CN108477384A - One kind is for veterinary drug solid fermentation feed addictive and preparation method thereof - Google Patents
One kind is for veterinary drug solid fermentation feed addictive and preparation method thereof Download PDFInfo
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- CN108477384A CN108477384A CN201810223220.9A CN201810223220A CN108477384A CN 108477384 A CN108477384 A CN 108477384A CN 201810223220 A CN201810223220 A CN 201810223220A CN 108477384 A CN108477384 A CN 108477384A
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- fermentation
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- veterinary drug
- feed addictive
- vitamin
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- 238000000855 fermentation Methods 0.000 title claims abstract description 41
- 230000004151 fermentation Effects 0.000 title claims abstract description 41
- 239000007787 solid Substances 0.000 title claims abstract description 25
- 239000000273 veterinary drug Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 150000001413 amino acids Chemical class 0.000 claims abstract description 21
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 16
- 238000010563 solid-state fermentation Methods 0.000 claims abstract description 16
- 229940088594 vitamin Drugs 0.000 claims abstract description 15
- 229930003231 vitamin Natural products 0.000 claims abstract description 15
- 235000013343 vitamin Nutrition 0.000 claims abstract description 15
- 239000011782 vitamin Substances 0.000 claims abstract description 15
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 15
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 9
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 8
- 244000068988 Glycine max Species 0.000 claims abstract description 8
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960000304 folic acid Drugs 0.000 claims abstract description 8
- 235000019152 folic acid Nutrition 0.000 claims abstract description 8
- 239000011724 folic acid Substances 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- 235000020183 skimmed milk Nutrition 0.000 claims abstract description 8
- 102000057297 Pepsin A Human genes 0.000 claims abstract description 7
- 108090000284 Pepsin A Proteins 0.000 claims abstract description 7
- 229940111202 pepsin Drugs 0.000 claims abstract description 7
- 239000004151 Calcium iodate Substances 0.000 claims abstract description 6
- UHWJJLGTKIWIJO-UHFFFAOYSA-L calcium iodate Chemical compound [Ca+2].[O-]I(=O)=O.[O-]I(=O)=O UHWJJLGTKIWIJO-UHFFFAOYSA-L 0.000 claims abstract description 6
- 235000019390 calcium iodate Nutrition 0.000 claims abstract description 6
- 239000001963 growth medium Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 235000001014 amino acid Nutrition 0.000 claims description 19
- 239000012530 fluid Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 7
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 7
- 241000194036 Lactococcus Species 0.000 claims description 7
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 7
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 7
- 238000011081 inoculation Methods 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004472 Lysine Substances 0.000 claims description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 4
- 229930003268 Vitamin C Natural products 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 235000013922 glutamic acid Nutrition 0.000 claims description 4
- 239000004220 glutamic acid Substances 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 235000019155 vitamin A Nutrition 0.000 claims description 4
- 239000011719 vitamin A Substances 0.000 claims description 4
- 235000019154 vitamin C Nutrition 0.000 claims description 4
- 239000011718 vitamin C Substances 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 229940045997 vitamin a Drugs 0.000 claims description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004473 Threonine Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000002609 medium Substances 0.000 claims description 3
- 235000015097 nutrients Nutrition 0.000 claims description 3
- 239000008234 soft water Substances 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 9
- 244000144977 poultry Species 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 5
- 244000144972 livestock Species 0.000 abstract description 5
- 244000079386 endoparasite Species 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000001846 repelling effect Effects 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000009395 breeding Methods 0.000 abstract description 2
- 230000001488 breeding effect Effects 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 238000005265 energy consumption Methods 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 239000002207 metabolite Substances 0.000 abstract description 2
- 230000000050 nutritive effect Effects 0.000 abstract description 2
- 239000002341 toxic gas Substances 0.000 abstract description 2
- 239000000654 additive Substances 0.000 description 8
- 230000000996 additive effect Effects 0.000 description 8
- 241000287828 Gallus gallus Species 0.000 description 5
- 235000013594 poultry meat Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000019629 palatability Nutrition 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- RDEIXVOBVLKYNT-HDZPSJEVSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1r)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2 Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@@H](C)N)N)[C@@H](N)C[C@H]1N.O1[C@H]([C@@H](C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-HDZPSJEVSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 210000001669 bursa of fabricius Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 229940063650 terramycin Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
- A23V2400/249—Thermophilus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Sustainable Development (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Fodder In General (AREA)
Abstract
The invention belongs to agriculture breeding technology fields, one kind is disclosed for veterinary drug solid fermentation feed addictive and preparation method thereof, raw materials used for veterinary drug solid fermentation feed addictive is soy bean powder 30%, skimmed milk power 20%, citric acid 5%, pepsin 5%, calcium iodate 6%, folic acid 3%, amino acid 8%, vitamin 5%, honeysuckle 5%, solid-state fermentation material 13%.The veterinary drug solid fermentation feed addictive is natural, safe green, containing abundant metabolite, nutritive value is high, be capable of providing the beneficial flora needed in livestock and poultry stomach, prevent disease, inhibit animal repelling endoparasite, amino acid ratio rationally, improve immunity of livestock, reduce livestock and poultry noxious gas emission, improve poultry house environment.Preparation method culture medium prescription provided by the invention is simple, can save production cost, reduce fermentation energy consumption, fermentation production rate height, good product quality.
