CN108478207B - Multi-modal brain physiological monitoring system - Google Patents
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Abstract
The invention discloses a multi-modal brain physiological monitoring system, which comprises a signal cache preprocessing unit (3), an upper computer (4), a signal synchronization module (10), a laser speckle blood flow imaging acquisition unit (21), a blood oxygen information acquisition unit (22) and an electrophysiological acquisition unit (23), wherein the signal synchronization module (10) is used for controlling the corresponding acquisition units to work, and simultaneously, signal receiving ends corresponding to the acquisition units in a cache region work under the driving of signal cache control signals to ensure the unification of the signals. Meanwhile, the invention can avoid the problems of disordered data formats and complex signal interfaces caused by the direct communication between the acquisition unit and the upper computer.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a multi-modal animal brain physiology real-time detection system used in an experimental device.
Background
Blood is vital to living organisms, and blood flow is an important index for measuring the functional state of living organisms. In particular, cerebral blood flow, which plays a role in the microcirculation, is closely related to the relationship between metabolic functional activities. Most of the conventional blood flow detection methods such as the doppler flow meter do not have imaging capability, and are not favorable for deep research of biological functions and diagnosis and treatment of diseases. The laser speckle imaging technology images speckle patterns through a CCD camera, and analyzes the spatial blurring degree caused by flow velocity to obtain a two-dimensional flow velocity distribution diagram with higher spatial and temporal resolution. The method does not need contrast medium, is simple and convenient to operate, and can monitor a plurality of hemodynamic indexes in a living body, dynamic state and non-contact mode. The processed pseudo-color blood flow graph can visually observe the change of the blood flow speed and the expansion or contraction of the blood vessels. The present invention uses this method to measure changes in blood flow velocity.
Secondly, the survival of human body cells is mainly dependent on an adequate oxygen supply. Wherein the oxygen consumption of brain tissue is 20% of the total oxygen consumption and is particularly sensitive to hypoxia. Therefore, real-time continuous monitoring of blood oxygen content is important. Blood oxygen saturation is an important parameter reflecting the oxygen content of blood. The blood oxygen saturation refers to the percentage of oxygen (oxygen content) actually bound in the blood (hemoglobin) to the maximum amount of oxygen (oxygen capacity) that can be bound in the blood (hemoglobin). The currently common non-invasive measurement technology is a dual-wavelength method, namely, near-infrared light with wavelengths of 760nm and 850nm is used as a light source, and the content of blood oxygen is determined by using absorption spectra with different intensities of the near-infrared light due to different oxygen carrying capacities of hemoglobin. The purpose of monitoring blood oxygen information and accurately reflecting the oxygen supply state of the brain in real time is achieved.
The nervous system electrical signals mainly include neuron spikes and field potentials. Spike potentials can be used to study behavioral patterns of neurons and interrelationships between neurons, and field potentials can be used to study overall activity of the brain nervous system. And simultaneously recording neuron spike potential signals and field potential signals, which is the basis for researching the working mechanism of the brain nervous system. While microelectrode arrays are capable of recording a large number of neuroelectrical signals including field potentials and spikes of neuronal populations. Therefore, the invention adopts a microelectrode array mode to collect the brain electrophysiological signals.
Disclosure of Invention
The purpose of the invention is as follows: in order to overcome the defects in the prior art, the invention provides a multi-mode brain physiological monitoring system which combines cerebral blood flow measurement, cerebral blood oxygen measurement and electroencephalogram physiological measurement. The device can continuously monitor the brain physiological change condition of animals in the experiment in a time-sharing manner, and the collected multi-modal data is stored and the upper computer at the rearmost end, so that further deep research at the later stage is facilitated.
