CN108478793A - A kind of stannous sulfide nanometer light thermit powder and preparation method thereof - Google Patents
A kind of stannous sulfide nanometer light thermit powder and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of stannous sulfide nanometer light thermit powders, including stannous sulfide quantum dot.The stannous sulfide nanometer light thermit powder photo-thermal effect is apparent, and chemical stability is high, and toxicity is low, abundant raw material, cheap, and preparation method is simple, has broad application prospects in photo-thermal therapy field.The present invention also provides the preparation methods of the stannous sulfide nanometer light thermit powder.The preparation method includes:After sixty minutes by stannous sulfide block grinding 20, it is scattered in organic solvent, obtains dispersion liquid;By the dispersion liquid in 5 DEG C of 10 DEG C of water bath sonicators 8 12 hours, the dispersion liquid after ultrasound is obtained;After the dispersion liquid centrifugation after ultrasound, precipitation is collected, drying obtains stannous sulfide quantum dot.The preparation method, raw material are easy to get, and preparation process is simple, it is easy to accomplish large-scale production.
Description
Technical field
The present invention relates to nanometer light thermit powder technical fields, more particularly to a kind of stannous sulfide nanometer light thermit powder and its preparation
Method.
Background technology
In recent years, photo-thermal therapy mainly utilizes light as a kind of novel cancer therapy by people's extensive concern
Thermit powder generates localized hyperthermia to kill cancer cell under the irradiation of 808nm laser, and Small side effects are efficient.
Currently, it includes the noble metals such as gold, silver, platinum, graphene, graphene oxide, carbon nano rod to study more light thermit powder
Etc. Carbon materials.But these light thermit powders, all there is respective deficiency, the photo-thermal property of the noble metals such as gold is mainly derived from table
Surface plasma resonance effect, and this effect is by the dielectric constant of the surface topography of nanostructure, size and surrounding medium
Influence it is very big, lead to the actual photo-thermal therapy effect unobvious of noble metal light thermit powder;In addition, expensive price also limit it is expensive
It applies in the market of metal light thermit powder.And then there is preparation process complexity for Carbon materials, it is more low scarce that 808nm locates absorptivity
Point.Thus, it is necessary to offer one kind is cheap, preparation method is simple, the apparent light thermit powder of photo-thermal effect is to push tumour light
The practical application of heat cure.
Invention content
In consideration of it, the present invention provides a kind of stannous sulfide nanometer light thermit powder, the stannous sulfide nanometer light thermit powder includes
Stannous sulfide quantum dot, the light thermit powder photo-thermal effect is apparent, and toxicity is low, and is easy from internal discharge, cheap, preparation process
Simply.
Specifically, in a first aspect, the present invention provides a kind of stannous sulfide nanometer light thermit powder, including stannous sulfide quantum
Point.
Wherein, the size of the stannous sulfide quantum dot is less than nm.The Assurance of Size stannous sulfide nanometer light of quantum dot
Thermit powder has preferable passive concentration effect in tumor locus.It avoids oversized light thermit powder being caused to cannot be introduced into tumor locus.
Wherein, the stannous sulfide nanometer light thermit powder further includes being coated on the poly- second two of the stannous sulfide quantum dot surface
Alcohol.
Wherein, the mass ratio of the stannous sulfide quantum dot and the polyethylene glycol is 1:0.5-1:10.
Wherein, the polyethylene glycol is adsorbed on the stannous sulfide quantum dot surface, the poly- second two by electrostatic attraction
The weight average molecular weight of alcohol is 2000-30000.
Coated with polyethylene glycol can improve the biocompatibility and stability of stannous sulfide quantum dot, improve it in water
Dispersibility.
The stannous sulfide nanometer light thermit powder that first aspect present invention provides, photo-thermal effect is apparent, and chemical stability is high, toxicity
Low, abundant raw material is cheap, has broad application prospects in photo-thermal therapy field.