Description
Technical field
The invention belongs to agriculture breeding technology field, more particularly to it is a kind of for veterinary drug solid fermentation feed addictive and its
Preparation method.
Background technology
Currently, with the quickening of Development of China's Urbanization, the demand of China's animal product increases in rigidity, and feed industry is facing
It is also faced with huge challenge while new opportunity.Wherein, feed addictive has important role in livestock and poultry cultivation.It is existing
There is the characteristics of additive cannot consider animal digestion organ comprehensively so that the utilization rate of additive is low, and palatability is poor；Existing addition
Agent does not have the effect for inhibiting animal repelling endoparasite, needs in addition to feed liquid progress expelling parasite；It cannot be satisfied animal pair
The demand of various amino acid, amino acid ratio are unreasonable.
In conclusion problem of the existing technology is：Existing additive utilization rate is low, and palatability is poor；Without inhibition
The effect of animal repelling endoparasite；It cannot be satisfied demand of the animal to various amino acid.
Invention content
In view of the problems of the existing technology, the present invention provides one kind for veterinary drug solid fermentation feed addictive and its
Preparation method.
The invention is realized in this way a kind of for veterinary drug solid fermentation feed addictive and preparation method thereof, the use
It is raw materials used for soy bean powder 30%, skimmed milk power 20%, citric acid 5%, stomach egg in veterinary drug solid fermentation feed addictive
White enzyme 5%, calcium iodate 6%, folic acid 3%, amino acid 8%, vitamin 5%, honeysuckle 5%, solid-state fermentation material 13%.
Further, the addictive preparation method mainly has following steps：
Step 1, by Lactococcus, streptococcus thermophilus, lactobacillus plantarum is purebred is inoculated in culture medium respectively, at 37 DEG C
Under the conditions of, fermentation for 24 hours, obtains liquid spawn；
Step 2, inoculation 8mL liquid spawns are sent out then in 38 DEG C of ferment at constant temperature in every 100mL fluid nutrient mediums
Zymotic fluid；
Then step 3 is added in zymotic fluid and solid medium input fermentation vat soft water, protects in 40 DEG C of totally-enclosed hairs
Ferment obtains solid-state fermentation material, and then cooling down 20 degrees Celsius is drying to obtain；
Step 4, be mixed, by soy bean powder 30%, skimmed milk power 20%, citric acid 5%, pepsin 5%,
After calcium iodate 6%, folic acid 3%, amino acid 8%, vitamin 5%, honeysuckle 5% crush, it is mixed with solid-state premix equal
It is even to get finished product.
Further, the amino acid is by 20% lysine, 20% glutamic acid, 20% threonine, 20% sulfur-bearing
Amino acid, 20% tryptophan composition.
Further, the vitamin by 30% vitamin E, 25% vitamin A, 25% vitamin B2,20%
Vitamin C.
Further, the solid-state fermentation material is by Lactococcus 35%, streptococcus thermophilus 35%, lactobacillus plantarum 30%
By inoculation fermentation, by zymotic fluid, the solid-state fermentation material obtained from by totally-enclosed fermentation.
