CN108478196A - Spectroscopic imaging device based on molecular image - Google Patents
Spectroscopic imaging device based on molecular image Download PDFInfo
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- CN108478196A CN108478196A CN201810545762.8A CN201810545762A CN108478196A CN 108478196 A CN108478196 A CN 108478196A CN 201810545762 A CN201810545762 A CN 201810545762A CN 108478196 A CN108478196 A CN 108478196A
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- 238000000701 chemical imaging Methods 0.000 title claims abstract description 31
- 230000003287 optical effect Effects 0.000 claims abstract description 29
- 238000003384 imaging method Methods 0.000 claims abstract description 23
- 230000004927 fusion Effects 0.000 claims abstract description 19
- 230000000007 visual effect Effects 0.000 claims abstract description 10
- 230000004075 alteration Effects 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 6
- 238000007747 plating Methods 0.000 claims description 3
- 206010010071 Coma Diseases 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 230000013011 mating Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 abstract description 5
- 238000010586 diagram Methods 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000003333 near-infrared imaging Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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Abstract
The present invention provides a kind of spectroscopic imaging device based on molecular image, including：Imaging device, the Amici prism being connect with imaging device, the visible filter being connect with Amici prism, the fluorescent optical filter being connect with Amici prism, the Visible Light Camera being connect with visible filter, the fluorescence camera being connect with fluorescent optical filter and the visual fusion device being connect respectively with Visible Light Camera and fluorescence camera；Imaging device generates picture according to incident ray；Amici prism is to as being divided, generating reflection image and dioptric image；Visible filter filters to reflection image, generates visible light image；Visible Light Camera generates visible light molecular image according to visible light image；Fluorescent optical filter doubling image filters, and generates fluorescence picture；Fluorescence camera generates fluorescence molecule image according to fluorescence picture；Visual fusion device will be seen that optical molecule image and fluorescence molecule image fusion, generates fusion molecule image, the effective integration of visible light and near-infrared fluorescent may be implemented.
Description
Technical field
The present invention relates to imaging fields, and in particular, to a kind of spectroscopic imaging device based on molecular image.
Background technology
In recent years, Medical Imaging Technology flourish, on imaging method from past structural, functional imaging to
It is broken through in terms of the molecular imaging method of cellular and molecular level.Medical diagnostic method is also from traditional doctors experience method towards accurate doctor
Target and stride forward.The method of molecular image can help the objective essence that illness is accurately judged from cellular and molecular level of doctor
The advantages that level is set, and the method for optical molecular image is due to its high-resolution, high specific by international extensive concern,
And wherein absorption and scattering effect of the near-infrared excitation fluorescence molecule image technology due to biological tissue is minimum, and sexual valence is higher etc.
Advantage has become the hot spot of research.
Realize the purpose of near infrared imaging about single camera at present, however this method only provides fluorescent image,
It is poor to the effect of visible optical detection.
Invention content
The main purpose of the embodiment of the present invention is to provide a kind of spectroscopic imaging device based on molecular image, with realize can
The light-exposed effective integration with near-infrared fluorescent.
To achieve the goals above, the embodiment of the present invention provides a kind of spectroscopic imaging device based on molecular image, including：
Imaging device, the Amici prism being connect with imaging device, the visible filter being connect with Amici prism are connect with Amici prism
Fluorescent optical filter, the Visible Light Camera being connect with visible filter, the fluorescence camera, the Yi Jifen that are connect with fluorescent optical filter
The visual fusion device not connect with Visible Light Camera and fluorescence camera；Imaging device is used to generate picture according to incident ray；Point
Light prism is used for as being divided, generating reflection image and dioptric image；Visible filter is raw for filtering to reflection image
At visible light image；Visible Light Camera is used to generate visible light molecular image according to visible light image；Fluorescent optical filter is used for birefringence
As filtering, fluorescence picture is generated；Fluorescence camera is used to generate fluorescence molecule image according to fluorescence picture；Visual fusion device is used for
It will be seen that optical molecule image and fluorescence molecule image fusion, generate fusion molecule image.