Second aspect, the present invention provides a kind of preparation methods of stannous sulfide nanometer light thermit powder, include the following steps:
After stannous sulfide block is ground 20-60 minutes, it is scattered in organic solvent, obtains dispersion liquid;
By the dispersion liquid in 5 DEG C of -10 DEG C of water bath sonicators 8-12 hours, the dispersion liquid after ultrasound is obtained;
After the dispersion liquid centrifugation after ultrasound, precipitation is collected, drying obtains stannous sulfide quantum dot.
Wherein, the organic solvent includes one or both of isopropanol and N-methyl pyrrolidones, the dispersion liquid
The mass concentration of middle stannous sulfide is 0.5-5mg/mL.
Wherein, before the water bath sonicator, the dispersion liquid is first used into Probe Ultrasonic Searching 4-8 hours, the probe is super
The probe power of sound is 150-600w.
Wherein, by described after ultrasound dispersion liquid centrifugation concrete operations be:By the dispersion liquid after ultrasound with
13000-16000 revs/min of rotating speed centrifuges 0.5-1h, takes supernatant, then turn the supernatant with 17000-25000/
The rotating speed of minute centrifuges 0.5-1h, collects precipitation.
Wherein, the preparation method of the stannous sulfide nanometer light thermit powder further comprises:By the stannous sulfide quantum
Point is dispersed in water, and obtains the aqueous dispersions of stannous sulfide quantum dot, then polyethylene glycol is added into the aqueous dispersions, is stirred
10-16 hours, precipitation is collected by centrifugation to get to stannous sulfide nanometer light thermit powder, the stannous sulfide nanometer light thermit powder includes sulphur
Change stannous quantum dot, and is coated on the polyethylene glycol of the stannous sulfide quantum dot surface.
The preparation method for the stannous sulfide nanometer light thermit powder that second aspect of the present invention provides, raw material are easy to get, preparation process letter
It is single, it is easy to accomplish large-scale production.
Advantages of the present invention will be illustrated partly in the following description, and a part is apparent according to specification
, or can be through the embodiment of the present invention implementation and know.
Description of the drawings
Fig. 1 is the electron microscope for the stannous sulfide quantum dot that the embodiment of the present invention 1 is prepared;
Fig. 2 is that the photo-thermal effect of the stannous sulfide nanometer light thermit powder of the embodiment of the present invention 1 measures heating curve figure;
Fig. 3 is the In vitro cell experiment result figure of the stannous sulfide nanometer light thermit powder of the embodiment of the present invention 1;
Fig. 4 is the internal cell experiment result figure of the stannous sulfide nanometer light thermit powder of the embodiment of the present invention 1.
Specific implementation mode
As described below is the preferred embodiment of the embodiment of the present invention, it is noted that for the common skill of the art
For art personnel, under the premise of not departing from principle of the embodiment of the present invention, several improvements and modifications can also be made, these improvement
The protection domain of the embodiment of the present invention is also considered as with retouching.
Embodiment of the present invention first aspect provides a kind of stannous sulfide nanometer light thermit powder, including stannous sulfide quantum
Point.
In embodiment of the present invention, the size of the stannous sulfide quantum dot is less than 10nm.Optionally, the stannous sulfide
The size of quantum dot is 1-10nm.Still optionally further, the size of the stannous sulfide quantum dot is 1-5nm.It is further optional
The size on ground, the stannous sulfide quantum dot is 5-10nm.Still optionally further, the size of the stannous sulfide quantum dot is
1nm, 2nm, 3nm, 4nm, 5nm, 6nm, 7nm, 8nm, 9nm or 10nm.Optionally, not to the number of plies of the stannous sulfide quantum dot
It does specifically limited.
The stannous sulfide quantum dot light thermal effect that embodiment of the present invention provides is apparent;Grain size is smaller simultaneously, quantum
Promise stannous sulfide nanometer light thermit powder has preferable passive concentration effect in tumor locus.It avoids oversized leading to photo-thermal
Agent cannot be introduced into tumor locus.And be easy from internal discharge, biocompatibility is good.