The additive of the present invention, natural, safe green, containing abundant metabolite, nutritive value is high, is capable of providing poultry
The beneficial flora that is needed in fowl stomach, prevent disease, inhibit animal repelling endoparasite, amino acid ratio rationally, improve poultry
Immunity of fowl reduces livestock and poultry noxious gas emission, improves poultry house environment.Preparation method culture medium prescription letter provided by the invention
It is single, production cost can be saved, reduce fermentation energy consumption, fermentation production rate height, good product quality.
Description of the drawings
Fig. 1 is the schematic diagram of the preparation method provided in an embodiment of the present invention for veterinary drug solid fermentation feed addictive；
Specific implementation mode
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and coordinate attached drawing
Detailed description are as follows.
The structure of the present invention is explained in detail below in conjunction with the accompanying drawings.
It is provided in an embodiment of the present invention for veterinary drug solid fermentation feed addictive it is raw materials used for soy bean powder 30%,
Skimmed milk power 20%, citric acid 5%, pepsin 5%, calcium iodate 6%, folic acid 3%, amino acid 8%, vitamin 5%, gold and silver
Spend 5% and solid-state fermentation material 13%.
The amino acid by 20% lysine, 20% glutamic acid, 20% threonine, 20% sulfur-containing amino acid,
20% tryptophan composition.The vitamin by 30% vitamin E, 25% vitamin A, 25% vitamin B2,
20% vitamin C.The solid-state fermentation material is by Lactococcus 35%, streptococcus thermophilus 35%, lactobacillus plantarum 30%
By inoculation fermentation, by zymotic fluid, the solid-state fermentation material obtained from by totally-enclosed fermentation.
As shown in Figure 1, the preparation method provided in an embodiment of the present invention for veterinary drug solid fermentation feed addictive includes
Following steps：
S101：By Lactococcus, streptococcus thermophilus, lactobacillus plantarum is purebred is inoculated in culture medium respectively, in 37 DEG C of items
Under part, fermentation for 24 hours, obtains liquid spawn；
S102：8mL liquid spawns are inoculated in every 100mL fluid nutrient mediums to be fermented then in 38 DEG C of ferment at constant temperature
Liquid.
S103：By in zymotic fluid and solid medium input fermentation vat, soft water is then added, protects in 40 DEG C of totally-enclosed hairs
Ferment obtains solid-state fermentation material, and then cooling and drying to obtain the final product.
S104：It is mixed, by soy bean powder 30%, skimmed milk power 20%, citric acid 5%, pepsin 5%, iodine
After sour calcium 6%, folic acid 3%, amino acid 8%, vitamin 5%, honeysuckle 5% crush, it is mixed evenly with solid-state premix,
It gets product.
With reference to specific embodiment, the invention will be further described.
Embodiment 1
It is provided in an embodiment of the present invention for veterinary drug solid fermentation feed addictive it is raw materials used for soy bean powder 30%,
Skimmed milk power 20%, citric acid 5%, pepsin 5%, calcium iodate 6%, folic acid 3%, amino acid 8%, vitamin 5%, gold and silver
Spend 5% and solid-state fermentation material 13%.
The honeysuckle is honeysuckle.The amino acid by 20% lysine, 20% glutamic acid, 20% Soviet Union's ammonia
Acid, 20% sulfur-containing amino acid, 20% tryptophan composition.The vitamin is by 30% vitamin E, 25% vitamin
A, 25% vitamin B2,20% vitamin C.The solid-state fermentation material is by Lactococcus 35%, streptococcus thermophilus
35%, lactobacillus plantarum 30% passes through inoculation fermentation, by zymotic fluid, the solid state fermentation obtained from by totally-enclosed fermentation
Material.
Embodiment 2
1. for trying animal：Duckling 100, is divided into 5 groups, every group 20,
2. experimental period is 14 days, wherein the 1st group of blank control group, the 2nd is additive of the present invention control group.
1st group：Blank control group does not add any drug.
2nd group：The addition present invention's is used for veterinary drug solid fermentation feed addictive, is added according to 5g/kg feeds, is used in conjunction 5
It.
3. testing index：Gain weight, feedstuff-meat ratio, infectious bursa of Fabricius vaccine antibody are horizontal.
4. the results are shown in Table 1
Table 1
As known from Table 1, duck is fed only using the present invention, gaining effect is apparent, also there is certain facilitation to antibody level.
Embodiment 3
The present invention's influences to grow for veterinary drug solid fermentation feed addictive on chicken.