The technical scheme is as follows: in order to achieve the purpose, the invention adopts the technical scheme that:
a multimodal brain physiological monitoring system, characterized by: including signal buffer memory preprocessing unit (3), host computer (4), signal synchronization module (10), laser speckle blood flow formation of image acquisition unit (21), blood oxygen information acquisition unit (22) and electrophysiological acquisition unit (23), wherein:
the upper computer (4) is used for sending acquisition signals to the signal synchronization module (10) and receiving signal data of the corresponding acquisition units transmitted from the signal cache preprocessing unit (3);
the signal synchronization module (10) is used for sending acquisition selection control signals to the laser speckle blood flow imaging acquisition unit (21), the blood oxygen information acquisition unit (22) and the electrophysiology acquisition unit (23) according to the acquisition signals, and sending signal cache control signals to the signal cache preprocessing unit (3), so that when the corresponding acquisition units are controlled to work, signal receiving ends corresponding to the acquisition units in a cache region work simultaneously under the driving of the signal cache control signals, and the signals are ensured to be uniform;
the laser speckle blood flow imaging acquisition unit (21) is used for acquiring a cerebral speckle pattern according to the received acquisition selection control signal and sending the acquired speckle pattern to the signal cache preprocessing unit (3);
the blood oxygen information acquisition unit (22) is used for acquiring the cerebral blood oxygen information according to the received acquisition selection control signal and sending the acquired cerebral blood oxygen information to the signal cache preprocessing unit (3);
the electrophysiological acquisition unit (23) is used for acquiring a brain nerve electrical signal according to the received acquisition selection control signal and sending the acquired brain nerve electrical signal to the signal cache preprocessing unit (3);
the signal caching preprocessing unit (3) is used for caching information acquired by the laser speckle blood flow imaging acquisition unit (21), the blood oxygen information acquisition unit (22) and the electrophysiological acquisition unit (23) according to a caching control signal, unifying the data format of the received information and transmitting the unified data information to the upper computer (4);
the signal caching preprocessing unit (3) comprises a signal-fetching address converter (31), an address bus (32), an interface module, a signal bus (36) and a data cache region (37), wherein the interface module comprises a USB3.0 image interface module (33), a blood oxygen serial port module (34) and an electrophysiological Ethernet module (35), one end of the address bus (32) is respectively connected with the USB3.0 image interface module (33), the blood oxygen serial port module (34) and the electrophysiological Ethernet module (35), and the other end of the address bus is connected with the signal-fetching address converter (31); the signal bus (36) is respectively connected with the USB3.0 image interface module (33), the blood oxygen serial port module (34) and the electrophysiological Ethernet module (35), and the other end of the signal bus is connected with the data buffer area (37); the USB3.0 image interface module (33) is connected with the laser speckle blood flow imaging acquisition unit (21), the blood oxygen serial port module (34) is connected with the blood oxygen information acquisition unit (22), and the electrophysiological Ethernet module (35) is connected with the electrophysiological acquisition unit (23); under the control of an address bus (32), each interface module only has the function of one interface module at the same time, corresponding data are transmitted to a data cache region (37) through a signal bus (36), and an upper computer (4) reads the collected data of a corresponding collecting unit from the data cache region (37).
Preferably: the laser speckle blood flow imaging acquisition unit (21) comprises a He-Ne laser (211), a brain irradiation region (213), an optical amplification lens barrel (214), a CMOS industrial camera (215) and a USB3.0 image interface (216), wherein the brain irradiation region (213), the optical amplification lens barrel (214) and the CMOS industrial camera (215) are arranged along an emission optical path of the He-Ne laser (211), the He-Ne laser (211) works according to a received acquisition selection control signal, one end of the USB3.0 image interface (216) is connected with the CMOS industrial camera (215), and the other end of the USB3.0 image interface is connected with the USB3.0 image interface module (33).
Preferably: blood oxygen information acquisition unit (22) includes MCU (221), dual wavelength blood sample collection chip (223) and serial communication module (226), MCU (221) is under the control of gathering the selection control signal, accomplish the drive initialization, later enable dual wavelength blood sample collection chip (223) through enabling signal line (222), after dual wavelength blood oxygen collection chip (223) accomplished signal acquisition, accomplish the signal communication with MCU (221) through data transmission signal line (224), it is IIC communication protocol to make the use of signal line (222) and data transmission signal line (224) here, after accomplishing this collection, the signal of storage in the MCU, signal buffer memory corresponding blood oxygen serial module (34) in preprocessing unit (3) of rear end is given data transmission through serial communication module (226).
Preferably: the electrophysiological acquisition unit (23) comprises a front-end power supply (231), a high-impedance neural electrode (232), a front-end amplification circuit (233), an optical fiber conducting signal line (234), an electrophysiological signal detection module (235) and an Ethernet interface (237), wherein the high-impedance neural electrode (232), the front-end amplification circuit (233), the optical fiber conducting signal line (234), the electrophysiological signal detection module (235) and the Ethernet interface (237) are sequentially connected, and the front-end power supply (231) is connected with the front-end amplification circuit (233).