In embodiment of the present invention, the stannous sulfide nanometer light thermit powder further includes being coated on the stannous sulfide quantum dot
The polyethylene glycol on surface.
In embodiment of the present invention, the mass ratio of the stannous sulfide quantum dot and the polyethylene glycol is 1:0.5-1:
10.Optionally, the mass ratio of the stannous sulfide quantum dot and the polyethylene glycol is 1:0.5-1:5.Optionally, the vulcanization
The mass ratio of stannous quantum dot and the polyethylene glycol is 1:5-1:10.Optionally, the stannous sulfide quantum dot gathers with described
The mass ratio of ethylene glycol is 1:0.5、1:1、1:1.5、1:2、1:2.5、1:3、1:3.5、1:4、1:4.5、1:5、1:5.5、1:6、
1:6.5、1:7、1:7.5、1:8、1:8.5、1:9、1:9.5 or 1:10.
In embodiment of the present invention, the polyethylene glycol is adsorbed on the stannous sulfide quantum dot table by electrostatic attraction
The weight average molecular weight in face, the polyethylene glycol is 2000-30000.Optionally, the polyethylene glycol includes methyl polyethylene glycol
(CH3-PEG-NH2), methoxy poly (ethylene glycol) (CH3O-PEG-NH2, referred to as mPEG-NH2) and polyethylene glycol diamines (NH2-
PEG-NH2At least one of).
The stannous sulfide nanometer light thermit powder that first aspect present invention provides, photo-thermal effect is apparent, and chemical stability is high, toxicity
Low, abundant raw material is cheap, has broad application prospects in photo-thermal therapy field.
Embodiment of the present invention second aspect provides a kind of preparation method of stannous sulfide nanometer light thermit powder, including following
Step:
After stannous sulfide block is ground 20-60 minutes, it is scattered in organic solvent, obtains dispersion liquid;
By the dispersion liquid in 5 DEG C of -10 DEG C of water bath sonicators 8-12 hours, the dispersion liquid after ultrasound is obtained;
After the dispersion liquid centrifugation after ultrasound, precipitation is collected, drying obtains stannous sulfide quantum dot.
In embodiment of the present invention, by the dispersion liquid in 10 DEG C of water bath sonicators 8-12 hours.
In embodiment of the present invention, the organic solvent includes isopropanol and one kind in N-methyl pyrrolidones or two
Kind, the mass concentration of stannous sulfide is 0.5-5mg/mL in the dispersion liquid, i.e., after the grinding of stannous sulfide block, is scattered in organic
The mass concentration of stannous sulfide is 0.5-5mg/mL in the dispersion liquid that solvent is formed.
In embodiment of the present invention, the temperature of water bath sonicator is maintained at 5 DEG C -10 DEG C.Bath temperature is excessively high to be caused to vulcanize
Stannous quantum dot is degraded, and the temperature range that the present invention uses is easily achieved under the premise of ensureing material settling out, and operation difficulty is low.
It, can be by changing water or other cooling measures to ensure bath temperature in a certain range when bath temperature raising.
It is first that the dispersion liquid is small using Probe Ultrasonic Searching 4-8 before the water bath sonicator in embodiment of the present invention
When, the probe power of the Probe Ultrasonic Searching is 150-600w.Since Probe Ultrasonic Searching is direct to the effect of stannous sulfide material, to keep away
Exempt from stannous sulfide material degradation, it is 5-10 DEG C that temperature is kept during the Probe Ultrasonic Searching, when the temperature increases, ice bag can be used
Cool down.By the way that Probe Ultrasonic Searching is used in combination with water bath sonicator so that finally obtained stannous sulfide quantum dot size is more
Small, more uniform, the yield for obtaining the stannous sulfide quantum dot of required size is high.
