavy ion that ion source generates is drawn and accelerates the preferable heavy ion beam of quality;First magnet unit is attached most importance to ion acceleration process
Magnetic field environment is provided;Radio frequency unit includes radio frequency cavity and radio frequency source, provides the high frequency accelerating potential of continuous-stable, is heavy ion
Accelerator provide current field condition;The electrostatic deflection plates of line extraction unit deviate line out of accelerator running track draws
Go out;First beam surveys unit and uses matter bar probe and bend probe, is measured to the quality and intensity of line;Vacuum unit includes
Vacuum pump, Roots's dry pump, the operation for entire accelerator provide high vacuum environment.
7. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, energy selection
System includes that degrader system, the second beam survey unit and line expanding element, limitation slit unit, the weight that accelerator is drawn from
Son is adjusted to the required energy in each therapeutic room's treatment head inlet, and adjusts beam center, line section according to Treatment need
Face, analyzer, line energy spread and Annual distribution and line dispersion parameters.
8. the system according to claim 1 for carrying out tumour radiotherapy based on heavy ion cyclotron, beam transport
System includes that the second magnet unit, line blocking unit and third beam survey unit, is responsible for that the beam steering of demand will have been met
The treatment port of fixed angle, and line is started or stoped according to the signal of control system at any time.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111408070A (en) * | 2020-03-30 | 2020-07-14 | 合肥中科离子医学技术装备有限公司 | Multi-ion treatment system based on isochronous cyclotron |
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2018
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JPH10106800A (en) * | 1996-09-25 | 1998-04-24 | Hitachi Ltd | Charged particle beam irradiation device |
CN101023715A (en) * | 2004-06-16 | 2007-08-22 | 重离子研究有限公司 | Particle accelerator for radiotherapy by means of ion beams |
CN101537232A (en) * | 2007-05-02 | 2009-09-23 | 西门子公司 | Particle therapy device |
JP2013055989A (en) * | 2011-09-07 | 2013-03-28 | Sumitomo Heavy Ind Ltd | Charged particle radiation irradiation apparatus |
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CN111408070A (en) * | 2020-03-30 | 2020-07-14 | 合肥中科离子医学技术装备有限公司 | Multi-ion treatment system based on isochronous cyclotron |
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