Preferably: the laser speckle blood flow imaging acquisition unit (21), the blood oxygen information acquisition unit (22) and the electrophysiology acquisition unit (23) work alternately under the action of CLK clock signals and do not intersect with each other.
Preferably: the enabling signal of the laser speckle blood flow imaging acquisition unit (21) is 100, the enabling signal of the blood oxygen information acquisition unit (22) is 010, and the enabling signal of the electrophysiology acquisition unit (23) is 001.
Compared with the prior art, the invention has the following beneficial effects:
the invention can continuously monitor the physiological change condition of the brain in a time-sharing manner, and store the collected multi-mode data with the rearmost upper computer, thereby facilitating further research in the later period. Meanwhile, the invention can avoid the problems of disordered data formats and complex signal interfaces caused by the direct communication between the acquisition unit and the upper computer.
Drawings
FIG. 1 is a general schematic block diagram of the present invention;
FIG. 2 is a schematic diagram of a laser speckle blood flow imaging acquisition unit according to the present invention;
FIG. 3 is a schematic block diagram of a blood oxygen information collecting unit according to the present invention;
FIG. 4 is a schematic block diagram of an electrophysiological acquisition unit shown in the present invention;
FIG. 5 is an internal schematic diagram of a signal synchronization module involved in the present invention;
FIG. 6 is a timing diagram illustrating the adjustment of the acquisition sequence among the acquisition systems in the present invention.
Detailed Description
The present invention is further illustrated by the following description in conjunction with the accompanying drawings and the specific embodiments, it is to be understood that these examples are given solely for the purpose of illustration and are not intended as a definition of the limits of the invention, since various equivalent modifications will occur to those skilled in the art upon reading the present invention and fall within the limits of the appended claims.
Fig. 1 is a block diagram of the multi-modal brain physiology inspection system according to the present invention. The invention relates to a brain physiology detection system combining blood flow measurement, blood oxygen measurement and brain electrophysiological measurement. In the detection system, the acquisition time sequences of the three acquisition systems are reasonably adjusted through the signal synchronization module 10, so that the purpose of measuring three physiological parameters in real time in the same physiological process is achieved. The system comprises a signal buffer preprocessing unit 3, an upper computer 4, a signal synchronization module 10, a laser speckle blood flow imaging acquisition unit 21, a blood oxygen information acquisition unit 22 and an electrophysiological acquisition unit 23.
The upper computer 4 is used for sending acquisition signals to the signal synchronization module 10 and receiving signal data of corresponding acquisition units transmitted from the signal cache preprocessing unit 3. Therefore, the upper computer 4 mainly has two functions: firstly, sending out a collection selection signal through a communication line 1 connected with a signal synchronization module 10; and secondly, receiving the signal data of the corresponding acquisition system transmitted from the signal buffer preprocessing unit 3.
The signal synchronization module 10 is configured to send a collection selection control signal 11 to the laser speckle blood flow imaging collection unit 21, the blood oxygen information collection unit 22, and the electrophysiology collection unit 23 according to the collected signal, and send a signal cache control signal 12 to the signal cache preprocessing unit 3. The synchronous signal module generates corresponding acquisition system control signals and data buffer area control signals according to a certain time sequence. The acquisition system control signal controls whether each acquisition unit works or not, the data buffer area control signal enables an interface module corresponding to each acquisition unit in the buffer area to receive corresponding data from the acquisition units, and the signal sent from the signal synchronization module 10 is divided into an acquisition selection control signal 11 and a signal buffer control signal 12 which are respectively connected with the acquisition system 2 and the signal buffer preprocessing unit 3. So as to control the corresponding acquisition system to work, and simultaneously, the corresponding signal receiving end in the buffer area works under the driving of the signal buffer control signal 12, thereby ensuring the uniformity of the signals. In more detail, the acquisition system 2 includes a laser speckle blood flow imaging acquisition unit 21, a blood oxygen information acquisition unit 22, and an electrophysiological acquisition unit 23.