In embodiment of the present invention, the concrete operations by the dispersion liquid centrifugation after ultrasound are:By described through ultrasound
Dispersion liquid afterwards centrifuges 0.5-1h with 13000-16000 revs/min of rotating speed, takes supernatant, then by the supernatant with
17000-25000 revs/min of rotating speed centrifuges 0.5-1h, collects precipitation.Optionally, the dispersion liquid by described after ultrasound with
15000 revs/min of rotating speed centrifuges 0.5-1h, takes supernatant, then by the supernatant with 20000 revs/min of rotating speed from
Heart 0.5-1h collects precipitation.The slow-speed of revolution centrifugation of the first step is to detach the larger-size part stannous sulfide amount of removal
Sub-, being centrifuged at a high speed for second step obtains the stannous sulfide quantum dot of required size.
In embodiment of the present invention, the drying operation can be carried out under vacuum room temperature.
In embodiment of the present invention, the preparation method of the stannous sulfide nanometer light thermit powder further comprises:It will be described
Stannous sulfide quantum dot is dispersed in water, and obtains the aqueous dispersions of stannous sulfide quantum dot, then be added into the aqueous dispersions
Polyethylene glycol stirs 10-16 hour, is collected by centrifugation and precipitates to get to stannous sulfide nanometer light thermit powder, the stannous sulfide nanometer
Light thermit powder includes stannous sulfide quantum dot, and is coated on the polyethylene glycol of the stannous sulfide quantum dot surface.Optionally, institute
The mass ratio for stating stannous sulfide quantum dot and the polyethylene glycol is 1:0.5-1:10.
In embodiment of the present invention, a concentration of 0.2-2mg/mL of the aqueous dispersions of the stannous sulfide quantum dot.
In embodiment of the present invention, after the completion of the stirring, 0.5- is centrifuged using 20000-25000 revs/min of rotating speed
1h obtains stannous sulfide nanometer light thermit powder.
The preparation method for the stannous sulfide nanometer light thermit powder that second aspect of the present invention provides, raw material is easy to get, manufacturing cost compared with
Low, preparation process is simple, it is easy to accomplish large-scale production.
Embodiment 1
A kind of preparation method of stannous sulfide nanometer light thermit powder, includes the following steps:
(1) it after grinding stannous sulfide block 30 minutes, is scattered in isopropanol, obtains the dispersion of a concentration of 1mg/mL
Liquid;
(2) above-mentioned dispersion liquid is used into Probe Ultrasonic Searching 5 hours, the probe power of Probe Ultrasonic Searching is 360w, Probe Ultrasonic Searching mistake
It is 5-10 DEG C that temperature is kept in journey, during which when the temperature increases, is cooled down using ice bag;
(3) again by dispersion liquid in water bath sonicator 8 hours, the dispersion liquid after ultrasound is obtained, the temperature of water bath sonicator is kept
At 5-10 DEG C;
(4) by after the dispersion liquid centrifugation after ultrasound, 0.5h is centrifuged with 15000 revs/min of rotating speed, takes supernatant, so
Supernatant is centrifuged into 0.5h with 20000 revs/min of rotating speed afterwards, collects precipitation, drying obtains stannous sulfide quantum dot;
(5) stannous sulfide quantum dot is dispersed in water, obtains the water of the stannous sulfide quantum dot of a concentration of 0.5mg/mL
Dispersion liquid, then polyethylene glycol diamines are added into aqueous dispersions, the mass ratio of stannous sulfide quantum dot and polyethylene glycol diamines is
1:0.5.After stirring 12 hours, 0.5h is centrifuged with 20000 revs/min of rotating speed, collects precipitation to get to stannous sulfide nanometer light
Thermit powder, stannous sulfide nanometer light thermit powder include stannous sulfide quantum dot, and are coated on the poly- second of stannous sulfide quantum dot surface
Two hydro diamines.
Fig. 1 is the electron microscope for the stannous sulfide quantum dot that the embodiment of the present invention 1 is prepared, it can be seen from the figure that institute
The size for obtaining stannous sulfide quantum dot is less than 10nm.