The imaging device of the spectroscopic imaging device based on molecular image of the embodiment of the present invention generates picture according to incident ray,
Amici prism is to as being divided, generating reflection image and dioptric image, it is seen that light optical filter filters to reflection image, generates visible
Light image, it is seen that light camera generates visible light molecular image according to visible light image, and fluorescent optical filter doubling image filters, and generates
Fluorescence picture, fluorescence camera generate fluorescence molecule image according to fluorescence picture, and visual fusion device will be seen that optical molecule image and fluorescence
Molecular image merges, and generates fusion molecule image, the effective integration of visible light and near-infrared fluorescent may be implemented, and improves at present
The drawbacks of existing research, enhances the scope of application of molecular image technology, to extending the research field of molecular image, reduces molecule
The threshold that image is applied in biomedical sector has important meaning and value.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, embodiment will be described below
Needed in attached drawing be briefly described, it should be apparent that, the accompanying drawings in the following description be only the present invention some
Embodiment for those of ordinary skill in the art without creative efforts, can also be attached according to these
Figure obtains other attached drawings.
Fig. 1 is the logic diagram of the spectroscopic imaging device based on molecular image in the embodiment of the present invention；
Fig. 2 is the logic diagram of the spectroscopic imaging device based on molecular image in another embodiment of the present invention；
Fig. 3 is the logic diagram of the first micromatic setting in the embodiment of the present invention；
Fig. 4 is the logic diagram of the second micromatic setting in the embodiment of the present invention；
Fig. 5 is the schematic diagram of the spectroscopic imaging device based on molecular image in the embodiment of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
In view of the prior art poor to the effect of visible optical detection, the embodiment of the present invention provides a kind of based on molecular image
The effective integration of visible light and near-infrared fluorescent may be implemented in spectroscopic imaging device.
Fig. 1 is the logic diagram of the spectroscopic imaging device based on molecular image in the embodiment of the present invention.As shown in Figure 1, base
Include in the spectroscopic imaging device of molecular image：Imaging device 1, the Amici prism 3 being connect with imaging device 1 and Amici prism 3
The visible filter 5 of connection, the fluorescent optical filter 8 being connect with Amici prism 3, the visible light being connect with visible filter 5
Camera 6, the fluorescence camera 9 being connect with fluorescent optical filter 8 and the image being connect respectively with Visible Light Camera 6 and fluorescence camera 9
Fusing device 10.
Imaging device 1 is used to generate picture according to incident ray, and Amici prism 3 is used for as being divided, generating reflection image
And dioptric image.Wherein, Amici prism 3 is five or five Amici prisms, and 50% plating reflective coating, 50% plates refracting film layer, may be implemented
Accurate light splitting, ensures the reflection image after light splitting and dioptric image energy coincidence, it is seen that the phase of optical molecule image and fluorescence molecule image
It is consistent to illumination, improve the resolution ratio of picture.
Visible filter 5 generates visible light image, fluorescent optical filter 8 is used for birefringence for filtering to reflection image
As filtering, fluorescence picture is generated.Wherein, it is seen that the plated film wave band of light optical filter 5 is：More than or equal to 440nm, it is less than or waits
In 687nm.The plated film wave band of fluorescent optical filter 8 is：More than or equal to 810nm, it is less than or equal to 870nm, light can be increased
Transmitance enhances the light transmission energy of picture.
Visible Light Camera 6 is used to generate visible light molecular image according to visible light image, and fluorescence camera 9 is used for according to fluorescence picture
Generate fluorescence molecule image；Visual fusion device 10 is for it will be seen that optical molecule image and fluorescence molecule image fusion, generation are melted
Close molecular image.