Fig. 2 is a detailed internal system block diagram of the laser speckle blood flow imaging acquisition unit 21 in fig. 1. The laser speckle blood flow imaging acquisition unit 21 is used for acquiring a cerebral speckle pattern according to a received acquisition selection control signal and sending the acquired speckle pattern to the signal caching and preprocessing unit 3, and comprises a set of light path which mainly comprises a He-Ne laser, an attenuation sheet, a beam expander and a reflector. The laser emitted by the laser is attenuated by the attenuation sheet and then passes through the beam expander, so that the diameter of the beam is enlarged. The laser after diameter amplification is reflected by a reflector to adjust the propagation direction of the light, and the laser irradiates the interested area of the brain at a proper angle. And then collecting image information of the region of interest through an optical magnifying lens cone connected with a CMOS industrial camera. The image information acquisition is carried out in a non-contact mode of shooting. And then, the acquired image information is transmitted to a data cache module at the rear end and then transmitted to an upper computer for image processing and display. In more detail, as shown in fig. 1, the laser speckle blood flow imaging collecting unit 21 includes a He-Ne laser 211, a brain irradiation region 213, an optical magnifying lens barrel 214, a CMOS industrial camera 215, and a USB3.0 image interface 216, the brain irradiation region 213, the optical magnifying lens barrel 214, and the CMOS industrial camera 215 are disposed along an emission optical path of the He-Ne laser 211, the He-Ne laser 211 operates according to a received collection selection control signal, and one end of the USB3.0 image interface 216 is connected to the CMOS industrial camera 215, and the other end is connected to the USB3.0 image interface module 33. The system is controlled by an acquisition selection control signal 11 issued from a signal synchronization module 10. When the sub-system is selected by the acquisition selection control signal 11, the acquisition selection control signal 11 drives the He-Ne laser 211 to emit laser with a specific 632.8nm wavelength, the laser irradiates the area of interest of the craniotomized brain in the brain irradiation area 213 at a proper angle after passing through a set of complete optical path 212 attenuation sheet, beam expander and reflector, then acquires image information of the area of interest 213 through an optical amplification lens barrel 214 connected with a CMOS industrial camera 215, and transmits the image information to a corresponding image acquisition card in a signal cache preprocessing unit 3 at the rear end through a USB3.0 image interface 216 connected with the camera.
Fig. 3 is a detailed internal block diagram of the blood oxygen information collecting unit 22 shown in fig. 1. The blood oxygen information acquisition unit 22 is used for acquiring the cerebral blood oxygen information according to the received acquisition selection control signal and sending the acquired cerebral blood oxygen information to the signal cache preprocessing unit 3; the brain blood oxygen monitoring system is completed by adopting a dual-wavelength technology. Specifically, the generation and the collection of the dual-wavelength light source signals are mainly completed by a blood oxygen chip, the chip is connected with a central processing unit, and chip enabling, dual-wavelength signal collection and signal transmission are completed under the control of the chip. The central processing unit is an MCU, and the acquired data are transmitted to a data cache module at the rear end in a serial port mode by the MCU and then transmitted to the upper computer. As shown in FIG. 1, the system is a part of the collection system 2, and is also controlled by the collection selection control signal 11, when the collection subsystem is operating, the MCU221 completes the drive initialization under the control of the collection selection control signal 11, then the dual-wavelength blood sample collection chip 223 is enabled through the enable signal line 222, after the dual-wavelength blood oxygen collection chip completes the signal collection, the signal communication with the MCU221 is completed through the data transmission signal line 224, and the enable signal line 222 and the data transmission signal line 224 both use IIC communication protocol. After the acquisition is completed, the signal 225 stored in the MCU transmits the data to the corresponding blood oxygen serial port module 34 in the back-end signal buffer preprocessing unit 3 through the serial port communication module 226. The signal transmitted to the upper computer by the MCU is a dual-wavelength original signal, and the signal processing, baseline removal, blood oxygen calculation and other functions need to be completed in the upper computer.