Embodiment 2
A kind of preparation method of stannous sulfide nanometer light thermit powder, includes the following steps:
(1) after forty minutes by the grinding of stannous sulfide block, it is scattered in N-methyl pyrrolidones, obtains a concentration of 1mg/mL
Dispersion liquid;
(2) above-mentioned dispersion liquid is used into Probe Ultrasonic Searching 8 hours, the probe power of Probe Ultrasonic Searching is 150w, Probe Ultrasonic Searching mistake
It is 10-10 DEG C that temperature is kept in journey, during which when the temperature increases, is cooled down using ice bag;
(3) again by dispersion liquid in water bath sonicator 12 hours, the dispersion liquid after ultrasound is obtained, the temperature of water bath sonicator is kept
At 5-10 DEG C;
(4) by after the dispersion liquid centrifugation after ultrasound, 1h is centrifuged with 13000 revs/min of rotating speed, takes supernatant, then
Supernatant is centrifuged into 1h with 18000 revs/min of rotating speed, collects precipitation, drying obtains stannous sulfide quantum dot;
(5) stannous sulfide quantum dot is dispersed in water, obtains the moisture of the stannous sulfide quantum dot of a concentration of 1mg/mL
Dispersion liquid, then polyethylene glycol diamines are added into aqueous dispersions, the mass ratio of stannous sulfide quantum dot and polyethylene glycol diamines is 1:
10.After stirring 16 hours, 0.5h is centrifuged with 25000 revs/min of rotating speed, collects precipitation to get to stannous sulfide nanometer photo-thermal
Agent, stannous sulfide nanometer light thermit powder include stannous sulfide quantum dot, and are coated on the poly- second two of stannous sulfide quantum dot surface
Hydro diamine.
Embodiment 3
A kind of preparation method of stannous sulfide nanometer light thermit powder, includes the following steps:
(1) after sixty minutes by the grinding of stannous sulfide block, it is scattered in isopropanol, obtains the dispersion of a concentration of 1mg/mL
Liquid;
(2) above-mentioned dispersion liquid is used into Probe Ultrasonic Searching 4 hours, the probe power of Probe Ultrasonic Searching is 600w, Probe Ultrasonic Searching mistake
It is 5-10 DEG C that temperature is kept in journey, during which when the temperature increases, is cooled down using ice bag;
(3) again by dispersion liquid in water bath sonicator 10 hours, the dispersion liquid after ultrasound is obtained, the temperature of water bath sonicator is kept
At 5-10 DEG C;
(4) by after the dispersion liquid centrifugation after ultrasound, 0.5h is centrifuged with 16000 revs/min of rotating speed, takes supernatant, so
Supernatant is centrifuged into 0.5h with 25000 revs/min of rotating speed afterwards, collects precipitation, drying obtains stannous sulfide quantum dot;
(5) stannous sulfide quantum dot is dispersed in water, obtains the moisture of the stannous sulfide quantum dot of a concentration of 2mg/mL
Dispersion liquid, then methoxy poly (ethylene glycol) is added into aqueous dispersions, the mass ratio of stannous sulfide quantum dot and methoxy poly (ethylene glycol)
It is 1:5.After stirring 10 hours, 0.5h is centrifuged with 22000 revs/min of rotating speed, collects precipitation to get to stannous sulfide nanometer light
Thermit powder, stannous sulfide nanometer light thermit powder includes stannous sulfide quantum dot, and is coated on the methoxy of stannous sulfide quantum dot surface
Base polyethylene glycol.
Effect example
Advantageous effect to be brought to technical solution of the embodiment of the present invention provides powerful support for, and provides following performance and surveys
Examination:
(1) photo-thermal effect measures
The stannous sulfide nanometer light thermit powder ultrasonic disperse that the embodiment of the present invention 1 is prepared obtains a concentration of in water
The stannous sulfide nanometer photo-thermal agent dispersing liquid of 0.1mg/mL, dispersion liquid is fitted into cuvette, uses power density for 1W/cm2,
Wavelength is the laser vertical irradiation cuvette of 808nm, and measures dispersion liquid temperature using infrared radiation thermometer, and irradiation is closed after ten minutes
Laser Power Devices are closed, are cooled down 10 minutes, recycles 6 times, obtains heating-temperature lowering curve as shown in Figure 2.Heating-cooling from Fig. 2 is bent
Line can know that the stannous sulfide nanometer light thermit powder of the embodiment of the present invention has good photo-thermal effect.