Fig. 2 is the logic diagram of the spectroscopic imaging device based on molecular image in another embodiment of the present invention.Fig. 5 is this hair
The schematic diagram of spectroscopic imaging device based on molecular image in bright embodiment.As shown in figures 2 and 5, point based on molecular image
Photoimaging equipment further includes：The non-spherical lens 2 being connect respectively with imaging device 1 and Amici prism 3, the picture for correcting picture
Difference.The first micromatic setting 4 being connect respectively with Amici prism 3 and visible filter 5, the position for adjusting Visible Light Camera 6
It sets.The second micromatic setting 7 being connect respectively with Amici prism 3 and fluorescent optical filter 8, for adjust the position of fluorescence camera 9 with
Fluorescence molecule image is enabled all to be overlapped with visible light molecular image.Wherein, aberration includes：Aberration, coma and spherical aberration.
Fig. 3 is the logic diagram of the first micromatic setting in the embodiment of the present invention.As shown in figure 3, the first micromatic setting 4 wraps
It includes：First adjusting handle 41, the spacing for adjusting non-spherical lens 2 and Visible Light Camera 6, to find the best of visible light image
Imaging surface, ensure visible light image and fluorescence as image planes size.First fastener 42, for pair can after the completion of adjusting
Light-exposed camera 6 is fastened, and ensures the stability of the spectroscopic imaging device based on molecular image.
Fig. 4 is the logic diagram of the second micromatic setting in the embodiment of the present invention.As shown in figure 4, the second micromatic setting 7 wraps
It includes：Up and down adjustment screw thread pair 71, for carrying out up and down adjustment to fluorescence camera 9；Left and right adjusting screw thread pair 72, for fluorescence phase
Machine 9 carries out left and right adjusting；Second adjusting handle 73, the spacing for adjusting non-spherical lens 2 and fluorescence camera 9 are glimmering to find
The optimal imaging face of light image ensures fluorescence as the image planes size of visible light image.Second fastener 74, for adjusting
Fluorescence camera 9 is fastened after the completion, ensures the stability of the spectroscopic imaging device based on molecular image.
Non-spherical lens 2 can be the lens group for including multiple non-spherical lenses.At this point, the first adjusting handle 41 adjust it is non-
The spacing of the last a piece of lens and Visible Light Camera 6 of spherical lens group, the second adjusting handle 42 adjust non-spherical lens group
The spacing of last a piece of lens and fluorescence camera 9.
When visible light molecular image and fluorescence molecule image do not overlap, the fusion molecule shadow of the generation of visual fusion device 10
As unclear.Upper and lower, left and right the upper and lower position for adjusting i.e. changeable fluorescence molecule image can be carried out to fluorescence camera 9 at this time
And left and right position improves image and overlaps precision, facilitate work to enable visible light molecular image and fluorescence molecule image be completely superposed
Make personnel to debug the spectroscopic imaging device based on molecular image, save debug time and improves the steady of spectroscopic imaging device
It is qualitative.
To sum up, the imaging device of the spectroscopic imaging device based on molecular image of the embodiment of the present invention is given birth to according to incident ray
Imaging, Amici prism is to as being divided, generating reflection image and dioptric image, it is seen that light optical filter filters to reflection image, raw
At visible light image, it is seen that light camera generates visible light molecular image according to visible light image, and fluorescent optical filter doubling image is filtered
Light generates fluorescence picture, and fluorescence camera generates fluorescence molecule image according to fluorescence picture, and visual fusion device will be seen that optical molecule image
It is merged with fluorescence molecule image, generates fusion molecule image, the effective integration of visible light and near-infrared fluorescent may be implemented, improved
The drawbacks of current existing research, the scope of application of molecular image technology is enhanced, to extending the research field of molecular image, drop
The threshold that low molecule image is applied in biomedical sector has important meaning and value.
In addition, the spectroscopic imaging device based on molecular image of the embodiment of the present invention also uses non-spherical lens perfection to correct
Aberration, using micromatic setting ensure that visible light molecular image and fluorescence molecule image precisely overlap, and debugging is convenient.