Fig. 4 shows a detailed schematic diagram of the electrophysiological acquisition unit 23 shown in fig. 1. The electrophysiological acquisition unit 23 is configured to acquire a cerebral nerve electrical signal according to the received acquisition selection control signal, and send the acquired cerebral nerve electrical signal to the signal cache preprocessing unit 3; the electrophysiological signal acquisition unit 23 employs a microelectrode array to acquire an electroencephalogram physiological signal, and includes a front-end power supply 231, a high-impedance neural electrode 232, a front-end amplification circuit 233, an optical fiber conducting signal line 234, an electrophysiological signal detection module 235, and an ethernet interface 237, where the high-impedance neural electrode 232, the front-end amplification circuit 233, the optical fiber conducting signal line 234, the electrophysiological signal detection module 235, and the ethernet interface 237 are sequentially connected, and the front-end power supply 231 is connected to the front-end amplification circuit 233. The high-impedance nerve electrode is arranged in a corresponding brain functional area of a brain in an implanted mode, collects an electric signal generated by potential change, transmits the electric signal to a discharge part at the rear end, and then transmits the amplified electric signal to the electrophysiological signal detection module which mainly performs certain signal processing on the collected electrophysiological signal, so that the signal of interest is enhanced, and interference signals are suppressed. And finally, the electrophysiological signals subjected to signal processing are transmitted to a data cache region at the rear end by the Ethernet interface and then transmitted to an upper computer for further processing and analysis of the electrophysiological signals. As shown in fig. 4, the system is also controlled by the acquisition selection control signal 11, the acquisition selection control signal 11 can control whether the system works or not by controlling the front-end power supply 231, and the front-end power supply 231 mainly supplies power to the front-end amplification circuit 233. In addition, the front end of the high-impedance nerve electrode 232 is inserted into a corresponding region of the brain such as the hippocampus, and the rear end is fixed above the brain by medical glue to stably insert the electrode front end portion of the brain. The electrophysiological signals collected by the high-impedance neural electrode 232 are transmitted to the front-end amplifier 232, and then the amplified signals are transmitted to an electrophysiological signal detection module 235 through an optical fiber transmission signal line 234, wherein the electrophysiological signals after amplification are mainly subjected to certain signal processing, so that interest signals are enhanced, and interference signals are suppressed. The processed signal is then transmitted to a corresponding extranet interface module in the signal buffer preprocessing unit 3 at the back end through the electrophysiological ethernet interface 237.
The signal caching preprocessing unit 3 is used for caching the information acquired by the laser speckle blood flow imaging acquisition unit 21, the blood oxygen information acquisition unit 22 and the electrophysiological acquisition unit 23 according to the caching control signal, unifying the data format of the received information, and transmitting the unified data information to the upper computer 4. The signal buffer preprocessing unit 3 is mainly used for receiving data from each sub-acquisition unit conveniently. The data cache region mainly aims to solve the problem that the inconvenience is caused when the sub-acquisition units are in direct communication with the upper computer due to the fact that the different communication interfaces are adopted by the acquisition units. The signal buffer preprocessing unit 3 comprises a signal-taking address converter 31, an address bus 32, an interface module, a signal bus 36 and a data buffer area 37, wherein the interface module comprises a USB3.0 image interface module 33, a blood oxygen serial port module 34 and an electrophysiological ethernet module 35, and the signal-taking address converter is responsible for receiving a synchronization signal of the data buffer area, converting the synchronization signal into an internal address signal, and transmitting the internal address signal to the address bus to select a corresponding interface module to work. The data signal received by the interface module is sent to the data buffer area through the data bus. The data buffer area finally completes the exchange of data signals with the upper computer, and the problems of disordered data formats and complex signal interfaces caused by the fact that the acquisition unit is directly communicated with the upper computer are avoided. One end of the address bus 32 is respectively connected with the USB3.0 image interface module 33, the blood oxygen serial port module 34 and the electrophysiological Ethernet module 35, and the other end is connected with the signal-taking address converter 31; the signal bus 36 is respectively connected with the USB3.0 image interface module 33, the blood oxygen serial port module 34 and the electrophysiological Ethernet module 35, and the other end of the signal bus is connected with the data buffer area 37; the USB3.0 image interface module 33 is connected with the laser speckle blood flow imaging acquisition unit 21, the blood oxygen serial port module 34 is connected with the blood oxygen information acquisition unit 22, and the electrophysiological Ethernet module 35 is connected with the electrophysiological acquisition unit 23; under the control of the address bus 32, each interface module only has one function at the same time, and transmits corresponding data to the data buffer area 37 through the signal bus 36, and the upper computer 4 reads the acquired data of the corresponding acquisition unit from the data buffer area 37. As shown in fig. 5, which is also controlled by a signal from signal synchronization module 10. The signal buffer control signal 12 is first transmitted to the signal buffer preprocessing unit 3 to be converted by the signal address converter 31, and then the address signal converted by the signal address converter 31 is transmitted to the address bus 32. The address bus is respectively connected with a USB3.0 image interface module 33, a blood oxygen serial port module 34 and an electrophysiological Ethernet module 35. The sub-modules are respectively connected with the speckle image acquisition card 331, the blood oxygen serial port communication module 341 and the electrophysiological Ethernet interface 351. Wherein the speckle image acquisition card 331, the blood oxygen serial port communication module 341 and the electrophysiological ethernet interface 351 correspond to the corresponding sub-acquisition modules in the acquisition system 2, respectively. Under the control of the address bus 32, each interface module only has one interface module active at a time and transmits corresponding data to the data buffer 37 via the signal bus 36. The data in the data buffer area 37 is connected to the upper computer 4 in fig. 1, and the upper computer reads the system data of the corresponding acquisition system from the buffer area for the later processing.