(2) In vitro cell experiment
Using the culture medium dispersion liquid of various concentration (0ppm, 25ppm, 50ppm, 100ppm) stannous sulfide nanometer light thermit powder
Cancer cell is cultivated, and uses power density for 1W/cm2, wavelength is the laser irradiation of 808nm, observes cancer cell death situation, knot
The culture medium of stannous sulfide nanometer light thermit powder of the embodiment of the present invention, cancer are not added as shown in figure 3, can know from figure for fruit
The culture medium of stannous sulfide nanometer light thermit powder of the embodiment of the present invention is added without death in cell, and wherein cancer cell has in various degree
Death, and with the increase of stannous sulfide nanometer photo-thermal agent concentration in culture medium, the death rate of cancer cell increases, therefore explanation
Stannous sulfide nanometer light thermit powder provided in an embodiment of the present invention has good photo-thermal therapy effect to cancer cell.
(3) internal cell experiment
PBS (phosphate buffer) dispersion liquid of the stannous sulfide nanometer light thermit powder of 100 μ g/mL is passed through into intratumor injection
Mode is squeezed into Mice Body, then uses power density for 1W/cm2, wavelength be 808nm laser irradiation carry out photo-thermal therapy.
Simultaneously by PBS solution of the another experiment mice intratumor injection without light thermit powder, and carry out identical laser irradiation as a control group.
Experimentation observes that injection has the temperature at the mouse tumor position of stannous sulfide nanometer light thermit powder to be apparently higher than control group, temperature
Line of writing music is as shown in Figure 4.
It should be noted that the announcement and elaboration of book, those skilled in the art in the invention may be used also according to the above description
To change and change to the above embodiment.Therefore, the invention is not limited in specific implementations disclosed and described above
Mode, some equivalent modifications and change to the present invention should also be as within the scope of the claims of the present invention.In addition,
Although having used some specific terms in this specification, these terms are merely for convenience of description, not to structure of the present invention
At any restrictions.
Claims (10)
1. a kind of stannous sulfide nanometer light thermit powder, which is characterized in that including stannous sulfide quantum dot.
2. stannous sulfide nanometer light thermit powder as described in claim 1, which is characterized in that the size of the stannous sulfide quantum dot
Less than 10nm.
3. stannous sulfide nanometer light thermit powder as described in claim 1, which is characterized in that the stannous sulfide nanometer light thermit powder is also
Polyethylene glycol including being coated on the stannous sulfide quantum dot surface.
4. stannous sulfide nanometer light thermit powder as claimed in claim 3, which is characterized in that the stannous sulfide quantum dot with it is described
The mass ratio of polyethylene glycol is 1:0.5-1:10.
5. stannous sulfide nanometer light thermit powder as claimed in claim 3, which is characterized in that the polyethylene glycol passes through electrostatic attraction
It is adsorbed on the stannous sulfide quantum dot surface, the weight average molecular weight of the polyethylene glycol is 2000-30000.
6. a kind of preparation method of stannous sulfide nanometer light thermit powder, which is characterized in that include the following steps:
After stannous sulfide block is ground 20-60 minutes, it is scattered in organic solvent, obtains dispersion liquid;
By the dispersion liquid in 5 DEG C of -10 DEG C of water bath sonicators 8-12 hours, the dispersion liquid after ultrasound is obtained;
After the dispersion liquid centrifugation after ultrasound, precipitation is collected, drying obtains stannous sulfide quantum dot.
7. preparation method as claimed in claim 6, which is characterized in that the organic solvent includes isopropanol and N-methyl pyrroles
One or both of alkanone, the mass concentration of stannous sulfide is 0.5-5mg/mL in the dispersion liquid.