Particular embodiments described above has carried out further in detail the purpose of the present invention, technical solution and advantageous effect
Describe in detail it is bright, it should be understood that the above is only a specific embodiment of the present invention, the guarantor being not intended to limit the present invention
Range is protected, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should be included in this
Within the protection domain of invention.
Claims (10)
1. a kind of spectroscopic imaging device based on molecular image, which is characterized in that including：
Imaging device, the Amici prism being connect with the imaging device, the visible filter being connect with the Amici prism, with
The fluorescent optical filter of the Amici prism connection, the Visible Light Camera being connect with the visible filter are filtered with the fluorescence
The fluorescence camera of mating plate connection and the visual fusion device being connect respectively with the Visible Light Camera and the fluorescence camera；
The imaging device is used to generate picture according to incident ray；
The Amici prism generates reflection image and dioptric image for being divided to the picture；
The visible filter generates visible light image for filtering to the reflection image；
The Visible Light Camera is used to generate visible light molecular image according to the visible light image；
The fluorescent optical filter generates fluorescence picture for filtering to the dioptric image；
The fluorescence camera is used to generate fluorescence molecule image according to the fluorescence picture；
The visual fusion device is used to merge the visible light molecular image and the fluorescence molecule image, generates fusion point
Sub-image.
2. the spectroscopic imaging device according to claim 1 based on molecular image, which is characterized in that further include：
The non-spherical lens being connect respectively with the imaging device and the Amici prism, the aberration for correcting the picture.
3. the spectroscopic imaging device according to claim 2 based on molecular image, which is characterized in that further include：
The first micromatic setting being connect respectively with the Amici prism and the visible filter, for adjusting the visible light
The position of camera.
4. the spectroscopic imaging device according to claim 3 based on molecular image, which is characterized in that the first fine tuning dress
Set including：
First adjusting handle, the spacing for adjusting the non-spherical lens and the Visible Light Camera；
First fastener, for being fastened to the Visible Light Camera after the completion of adjusting.
5. the spectroscopic imaging device according to claim 2 based on molecular image, which is characterized in that further include：
The second micromatic setting being connect respectively with the Amici prism and the fluorescent optical filter, for adjusting the fluorescence camera
Position.
6. the spectroscopic imaging device according to claim 5 based on molecular image, which is characterized in that the second fine tuning dress
Set including：
Up and down adjustment screw thread pair, for carrying out up and down adjustment to the fluorescence camera；
Left and right adjusting screw thread pair, for carrying out left and right adjusting to the fluorescence camera；
Second adjusting handle, the spacing for adjusting the non-spherical lens and the fluorescence camera；
Second fastener, for being fastened to the fluorescence camera after the completion of adjusting.
7. the spectroscopic imaging device according to claim 1 based on molecular image, which is characterized in that
The plated film wave band of the visible filter is：More than or equal to 440nm, it is less than or equal to 687nm.
8. the spectroscopic imaging device according to claim 1 based on molecular image, which is characterized in that
The plated film wave band of the fluorescent optical filter is：More than or equal to 810nm, it is less than or equal to 870nm.
9. the spectroscopic imaging device according to claim 1 based on molecular image, which is characterized in that
The Amici prism is five or five Amici prisms, 50% plating reflective coating, 50% plating refracting film layer.
10. the spectroscopic imaging device according to claim 2 based on molecular image, which is characterized in that
The aberration includes：Aberration, coma and spherical aberration.
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| CN201810545762.8A CN108478196A (en) | 2018-05-25 | 2018-05-25 | Spectroscopic imaging device based on molecular image |
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| CN201810545762.8A CN108478196A (en) | 2018-05-25 | 2018-05-25 | Spectroscopic imaging device based on molecular image |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111756969A (en) * | 2020-06-16 | 2020-10-09 | RealMe重庆移动通信有限公司 | Optical module and electronic equipment |
| CN113109306A (en) * | 2021-04-01 | 2021-07-13 | 合肥泰禾智能科技集团股份有限公司 | Sorting device and sorting method with aflatoxin detection function |
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