As shown in fig. 6, it is mainly used to explain one implementation of the synchronization signal shown in fig. 5. In the scheme shown in the figure, the enabling signal of the laser speckle blood flow imaging acquisition unit 21 is 100, the enabling signal of the blood oxygen information acquisition unit 22 is 010, and the enabling signal of the electrophysiology acquisition unit 23 is 001. The enable signal is transmitted to the acquisition system 2 and the control signal is buffered. So as to control the collection and data storage of the whole system.
The above description is only of the preferred embodiments of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the invention and these are intended to be within the scope of the invention.
Claims (2)
1. A multimodal brain physiological monitoring system, characterized by: including signal buffer memory preprocessing unit (3), host computer (4), signal synchronization module (10), the collection unit includes laser speckle blood flow formation of image collection unit (21), blood oxygen information collection unit (22) and electrophysiological acquisition unit (23), wherein:
the upper computer (4) is used for sending acquisition signals to the signal synchronization module (10) and receiving signal data of the corresponding acquisition units transmitted from the signal cache preprocessing unit (3);
the signal synchronization module (10) is used for sending acquisition selection control signals to the laser speckle blood flow imaging acquisition unit (21), the blood oxygen information acquisition unit (22) and the electrophysiological acquisition unit (23) according to the acquisition signals, the synchronization signal module generates corresponding acquisition system control signals and data cache region control signals according to a certain time sequence, wherein the acquisition system control signals control whether each acquisition unit works or not, the data cache region control signals enable the interface modules corresponding to each acquisition unit in the cache region to receive corresponding data from the acquisition units, the signals sent by the signal synchronization module are divided into the acquisition selection control signals and the signal cache control signals which are respectively connected with the acquisition system and the signal cache preprocessing unit and send the signal cache control signals to the signal cache preprocessing unit (3) to control the corresponding acquisition units to work, the signal receiving ends in the cache region corresponding to the acquisition units are driven by the signal cache control signals to work simultaneously, so that the uniformity of the signals is ensured;
the laser speckle blood flow imaging acquisition unit (21) is used for acquiring a cerebral speckle pattern according to the received acquisition selection control signal and sending the acquired speckle pattern to the signal cache preprocessing unit (3);
the laser speckle blood flow imaging acquisition unit (21) comprises a He-Ne laser (211), a brain irradiation region (213), an optical amplification lens barrel (214), a CMOS industrial camera (215) and a USB3.0 image interface (216), wherein the brain irradiation region (213), the optical amplification lens barrel (214) and the CMOS industrial camera (215) are arranged along an emission optical path of the He-Ne laser (211), the He-Ne laser (211) works according to a received acquisition selection control signal, one end of the USB3.0 image interface (216) is connected with the CMOS industrial camera (215), and the other end of the USB3.0 image interface is connected with the USB3.0 image interface module (33);
the blood oxygen information acquisition unit (22) is used for acquiring the cerebral blood oxygen information according to the received acquisition selection control signal and sending the acquired cerebral blood oxygen information to the signal cache preprocessing unit (3);
the blood oxygen information acquisition unit (22) comprises an MCU (221), a dual-wavelength blood sample acquisition chip (223) and a serial communication module (226), the MCU (221) completes drive initialization under the control of acquisition selection control signals, then the dual-wavelength blood sample acquisition chip (223) is enabled through an enabling signal line (222), after the dual-wavelength blood oxygen acquisition chip (223) completes signal acquisition, signal communication with the MCU (221) is completed through a data transmission signal line (224), the enabling signal line (222) and the data transmission signal line (224) both use IIC communication protocols, after the acquisition is completed, signals stored in the MCU transmit data to a corresponding blood oxygen serial module (34) in a signal buffer preprocessing unit (3) at the rear end through the serial communication module (226);
