CN108472255A - 调节胞质dna监测分子的方法 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Biochemistry (AREA)
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US201562185230P | 2015-06-26 | 2015-06-26 | |
| US62/185230 | 2015-06-26 | ||
| PCT/EP2016/064613 WO2016207314A2 (en) | 2015-06-26 | 2016-06-23 | Methods of modulating cytosolic dna surveillance molecules |
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| CN108472255A true CN108472255A (zh) | 2018-08-31 |
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| WO2016081911A2 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| EP3490598A1 (en) | 2016-07-26 | 2019-06-05 | Bayer Animal Health GmbH | Increased fertility in bovine species |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
Citations (4)
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|---|---|---|---|---|
| WO1999066879A2 (en) * | 1998-06-25 | 1999-12-29 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| US6194388B1 (en) * | 1994-07-15 | 2001-02-27 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| EP1326969A2 (en) * | 2000-09-25 | 2003-07-16 | Valentis Inc. | Improved system for regulation of transgene expression |
| CN103501810A (zh) * | 2010-12-22 | 2014-01-08 | 拜耳知识产权有限责任公司 | 牛物种中增强的免疫应答 |
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| US155950A (en) * | 1874-10-13 | Improvement in hand-saws | ||
| EP1003531B1 (en) * | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| AU2002953015A0 (en) * | 2002-12-02 | 2002-12-12 | Women's And Children's Hospital | Modified lacz gene |
| WO2005033265A2 (en) * | 2003-04-25 | 2005-04-14 | Epimmune Inc. | Optimized multi-epitope constructs and uses thereof |
| CL2004001293A1 (es) * | 2003-05-29 | 2005-05-06 | Schering Plough Ltd | Composicion farmaceutica que comprende compuestos antibacterianos como florfenicol, tiamfenicol, cloramfenicol en combinacion con al menos un portador seleccionado de triacetina, dimetilacetamida o una mezcla de ellas; y su uso en el tratamiento de u |
| EP1786461A4 (en) * | 2004-08-13 | 2010-03-03 | Univ Pennsylvania | ANTIBIOTICINESIS-FREE DNA VACCINES |
| AU2005271246A1 (en) * | 2004-08-13 | 2006-02-16 | The Trustees Of The University Of Pennsylvania | Methods for constructing antibiotic resistance free vaccines |
| US20120064151A1 (en) * | 2009-05-14 | 2012-03-15 | Bayer Animal Health Gmbh | Enhanced immune response in avian species |
| BR112013029968A2 (pt) * | 2011-05-26 | 2017-01-31 | Intervet Int Bv | oligodesoxinucleotídeo imunoestimulatório não metilado, vetor, vacina para prevenir ou combater uma doença infecciosa, e, método para a detecção de oligodesoxinucleotídeos imunoestimulatórios |
| AR091569A1 (es) * | 2012-06-28 | 2015-02-11 | Intervet Int Bv | Receptores de tipo toll |
| MX2016010993A (es) * | 2014-02-28 | 2017-05-01 | Bayer Animal Health Gmbh | Plasmidos inmunoestimuladores. |
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- 2016-06-23 CA CA2990526A patent/CA2990526A1/en not_active Abandoned
- 2016-06-23 SG SG10201913395VA patent/SG10201913395VA/en unknown
- 2016-06-23 RU RU2018102915A patent/RU2018102915A/ru not_active Application Discontinuation
- 2016-06-23 HK HK18115209.5A patent/HK1256128A1/zh unknown
- 2016-06-23 AU AU2016282879A patent/AU2016282879A1/en not_active Abandoned
- 2016-06-24 TW TW105120099A patent/TW201710509A/zh unknown
- 2016-06-27 UY UY0001036756A patent/UY36756A/es not_active Application Discontinuation
- 2016-06-28 AR ARP160101937A patent/AR105160A1/es not_active Application Discontinuation
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2017
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194388B1 (en) * | 1994-07-15 | 2001-02-27 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| WO1999066879A2 (en) * | 1998-06-25 | 1999-12-29 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| EP1326969A2 (en) * | 2000-09-25 | 2003-07-16 | Valentis Inc. | Improved system for regulation of transgene expression |
| CN103501810A (zh) * | 2010-12-22 | 2014-01-08 | 拜耳知识产权有限责任公司 | 牛物种中增强的免疫应答 |
Non-Patent Citations (4)
| Title |
|---|
| GHANIA CHIKH等: ""Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles"", 《INTERNATIONAL IMMUNOLOGY,》 * |
| KOUJI KOBIYAMA等: ""Innate ImmuneGenetic Adjuvants for DNA VACCINES"", 《VACCINES》 * |
| M .RERAT等: ""Bovine respiratorydisease:Efficacy of different prophylactic treatments in veal calves and antimicrobial resistance of isolated Pasteurellaceae"", 《PREUENTIUE VETERINARY MEDICINE》 * |
| MARIJKE KEESTRA等: ""Chicken TLR21is an innate CpG DNA receptor distinctfrom mammalian TLR9"", 《THE JOURNAL OF IMMUNOLOGY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| PH12017502413A1 (en) | 2018-06-25 |
| AR105160A1 (es) | 2017-09-13 |
| UY36756A (es) | 2017-01-31 |
| PE20181208A1 (es) | 2018-07-23 |
| CL2017003373A1 (es) | 2018-06-29 |
| AU2016282879A1 (en) | 2018-01-18 |
| TW201710509A (zh) | 2017-03-16 |
| BR112017028121A2 (pt) | 2018-09-04 |
| MX2017017141A (es) | 2018-03-09 |
| WO2016207314A3 (en) | 2017-02-09 |
| EP3313376A2 (en) | 2018-05-02 |
| CR20180003A (es) | 2018-03-20 |
| CA2990526A1 (en) | 2016-12-29 |
| DOP2017000313A (es) | 2018-02-28 |
| KR20180021874A (ko) | 2018-03-05 |
| WO2016207314A2 (en) | 2016-12-29 |
| RU2018102915A (ru) | 2019-07-29 |
| RU2018102915A3 (cg-RX-API-DMAC7.html) | 2019-12-05 |
| HK1256128A1 (zh) | 2019-09-13 |
| IL256264A (en) | 2018-02-28 |
| US20190233825A1 (en) | 2019-08-01 |
| SG10201913395VA (en) | 2020-03-30 |
| JP2018518511A (ja) | 2018-07-12 |
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