8. preparation method as claimed in claim 6, which is characterized in that before the water bath sonicator, first by the dispersion liquid
Using Probe Ultrasonic Searching 4-8 hours, the probe power of the Probe Ultrasonic Searching was 150-600w.
9. preparation method as claimed in claim 6, which is characterized in that by the specific behaviour of the dispersion liquid centrifugation after ultrasound
As:The dispersion liquid after ultrasound is centrifuged into 0.5-1h with 13000-16000 revs/min of rotating speed, takes supernatant, then
The supernatant is centrifuged into 0.5-1h with 17000-25000 revs/min of rotating speed, collects precipitation.
10. preparation method as claimed in claim 6, which is characterized in that the preparation method of the stannous sulfide nanometer light thermit powder
Further comprise:The stannous sulfide quantum dot is dispersed in water, obtains the aqueous dispersions of stannous sulfide quantum dot, then to
It is added polyethylene glycol in the aqueous dispersions, stirs 10-16 hour, be collected by centrifugation and precipitate to get to stannous sulfide nanometer photo-thermal
Agent, the stannous sulfide nanometer light thermit powder include stannous sulfide quantum dot, and are coated on the stannous sulfide quantum dot surface
Polyethylene glycol.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN201810134807.2A CN108478793B (en) | 2018-02-09 | 2018-02-09 | Stannous sulfide nano-grade photo-thermal agent and preparation method thereof |
PCT/CN2018/100238 WO2019153689A1 (en) | 2018-02-09 | 2018-08-13 | Stannous sulfide nanometer photo-thermal agent and preparation method therefor |
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CN201810134807.2A CN108478793B (en) | 2018-02-09 | 2018-02-09 | Stannous sulfide nano-grade photo-thermal agent and preparation method thereof |
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CN109439323A (en) * | 2018-09-28 | 2019-03-08 | 深圳大学 | Beta oxidation Asia lead quantum dot and preparation method thereof, photodetector and preparation method thereof |
CN109455756A (en) * | 2018-10-23 | 2019-03-12 | 湖北大学 | A kind of preparation method and application of SnS quantum dot and nanometer sheet |
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US20110270153A1 (en) * | 2009-01-13 | 2011-11-03 | The Regents Of The University Of Colorado, A Body Corporate | Cell stimulation using quantum dots |
CN103449524A (en) * | 2013-08-23 | 2013-12-18 | 东华大学 | Molybdenum oxide based nano photothermal conversion material and preparation method thereof |
CN104860345A (en) * | 2015-04-20 | 2015-08-26 | 河南师范大学 | Preparation method for water-soluble tin-monosulfide quantum dot |
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CN108114280B (en) * | 2017-12-26 | 2019-11-12 | 深圳大学 | A kind of delivery system and preparation method thereof based on stannous sulfide nanometer sheet |
CN108175858A (en) * | 2017-12-26 | 2018-06-19 | 深圳大学 | A kind of stannous sulfide nanometer light thermit powder and preparation method thereof |
CN108452302B (en) * | 2018-02-09 | 2020-08-18 | 深圳大学 | Stannous sulfide quantum dot-based drug delivery system and preparation method thereof |
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CN103449524A (en) * | 2013-08-23 | 2013-12-18 | 东华大学 | Molybdenum oxide based nano photothermal conversion material and preparation method thereof |
CN104860345A (en) * | 2015-04-20 | 2015-08-26 | 河南师范大学 | Preparation method for water-soluble tin-monosulfide quantum dot |
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CN109439323A (en) * | 2018-09-28 | 2019-03-08 | 深圳大学 | Beta oxidation Asia lead quantum dot and preparation method thereof, photodetector and preparation method thereof |
CN109439323B (en) * | 2018-09-28 | 2021-11-12 | 深圳大学 | Beta-lead protoxide quantum dot and preparation method thereof, photoelectric detector and preparation method thereof |
CN109455756A (en) * | 2018-10-23 | 2019-03-12 | 湖北大学 | A kind of preparation method and application of SnS quantum dot and nanometer sheet |
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