the electrophysiological acquisition unit (23) is used for acquiring a brain nerve electrical signal according to the received acquisition selection control signal and sending the acquired brain nerve electrical signal to the signal cache preprocessing unit (3);
the electrophysiological acquisition unit (23) comprises a front-end power supply (231), a high-impedance neural electrode (232), a front-end amplification circuit (233), an optical fiber conducting signal line (234), an electrophysiological signal detection module (235) and an Ethernet interface (237), wherein the high-impedance neural electrode (232), the front-end amplification circuit (233), the optical fiber conducting signal line (234), the electrophysiological signal detection module (235) and the Ethernet interface (237) are sequentially connected, and the front-end power supply (231) is connected with the front-end amplification circuit (233);
the laser speckle blood flow imaging acquisition unit (21), the blood oxygen information acquisition unit (22) and the electrophysiology acquisition unit (23) work alternately under the action of a CLK clock signal and do not intersect with each other;
the signal caching preprocessing unit (3) is used for caching information acquired by the laser speckle blood flow imaging acquisition unit (21), the blood oxygen information acquisition unit (22) and the electrophysiological acquisition unit (23) according to a caching control signal, unifying the data format of the received information and transmitting the unified data information to the upper computer (4);
the signal caching preprocessing unit (3) comprises a signal-fetching address converter (31), an address bus (32), an interface module, a signal bus (36) and a data cache region (37), wherein the interface module comprises a USB3.0 image interface module (33), a blood oxygen serial port module (34) and an electrophysiological Ethernet module (35), one end of the address bus (32) is respectively connected with the USB3.0 image interface module (33), the blood oxygen serial port module (34) and the electrophysiological Ethernet module (35), and the other end of the address bus is connected with the signal-fetching address converter (31); the signal bus (36) is respectively connected with the USB3.0 image interface module (33), the blood oxygen serial port module (34) and the electrophysiological Ethernet module (35), and the other end of the signal bus is connected with the data buffer area (37); the USB3.0 image interface module (33) is connected with the laser speckle blood flow imaging acquisition unit (21), the blood oxygen serial port module (34) is connected with the blood oxygen information acquisition unit (22), and the electrophysiological Ethernet module (35) is connected with the electrophysiological acquisition unit (23); under the control of an address bus (32), each interface module only has the function of one interface module at the same time, corresponding data are transmitted to a data cache region (37) through a signal bus (36), and an upper computer (4) reads the acquired data of a corresponding acquisition unit from the data cache region (37);
the signal buffer control signal is firstly transmitted to the signal buffer preprocessing unit to fetch the signal address converter, and then the address signal converted by the signal address fetching converter is transmitted to the address bus; the address bus is respectively connected with a USB.0 image interface module, a blood oxygen serial port module and an electrophysiological Ethernet module; the sub-modules are respectively connected with the speckle image acquisition card, the blood oxygen serial port communication module and the electrophysiological Ethernet interface; wherein the speckle image acquisition card, the blood oxygen serial port communication module and the electrophysiological Ethernet interface respectively correspond to corresponding sub-acquisition modules in the acquisition system; under the control of the address bus, each interface module only has the function of one interface module at the same time and transmits corresponding data to the data cache region through the signal bus; and the data in the data cache region is connected with an upper computer, and the upper computer reads the system data of the corresponding acquisition system from the cache region for later processing.
2. The multimodal brain physiological monitoring system of claim 1, wherein: the enabling signal of the laser speckle blood flow imaging acquisition unit (21) is 100, the enabling signal of the blood oxygen information acquisition unit (22) is 010, and the enabling signal of the electrophysiology acquisition unit (23) is 001.
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