1. experimental animal：1 Day-old Broiler Chickens 5000 are selected, male and female is unlimited, is randomly divided into 5 groups, every group 1000, carries out mark
Note, subfield raising；
2. culturing feed：5 groups of difference label Y1 eat the additive of embodiment 1, Y2 blank control groups, do not add the present invention
Additive, above two groups are added 1% in daily scale of feeding kind respectively, diet feed；
3. it is identical to feed way to manage；
To the influence of chicken growth result after 4.30 days, it is shown in Table 2
From 2 kinds of table as can be seen that the additive meat feed ratio of the addition present invention is significantly less than the broiler chicken that chow diet is fed, but
It increases day by day great, the death rate is low, good economical benefit, when comparing per column, can be clearly felt that the henhouse foul smell of common feeding feed
Taste is maximum, illustrates that terramycin 45%, gentamicin sulphate 30%, honeysuckle can also play work to improving raising sterilized environment
With.The death rate is low to illustrate that broiler chicken immune system enhances, and to reduce aquaculture cost, increases economic efficiency.
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form,
Every any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to
In the range of technical solution of the present invention.
Claims (5)
1. one kind being used for veterinary drug solid fermentation feed addictive, which is characterized in that described to be added for veterinary drug solid fermentation feed
Agent is raw materials used for soy bean powder 30%, skimmed milk power 20%, citric acid 5%, pepsin 5%, calcium iodate 6%, folic acid
3%, amino acid 8%, vitamin 5%, honeysuckle 5% and solid-state fermentation material 13%.
2. a kind of preparation method being used for veterinary drug solid fermentation feed addictive as described in claim 1, which is characterized in that described
Preparation method for veterinary drug solid fermentation feed addictive includes the following steps：
Step 1, by Lactococcus, streptococcus thermophilus, lactobacillus plantarum is purebred is inoculated in culture medium respectively, in 37 DEG C of conditions
Under, fermentation for 24 hours, obtains liquid spawn；
Step 2, inoculation 8mL liquid spawns are fermented then in 38 DEG C of ferment at constant temperature in every 100mL fluid nutrient mediums
Liquid；
Then step 3 is added in zymotic fluid and solid medium input fermentation vat soft water, protects in 40 DEG C of totally-enclosed fermentations,
Obtain solid-state fermentation material, then cooling and drying to obtain the final product；
Step 4 is mixed, by soy bean powder 30%, skimmed milk power 20%, citric acid 5%, pepsin 5%, acid iodide
After calcium 6%, folic acid 3%, amino acid 8%, vitamin 5%, honeysuckle 5% crush, it is mixed evenly with solid-state premix, i.e.,
Obtain finished product.
3. being used for the preparation method of veterinary drug solid fermentation feed addictive as claimed in claim 2, which is characterized in that described
Amino acid by 20% lysine, 20% glutamic acid, 20% threonine, 20% sulfur-containing amino acid, 20% tryptophan group
At.
4. being used for the preparation method of veterinary drug solid fermentation feed addictive as claimed in claim 2, which is characterized in that described
Vitamin is by 30% vitamin E, 25% vitamin A, 25% vitamin B2,20% vitamin C.
5. being used for the preparation method of veterinary drug solid fermentation feed addictive as claimed in claim 2, which is characterized in that described
Solid-state fermentation material is to pass through inoculation fermentation by Lactococcus 35%, streptococcus thermophilus 35%, lactobacillus plantarum 30%, through everfermentation
Liquid, the solid-state fermentation material obtained from by totally-enclosed fermentation.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105285337A (en) * | 2015-11-27 | 2016-02-03 | 闫桃 | Feed additive for anthony pigs and preparation method of feed additive |
| CN105395585A (en) * | 2015-12-14 | 2016-03-16 | 暨南大学 | Application of elephantopus plant extract in preparation of veterinary drugs or feed additives |
-
2018
- 2018-03-19 CN CN201810223220.9A patent/CN108477384A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105285337A (en) * | 2015-11-27 | 2016-02-03 | 闫桃 | Feed additive for anthony pigs and preparation method of feed additive |
| CN105395585A (en) * | 2015-12-14 | 2016-03-16 | 暨南大学 | Application of elephantopus plant extract in preparation of veterinary drugs or feed additives |
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